Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

Abstract: Apparatuses, systems and methods for producing hydrocarbon material from a subterranean formation using a displacement process are disclosed. In one aspect, there is provided a method of controlling hydrocarbon production of hydrocarbon material disposed within a subterranean formation by a displacement process via a plurality of flow communication stations of an injection well. Characteristics of a supplied production-initiating fluid are determined uphole of the flow communication stations for a plurality of states of the injection well, wherein in each of the states of the injection well a different subset of the flow communication stations are disposed in an opened condition and a different subset of the flow communication stations are disposed in a closed condition. Characteristics may be determined at the surface, for example, at the wellhead. A state of the injection well that optimizes one or more operating parameters is determined.

Abstract: The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.

Abstract: The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.

Abstract: Apparatuses, systems and methods for producing hydrocarbon material from a subterranean formation using a displacement process are disclosed. In one aspect, there is provided a method of controlling hydrocarbon production of hydrocarbon material disposed within a subterranean formation by a displacement process via a plurality of flow communication stations of an injection well. Characteristics of a supplied production-initiating fluid are determined uphole of the flow communication stations for a plurality of states of the injection well, wherein in each of the states of the injection well a different subset of the flow communication stations are disposed in an opened condition and a different subset of the flow communication stations are disposed in a closed condition. Characteristics may be determined at the surface, for example, at the wellhead. A state of the injection well that optimizes one or more operating parameters is determined.

Abstract: A method of optimizing operation one or more tubing strings in a hydrocarbon well, apparatus and system for same. Each tubing string is located in a hydrocarbon well and has a plurality of valves. Each valve is actuatable between a fully open position and a fully closed position, and is in communication with a respective zone of a formation defining a reservoir containing hydrocarbon material.

Abstract: A downhole tool deployable within a wellbore for controlling the supply of treatment to fluid to a reservoir is disclosed. The downhole tool includes a housing defining a passage and a port extending through the housing. The housing includes a seat that is configured for displacement into a plug-receiving position for receiving a plug that is deployed through the passage. A key profile for effecting actuation of the seat to the plug-receiving position in response to registration of the key profile with a matching key on the plug being deployed through the passage is provided. The downhole tool further includes a flow control member configured for displacement relative to the port in response to application of a sufficient net force effected by a fluid pressure differential that is created by supplying pressurized fluid to the passage while the plug is deployed on the seat.

Abstract: A discectomy instrument for use with a cutting tool including a flexible shaft and an implement extending from the shaft generally includes a guard including a shaft and a foot extending therefrom, wherein the foot has a port and a plurality of teeth. The instrument also includes a guide including a rod, a finger extending from the rod, and an actuator operably connected to the finger such that the finger is adjustable via the actuator. The instrument further includes a sheath including at least one channel, wherein, when the guide and the sheath are coupled to the guard, the channel aligns with the port to permit insertion of the implement through the port via the channel.

Abstract: In one aspect, there is provided a flow control apparatus comprising a confirmation profile that is establishable, in response to completion of a wellbore operation that has changed a condition of the flow control apparatus, for releasably retaining an indicator tool that is being displaced within the wellbore via a workstring.

Abstract: A bottomhole assembly for deployment within a wellbore string disposed within a wellbore. The assembly comprises a first mandrel; a second mandrel including a locator for becoming disposed within a locate profile of the wellbore string; a shifting tool including a first gripper surface and a second gripper surfaces; a first shifting tool actuator and a second shifting tool actuator that are translatable with the first mandrel. The shifting tool is displaceable in response to urging by the first shifting tool actuator and the second shifting tool actuator to become disposed in gripping engagement with a flow control member. The second mandrel includes a retainer for limiting displacement of the shifting tool, relative to second mandrel, in both downhole and uphole directions.

Abstract: There is provided a plurality of injection stations, wherein each one of the injection stations, independently, comprising: a housing; a port extending through the housing; a flow control member configured for displacement for effecting at least opening of the port such that, when the injection station is integrated within a wellbore string that is disposed within a wellbore of a subterranean formation, and treatment fluid is being supplied through a wellbore string passage of the wellbore string, injection of the supplied treatment fluid into the subterranean formation is effected through the port; and a deployable seat, mounted to the housing, and including an aperture, and configured such that, when the seat is deployed in a deployed position, the seat is configured for receiving a respective plug for seating of the respective plug over the aperture of the seat; such that a plurality of plugs are respective to the injection stations, wherein each one of the plugs is respective to a deployable seat of a one

Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

Abstract: This disclosure generally relates to systems and methods that facilitate transitioning a current playback of a video in a video application to a video widget when the video application is moved to a background of a multitasking operating system in which the video application is executing. The transition occurs seamlessly at a point of the current playback in the video application when the video application is moved to the background. Furthermore, upon the video application being moved to the foreground of the multitasking operating system, current playback of the video in the video widget is seamlessly transitioned to the video application.

Abstract: There is provided a downhole tool comprising a locator. The locator includes a wellbore coupler for becoming releasably retained relative to a locate profile; and a wellbore coupler release opposer configured for opposing release of the wellbore coupler from the retention relative to the locate profile. While the opposing of the release of the wellbore coupler from the retention relative to the locate profile is being effected by the wellbore coupler release opposer, relative displacement between the wellbore coupler release opposer and the wellbore coupler is effectible, with effect that the opposing is defeated. The locator also includes a displacement impeder for impeding the relative displacement between the wellbore coupler release opposer and the wellbore coupler.

Abstract: Systems and methods that automatically identify and extract or distinguish sub-conversations within a live chat session, are provided. In an aspect, a system includes a reception component configured to receive comments associated with a common topic, wherein the comments are displayed via a first graphical user interface. The system further includes an identification component configured to identify a subset of the comments associated with a sub-topic within the common topic, wherein in response to identification of the subset of comments, the subset of comments are distinguished among the comments as displayed via the first graphical user interface or another graphical user interface.

Abstract: A method for displaying content between loops of a looping media item is provided herein. The method includes receiving a request for a primary media item and determining that the requested primary media item is a looping media item. The method further includes identifying a secondary media item for the primary media item, and providing the primary media item and the secondary media item for presentation between loops of the primary media item.

Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

Abstract: This disclosure generally relates to systems and methods that facilitate transitioning a current playback of a video in a video application to a video widget when the video application is moved to a background of a multitasking operating system in which the video application is executing. The transition occurs seamlessly at a point of the current playback in the video application when the video application is moved to the background. Furthermore, upon the video application being moved to the foreground of the multitasking operating system, current playback of the video in the video widget is seamlessly transitioned to the video application.

Abstract: There is provided a downhole tool comprising a locator. The locator includes a wellbore coupler for becoming releasably retained relative to a locate profile; and a wellbore coupler release opposer configured for opposing release of the wellbore coupler from the retention relative to the locate profile. While the opposing of the release of the wellbore coupler from the retention relative to the locate profile is being effected by the wellbore coupler release opposer, relative displacement between the wellbore coupler release opposer and the wellbore coupler is effectible, with effect that the opposing is defeated. The locator also includes a displacement impeder for impeding the relative displacement between the wellbore coupler release opposer and the wellbore coupler.

Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.