Abstract: The present invention relates to processes and intermediates for preparing 3-(cyanomethyl)-3-(4-{[(1R,2S)-2-phenylcyclopropyl]amino}piperidin-1-yl)azetidine-1-sulfonamide, and salts and solid forms thereof, which selectively modulate demethylase. Particular embodiments contemplate compounds and disease indications amenable to treatment by modulation of lysine specific demethylase-1 (LSD1).

Abstract: An apparatus comprises a main processor to execute a main stream of program instructions, two or more checker processors to execute respective checker streams of program instructions in parallel with each other, the checker streams corresponding to different portions of the main stream executed by the main processor, and error detection circuitry to detect an error when a mismatch is detected between an outcome of a given portion of the main stream executed on the main processor and an outcome of the corresponding checker stream executed on one of the plurality of checker processors. This approach enables high performance main processors 4 to be checked for errors with lower circuit area and power consumption overhead than a dual-core lockstep technique.

Abstract: A materials handling vehicle including a load handling assembly having a mast assembly, and a fork carriage assembly including a fork support and at least one fork assembly, the at least one fork assembly including a first fork member, which is fixed to the fork support, and a second fork member. The vehicle includes a tilt assembly that tilts the fork support relative to the mast assembly such that a central axis of the at least one fork assembly is positionable in a plurality of different positions relative to a horizontal direction. The vehicle includes a fork extension/retraction assembly that moves the second fork member relative to the first fork member in a first direction that is parallel to the central axis such that the fork extension/retraction assembly selectively moves the second fork member toward or away from the fork support in the first direction.

Abstract: A method and dishwasher utilize a spray basket that includes a container body that defines a compartment for retaining utensils as well as multiple sets of nozzles, a portion of which are configured to direct a spray of fluid into the compartment, and another portion of which are configured to direct a spray of fluid external from the container body. The spray of fluid directed external from the container body may be used, for example, to provide a power wash zone adjacent to the spray basket to assist in cleaning other utensils in a dishwasher.

Abstract: In some examples, a system tests a program that includes code to invoke calls of an application programming interface (API) for managing resources of a cloud environment. As part of the testing of the program, the system determines permissions for the invoked calls of the API, creates a collection of the determined permissions, and associates the collection of the determined permissions with an access policy of the cloud environment, the access policy to control use of the API for managing resources of the cloud environment.

Abstract: A method for quantifying resource usage may include measuring a quantity of a plurality of physical computing resources being used over a period of time. The method may also include normalizing each measured quantity of each physical computing resource being used. The method may also include summing the normalized measured quantities of the physical computing resources being used to generate a single usage value representative of the physical computing resources being used over the period of time.

Abstract: A main processor 4 executes a main program and has an associated cache memory 6. Event detection circuitry 12 detects events consequent upon execution of the main program and indicative of data to be used by the main processor. One or more programmable further processors 16, 18 is triggered to execute a further program by the events detected by the event detection circuitry 12. Prefetch circuitry 28 is responsive to the further program executed by the one or more programmable further processors to trigger prefetching of the data to be used by the main processor to the cache memory.

Abstract: A method for quantifying resource usage may include measuring a quantity of a plurality of physical computing resources being used over a period of time. The method may also include normalizing each measured quantity of each physical computing resource being used. The method may also include summing the normalized measured quantities of the physical computing resources being used to generate a single usage value representative of the physical computing resources being used over the period of time.

Abstract: A method for attaching a first object to one or more second objects of dissimilar materials, without any bonding material, using a molded attachment block is provided. Anchoring grooves are created and a constrained assembly is positioned at opposing sections on a surface of the first object. A tension is generated in tension bearing members anchored in the anchoring grooves and extended along a length of the constrained assembly. The constrained assembly is constricted between mold side members positioned perpendicular to the mold end members. The tension bearing members are clamped between bolt assemblies. A viscous liquid is poured and cured on the constrained assembly, the tension bearing members, the anchoring grooves, and the bolt assemblies for creating the molded attachment block with opposing ends of the threaded members of the constrained assembly extending outwardly from the molded attachment block for attachment to second objects without any bonding material.

