Abstract: Example medical device loading devices are disclosed. An example loading device for a stent-valve includes an elongated body having a proximal end region, a distal end region and a lumen extending therein. The loading device also includes a collar coupled to the distal end region of the body, the collar including first end region, a second end region and a lumen extending therein. Further, the loading device includes a first compression assembly coupled to the collar, wherein the first compression assembly is configured to shift between a first position a second position. The loading device also includes a second compression assembly coupled to the collar, wherein the second compression assembly is configured to shift between a third position and a fourth position.

Abstract: An improved guidewire may include an elongate shaft including a distal section and a proximal section extending proximally from the distal section. The elongate shaft includes a coiled portion disposed within the distal section. The coiled portion is curved in a first direction in a first plane. The elongate shaft includes a reverse curve portion curved in a second direction opposite the first direction. The reverse curve portion is disposed proximal of the coiled portion. A kit for forming the improved guidewire may include a guidewire having a coiled portion and a forming tool configured to form a reverse curve portion in the guidewire proximal of the coiled portion.

Abstract: A storage reclamation orchestrator is implemented to identify and recover unused storage resources on a storage system. The storage reclamation orchestrator analyses storage usage attributes of storage groups occupying storage resources of the storage system. The storage reclamation orchestrator assigns individual usage point values to each storage usage attribute of a given storage group. The individual usage point values are combined to assign a final usage point value to the storage group. Storage groups with usage point values above a threshold are candidate storage groups for recovery on the storage system. Example storage usage attributes include whether the storage group has been masked to a host device, an amount of time since IO activity has occurred on the storage group, an amount of time since local protection was implemented on the storage group, and an amount of time since remote protection was implemented on the storage group.

Abstract: A master profile may be created defining a plurality of values for a plurality of storage system parameters. The master profile may be stored and applied to a plurality of storage systems. In some embodiments, one or more values defined in the master profile may be changed and the resulting plurality of parameter values stored in a new master profile. Current values of storage system parameters may be monitored, for example, determined according to a predefined schedule or in response to user input, and the current values may be compared against the values defined in the master profiles. The results of these comparisons may be recorded as part of compliance information that indicates the extent of compliance of the parameter values of a storage system with the master profile parameter values. The compliance information may be included as part of a compliance report, notification or some other communication.

Abstract: A balloon valvuloplasty catheter may include an elongate shaft having a guidewire lumen and a device lumen extending longitudinally therein, an expandable balloon secured to a distal portion of the elongate shaft, and an intravascular ultrasound catheter slidably disposed within the device lumen. The device lumen is in fluid communication with an interior of the expandable balloon. A method of preparing a native aortic heart valve of a patient's heart for transcatheter aortic valve replacement may include using the balloon valvuloplasty to observe via intravascular ultrasound and evaluate a position of the native leaflets relative to the left and right coronary artery ostia to determine if the native leaflets block the left coronary artery ostium and/or the right coronary artery ostium when the expandable balloon is inflated.

Abstract: A medical device system may include a delivery device including an outer sheath and an inner shaft having a coupler fixed to a distal end of the inner shaft; and a replacement heart valve implant releasably attached to the coupler. The replacement heart valve implant may include an expandable anchor member defining a central longitudinal axis; and a locking mechanism attached to the expandable anchor member, the locking mechanism being configured to engage with the coupler. The delivery device may include a collar configured to releasably secure the coupler to the locking mechanism.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example device may include an elongate shaft having a distal end region. An expandable framework may be disposed adjacent to the distal end region. An ultraviolet light-emitting member may be disposed within the expandable framework. A covering may be disposed along an outer surface of the expandable framework.

Abstract: A radiopaque anchor and delivery device system may comprise a pigtail catheter and a radiopaque anchor. The pigtail catheter may be a dual lumen catheter configured to deploy the radiopaque anchor and delivery a radiopaque fluid or contrast agent. The implantable radiopaque anchor may be slidably disposed within and deployable from a lumen of the elongate shaft.

Abstract: Methods and systems for securing a medical implant at a valve. An illustrative method may include advancing a delivery system though a vasculature to a target location. At the target location, the delivery system may be proximally retracted to expose a medical implant carried within a lumen of the delivery system. The medical implant may be radially expanded from a collapsed delivery configuration an expanded deployed configuration. A fixation mechanism delivery system may be advanced through the vasculature to the target location. A first fixation mechanism configured to engage a native tissue and a portion of the medical implant may be deployed from the fixation mechanism delivery system. After deploying the fixation mechanism, the medical implant may be released from the delivery system.

Abstract: A medical device system may include a delivery device including an outer sheath and an inner shaft having a coupler fixed to a distal end of the inner shaft, and a replacement heart valve implant releasably attached to the coupler, the replacement heart valve implant including an expandable anchor member and a plurality of locking mechanisms configured to engage with the coupler. The delivery device may include a plurality of collars configured to secure the coupler to the plurality of locking mechanisms. The delivery device may include a stop element configured to selectively prevent disengagement of the plurality of collars from the plurality of locking mechanisms.

Abstract: A system for treating mitral regurgitation may include an outer sheath having a lumen extending to a distal end of the outer sheath, an intermediate sheath slidably disposed within the lumen of the outer sheath, the intermediate sheath having a lumen extending to a distal end of the intermediate sheath, and an inner sheath slidably disposed within the lumen of the intermediate sheath, wherein the inner sheath includes a first anchor disposed within a lumen of the inner sheath, the first anchor being configured to penetrate and secure to a first papillary muscle. The intermediate sheath may include a tissue grasping mechanism at the distal end of the intermediate sheath, the tissue grasping mechanism being configured to hold and stabilize the first papillary muscle for penetration and securement of the first anchor to the first papillary muscle.

