Abstract: This invention relates to methods employing IL-1?-ligand/IL-1 receptor disrupting compounds (herein referred to as “IL-1beta Compounds”); such as small molecular compounds disrupting IL-1? ligand-IL-1 receptor interaction, IL-1? antibodies or IL-1 receptor antibodies, e.g. IL-1? binding molecules as described herein, e.g. antibodies disclosed herein, e.g. IL-1? binding compounds or IL-1 receptor binding compounds, and/or RNA compounds decreasing either IL-1? ligands or IL-1 receptor protein levels, in the treatment and/or prevention of auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome and to methods of treating and/or preventing auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome, in mammals, particularly humans.

Abstract: An optical system includes an outer reflector and at least one inner reflector, wherein the inner reflector is disposed within the outer reflector. The outer reflector has a proximal end, a distal end, and an interior surface extending from the distal end to the proximal end. The inner reflector has a proximal end, a distal end, and an interior surface and exterior surface extending from the distal end to the proximal end. The proximal end of the outer reflector is positioned adjacent a light source, wherein the light source is surrounded by the outer reflector's proximal end. The light source emits narrow angle beams of light through the inner reflector and emits wide angle beams of light between the outer reflector's inner surface and the inner reflector's external surface. The positioning and dimension of the inner reflector prevents the light source from emitting wide angle beams of light directly to an illuminated surface.

Abstract: A light emitting diode (LED) sign lighter is positioned to illuminate a sign. One or more LED modules on the LED sign lighter are directed toward different portions of the sign. Each LED module is configured with a reflector or over-optic to control the angle of the light emitted toward the sign. Each LED module includes an array of LEDs. The configuration of each LED module within the LED sign lighter helps to reduce the build-up of environmental contaminants on the LED module. The center section of the LED sign lighter includes a compartment for housing electrical components to power the LED modules. Heat sink fins are oriented along the back side of the LED sign lighter to provide thermal efficiency for the LED modules.

Abstract: The use of an S1P receptor modulator of the formula (Ia) or (Ib) wherein the meaning of the different residues is that indicated in claim 14, in the preparation of a medicament for preventing, inhibiting or treating an inflammatory condition selected from polymyositis, dermatomyositis and nerve-muscle diseases e.g. muscular dystrophies and inclusion body myositis.

Abstract: A method of verifying the validity of a message received by a telecommunications terminal (8) having a processor (30) and which is operable in a boot mode and a runtime mode is disclosed. In the embodiments the message is a SIM unlock message, for removing or modifying a restriction of the types of subscriber identity module (SIM) with which the mobile terminal may be used. In response to reception of the SIM unlock message when the terminal (1) is in the runtime mode, the processor 30 of the terminal (1) causes the terminal to enter the boot mode and verify the validity of the message during the boot mode. Because the validity of the message is checked during the boot mode, the check can be performed with greater security.

Abstract: A charge pump circuit can include a pump-up circuit having a first disable switch coupled between a pump-up output node and a first power supply node that is enabled and then disabled in response to a source current path between the pump-up node and a second power supply node being disabled, and a source off switch coupled in series with the first disable switch that is enabled in response to the source current path being disabled. The charge pump circuit can also include a pump-down circuit having a second disable switch coupled between a pump-down output node and the second power supply node that is enabled and then disabled in response to a sink current path between the pump-down node and a first power supply node being disabled. A sink off switch can be coupled in series with the second disable switch that is enabled in response to the sink current path being disabled.

Abstract: A mobile terminal for use with a cellular or mobile telecommunications network includes a normal execution environment (operating system) (30) and a secure execution environment (32) comprising a Mobile Trusted Module (MTM). The mobile terminal enables the software of the terminal in the secure execution environment (32) to be updated. The terminal 1 may be provided with minimal software initially in the secure execution environment (32), and is operable to subsequently update the software by over the air transmission of software. Also disclosed is a method for managing rights in respect of broadcast, multicast and/or unicast (downloaded) data, relevant in particular to managing access to a broadcast video data stream complying with a mobile digital broadcast scheme. The method defines a service protection platform implemented on mobile terminals having both normal execution environment (i.e. the operating system) and secure execution environment.

