Patents by Inventor Timothy Coleman
Timothy Coleman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9512474Abstract: Methods and kits are disclosed for distinguishing viable from nonviable microbial cells. The methods and kits are useful in the screening of cell culture formulations and the testing of preservative efficacy. The methods involve the amplification and quantitation of microbe-specific DNA from precursor rRNA or Elongation Factor 3 mRNA in treated versus nontreated test samples using the reverse transcription polymerase chain reaction.Type: GrantFiled: September 28, 2012Date of Patent: December 6, 2016Assignee: LONZA WALKERSVILLE, INC.Inventors: Sophie Seone, Stephanie Gontard, Timothy Coleman
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Publication number: 20140272977Abstract: Methods and kits are disclosed for distinguishing viable from nonviable microbial cells. The methods and kits are useful in the screening of cell culture formulations and the testing of preservative efficacy. The methods involve the amplification and quantitation of microbe-specific DNA from precursor rRNA or Elongation Factor 3 mRNA in treated versus nontreated test samples using the reverse transcription polymerase chain reaction.Type: ApplicationFiled: September 28, 2012Publication date: September 18, 2014Inventors: Sophie Seone, Stephanie Gontard, Timothy Coleman
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Publication number: 20140024812Abstract: Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the implementation of new carbohydrate bioassays, the examination of a selection of insect cell lines and the use of bioinformatics to identify gene sequences for critical processing enzymes. The compositions comprise cells of interest producing sialylated glycoproteins. The methods and compositions are useful for heterologous expression of glycoproteins.Type: ApplicationFiled: August 27, 2013Publication date: January 23, 2014Applicants: THE UNIVERSITY OF WYOMING, HUMAN GENOME SCIENCES, INC., THE JOHN HOPKINS UNIVERSITYInventors: Donald JARVIS, Yuan C. LEE, Michael J. BETENBAUGH, Shawn LAWRENCE, Timothy A. COLEMAN
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Patent number: 8546105Abstract: Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the implementation of new carbohydrate bioassays, the examination of a selection of insect cell lines and the use of bioinformatics to identify gene sequences for critical processing enzymes. The compositions comprise cells of interest producing sialylated glycoproteins. The methods and compositions are useful for heterologous expression of glycoproteins.Type: GrantFiled: August 9, 2010Date of Patent: October 1, 2013Assignees: The University of Wyoming, The John Hopkins University, Human Genome Sciences, Inc.Inventors: Donald Jarvis, Michael J. Betenbaugh, Shawn Lawrence, Yuan C. Lee, Timothy A. Coleman
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Publication number: 20110229931Abstract: Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the implementation of new carbohydrate bioassays, the examination of a selection of insect cell lines and the use of bioinformatics to identify gene sequences for critical processing enzymes. The compositions comprise cells of interest producing sialylated glycoproteins. The methods and compositions are useful for heterologous expression of glycoproteins.Type: ApplicationFiled: August 9, 2010Publication date: September 22, 2011Inventors: Donald Jarvis, Michael J. Betenbaugh, Shawn Lawrence, Yuan C. Lee, Timothy A. Coleman
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Patent number: 7776565Abstract: Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the implementation of new carbohydrate bioassays, the examination of a selection of insect cell lines and the use of bioinformatics to identify gene sequences for critical processing enzymes. The compositions comprise cells of interest producing sialylated glycoproteins. The methods and compositions are useful for heterologous expression of glycoproteins.Type: GrantFiled: February 27, 2009Date of Patent: August 17, 2010Assignees: The John Hopkins University, Human Genome Sciences, Inc.Inventors: Michael J. Betenbaugh, Shawn Lawrence, Yuan C. Lee, Timothy A. Coleman
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Publication number: 20090226968Abstract: Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the implementation of new carbohydrate bioassays, the examination of a selection of insect cell lines and the use of bioinformatics to identify gene sequences for critical processing enzymes. The compositions comprise cells of interest producing sialylated glycoproteins. The methods and compositions are useful for heterologous expression of glycoproteins.Type: ApplicationFiled: February 27, 2009Publication date: September 10, 2009Inventors: Michael J. Betenbaugh, Shawn Lawrence, Yuan C. Lee, Timothy A. Coleman
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Patent number: 7482326Abstract: A human EMAP III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.Type: GrantFiled: November 15, 2005Date of Patent: January 27, 2009Assignee: Human Genome Sciences, Inc.Inventors: Timothy A. Coleman, Craig A. Rosen, Henrik S. Olsen
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Publication number: 20080195323Abstract: The invention relates to a method of quality assurance/quality control for high-throughput bioassay processes. The method permits monitoring of an entire system for obtaining spectral data from biological samples. Generally, the method includes generating a bioassay process model, comparing a test sample against the bioassay process model. The bioassay process model may be based on the position of a centroid in n-dimensional space. The comparing may include comparing the location of a centroid associated with the test model against the centroid associated with the control model to determine the distance between the two centroids. By generating a trend plot of the distance between the centroid associated with the test sample and the centroid associated with the control model, overall system performance may be monitored over time.Type: ApplicationFiled: January 2, 2008Publication date: August 14, 2008Inventors: Ben A. Hitt, Peter J. Levine, Timothy A. Coleman
