Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

Abstract: A valve assembly for integration within a wellbore string is provided. The valve assembly has a valve housing with a housing port, a bottom sleeve mounted and slidable within the valve housing between closed and open positions, and a top sleeve mounted within the valve housing and defining an annular region therebetween. The top sleeve has a sleeve port and is slidable within the valve housing between a first position where the top sleeve engages the valve housing and defines an annular chamber within the annular region, and a production position where the sleeve port is in fluid communication with the housing port to define a fluid pathway along which fluids flow from the reservoir through the annular chamber. While in the first position, the annular chamber has an inlet allowing fluid to flow into and pressurize the annular chamber to prevent particulates from flowing into the annular region.

Abstract: A valve assembly for disposition within a subterranean reservoir is provided. The valve assembly includes a valve housing defining a fluid passage, and a housing outlet for establishing fluid communication between the fluid passage and the reservoir. The valve assembly further includes a valve sleeve displaceable between closed and open positions for controlling fluid communication between the fluid passage and the reservoir. The valve assembly also includes a hydraulic actuator operable to displace the valve sleeve, the hydraulic actuator including a hydraulic fluid container and a pump.

Abstract: Disclosed herein is a robot of a robotic system for moving objects such as packages, containers, totes, cases, bins, and/or boxes in a site, such as a warehouse, for fulfillment automation. The robot includes a base, a lift mechanism, and an object transitioning apparatus. The lift mechanism is coupled to the base. The lift mechanism is configured to vertically displace the object transitioning apparatus, relative to the base. The object transitioning apparatus includes an object manipulator for grasping an object. The object manipulator includes an extendible arm and an end effector for grasping the object. Lateral displacement of the end effector is effected by extension and retraction of the extendible arm. The extendible arm is laterally extendible, relative to the base, in a first direction, and also in a second direction that is opposite the first direction.

Abstract: There is provided a flow control apparatus configured for integration within a wellbore string disposed within a wellbore extending into a subterranean formation and useable for effecting production of hydrocarbon material by providing flow communication for injection of treatment material for stimulating the reservoir and then receiving hydrocarbon material from the stimulated reservoir, and also for effecting production of hydrocarbon material by providing flow communication for injection of a displacement fluid for displacing hydrocarbon material to a second wellbore.

Abstract: There is provided a downhole tool comprising a locator. The locator includes a wellbore coupler for becoming releasably retained relative to a locate profile; and a wellbore coupler release opposer configured for opposing release of the wellbore coupler from the retention relative to the locate profile. While the opposing of the release of the wellbore coupler from the retention relative to the locate profile is being effected by the wellbore coupler release opposer, relative displacement between the wellbore coupler release opposer and the wellbore coupler is effectible, with effect that the opposing is defeated. The locator also includes a displacement impeder for impeding the relative displacement between the wellbore coupler release opposer and the wellbore coupler.

Abstract: The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.

Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

Abstract: There is provided a flow control apparatus configured for integration within a wellbore string disposed within a wellbore extending into a subterranean formation and useable for effecting production of hydrocarbon material by providing flow communication for injection of treatment material for stimulating the reservoir and then receiving hydrocarbon material from the stimulated reservoir, and also for effecting production of hydrocarbon material by providing flow communication for injection of a displacement fluid for displacing hydrocarbon material to a second wellbore.

Abstract: Apparatuses, systems and methods for controlling production of hydrocarbon material disposed within a subterranean formation are provided. In one aspect, a method is provided for producing hydrocarbon material by displacement via flow communication station of a production well. Working states of the production well are analyzed by setting the flow communication stations in the working state, producing hydrocarbon material while in the working state, and sensing a characteristic of the produced material while in the working state. A working state that optimizes operating parameters of the of the production well is determined based on the sensed characteristic, and the production well is subsequently operated in that working state.

Abstract: There is provided a flow control apparatus configured for integration within a wellbore string disposed within a wellbore extending into a subterranean formation and useable for effecting production of hydrocarbon material by providing flow communication for injection of treatment material for stimulating the reservoir and then receiving hydrocarbon material from the stimulated reservoir, and also for effecting production of hydrocarbon material by providing flow communication for injection of a displacement fluid for displacing hydrocarbon material to a second wellbore.

