Patents by Inventor Tomoyuki Yamazaki
Tomoyuki Yamazaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11103806Abstract: In a preparative separation-purification system for passing a solution containing a target component through a trap column 21 to capture the target component in the column 21, and for subsequently passing an eluting solvent through the column 21 to elute the captured component and collect it in a container, an outlet aperture 27 of the column 21 has a tapered shape whose sectional area is largest on a plane facing an inner space of the column 21 and decreases in the flowing direction of the liquid. A filter 26 for preventing deposition of the target component is also provided at the boundary between the inner space of the column 21 and a passage for discharging liquid from the inner space. By this configuration, clogging of the passage at the outlet end of the column 21 due to deposition of the target component is prevented.Type: GrantFiled: April 30, 2013Date of Patent: August 31, 2021Assignee: Shimadzu Corp.Inventors: Tomoyuki Yamazaki, Przemyslaw Stasica, Bob Boughtflower
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Patent number: 11047834Abstract: A preparative liquid chromatograph that separates components in a sample in a separating column and captures a plurality of target components in an eluate from the separating column in individual trap columns, includes: a column switching means configured to switch passages to cause the eluate having been eluted from the separating column and passed through a detector to selectively flow into one of the trap columns, a passage switching means disposed in a passage between the detector and the column switching means and configured to switch between a first state in which the eluate flows to the column switching means and a second state in which the eluate is discharged without flowing to the column switching means. For the switching among the trap columns, the passage switching means and the column switching means are controlled to set the passage switching means in the second state (step S17) before performing the switching operation of the column switching means (step S18).Type: GrantFiled: July 6, 2016Date of Patent: June 29, 2021Assignee: Shimadzu CorporationInventor: Tomoyuki Yamazaki
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Patent number: 10746170Abstract: A preparative separation-purification system has controlling apparatus, which has a pump housing for pumping liquid. The apparatus also has a moving component for reciprocating in the pump housing so as to draw a liquid into the pump housing and discharge the liquid from the pump housing and a driving source for reciprocating the moving component. A setting unit is provided for setting a target liquid supply amount or a target amount which corresponds thereto. A unit amount memory unit is provided for storing a discharge amount of the reciprocating pump per a reciprocal movement of the moving component or a unit amount which is a value corresponding to the discharge amount. A computation unit is provided for computing the smallest multiple number of the unit amount which is equal to or larger than the target amount; and a motor controller for controlling the driving source.Type: GrantFiled: May 13, 2013Date of Patent: August 18, 2020Assignee: Shimadzu Co.Inventor: Tomoyuki Yamazaki
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Patent number: 10732153Abstract: A preparative purification apparatus capable of adjusting a mixing ratio of a mobile phase and an elution solvent contained in a solution to be collected. A liquid feeding unit which feeds an elution solvent to an inlet of a trap column; a flow path switching unit which selectively connects an outlet of the trap column to one of a waste liquid flow path or a recovery flow path; a liquid feed amount measurement unit; and a flow path control unit which performs a control such that the flow path switching unit is connected to the recovery flow path when the amount of the elution solvent fed to the trap column reaches a predetermined initial waste liquid amount, and thereafter, the flow path switching unit is connected to the waste liquid flow path at a timing of reaching a predetermined solution recovery amount.Type: GrantFiled: August 24, 2015Date of Patent: August 4, 2020Assignee: Shimadzu CorporationInventors: Tomoyuki Yamazaki, Yosuke Iwata
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Patent number: 10722893Abstract: A mounting and heating mechanism of sample collection containers for heating sample collection containers includes cup-shaped container heat transfer members for heating sample collection containers from the bottom surface and the side surface, a plate-like bottom surface member heated by a heater, frame members attached to an upper side of the bottom surface member and vertically movably storing the container heat transfer members, and sheet-like elastic heat transfer member disposed between the bottom surfaces of the container heat transfer members stored in the frame members and the upper surface of the bottom surface member.Type: GrantFiled: January 13, 2017Date of Patent: July 28, 2020Assignee: SHIMADZU CORPORATIONInventor: Tomoyuki Yamazaki