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Patent number: 7395160Abstract: The present invention relates to a method of quality assurance/quality control for high-throughput bioassay processes. The method includes generating a bioassay process model, and then comparing spectral data based on a combination of a biochip and a test serum to the bioassay process model to determine if the test sample and the bioassay process are producing acceptable data. Alternatively, the method may include comparing spectral data based on a combination of serum and diluents used in an electrospray process to the bioassay process model. If the bioassay process and test sample fall within the model, then the spectrum produced may be further analyzed.Type: GrantFiled: July 28, 2003Date of Patent: July 1, 2008Assignee: Correlogic Systems, Inc.Inventors: Ben A. Hitt, Peter J. Levine, Timothy A. Coleman
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Patent number: 7333895Abstract: The invention relates to a method of quality assurance/quality control for high-throughput bioassay processes. The method permits monitoring of an entire system for obtaining spectral data from biological samples. Generally, the method includes generating a bioassay process model, comparing a test sample against the bioassay process model. The bioassay process model may be based on the position of a centroid in n-dimensional space. The comparing may include comparing the location of a centroid associated with the test model against the centroid associated with the control model to determine the distance between the two centroids. By generating a trend plot of the distance between the centroid associated with the test sample and the centroid associated with the control model, overall system performance may be monitored over time.Type: GrantFiled: July 28, 2003Date of Patent: February 19, 2008Assignee: Correlogic Systems, Inc.Inventors: Ben A. Hitt, Peter J. Levine, Timothy A. Coleman
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Publication number: 20070259806Abstract: The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders. Additionally, the present invention is related to methods of treating patients with BAIT polynucleotides or polypeptides, wherein said patients have had seizures or epilepsy.Type: ApplicationFiled: June 4, 2007Publication date: November 8, 2007Applicants: Human Genome Sciences, Inc., The Regents of the University of MichiganInventors: Gregg Hastings, Timothy Coleman, Patrick Dillon, Daniel Lawrence, Maria Sandkvist, Manuel Yepes, Michael Wong
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Patent number: 7273751Abstract: Disclosed are human VEGF-2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF-2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides and polynucleotides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.Type: GrantFiled: August 3, 2001Date of Patent: September 25, 2007Assignee: Human Genome Science, Inc.Inventor: Timothy A. Coleman
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Patent number: 7235529Abstract: The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders. Additionally, the present invention is related to methods of treating patients with BAIT polynucleotides or polypeptides, wherein said patients have had seizures or epilepsy.Type: GrantFiled: January 7, 2004Date of Patent: June 26, 2007Assignees: Human Genome Sciences, Inc., The Regents of the University of MichiganInventors: Timothy A. Coleman, Daniel A. Lawrence, Manuel Yepes
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Patent number: 7232667Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.Type: GrantFiled: December 12, 2003Date of Patent: June 19, 2007Assignee: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Joachim R. Gruber, D. Roxanne Duan, Mark A. Rampy, Donna Mendrick, Jun Zhang, Jian Ni, Paul A. Moore, Timothy A. Coleman, Patrick J. Dillon, Reiner L. Gentz, Pablo Jimenez
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Patent number: 7087574Abstract: The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders. Additionally, the present invention is related to methods of treating patients with BAIT polynucleotides or polypeptides, wherein said patients have had a stroke.Type: GrantFiled: January 31, 2003Date of Patent: August 8, 2006Assignees: Human Genome Sciences, Inc., The American Red CrossInventors: Daniel A. Lawrence, Manuel Yepes, Maria Sandkvist, Timothy A. Coleman, Michael K. K. Wong
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Patent number: 7045301Abstract: A human EMAP III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.Type: GrantFiled: August 4, 2004Date of Patent: May 16, 2006Assignee: Human Genome Sciences, Inc.Inventors: Timothy A. Coleman, Craig A. Rosen
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Publication number: 20060068474Abstract: A human EMAP III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.Type: ApplicationFiled: November 15, 2005Publication date: March 30, 2006Applicant: Human Genome Sciences, Inc.Inventors: Timothy Coleman, Craig Rosen
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Publication number: 20060057117Abstract: Disclosed are human VEGF-2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF-2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides and polynucleotides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.Type: ApplicationFiled: October 14, 2005Publication date: March 16, 2006Applicant: Human Genome Sciences, Inc.Inventor: Timothy Coleman
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Publication number: 20050287637Abstract: Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the implementation of new carbohydrate bioassays, the examination of a selection of insect cell lines and the use of bioinformatics to identify gene sequences for critical processing enzymes. The compositions comprise cells of interest producing sialylated glycoproteins. The methods and compositions are useful for heterologous expression of glycoproteins.Type: ApplicationFiled: May 6, 2005Publication date: December 29, 2005Inventors: Michael Betenbaugh, Shawn Lawrence, Yuan Lee, Timothy Coleman