Abstract: Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of biomarkers in a body sample, wherein overexpression of the biomarkers is indicative of an increased likelihood of having ovarian cancer. The screening methods may further comprise a two-step analysis. Biomarkers of interest include genes and proteins that are, for example, involved in defects in DNA replication/cell cycle control, cell growth and proliferation, escape from apoptosis, angiogenesis or lymphogenesis, or the mechanisms of cancer cell motility and invasion. In some aspects of the invention, expression of a biomarker is detected at the protein level using a biomarker-specific antibody or at the nucleic acid level using nucleic acid hybridization techniques. Methods for detecting ovarian cancer in patients are further disclosed herein. Kits for practicing the methods of the invention are further provided.

Abstract: A method for diagnosing a condition of a patient involves the steps of (a) adding one or more reagents to a test sample from a patient, the test samples comprising at least part of a blood sample from the patient, in order to cause formation of a complex comprising at least one acute phase protein at at least one human lipoprotein, while causing substantially no fiber polymerization; (b) measuring the formation of the complex over time so as to derive a time-dependent measurement profile, and (c) determining a slope and/or total change in the time-dependent measurement profile, so as to diagnose a condition of the patient. A greater formation of the complex is correlated to increased probability of death of the patient.

Abstract: Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an MCM2 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM2 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM2 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM2 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.

Abstract: A color mapping method is used in transforming colors between color imaging systems. The method includes using forward transformation profiles that characterize the color imaging systems to generate respective sets of device-independent color values for the color imaging systems. Color conversions are calculated by recursively reducing differences between the respective sets of device-independent color values. Based on these color conversions, a color map is constructed that describes a relationship between the color imaging systems.

Abstract: A complimentary metal oxide semiconductor (CMOS) circuit may include a CMOS output stage comprising at least one p-channel metal oxide semiconductor (PMOS) component and at least one n-channel metal oxide semiconductor (NMOS) component connected in series between first and second voltage rails, a juncture between the at least one PMOS component and at least one NMOS component providing an output. A predriver stage includes first and second predriver paths electrically connected between at least one input and the output stage. The first predriver path is configured to perform a logic function on the at least one input and to provide a first logic signal to an input of the at least one PMOS component. The second predriver path is configured to perform the logic function on the at least one input and to provide a second logic signal to an input of the at least one NMOS component.

Abstract: Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical smear or monolayer of cervical cells. The biomarkers of the invention include genes and proteins that are involved in cell cycle regulation, signal transduction, and DNA replication and transcription. In particular claims, the biomarker is an S-phase gene. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided.

Abstract: Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical smear or monolayer of cervical cells. The biomarkers of the invention include genes and proteins that are involved in cell cycle regulation, signal transduction, and DNA replication and transcription. In particular claims, the biomarker is an S-phase gene. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided.

Abstract: Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an MCM2 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM2 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM2 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM2 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.

Abstract: Systems and methods of edge calibration for synchronous data transfer between clock domains are disclosed. An exemplary method may comprise comparing a drive clock signal to a receive clock signal, generating a select clock signal, and configuring a data path based a least in part on the select clock signal for synchronous data transfer between clock domains so that data arrives in an early clock domain at the desired logical clock cycle.

Abstract: Systems and methods for implanting synchronous data transfer between clock domains are disclosed. An exemplary system may comprise an adaptable data path having an input for receiving a signal from a first clock domain and an output in a second clock domain. A controller is operatively associated with the adaptable data path.

Abstract: Systems and methods for implementing count calibration for synchronous data transfer between clock domains are disclosed. An exemplary system may include a count calibration circuit for determining latency between an early clock domain and a late clock domain. The system may also include a data path configurable for synchronous data transfer between clock domains based at least in part on the latency.

Abstract: A method of characterizing a color imaging system is provided. The method comprises obtaining first data indicative of output of the color imaging system. The first data is processed, to yield second data, according to a color appearance model that varies in accordance with neutrality of colors indicated by the first data. Other methods are provided as well as systems and computer program products for characterizing color imaging systems and devices and for producing colors.

