Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.

Abstract: The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or second surface. The invention also relates to corresponding methods for the detection of particles.

Abstract: The present invention concerns a compound of formula (I) or a salt, suitably a pharmaceutically acceptable salt, or solvate thereof, wherein the groups R1, R2, Ar?, A and B are defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.

Abstract: The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or second surface. The invention also relates to corresponding methods for the detection of particles.

Abstract: The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or the second surface.

Abstract: A method of calibrating a position sensor in an automotive transmission having a transmission housing having mounted therein a casing (10) for the position sensor which includes a pressure member (14) movably supported in the casing (10), and an electrical displacement sensor (38) actuated by the pressure member (14) for measuring the position of the pressure member (14) relative to the casing (10), such that, after the casing (10) of the position sensor has been mounted in the transmission housing, the displacement sensor (38) is used for performing at least one calibration measurement for at least one gear position, and, for each gear position to be detected, a tolerance range for the corresponding measurement value of the displacement sensor is defined on the basis of the result of the calibration measurement.

Abstract: A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative for the presence and/or amount of the target molecules, a microfluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the microfluidic network.

Abstract: The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or quantitative detection of analytes, comprising a microarray on a substrate, onto which probe molecules are immobilized on array elements, said microarray being disposed on a first surface of the device; and a detection chamber formed between the first surface including the microarray disposed thereon and a second surface, wherein the distance between the microarray and the second surface is variable, and wherein the second surface has a displacement structure.

Abstract: The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or the second surface.

Abstract: A compound of formula (I), wherein substituents are as given above, useful in the treatment of a disease mediated by the action of CCR3, in particular inflammatory or obstructive airway diseases.

Abstract: The use of a metathesis catalyst in the preparation of a functionalized sphingolipid.

Abstract: The use of compound of formula I in the preparation of a medicament, e.g. for the treatment of condition mediated by CCR3.

Abstract: The invention specifies a blister pack (1) with a radio-frequency identification device (2, 2?) which comprises—a support body (3) which is made of flat plastic material and which has a plurality of depressions (5), produced from deforming this material, within a planar region (4) for the purpose of holding the packed goods,—an aluminium sealing foil (7) which is connected flat to the planar region (4) of the support body (3), and—a radio-frequency identification device (2, 2?) which is fitted in the region (8) of the support body (3) which projects over the aluminium sealing foil (7).

Abstract: A case or bag for holding items has a basic body that is defined by wall elements and a floor element. The basic body has opening that can be closed by a lid element that is disposed on the basic body and can be moved out of an open position into a closed position. The lid element is configured in one piece and with inherent rigidity and can be moved out of its closed position into the open position by interacting guide elements disposed on the basic body and on the lid element through a combined pivoting and displacing movement.

Abstract: The invention relates to devices and methods for the detection of specific interactions between probe and target molecules. In particular, the invention relates to methods for the qualitative and/or quantitative detection of targets, including: introducing a sample containing targets into a reaction chamber formed between a first surface of the device and a second surface of a device, which is preferably located opposite to the first surface, wherein the distance between the first and the second surface is variable; and detecting the targets.

Abstract: The invention relates to a holding device for substance libraries which can be used, more particularly, for the detection of target molecules with the aid of substance libraries. Said device comprises: (i) a holder for a substance library carrier; (ii) a substance library carrier, which can be fixed to the holder; and (iii) a detection area applied to the substance library carrier, whereon a substance library is immobilized; and wherein at least one substance library carrier can be introduced into a laboratory reaction vessel.

Abstract: The present invention relates to a device for the amplification and for the detection of nucleic acids comprising a temperature controlling and/or regulating unit; a reaction chamber containing a support with a detection area, on which a compound library is immobilized, wherein the temperature in the reaction chamber can be controlled and/or regulated by means of the temperature controlling and regulating unit; and an optical system, by means of which the time-dependent behavior of precipitate formations on the detection area is detectable. Methods of using the device are also disclosed.

Abstract: Disclosed are devices for holding a substance library carrier, and which are useful in conducting reactions in which binding between complementary molecules is measured qualitatively or quantitatively. Also disclosed are methods for conducting such reactions in the device.

Abstract: Disclosed is a method for qualitative and/or quantitative detection of nucleic acid molecules amplified in an amplification reaction such as PCR. The change of the mass of oligonucleotides in an amplification solution, comprising the mass of target DNA and optionally, the mass of oligonucleotide primers, is determined during the amplification reaction. Also disclosed is a device for conducting the method.