Abstract: The present invention is a method for seaming a polymeric material. The method involves forming an interface between a plurality of separate polymeric sheets of materials. Next, heat and pressure are applied to facilitate the diffusion of the polymer molecules at the interface. A diffusion weld is made when the polymer molecules diffuse across the interface.

Abstract: The present invention is a method for seaming a polyimide material. The method involves forming an interface between multiple the polyimide materials. Next, heat is applied to the interface to soften the polyimide material. The temperature of the heat source is below the melting point of the polyimide material. Finally, pressure is applied to the interface to create a seam between the polyimide materials.

Abstract: The present invention relates to new pharmaceutical formulations comprising pharmaceutically active agents which can induce one or more involuntary coughs in a patient when administered as conventional formulations and/or via conventional routes. Formulations are provided comprising a cough-inducing pharmaceutically active agent, wherein the formulation may be administered by pulmonary inhalation without inducing a cough. Alternatively, formulations are provided for administering the cough-inducing active agent via an alternative route.

Abstract: This invention relates to a novel use of IL-1?-ligand/IL-1 receptor disrupting compounds (herein referred to as “IL-1beta Compounds”); such as small molecular compounds disrupting IL-1? ligand-IL-1 receptor interaction, IL-1? antibodies or IL-1 receptor antibodies, e.g. IL-1? binding molecules described herein, e.g. antibodies disclosed herein, e.g. IL-1? binding compounds or IL-1 receptor binding compounds, and/or RNA compounds decreasing either IL-1? ligands or IL-1 receptor protein levels, in the treatment and/or prevention of auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome and to methods of treating and/or preventing auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome, in mammals, particularly humans.

Abstract: The present invention is a method for seaming a polumide material. The method involves forming an interface between multiple the polymide materials. Next, heat is applied to the interface to soften the polymide material. The temperature of the heat source is below the melting point of the polyimide material. Finally, pressure is applied to the interface to create a seam between the poluimide materials.

Abstract: This invention relates to the use of a CXCR binding molecules as described in the specification, in WHIM syndrome.

Abstract: A method, system and computer-readable medium for calibrating the radio frequency power generator in a semiconductor processing system. The output of the radio frequency power generator is routed to a dummy load. An input control of the radio frequency power generator is adjusted to produce a desired output power conversion factors and calculated and used to control the radio frequency power generator.

Abstract: The present invention relates to methods of treating pulmonary hypertension, facilitating joint fusion, facilitating tendon and ligament repair, reducing the occurrence of secondary fracture, treating avascular necrosis, facilitating cartilage repair, facilitating bone healing after limb transplantation, facilitating liver regeneration, facilitating wound healing, reducing the occurrence of gastric ulceration, treating hypertension, facilitating the growth of tooth enamel or finger or toe nails, treating glaucoma, treating ocular hypertension, and repairing damage caused by metastatic bone disease using an EP2 selective receptor agonist.

Abstract: This invention is directed to a method of treating fibromyalgia in a patient which comprises administering a growth hormone secretagogue, prodrugs thereof or pharmaceutically acceptable salts of said secretagogues or said prodrugs to a patient in need thereof. The present invention provides such a method wherein the growth hormone secretagogue is a compound of Formula I: a prodrug thereof or a pharmaceutically acceptable salt of said secretagogue or said prodrug and wherein the variables HET, R3, R4, X4, R6, R7 and R8 are as defined in the specification.

Abstract: A method is disclosed for creating a customized folder structure for a web-enabled collaborative insurance process. The method includes, for each of a plurality of users, automatically creating a plurality of standardized folders consistent with a role of the user in a web-enabled collaborative insurance process. The method also includes, automatically hierarchically organizing the plurality of standardized folders into a folder structure and providing the user with access via a networked computer to the user's hierarchically organized folder structure and plurality of standardized folders.

Abstract: The invention provides a medical or veterinary procedure review system comprising an application to perform a nonstandard procedure on a patient, a computer for receiving the application, a program to forward the application to a reviewer, storage of a review together with the application, and a record of the review process for consideration by a third party. In another aspect the invention provides a system for auditing the application review process to assume compliance with established guidelines.