Abstract: Provided herein are heterocyclic derivative compounds and tablet pharmaceutical compositions comprising said compounds that are useful for the treatment of retinal binding protein (RBP4) related diseases, such as macular degeneration and the like.

Abstract: A self-loosening tourniquet cuff for optimization of tourniquet time comprises an inflatable bladder, an elastic self-loosening tether and an inelastic safety tether. The bladder has a length between first and second ends sufficient for the bladder to encircle a patient's limb and overlap itself. The elastic self-loosening tether has an elastic member non-releasably attached to the bladder near the first end and a securing member non-releasably attached to the elastic member and adapted to releasably attach to the bladder when overlapped to establish a first bladder overlap length. The elastic member is adapted for stretching to establish a second bladder overlap length less than the first bladder overlap length. The inelastic safety retainer retains the bladder around the patient's limb near the second bladder overlap length when the bladder is inflated to a pressure sufficient to stop the flow of arterial blood into the patient's limb distal to the bladder.

Abstract: A tourniquet apparatus comprises a cuff, a user interface, a controller, a protocol hazard key and a protocol safety interlock. The cuff encircles the patient's limb and applies a level of pressure. The UI presents a protocol symbol from a plurality of protocol symbols wherein each protocol symbol is indicative of a corresponding safety protocol. The controller is responsive to stored pressure levels and stored times specified by the safety protocol, after any adjustments by the user, and operable during the stored protocol time period for maintaining the level of pressure applied by the cuff to the individual patient near the plurality of stored pressure levels at the plurality of stored times. The protocol hazard key is actuatable to end the stored protocol time period while the controller is operable. The protocol safety interlock prevents selection of a second protocol symbol while the controller is operable.

Abstract: An automatic tourniquet apparatus comprises a tourniquet cuff, a pressure transducer, a user interface, a patient hazard shield and a pressure regulator. The pressure transducer produces a cuff pressure signal. The user interface produces a reference pressure signal. The patient hazard shield is responsive to the cuff pressure signal and the reference pressure signal, and operable during a regulation time period to produce a patient hazard signal if, in one implementation, a current level of pressure in the tourniquet cuff is greater than the reference level of pressure by at least a predetermined overpressure limit. The pressure regulator is responsive to the patient hazard signal, and has a pressurizing element for increasing pressure in the cuff and a depressurizing element for decreasing pressure in the cuff. The pressurizing element is configured to be non-responsive if the patient hazard signal is produced.

Abstract: A method of forming a metasurface includes forming a plurality of channels on a surface of a formed from a first material, like a metal, ceramic, or polymer. The method also includes filling the plurality of channels in the surface of the base substrate with a second material that is different from the first material to form a metasurface on the base substrate. The method further includes placing the metasurface into a heat exchange system such that the metasurface is proximate to a liquid used in the heat exchange system.

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for the treatment of retinal binding protein (RBP4) related diseases, such as obesity and the like.

Abstract: An automatic tourniquet apparatus comprises a tourniquet cuff, a pressure transducer, a user interface, a patient hazard shield and a pressure regulator. The pressure transducer produces a cuff pressure signal. The user interface produces a reference pressure signal. The patient hazard shield is responsive to the cuff pressure signal and the reference pressure signal, and operable during a regulation time period to produce a patient hazard signal if, in one implementation, a current level of pressure in the tourniquet cuff is greater than the reference level of pressure by at least a predetermined overpressure limit. The pressure regulator is responsive to the patient hazard signal, and has a pressurizing element for increasing pressure in the cuff and a depressurizing element for decreasing pressure in the cuff. The pressurizing element is configured to be non-responsive if the patient hazard signal is produced.

Abstract: A low-cost contour cuff for surgical tourniquet systems comprises: a sheath containing an inflatable bladder, the sheath having an arcuate shape, an outer surface and a centerline equidistant between first and second side edges; a securing strap non-releasably attached to the outer surface and formed of substantially inextensible material having a shape that is predetermined and substantially flat, wherein the strap includes a bending portion near a first strap end and a fastening portion near a second strap end, and wherein the bending portion is adapted to allow twisting of the bending portion out of the substantially flat shape to facilitate positioning of the fastening portion into any of a plurality of positions in the substantially flat shape; and fastening means for releasably attaching the fastening portion of the securing strap to the outer surface whenever the sheath is curved into a position for surrounding a limb.

