Abstract: The invention is directed to a method and composition of matter for enhancing the staining of tissue or features of interest therein by applying an effective amount of a bile salt in combination with a special stain to a tissue suspected of harboring a microorganism or other feature of diagnostic interest. The particular invention herein is directed to detecting H. pylori, the microorganism responsible for gastrointestinal ulcers. The composition of matter is a sensitizer for Alcian Yellow stain.

Abstract: A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sample is analyzed. Alternatively, the spatial position of a statistically significant number of patient blood samples can be used. The method enables the monitoring of an instrument for problems associated with debris and noise caused by red cell lysis inefficiency; instrument reagents pup volume settings; instrument laser alignments; instrument gain settings; and flow noise caused by partial plugs, residual plugs or other flow problems. The method provides a more specific indication of the type and cause of an instrument malfunctioning than non specific flagging provided by prior art methods.

Abstract: A reagent and kit are disclosed for determining if a patient is hypercoagulable, hypocoagulable or normal. The test involves providing a test sample from the patient and initiating coagulation in the sample in the presence of an activator, which is added to the sample in an amount which will result in intrinsic tenase-dependent fibrin. Then the formation of the intrinsic tenase-dependent fibrin polymerization is monitored over time so as to derive a time-dependent profile, with the results of the fibrin polymerization monitoring determining whether the patient is hypercoagulable, normal or hypocoagulable. The coagulation activator is added in an amount that triggers a thrombin explosion that is dependent on the propagation phase and amplification pathways. In this way, a single assay can assess the hemostatic potential of a sample.

Abstract: Improved color image display accuracy can be achieved across a computer network by obtaining information characterizing the color response of display devices associated with a client residing on the computer network, and using the information to modify color images delivered to the client. The information may include a gamma estimate. In one embodiment, the gamma estimate is limited to only the green color channel, without reference to the gammas for the red and blue channels. In this manner, the gamma estimate concentrates on the most dominant color channel and avoids errors that can arise due to the red-blue imbalances that are highly prevalent in many display devices. The information can be obtained, for example, by guiding the client through a color profiling process that profiles the color response of the display device. For example, such guidance may take the form of a series of instructional web pages that are delivered to the client.

Abstract: A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sample is analyzed. Alternatively, the spatial position of a statistically significant number of patient blood samples can be used. The method enables the monitoring of an instrument for problems associated with debris and noise caused by red cell lysis inefficiency; instrument reagents pump volume settings; instrument laser alignments; instrument gain settings; and flow noise caused by partial plugs, residual plugs or other flow problems. The method provides a more specific indication of the type and cause of an instrument malfunctioning than non specific flagging provided by prior art methods.

Abstract: One embodiment of the invention comprises, in each clock zone of a central processing unit, at least one sensor that generates a power signal indicative of a power supply voltage within the clock zone, a clock generator for providing a variable frequency clock to the clock zone, and a controller for controlling an operating frequency of the clock generator in response to the power signal and in response to frequency adjustment communications from other clock zones.

Abstract: In one embodiment, a central processing unit (CPU) includes multiple clock zones. Each clock zone includes at least one sensor that generates a signal indicative of a power supply voltage within the clock zone, a clock generator for providing a variable frequency clock to the clock zone, a first controller for controlling a frequency of operation of the clock generator in response to the at least one sensor, wherein the first controller further controls the frequency of operation in response to communication of frequency adjustments from first controllers in other clock zones within one cycle of latency, and a second controller that provides an overdrive signal, that is combined with adjustment signals from the first controller for the clock generator, in response to communication of frequency adjustments from other clock zones beyond one cycle of latency.

Abstract: A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sample is analyzed. Alternatively, the spatial position of a statistically significant number of patient blood samples can be used. The method enables the monitoring of an instrument for problems associated with debris and noise caused by red cell lysis inefficiency; instrument reagents pump volume settings; instrument laser alignments: instrument gain settings; and flow noise caused by partial plugs, residual plugs or other flow problems. The method provides a more specific indication of the type and cause of an instrument malfunctioning than non specific flagging provided by prior art methods.

Abstract: A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sample is analyzed. Alternatively, the spatial position of a statistically significant number of patient blood samples can be used. The method enables the monitoring of an instrument for problems associated with debris and noise caused by red cell lysis inefficiency; instrument reagents pump volume settings; instrument laser alignments; instrument gain settings; and flow noise caused by partial plugs, residual plugs or other flow problems. The method provides a more specific indication of the type and cause of an instrument malfunctioning than non specific flagging provided by prior art methods.

Abstract: In a pipelined computer architecture in which instructions may be removed from the instruction queue out of sequence, instruction queue status at a cycle K is determined by adding together the number of invalid instructions or free rows in the queue during cycle K-2, the number of instructions issued for cycle K-1 and the number of instructions speculatively issued in cycle K-1 that have produced a cache hit, and subtracting from the sum the number of instructions enqueued for cycle K-1. The result indicates the number of invalid instructions in the queue cycle K. The number of invalid entries instructions, the number of issued instructions, and the number of enqueued instructions are preferably represented as flat vectors, so that adding is performed by shifting in one direction, while subtracting is performed by shifting in the opposite direction. The result is compared with either the number of instructions to be enqueued in the present cycle, which number is encoded, or with a predetermined value.