Abstract: Improved color image display accuracy can be achieved across a computer network by obtaining information characterizing the color response of display devices associated with a client residing on the computer network, and using the information to modify color images delivered to the client. The information may include a gamma estimate. In one embodiment, the gamma estimate is limited to only the green color channel, without reference to the gammas for the red and blue channels. In this manner, the gamma estimate concentrates on the most dominant color channel and avoids errors that can arise due to the red-blue imbalances that are highly prevalent in many display devices. The information can be obtained, for example, by guiding the client through a color profiling process that profiles the color response of the display device. For example, such guidance may take the form of a series of instructional web pages that are delivered to the client.

Abstract: A system and method for multi-dimensional color transformation apply constraints to the transformation function to preserve the presence or absence of particular color information while achieving high accuracy color match. With a constrained multi-dimensional color transformation (CMT), a destination device, such as a color proofer, can provide an accurate color match relative to a source or “target” device, such as a printing press, and preserve dot integrity. In particular, the constraints can preserve selected color information that is present in an image produced by the source device, and prevent addition of other selected color information that would not be present in the source device image. In a halftone imaging device, the constraints prevent the removal or addition of dots from and to the image produced by destination device.

Abstract: The invention provides a color processing method comprising determining whether a desired mapping between a first arrangement, including a first color device, and a second arrangement, including a second color device, exists, and automatically producing a mapping between the first arrangement and the second arrangement in the absence of such a desired mapping.

Abstract: Methods and computer program products for evaluating and optimizing one or more markers for use in establishing a prognosis for a patient suffering from a disease are provided. More particularly, the methods include steps for systematically evaluating a number of features that may be extracted from an image of a body sample, such as a histological slide, that has been exposed to one or more biomarkers so as to establish a prognostic decision rule based on one or more of the extracted features such that the decision rule yields a prognosis that is optimally predictive of actual patient outcome. Thus, the methods and computer program products provided yield optimally predictive prognoses to assist clinicians in developing strategies for effective patient care management.

Abstract: Methods and compositions for evaluating the prognosis of a breast cancer patient, particularly an early-stage breast cancer patient, are provided. The methods of the invention comprise detecting expression of at least one, more particularly at least two, biomarker(s) in a body sample, wherein overexpression of the biomarker or a combination of biomarkers is indicative of breast cancer prognosis. In some embodiments, the body sample is a breast tissue sample, particularly a primary breast tumor sample. The biomarkers of the invention are proteins and/or genes whose overexpression is indicative of either a good or bad cancer prognosis. Biomarkers of interest include proteins and genes involved in cell cycle regulation, DNA replication, transcription, signal transduction, cell proliferation, invasion, proteolysis, or metastasis.

Abstract: Systems, methodologies, media, and other embodiments associated with activity factor based design are described. One exemplary system embodiment includes an activity factor logic configured to determine an activity factor for a first node. The activity factor relates an input activity for the first node to an output activity for the first node. The example system may also include a transmission factor logic configured to determine a transmission factor for the first node. The transmission factor describes a degree of causal power switching between the first node and a second node. The example system may also include a downstream power logic operably connected to the activity factor logic or the transmission factor logic. The downstream power logic may be configured to determine a power consumption amount for the second node. The power consumption amount may depend, for example, on the activity factor and the transmission factor.

Abstract: Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical smear or monolayer of cervical cells. The biomarkers of the invention include genes and proteins that are involved in cell cycle regulation, signal transduction, and DNA replication and transcription. In particular claims, the biomarker is an S-phase gene. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided.

Abstract: A color mapping method is used in transforming colors between color imaging systems. The method includes using forward transformation profiles that characterize the color imaging systems to generate respective sets of device-independent color values for the color imaging systems. Color conversions are calculated by reducing differences between the respective sets of device-independent color values. Based on these color conversions, a color map is constructed that describes a relationship between the color imaging systems.