Patents by Inventor Timothy Coleman
Timothy Coleman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20030211561Abstract: A human oxalyl-COA decarboxylase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide are disclosed. Also disclosed is a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of urolithiasis and hyperoxaluria. Also disclosed are assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention.Type: ApplicationFiled: May 6, 2002Publication date: November 13, 2003Applicant: Human Genome Sciences, Inc.Inventors: Henrik S. Olsen, Timothy A. Coleman, Mark D. Adams
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Publication number: 20030186904Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.Type: ApplicationFiled: January 4, 2002Publication date: October 2, 2003Applicant: HUMAN GENOME SCIENCES, INC.Inventors: Steven M. Ruben, Pablo Jimenez, Roxanne D. Duan, Mark A. Rampy, Donna Mendrick, Jun Zhang, Jian Ni, Paul A. Moore, Timothy A. Coleman, Joachim R. Gruber, Patrick J. Dillon, Reiner L. Gentz
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Publication number: 20030129687Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.Type: ApplicationFiled: February 15, 2002Publication date: July 10, 2003Inventors: Steven M. Ruben, Pablo Jimenez, D. Roxanne Duan, Mark A. Rampy, Donna Mendrick, Jun Zhang, Jian Ni, Paul A. Moore, Timothy A. Coleman, Joachim R. Gruber, Patrick J. Dillon, Reiner L. Gentz
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Patent number: 6566328Abstract: The present invention relates to a method of treatment of patients by administration of human growth hormone. Also disclosed are DNA (or RNA) polynucleotide sequences that encode naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGV-3(53), as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type human growth hormone. The growth hormone variants of the present invention are of human origin and are useful for diagnostic, preventive and therapeutic purposes with respect to certain human diseases. Also disclosed is a method for producing the human growth hormone variants of the present invention by recombinant DNA techniques, as well as a method for generating antibodies directed against (and therefore inhibiting the activity of) wild-type growth hormone.Type: GrantFiled: October 4, 1999Date of Patent: May 20, 2003Assignee: Human Genome Sciences, Inc.Inventors: Craig A. Rosen, Timothy A. Coleman, Mark D. Adams, Jeannine D. Gocayne
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Publication number: 20030077695Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.Type: ApplicationFiled: July 1, 1999Publication date: April 24, 2003Applicant: HUMAN GENOME SCIENCES, INC.Inventors: STEVEN M. RUBEN, PABLO JIMENEZ, D. ROXANNE DUAN, MARK A. RAMPY, DONNA MENDRICK, JUN ZHANG, JIAN NI, PAUL A. MOORE, TIMOTHY A. COLEMAN, JOACHIM R. GRUBER, PATRICK J. DILLON, REINER L. GENTZ
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Patent number: 6541452Abstract: The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human BAIT protein. BAIT polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders.Type: GrantFiled: November 28, 2000Date of Patent: April 1, 2003Assignee: Human Genome Sciences, Inc.Inventors: Gregg A. Hastings, Timothy A. Coleman, Daniel A. Lawrence, Patrick J. Dillon
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Publication number: 20030044901Abstract: The present invention provides soluble forms of integral membrane proteins, or domains or portions thereof, that retain the biological activity of the integral membrane protein, domain or portion from which they are designed or derived and that can readily be expressed in high yield.Type: ApplicationFiled: January 29, 2002Publication date: March 6, 2003Inventors: Timothy A. Coleman, Brian Charles Mansfield
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Publication number: 20020192749Abstract: The present invention relates to novel human human polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human human polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human human polypeptides.Type: ApplicationFiled: October 3, 2001Publication date: December 19, 2002Inventors: Paul A. Moore, Timothy A. Coleman, Reiner L. Gentz, Patrick J. Dillon, Jian Ni, Yi Li, Gregory A. Endress, Daniel R. Soppet
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Publication number: 20020165147Abstract: The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders. Additionally, the present invention is related to methods of treating patients with BAIT polynucleotides or polypeptides, wherein said patients have had seizures or epilepsy.Type: ApplicationFiled: November 13, 2001Publication date: November 7, 2002Inventors: Manuel Yepes, Daniel A. Lawrence, Timothy A. Coleman
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Publication number: 20020143165Abstract: The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders. Additionally, the present invention is related to methods of treating patients with BAIT polynucleotides or polypeptides, wherein said patients have had a stroke.Type: ApplicationFiled: September 21, 2001Publication date: October 3, 2002Applicant: Human Genome Sciences, Inc.Inventors: Daniel A. Lawrence, Manuel Yepes, Maria Sandkvist, Michael K. K. Wong, Timothy A. Coleman
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Publication number: 20020142386Abstract: Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the implementation of new carbohydrate bioassays, the examination of a selection of insect cell lines and the use of bioinformatics to identify gene sequences for critical processing enzymes. The compositions comprise cells of interest producing sialylated glycoproteins. The methods and compositions are useful for heterologous expression of glycoproteins.Type: ApplicationFiled: August 16, 2001Publication date: October 3, 2002Inventors: Michael J. Betenbaugh, Shawn Lawrence, Yuan C. Lee, Timothy A. Coleman