Abstract: Improved color image display accuracy can be achieved across a computer network by obtaining information characterizing the color response of display devices associated with a client residing on the computer network, and using the information to modify color images delivered to the client. To determine gamma and gray balance, a set of gray elements is displayed against a dithered gray background representing a gray level of approximately 25 to 40% and, more preferably, approximately 33%. In some embodiments, the gray elements and the dithered gray background may be limited to the green color channel of the display device. Dithered backgrounds in the range approaching approximately 33% more closely match the actual midpoint of black to gray transition for most display devices. The gamma and gray balance information can be obtained, for example, by guiding the client through a color profiling process that profiles the color response of the display device.

Abstract: A method of characterizing a color imaging system is provided. The method comprises obtaining first data indicative of output of the color imaging system. The first data is processed, to yield second data, according to a color appearance model that varies in accordance with neutrality of colors indicated by the first data. Other methods are provided as well as systems and computer program products for characterizing color imaging systems and devices and for producing colors.

Abstract: A method of characterizing a color imaging system is provided. The method comprises obtaining first data indicative of output of the color imaging system. The first data is processed, to yield second data, according to a color appearance model that varies in accordance with neutrality of colors indicated by the first data. Other methods are provided as well as systems and computer program products for characterizing color imaging systems and devices and for producing colors.

Abstract: Improved color image display accuracy can be achieved across a computer network by obtaining information characterizing the color response of display devices associated with a client residing on the computer network and using the information to modify color images delivered to the client. The information includes a blackpoint estimate for the display devices. The invention, in one embodiment, makes use of dark elements in the form of non-rectangular shapes such as numerals, letters, and the like to aid in determination of the blackpoint estimate. In particular, rows or columns of complex shapes with varying gray values can be displayed against a black background. The use of complex shapes to determine the blackpoint can help resolve minor differences in R, G, and B that can cause poor gray balance. Instead of patches or bars, which may be generally rectangular, more complex shapes can be used to aid the human eye in resolving such differences.

Abstract: Improved color image display accuracy can be achieved across a computer network by obtaining information characterizing the color response of display devices associated with a client residing on the computer network, and using the information to modify color images delivered to the client. The information may include a gamma estimate. In one embodiment, the gamma estimate is limited to only the green color channel, without reference to the gammas for the red and blue channels. In this manner, the gamma estimate concentrates on the most dominant color channel and avoids errors that can arise due to the red-blue imbalances that are highly prevalent in many display devices. The information can be obtained, for example, by guiding the client through a color profiling process that profiles the color response of the display device. For example, such guidance may take the form of a series of instructional web pages that are delivered to the client.

Abstract: The invention is directed to a method and composition of matter for enhancing the staining of tissue or features of interest therein by applying an effective amount of a bile salt in combination with a special stain to a tissue suspected of harboring a microorganism or other feature of diagnostic interest. The particular invention herein is directed to detecting H. pylori, the microorganism responsible for gastrointestinal ulcers. The composition of matter is a sensitizer for Alcian Yellow stain.

Abstract: Improved color image display accuracy can be achieved across a computer network by obtaining information characterizing the color response of display devices associated with a client residing on the computer network, and using the information to modify color images delivered to the client. To determine gamma and gray balance, a set of gray elements is displayed against a dithered gray background representing a gray level of approximately 25 to 40% and, more preferably, approximately 33%. In some embodiments, the gray elements and the dithered gray background may be limited to the green color channel of the display device. Dithered backgrounds in the range approaching approximately 33% more closely match the actual midpoint of black to gray transition for most display devices. The gamma and gray balance information can be obtained, for example, by guiding the client through a color profiling process that profiles the color response of the display device.

Abstract: A color mapping method is used in transforming colors between color imaging systems. The method includes using forward transformation profiles that characterize the color imaging systems to generate respective sets of device-independent color values for the color imaging systems. Color conversions are calculated by reducing differences between the respective sets of device-independent color values. Based on these color conversions, a color map is constructed that describes a relationship between the color imaging systems.

Abstract: Improved color image display accuracy can be achieved across a computer network by obtaining information characterizing the color response of display devices associated with a client residing on the computer network, and using the information to modify color images delivered to the client. The information may include a gamma estimate and a gray balance estimate. In one embodiment, the gamma estimate is limited to only the green color channel, without reference to the gammas for the red and blue channels. Then, the gray balance of the display device is estimated using the green-limited gamma estimate as a starting point, in combination with a number of red-blue shifts away from the gamma estimate. In particular, in the gray balance process, the green intensity value indicative of the gamma estimate is used to generate a set of gray patches that exhibit +/− (plus/minus) differences or “shifts” in red and blue away from the green value.

Abstract: Characterizing a color imaging system involves generating color values representing colors of output samples of the color imaging system. The color values are converted into a device-independent color coordinate system using an adjustable white reference vector and a black reference vector. The white reference vector is calculated using the black reference vector. Color values can be transformed between color imaging systems using the device-independent color coordinate system.