Abstract: A mitral valve leaflet repair system may include a delivery catheter having at least one lumen extending proximally from a distal end of the delivery catheter, a plurality of anchor elements disposed within the at least one lumen, each of the plurality of anchor elements being configured to extend through one layer of mitral valve leaflet tissue, and a securing element configured to secure at least two of the plurality of anchor elements together on one side of the mitral valve leaflet tissue. The at least one lumen may include a suction lumen configured to grasp a mitral valve leaflet prior to extending the plurality of anchor elements through one layer of mitral valve leaflet tissue.

Abstract: Disclosed is a reinforced hose comprising a pressure sleeve concentrically installed over an outer surface of the hose tubing, either above or below the ferrule. An inner diameter of the pressure sleeve is larger than an outer diameter of the hose tubing and the first terminal end of the pressure sleeve is longitudinally aligned with the first open end of the hose tubing. The longitudinal length of the pressure sleeve is greater than that of the ferrule and extends beyond a proximal end of the ferrule. A first interference joint couples the outer surface of the hose tubing to an inner surface of the pressure sleeve, the first interference joint comprising a contact patch located between the second terminal end of the pressure sleeve and the proximal end of the ferrule.

Abstract: Device sand methods for improving cardiac function are provided. The device includes a dome structure having a top end with an engagement element disposed thereon. The dome structure is moveable from a first inside out configuration to a second deployed configuration, and the dome structure is biased in the second deployed configuration. The dome structure includes a plurality of anchor members disposed around a bottom open end of the dome structure.

Abstract: A system for treating mitral regurgitation may include an outer sheath having a lumen extending to a distal end of the outer sheath, an intermediate sheath slidably disposed within the lumen of the outer sheath, the intermediate sheath having a lumen extending to a distal end of the intermediate sheath, and an inner sheath slidably disposed within the lumen of the intermediate sheath, wherein the inner sheath includes a first anchor disposed within a lumen of the inner sheath, the first anchor being configured to penetrate and secure to a first papillary muscle. The intermediate sheath may include a tissue grasping mechanism at the distal end of the intermediate sheath, the tissue grasping mechanism being configured to hold and stabilize the first papillary muscle for penetration and securement of the first anchor to the first papillary muscle.

Abstract: A mitral valve leaflet repair system may include a delivery catheter having at least one lumen extending proximally from a distal end of the delivery catheter, a plurality of anchor elements disposed within the at least one lumen, each of the plurality of anchor elements being configured to extend through one layer of mitral valve leaflet tissue, and a securing element configured to secure at least two of the plurality of anchor elements together on one side of the mitral valve leaflet tissue. The at least one lumen may include a suction lumen configured to grasp a mitral valve leaflet prior to extending the plurality of anchor elements through one layer of mitral valve leaflet tissue.

Abstract: An implant system and method of delivery includes a catheter system including a sling catheter having a plurality of distal openings and a delivery catheter, disposed within the sling catheter and having a distal port. Suture coupled anchors may be sequentially delivered by the delivery catheter to a cardiac treatment site by aligning the port of the delivery catheter with different openings of the sling catheter and pushing the anchor through the port and the sling catheter to embed the anchor into cardiac tissue such as tissue of a papillary muscle. Each anchor may have a linear configuration for translation within the delivery catheter and a biased configuration that inhibits its reentry into the sling catheter once deployed. Once all anchors are deployed, the suture may be tightened, the anchored portion of the sling catheter may be detached, and the catheter system withdrawn.

Abstract: A system for transluminal delivery of cardiac repair components into a heart includes a visualization catheter having an imaging device disposed at a distal end. An anchor lumen extends through the visualization catheter to an anchor port disposed on its distal wall. An adjustment mechanism is translatably disposed within the visualization catheter and configured to adjust a height of the anchor port relative to a septum of the heart. The imaging device may be used to visualize the placement of anchors expelled from the port into a tissue target. The adjustment mechanism enables accurate placement of multiple anchors along a consistent axis within the heart by rotating the visualization catheter to align the port with different tissue targets. The anchors may be coupled to sutures and the tissue targets may include papillary muscles that are reconfigured by pulling together and securing the sutures to approximate a healthy papillary structure.

Abstract: A heart valve repair implant may include a first implant section having a first axial core, and a plurality of spines extending radially outward from the first axial core in an expanded configuration; a second implant section having a second axial core configured to slide over the first axial core, and a mesh portion configured to extend radially outward from the second axial core in an expanded configuration; a third implant section having a central tensioning element extending through the first axial core, and a plurality of arms extending radially outward from the central tensioning element and configured to extend axially between the plurality of spines and through the mesh portion; and a securement element disposed on the central tensioning element.

Abstract: A mitral regurgitation treatment system may include an annuloplasty device configured for placement on an atrial side of a mitral valve, a tethering element configured to extend between a first papillary muscle and a second papillary muscle, wherein the tethering element includes a first anchor securing the tethering element to the first papillary muscle and a second anchor securing the tethering element to the second papillary muscle, and a linking element extending from the annuloplasty device to the tethering element. The linking element may include a spring element disposed between the annuloplasty device and the tethering element.