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Publication number: 20020137175Abstract: The present invention relates to novel human glycosylation enzyme polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human glycosylation enzyme polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human glycosylation enzyme polypeptides.Type: ApplicationFiled: October 29, 2001Publication date: September 26, 2002Applicant: Human Genome Sciences, Inc.Inventors: Timothy A. Coleman, Michael J. Betenbaugh
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Patent number: 6420138Abstract: Expression control sequences are provided for the expression of proteins from a gene of interest. The gene may express viral, prokaryotic, or eukaryotic proteins. These control sequences are produced by combining phage promoter and operator/repressor systems. Expression vectors containing such expression control sequences, microorganisms transformed with such expression vectors and methods for producing viral, prokaryotic, and eukaryotic proteins using the expression control sequences, expression vectors and transformed microorganisms are also provided.Type: GrantFiled: November 30, 2000Date of Patent: July 16, 2002Assignee: Human Genome Sciences, Inc.Inventors: Reiner L. Gentz, Timothy A. Coleman
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Patent number: 6383737Abstract: A human oxalyl-CoA decarboxylase polypeptide and DNA(RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide are disclosed. Also disclosed is a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of urolithiasis and hyperoxaluria. Also disclosed are assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention.Type: GrantFiled: December 8, 2000Date of Patent: May 7, 2002Assignee: Human Genome Sciences, Inc.Inventors: Henrik S. Olsen, Timothy A. Coleman, Mark D. Adams
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Publication number: 20020037587Abstract: Expression control sequences are provided for the expression of proteins from a gene of interest. The gene may express viral, prokaryotic, or eukaryotic proteins. These control sequences are produced by combining phage promoter and operator/repressor systems. Expression vectors containing such expression control sequences, microorganisms transformed with such expression vectors and methods for producing viral, prokaryotic, and eukaryotic proteins using the expression control sequences, expression vectors and transformed microorganisms are also provided.Type: ApplicationFiled: November 30, 2000Publication date: March 28, 2002Inventors: Reiner L. Gentz, Timothy A. Coleman
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Patent number: 6333182Abstract: The present invention relates to novel human glycosylation enzyme polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human glycosylation enzyme polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human glycosylation enzyme polypeptides.Type: GrantFiled: March 1, 2000Date of Patent: December 25, 2001Assignees: Human Genome Sciences, Inc., Johns Hopkins UniversityInventors: Timothy A. Coleman, Michael J. Betenbaugh
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Publication number: 20010003743Abstract: A human oxalyl-CoA decarboxylase polypeptide and DNA(RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide are disclosed. Also disclosed is a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of urolithiasis and hyperoxaluria. Also disclosed are assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention.Type: ApplicationFiled: December 8, 2000Publication date: June 14, 2001Applicant: Human Genome Sciences, Inc.Inventors: Henrik S. Olsen, Timothy A. Coleman, Mark D. Adams
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Patent number: 6200796Abstract: A human oxalyl-CoA decarboxylase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide are disclosed. Also disclosed is a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of urolithiasis and hyperoxaluria. Also disclosed are assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention.Type: GrantFiled: June 3, 1999Date of Patent: March 13, 2001Assignee: Human Genome Sciences, Inc.Inventors: Henrik S. Olsen, Timothy A. Coleman, Mark D. Adams
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Patent number: 6194168Abstract: Expression control sequences are provided for the expression of proteins from a gene of interest. The gene may express viral, prokaryotic, or eukaryotic proteins. These control sequences are produced by combining phage promoter and operator/repressor systems. Expression vectors containing such expression control sequences, microorganisms transformed with such expression vectors and methods for producing viral, prokaryotic, and eukaryotic proteins using the expression control sequences, expression vectors and transformed microorganisms are also provided.Type: GrantFiled: March 20, 1998Date of Patent: February 27, 2001Assignee: Human Genome Sciences, Inc.Inventors: Reiner L. Gentz, Timothy A. Coleman
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Patent number: 6191260Abstract: The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human BAIT protein. BAIT polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders.Type: GrantFiled: July 8, 1999Date of Patent: February 20, 2001Assignees: American Red Cross, The Human Genome Sciences, Inc.Inventors: Gregg A. Hastings, Timothy A. Coleman, Daniel A. Lawrence, Patrick J. Dillon