Abstract: There is provided a downhole tool comprising a locator. The locator includes a wellbore coupler for becoming releasably retained relative to a locate profile; and a wellbore coupler release opposer configured for opposing release of the wellbore coupler from the retention relative to the locate profile. While the opposing of the release of the wellbore coupler from the retention relative to the locate profile is being effected by the wellbore coupler release opposer, relative displacement between the wellbore coupler release opposer and the wellbore coupler is effectible, with effect that the opposing is defeated. The locator also includes a displacement impeder for impeding the relative displacement between the wellbore coupler release opposer and the wellbore coupler.

Abstract: A flow control apparatus is provided comprising: a housing including a port; a housing passage disposed within the housing; a flow control member, displaceable, relative to the port, for effecting opening of the port; and a co-operating member. The flow control member and the co-operating member are co-operatively configured such that displacement of the flow control member, relative to the port, is with effect that a force is applied by the flow control member to the co-operating member, with effect that a seating surface is obtained for receiving a flow communication interference body that is being conducted through the housing passage. The seating surface is obtained in response to a deformation effected by the applied force.

Abstract: There is provided a flow control apparatus configured for optimizing use of available space within the wellbore for conducting of fluids between the surface and the subterranean formation. The flow control apparatus is useable for conducting all forms of fluid, such as, for example, liquids, gases, or mixtures of liquids and gases. As well, the flow control apparatus is useable for effecting injection of fluid (e.g. a fluid for stimulating hydrocarbon production via a drive process, such as, for example, waterflooding, or via a cyclic process, such as “huff and puff”) into the subterranean formation, and for receiving production of fluid (e.g. hydrocarbon material) from the subterranean formation (including production that is stimulated by gas lift).

Abstract: There is provided a downhole tool comprising a locator. The locator includes a wellbore coupler for becoming releasably retained relative to a locate profile; and a wellbore coupler release opposer configured for opposing release of the wellbore coupler from the retention relative to the locate profile. While the opposing of the release of the wellbore coupler from the retention relative to the locate profile is being effected by the wellbore coupler release opposer, relative displacement between the wellbore coupler release opposer and the wellbore coupler is effectible, with effect that the opposing is defeated. The locator also includes a displacement impeder for impeding the relative displacement between the wellbore coupler release opposer and the wellbore coupler.

Abstract: There is provided a plurality of injection stations, wherein each one of the injection stations, independently, comprising: a housing; a port extending through the housing; a flow control member configured for displacement for effecting at least opening of the port such that, when the injection station is integrated within a wellbore string that is disposed within a wellbore of a subterranean formation, and treatment fluid is being supplied through a wellbore string passage of the wellbore string, injection of the supplied treatment fluid into the subterranean formation is effected through the port; and a deployable seat, mounted to the housing, and including an aperture, and configured such that, when the seat is deployed in a deployed position, the seat is configured for receiving a respective plug for seating of the respective plug over the aperture of the seat; such that a plurality of plugs are respective to the injection stations, wherein each one of the plugs is respective to a deployable seat of a one

Abstract: There is provided a flow control apparatus configured for integration within a wellbore string disposed within a wellbore extending into a subterranean formation and useable for effecting production of hydrocarbon material by providing flow communication for injection of treatment material for stimulating the reservoir and then receiving hydrocarbon material from the stimulated reservoir, and also for effecting production of hydrocarbon material by providing flow communication for injection of a displacement fluid for displacing hydrocarbon material to a second wellbore.

Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

Abstract: Apparatuses, systems and methods for producing hydrocarbon material from a subterranean formation using a displacement process are disclosed. In one aspect, there is provided a method of controlling hydrocarbon production of hydrocarbon material disposed within a subterranean formation by a displacement process via a plurality of flow communication stations of an injection well. Characteristics of a supplied production-initiating fluid are determined uphole of the flow communication stations for a plurality of states of the injection well, wherein in each of the states of the injection well a different subset of the flow communication stations are disposed in an opened condition and a different subset of the flow communication stations are disposed in a closed condition. Characteristics may be determined at the surface, for example, at the wellhead. A state of the injection well that optimizes one or more operating parameters is determined.