Abstract: Device sand methods for improving cardiac function are provided. The device includes a dome structure having a top end with an engagement element disposed thereon. The dome structure is moveable from a first inside out configuration to a second deployed configuration, and the dome structure is biased in the second deployed configuration. The dome structure includes a plurality of anchor members disposed around a bottom open end of the dome structure.

Abstract: A gas turbine engine comprising a planetary gear train, and a core engine casing. The gear train has a ratio of greater than approximately 3.0, with an input to the gear train being operatively connected to the compressor section, and an output from the gear train being operatively connected to the fan. The core engine casing encloses the compressor section and the turbine section. The fan has a diameter F, and the core engine casing has a diameter C. The core engine casing diameter C varies along an axial length of the core engine casing, and a ratio (C/F) of the core engine casing diameter C to the fan diameter F is within the range 0.2<(C/F)<0.4, along an axial length of the core engine casing.

Abstract: A system for treating mitral regurgitation may include an outer sheath having a lumen extending to a distal end of the outer sheath, an intermediate sheath slidably disposed within the lumen of the outer sheath, the intermediate sheath having a lumen extending to a distal end of the intermediate sheath, and an inner sheath slidably disposed within the lumen of the intermediate sheath, wherein the inner sheath includes a first anchor disposed within a lumen of the inner sheath, the first anchor being configured to penetrate and secure to a first papillary muscle. The intermediate sheath may include a tissue grasping mechanism at the distal end of the intermediate sheath, the tissue grasping mechanism being configured to hold and stabilize the first papillary muscle for penetration and securement of the first anchor to the first papillary muscle.

Abstract: A sensor system for measuring blood perfusion, blood temperature, and thermal resistance using heat transfer and temperature measurements. The system uses a heat flux sensor, temperature sensor and electric resistance heater with a data analysis device using measurements before, during and after the thermal event provided by the heater.

Abstract: A mitral valve leaflet repair system may include a delivery catheter having at least one lumen extending proximally from a distal end of the delivery catheter, a plurality of anchor elements disposed within the at least one lumen, each of the plurality of anchor elements being configured to extend through one layer of mitral valve leaflet tissue, and a securing element configured to secure at least two of the plurality of anchor elements together on one side of the mitral valve leaflet tissue. The at least one lumen may include a suction lumen configured to grasp a mitral valve leaflet prior to extending the plurality of anchor elements through one layer of mitral valve leaflet tissue.

Abstract: A gas turbine engine comprising a planetary gear train, and a core engine casing. The gear train has a ratio of greater than approximately 3.0, with an input to the gear train being operatively connected to the compressor section, and an output from the gear train being operatively connected to the fan. The core engine casing encloses the compressor section and the turbine section. The fan has a diameter F, and the core engine casing has a diameter C. The core engine casing diameter C varies along an axial length of the core engine casing, and a ratio (C/F) of the core engine casing diameter C to the fan diameter F is within the range 0.2<(C/F)<0.4, along an axial length of the core engine casing.

Abstract: An implant system and method of delivery includes a catheter system including a sling catheter having a plurality of distal openings and a delivery catheter, disposed within the sling catheter and having a distal port. Suture coupled anchors may be sequentially delivered by the delivery catheter to a cardiac treatment site by aligning the port of the delivery catheter with different openings of the sling catheter and pushing the anchor through the port and the sling catheter to embed the anchor into cardiac tissue such as tissue of a papillary muscle. Each anchor may have a linear configuration for translation within the delivery catheter and a biased configuration that inhibits its reentry into the sling catheter once deployed. Once all anchors are deployed, the suture may be tightened, the anchored portion of the sling catheter may be detached, and the catheter system withdrawn.

Abstract: A system for transluminal delivery of cardiac repair components into a heart includes a visualization catheter having an imaging device disposed at a distal end. An anchor lumen extends through the visualization catheter to an anchor port disposed on its distal wall. An adjustment mechanism is translatably disposed within the visualization catheter and configured to adjust a height of the anchor port relative to a septum of the heart. The imaging device may be used to visualize the placement of anchors expelled from the port into a tissue target. The adjustment mechanism enables accurate placement of multiple anchors along a consistent axis within the heart by rotating the visualization catheter to align the port with different tissue targets. The anchors may be coupled to sutures and the tissue targets may include papillary muscles that are reconfigured by pulling together and securing the sutures to approximate a healthy papillary structure.

Abstract: A heart valve repair implant may include a first implant section having a first axial core, and a plurality of spines extending radially outward from the first axial core in an expanded configuration; a second implant section having a second axial core configured to slide over the first axial core, and a mesh portion configured to extend radially outward from the second axial core in an expanded configuration; a third implant section having a central tensioning element extending through the first axial core, and a plurality of arms extending radially outward from the central tensioning element and configured to extend axially between the plurality of spines and through the mesh portion; and a securement element disposed on the central tensioning element.

Abstract: A mitral regurgitation treatment system may include an annuloplasty device configured for placement on an atrial side of a mitral valve, a tethering element configured to extend between a first papillary muscle and a second papillary muscle, wherein the tethering element includes a first anchor securing the tethering element to the first papillary muscle and a second anchor securing the tethering element to the second papillary muscle, and a linking element extending from the annuloplasty device to the tethering element. The linking element may include a spring element disposed between the annuloplasty device and the tethering element.