Abstract: A gas turbine system includes a plenum that includes an inlet and an outlet. The inlet is configured to receive a flow of oxidant and the outlet is configured to direct the flow of oxidant in a downstream direction. Additionally, a support system is coupled to the plenum and to a cone. The support system enables the cone to move along the support system from a first position to a second position. The cone includes an upstream end and the upstream end is removably coupled to the outlet of the plenum in the first position. When the cone is in the first position, the cone is configured to direct the flow of oxidant in the downstream direction to a gas turbine engine. The upstream end is disposed upstream of the outlet and is decoupled from the outlet when the cone is in the second position.

Abstract: A memory stores a catalog of applications and a catalog of trusted sources. A processor detects that a first user attempted to install an application, determines that a source of the application is in the catalog of trusted sources, scans the application to determine that the application does not contain a virus, and determines that there is a first license that allows the first user to install the application. The processor also stores the application into a repository and adds the application to the catalog of applications. The processor receives a request from a second user to install the application, determines that the application is in the catalog of applications, and determines that there is a second license that allows the second user to install the application. The processor further retrieves the application from the repository and initiates installation of the application on a device of the second user.

Abstract: A method and a dishwasher utilize a dock detection system to determine when a connector of a spray device is docked to a docking port provided on a manifold of the dishwasher. A dock detector is coupled to the docking port and is electrically coupled to a controller of the dishwasher through electrical conductors that extend along the manifold, thereby enabling a dishwasher controller to detect when spray devices are coupled to the manifold, e.g., to optimize a wash cycle to use a particular spray device docked to the docking port.

Abstract: A method and dishwasher utilize one or more tubular spray elements that are both rotatable about longitudinal axes thereof and discretely directable by one or more tubular spray element drives between a plurality of rotational positions about the longitudinal axes thereof. Thus, through the provision of discretely directable tubular spray elements, fluid such as wash fluid and/or pressurized air may be focused in a wash tub, in many cases providing more efficient resource usage in the dishwasher.

Abstract: An apparatus comprises a main processor to execute a main stream of program instructions, two or more checker processors to execute respective checker streams of program instructions in parallel with each other, the checker streams corresponding to different portions of the main stream executed by the main processor, and error detection circuitry to detect an error when a mismatch is detected between an outcome of a given portion of the main stream executed on the main processor and an outcome of the corresponding checker stream executed on one of the plurality of checker processors. This approach enables high performance main processors 4 to be checked for errors with lower circuit area and power consumption overhead than a dual-core lockstep technique.

Abstract: Methods and systems for managing application performance in a distributed computing environment. Embodiments commence when an application seeks to perform a function over a content object. The application submits a request to perform the function on the content object, and the request is received by an application programming interface processor. The application programming interface processor accesses a data structure comprising entries that relate the requested function to one or more code instances that are accessible at one or more code locations. An evaluator predicts performance of the function using a first location of a first code instance and compares that predicted performance to a predicted or measured performance of the same function using a second location of a second code instance that implements the same function. The better performing code instance at the determined code location is invoked. Results are collated, formatted, and returned to the calling application.

Abstract: The present application provides sintered porous elastomeric liquid applicators with or without flocking fibers that provide improved liquid and gel delivery properties and a comfortable experience for the user of the applicators when applying liquid to a surface, such as skin.

Abstract: The present invention relates to processes and intermediates for preparing 3-(cyanomethyl)-3-(4-{[(1R,2S)-2-phenylcyclopropyl]amino}piperidin-1-yl)azetidine-1-sulfonamide, and salts and solid forms thereof, which selectively modulate demethylase. Particular embodiments contemplate compounds and disease indications amenable to treatment by modulation of lysine specific demethylase-1 (LSD1).

Abstract: The invention relates to the field of downstream processing (DSP) of an alkaline phosphatase (AP). More specifically, it relates to a method for reducing host cell protein content in a composition comprising AP. The invention further relates to a composition comprising an AP and a reduced content of a host cell protein.

Abstract: The invention relates to the field of downstream processing (DSP) of an alkaline phosphatase (AP). More specifically, it relates to a method for reducing host cell protein content in a composition comprising AP. The invention further relates to a composition comprising an AP and a reduced content of a host cell protein.

Abstract: A method and a dishwasher utilize a dock detection system to determine when a connector of a spray device is docked to a docking port provided on a manifold of the dishwasher. A dock detector is coupled to the docking port and is electrically coupled to a controller of the dishwasher through electrical conductors that extend along the manifold, thereby enabling a dishwasher controller to detect when spray devices are coupled to the manifold, e.g., to optimize a wash cycle to use a particular spray device docked to the docking port.