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Publication number: 20190391117Abstract: A preparative liquid chromatograph includes a liquid chromatograph section, a trap section, an eluent supply section, a collector, and a flow path switching section. The flow path switching section is configured to be selectively switched to a component trap mode that connects the liquid chromatograph section and the trap section in such a way that a sample component separated in a separation column is trapped by a trap column of the trap section; and a collection mode that connects the eluent supply section and the trap section and connects the trap section and the collector in such a way that the components trapped in the trap column are eluted by an eluent from the eluent supply section and are guided to the collector.Type: ApplicationFiled: March 16, 2017Publication date: December 26, 2019Applicant: Shimadzu CorporationInventor: Tomoyuki YAMAZAKI
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Patent number: 10514364Abstract: Provided is a preparative separation-purification method in which an eluting solvent is passed through a trap column 20 to elute a target component captured in the trap column and collect the target component through a collection passage 34 into a collection container 21, the method including: a process of transferring the eluting solvent containing the eluted target component from the trap column to the collection container through the collection passage; a process of suctioning the eluting solvent remaining in the collection passage through a suction passage 6 connected to the collection passage; and a process of removing the collection passage from the trap column and the collection container. By this method, the eluate or eluting solvent remaining in the collection passage is prevented from being dropped into the collection container. A backflow of the eluate into the trap column is also prevented.Type: GrantFiled: October 7, 2016Date of Patent: December 24, 2019Assignee: SHIMADZU CORPORATIONInventor: Tomoyuki Yamazaki
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Patent number: 10434436Abstract: Provided is a gas-blowing vaporizing and drying device, which includes: a sample tube in the form of a double tube including an inner tube for a solution and an outer tube for a gas, the inner tube protruding from one end of the outer tube by length L; and a collection container including a container body and a lid provided with a protrusion sleeve tube, the protrusion sleeve tube including a coupling portion at an end to be located outside the container body and a sleeve portion of a length equal to or longer than L having an open end to be located inside the container body, the coupling portion being designed to be coupled to the aforementioned one end of the outer tube in an air-tight manner.Type: GrantFiled: August 21, 2013Date of Patent: October 8, 2019Assignee: Shimadzu Co.Inventors: Tomoyuki Yamazaki, Przemyslaw Stasica, Bob Boughtflower
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Publication number: 20190302065Abstract: A preparative liquid chromatograph that separates components in a sample in a separating column and captures a plurality of target components in an eluate from the separating column in individual trap columns, includes: a column switching means configured to switch passages to cause the eluate having been eluted from the separating column and passed through a detector to selectively flow into one of the trap columns, a passage switching means disposed in a passage between the detector and the column switching means and configured to switch between a first state in which the eluate flows to the column switching means and a second state in which the eluate is discharged without flowing to the column switching means. For the switching among the trap columns, the passage switching means and the column switching means are controlled to set the passage switching means in the second state (step S17) before performing the switching operation of the column switching means (step S18).Type: ApplicationFiled: July 6, 2016Publication date: October 3, 2019Inventor: Tomoyuki YAMAZAKI
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Patent number: 10184918Abstract: Provided is a gas-spouting liquid-sample injector, for supplying a mist of liquid sample into a container, including: a sample introduction tube having an outer tube for a nebulizer gas and an inner tube for a liquid, the inner tube having a projecting section protruding from the lower end of the outer tube; a branch tube provided in the container, having a main line allowing an insertion of the sample introduction tube and a bypass line branched from the main line; an inlet portion provided at the upper end of the main line, for making gas-tight contact with the lower end of the outer tube; an outlet portion provided at the lower end of the main line, for making gas-tight contact with the outer circumferential surface of the inner tube; and a blower tube extending from the lower end of the bypass line toward an area below the outlet portion.Type: GrantFiled: October 7, 2016Date of Patent: January 22, 2019Assignee: SHIMADZU CORPORATIONInventor: Tomoyuki Yamazaki