Abstract: A vascular closure system for sealing an opening in a blood vessel may include an introducer sheath extending through the opening, the introducer sheath having a lumen extending through the introducer sheath, wherein partial withdrawal of the introducer sheath from the opening everts tissue of the blood vessel at the opening, and a shaping sheath slidably disposed over the introducer sheath, the shaping sheath having a split distal portion configured to engage the everted tissue.

Abstract: A heart valve remodeling device may include a delivery device including an inner shaft slidably disposed over a guidewire and an outer shaft slidably disposed over the inner shaft, and a braided stent fixedly attached to the inner shaft and the outer shaft. The braided stent may be translatable between an elongated configuration and a deployed configuration by movement of the inner shaft relative to the outer shaft. The braided stent may include a valve having two or more leaflets disposed within the braided stent. Adjacent leaflets of the two or more leaflets may form longitudinally-oriented commissures proximate a perimeter of the valve, the commissures being fixedly secured to the braided stent along their length.

Abstract: A series of devices that allow for embedding of an image as a background while also affording the user the ability to write and print on the surface, with erasable capabilities, thus providing a multifunctional product for use in numerous industries. The devices are manufactured from predominately corrugated plastic. In one embodiment a one piece, removably attachable, cabinet system and graphic display system. In an additional embodiment, a writable board, or peg board comprising a front panel and a rear panel wherein the panels are interconnected by parallel rows, or corrugations, these panels include a writable and erasable surface. The present invention relates to assemblies of corrugated systems to better serve personal, business, and educational needs.

Abstract: A static gasket and method of construction thereof is provided. The gasket includes a functional layer constructed of one type of metal having an opening bounded by an inner periphery an outer periphery. The gasket further includes a carrier layer constructed of a different metal than the functional layer. The carrier layer has an opening bounded by an inner periphery configured to receive the outer periphery of the functional layer in a line-to-line or loose fit. The functional layer is configured in substantially coplanar relation with the carrier layer with a first portion of the outer periphery of the functional layer being welded to a radially aligned first portion of the inner periphery of the carrier layer. A second portion of the outer periphery of the functional layer remains detached from a radially aligned second portion of the inner periphery of the carrier layer.

Abstract: A static gasket and method of construction thereof is provided. The gasket includes a functional layer constructed of one type of metal having an opening bounded by an inner periphery an outer periphery. The gasket further includes a carrier layer constructed of a different metal than the functional layer. The carrier layer has an opening bounded by an inner periphery configured to receive the outer periphery of the functional layer in a line-to-line or loose fit. The functional layer is configured in substantially coplanar relation with the carrier layer with a first portion of the outer periphery of the functional layer being welded to a radially aligned first portion of the inner periphery of the carrier layer. A second portion of the outer periphery of the functional layer remains detached from a radially aligned second portion of the inner periphery of the carrier layer.

Abstract: A medical device system may include a delivery device including an outer sheath and an inner shaft having a coupler fixed to a distal end of the inner shaft, and a replacement heart valve implant releasably attached to the coupler, the replacement heart valve implant including an expandable anchor member and a plurality of locking mechanisms configured to engage with the coupler. The delivery device may include a plurality of collars configured to secure the coupler to the plurality of locking mechanisms. The delivery device may include a stop element configured to selectively prevent disengagement of the plurality of collars from the plurality of locking mechanisms.

Abstract: A system for treating mitral regurgitation may include an outer sheath having a lumen extending to a distal end of the outer sheath, an intermediate sheath slidably disposed within the lumen of the outer sheath, the intermediate sheath having a lumen extending to a distal end of the intermediate sheath, and an inner sheath slidably disposed within the lumen of the intermediate sheath, wherein the inner sheath includes a first anchor disposed within a lumen of the inner sheath, the first anchor being configured to penetrate and secure to a first papillary muscle. The intermediate sheath may include a tissue grasping mechanism at the distal end of the intermediate sheath, the tissue grasping mechanism being configured to hold and stabilize the first papillary muscle for penetration and securement of the first anchor to the first papillary muscle.

Abstract: A series of devices that allow for embedding of an image as a background while also affording the user the ability to write and print on the surface, with erasable capabilities, thus providing a multifunctional product for use in numerous industries. The devices are manufactured from predominately corrugated plastic. In one embodiment a one piece, removably attachable, cabinet system and graphic display system. In an additional embodiment, a writable board, or peg board comprising a front panel and a rear panel wherein the panels are interconnected by parallel rows, or corrugations, these panels include a writable and erasable surface. The present invention relates to assemblies of corrugated systems to better serve personal, business, and educational needs.

Abstract: A medical device system may include a valve replacement implant including an anchor member reversibly actuatable between a delivery configuration and a deployed configuration, wherein the implant includes at least one locking element configured to lock the anchor member in the deployed configuration, and at least one actuator element configured to engage the at least one locking element and actuate the anchor member between the delivery configuration and the deployed configuration. The at least one actuator element may include a self-biased cam mechanism configured to extend into and engage a first locking portion of the at least one locking element.

Abstract: Certain aspects of the present disclosure provide a method for managing distributed computing resources, including: receiving a processing job request; determining that available system resources are insufficient to process the job; installing a container in a cloud processing node; installing an application in the container in the cloud processing node; splitting a processing job into a plurality of chunks; and distributing at least one of the plurality of chunks to an on-site processing node and at least another one of the plurality of chunks to a cloud processing node.