Abstract: A tourniquet apparatus comprises a cuff, a user interface, a controller, a protocol hazard key and a protocol safety interlock. The cuff encircles the patient's limb and applies a level of pressure. The UI presents a protocol symbol from a plurality of protocol symbols wherein each protocol symbol is indicative of a corresponding safety protocol. The controller is responsive to stored pressure levels and stored times specified by the safety protocol, after any adjustments by the user, and operable during the stored protocol time period for maintaining the level of pressure applied by the cuff to the individual patient near the plurality of stored pressure levels at the plurality of stored times. The protocol hazard key is actuatable to end the stored protocol time period while the controller is operable. The protocol safety interlock prevents selection of a second protocol symbol while the controller is operable.

Abstract: A personalized tourniquet cuff assembly comprises a sterile tourniquet cuff, a machine-readable instrument symbol, machine-readable personalization data and a sterile connector. The instrument symbol identifies a predetermined first type of tourniquet instrument from a plurality of types of tourniquet instruments, and is adapted for contactless reading by an optical tourniquet interface of the first type of tourniquet instrument. The personalization data represents a value of a personalization parameter for safe operation of the tourniquet cuff with the first type of tourniquet instrument and is adapted for contactless reading by the optical tourniquet interface. The connector is adapted for releasably connecting the tourniquet cuff to the first type of tourniquet instrument.

Abstract: A sleeve for use with a tourniquet cuff to protect a patient's limb from tourniquet-related injury includes a stretchable body extending longitudinally over a sleeve length between a proximal end and a distal end. The body has a tubular shape, and the sleeve length is greater than a width of the tourniquet cuff. The body tapers from the proximal end to the distal end such that a proximal end circumference is greater than a distal end circumference. The body is formed to apply substantially uniform pressure to the patient's limb from the proximal end of the sleeve to the distal end of the sleeve varying only within a predetermined pressure range.

Abstract: A hearing aid device comprising: a body, accommodating a circuit unit; a ear mold, capable of being accommodated in ear canal to convey sound; a connecting portion, capable of connecting the body with the ear mold; a wireless transmission unit, electrically coupled with the circuit unit, capable of communicating with at least one wireless device; and a rechargeable battery unit, coupled with the body and provided with a convex structure on a side facing the body.

Abstract: A tourniquet apparatus having an optical tourniquet interface for safe personalization, a safe transfer key and a pressure controller. The optical tourniquet interface communicates with the pressure controller and is operable for contactlessly reading and authenticating a machine-readable instrument symbol associated with a tourniquet cuff if it matches stored instrument authentication data and for contactlessly reading machine-readable personalization data associated with the cuff. The optical tourniquet interface presents a personalization parameter value if the machine-readable instrument symbol has been authenticated. The safe transfer key enables the user to selectively transfer the presented value of the personalization parameter to the pressure controller only if the pressure controller is inoperable. The pressure controller is releasably connectable to the tourniquet cuff and responsive to the transferred value of the personalization parameter.

Abstract: Intercalation pastes for use with semiconductor devices are disclosed. The pastes contain precious metal particles, intercalating particles, and an organic vehicle and can be used to improve the material properties of metal particle layers. Specific formulations have been developed to be screen-printed directly onto a dried metal particle layer and fired to make a fired multilayer stack. The fired multilayer stack can be tailored to create a solderable surface, high mechanical strength, and low contact resistance. In some embodiments, the fired multilayer stack can etch through a dielectric layer to improve adhesion to a substrate. Such pastes can be used to increase the efficiency of silicon solar cells, specifically multi- and mono-crystalline silicon back-surface field (BSF), and passivated emitter and rear contact (PERC) photovoltaic cells. Other applications include integrated circuits and more broadly, electronic devices.

Abstract: A hearing aid device comprising: a body, accommodating a circuit unit; a ear mold, capable of being accommodated in ear canal to convey sound; a connecting portion, capable of connecting the body with the ear mold; a wireless transmission unit, electrically coupled with the circuit unit, capable of communicating with at least one wireless device; and a rechargeable battery unit, coupled with the body and provided with a convex structure on a side facing the body.