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Patent number: 10124270Abstract: Provided is a gas-blowing vaporizing and drying device for blowing gas at a solution containing a target component, and thus nebulizing the solution to promote vaporization of the solvent while dropping the solution into the collection container, in which contamination does not occur even if different solutes are successively powderized. In the gas-blowing vaporizing and drying device according to the present invention, a cap 20 to be fitted to the upper opening of a collection container body 19 includes: a solution-introducing tube 20A for introducing a solution supplied from a passage 14, into a collection container 21; a gas-introducing tube 20B for introducing a gas supplied from a passage 22, into the collection container 21; and an exhaust port 20C. Further, the exhaust port 20C includes a filter 20D for preventing the powderized solute from passing therethrough.Type: GrantFiled: July 4, 2012Date of Patent: November 13, 2018Assignee: SHIMADZU CORPORATIONInventors: Tomoyuki Yamazaki, Przemyslaw Stasica, Bob Boughtflower
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Publication number: 20180238841Abstract: A target component is collected using a preparative separation and purification device having a holder for holding a trap column in which the target component has been captured, a liquid feeder for feeding a first solvent having compatibility with the water remaining in the trap column and a second solvent having low compatibility with water and high compatibility with the first solvent into the trap column, a flow-path switch for connecting the exit end of the trap column to a waste liquid flow path and a collection flow path, and a control unit for controlling the flow-path switch so that solution including water flows into the waste liquid flow path.Type: ApplicationFiled: May 23, 2016Publication date: August 23, 2018Applicant: Shimadzu CorporationInventor: Tomoyuki YAMAZAKI
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Publication number: 20180231510Abstract: A preparative purification apparatus capable of adjusting a mixing ratio of a mobile phase and an elution solvent contained in a solution to be collected. A liquid feeding unit which feeds an elution solvent to an inlet of a trap column; a flow path switching unit which selectively connects an outlet of the trap column to one of a waste liquid flow path or a recovery flow path; a liquid feed amount measurement unit; and a flow path control unit which performs a control such that the flow path switching unit is connected to the recovery flow path when the amount of the elution solvent fed to the trap column reaches a predetermined initial waste liquid amount, and thereafter, the flow path switching unit is connected to the waste liquid flow path at a timing of reaching a predetermined solution recovery amount.Type: ApplicationFiled: August 24, 2015Publication date: August 16, 2018Applicant: Shimadzu CorporationInventors: Tomoyuki YAMAZAKI, Yosuke IWATA
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Patent number: 10041914Abstract: A degassing device 2 includes: a built-in absorbance measurement section 28 using an LED light source and measuring the intensity of light transmitted through a mobile phase passing through a flow cell; and a solenoid valve 26 switchable between two states with and without the mobile phase passed through a degassing tube 21. The passage-switching operation by the solenoid valve is performed so as to obtain detection signals of the transmitted light in the absorbance measurement section when the mobile phase drawn from a mobile phase container by a liquid-feeding pump 40 is passed through the degassing tube for degassing as well as when the mobile phase is not passed through the degassing tube for degassing. A signal processor 29 calculates the difference in absorbance based on those detection signals, estimates the degree of degassing based on that difference, and displays the result on a display unit 32.Type: GrantFiled: June 2, 2017Date of Patent: August 7, 2018Assignee: SHIMADZU CORPORATIONInventors: Kumiko Jingu, Keisuke Ogawa, Masato Watanabe, Yusuke Nagai, Masanori Fujiwara, Tomoyuki Yamazaki
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Publication number: 20180200719Abstract: A mounting and heating mechanism of sample collection containers for heating sample collection containers includes cup-shaped container heat transfer members for heating sample collection containers from the bottom surface and the side surface, a plate-like bottom surface member heated by a heater, frame members attached to an upper side of the bottom surface member and vertically movably storing the container heat transfer members, and sheet-like elastic heat transfer member disposed between the bottom surfaces of the container heat transfer members stored in the frame members and the upper surface of the bottom surface member.Type: ApplicationFiled: January 13, 2017Publication date: July 19, 2018Applicant: SHIMADZU CORPORATIONInventor: Tomoyuki YAMAZAKI
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Publication number: 20180100834Abstract: Provided is a preparative separation-purification method in which an eluting solvent is passed through a trap column 20 to elute a target component captured in the trap column and collect the target component through a collection passage 34 into a collection container 21, the method including: a process of transferring the eluting solvent containing the eluted target component from the trap column to the collection container through the collection passage; a process of suctioning the eluting solvent remaining in the collection passage through a suction passage 6 connected to the collection passage; and a process of removing the collection passage from the trap column and the collection container. By this method, the eluate or eluting solvent remaining in the collection passage is prevented from being dropped into the collection container. A backflow of the eluate into the trap column is also prevented.Type: ApplicationFiled: October 7, 2016Publication date: April 12, 2018Applicant: SHIMADZU CORPORATIONInventor: Tomoyuki YAMAZAKI
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Publication number: 20180100835Abstract: Provided is a gas-spouting liquid-sample injector, for supplying a mist of liquid sample into a container, including: a sample introduction tube having an outer tube for a nebulizer gas and an inner tube for a liquid, the inner tube having a projecting section protruding from the lower end of the outer tube; a branch tube provided in the container, having a main line allowing an insertion of the sample introduction tube and a bypass line branched from the main line; an inlet portion provided at the upper end of the main line, for making gas-tight contact with the lower end of the outer tube; an outlet portion provided at the lower end of the main line, for making gas-tight contact with the outer circumferential surface of the inner tube; and a blower tube extending from the lower end of the bypass line toward an area below the outlet portion.Type: ApplicationFiled: October 7, 2016Publication date: April 12, 2018Applicant: SHIMADZU CORPORATIONInventor: Tomoyuki YAMAZAKI
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Patent number: 9884267Abstract: An eluate-collecting mechanism is constructed, including: a collection passage and having an inlet to be inserted into and removed from the upper end of a trap column and an outlet to be inserted into and removed from a collection container; a support member for supporting the collection passage in such a manner that the inlet is fixed while the outlet is vertically movable; a contact part provided at the outlet to come in contact with the collection container when the outlet is inserted into this container; and an elastic member for pressing the outlet downward so that a tip of the outlet is lower than the tip of the inlet, the elastic member being compressed when the support member and the collection container are brought closer to each other while keeping the contact part in contact with the container.Type: GrantFiled: May 13, 2013Date of Patent: February 6, 2018Assignee: Shimadzu CorporationInventors: Tomoyuki Yamazaki, Stasica Przemyslaw, Bob Boughtflower
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Patent number: 9877368Abstract: Provided is an optical analyzer for performing a feedback control on the amount of light emitted from an LED as a light source, in which the configuration of an optical system is made simple and the degree of freedom in optical system arrangement is secured. An optical member 2 for focusing most of light while discharging part of the light as unfocused light is provided on an optical path from a light casting unit 1 to a sample cell 3. The optical member 2 can be achieved with a simple configuration, for example, two ball lenses spaced apart by a predetermined distance from each other. The light focused by the optical member 2 is cast as measurement light into the sample cell 3. Meanwhile, a second photodetector 5 is arranged at a position where the unfocused light reaches.Type: GrantFiled: February 4, 2016Date of Patent: January 23, 2018Assignee: SHIMADZU CORPORATIONInventors: Yusuke Nagai, Keisuke Ogawa, Masato Watanabe, Kumiko Jingu, Masanori Fujiwara, Tomoyuki Yamazaki
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Patent number: 9821250Abstract: In a preparative separation-purification system for passing a solution containing a target component through a trap column to capture the target component in the column, and for subsequently passing an eluting solvent through the column to elute the captured component and collect it in a container, a dilution passage is merged with a collection passage for sending an eluate from the outlet end of the trap column to the collection container, and a diluting liquid is intermittently introduced through the dilution passage into the collection passage. The diluting liquid lowers the concentration of the target component in the eluate and impedes the deposition of the target component. Thus, clogging of the passage due to the deposition of the target component eluted from the trap column is effectively prevented.Type: GrantFiled: May 13, 2013Date of Patent: November 21, 2017Assignee: Shimadzu CorporationInventors: Tomoyuki Yamazaki, Przemyslaw Stasica, Bob Boughtflower