Abstract: The present invention addresses the problem of providing a pharmaceutical combination composition and drug combinations for the prevention and/or treatment of dyslipidemic conditions such as atherosclerosis, hypercholesterolemia, low HDL blood disease in mammals including humans. A pharmaceutical composition for the prevention and/or treatment of dyslipidemia, etc. which comprises (a) a compound represented by the general formula (1) (in the formula, each symbol is the same as defined in the specification) or a salt thereof or a solvate thereof and (b) a cholesterol absorption inhibitor.

Abstract: The present invention addresses the problem of providing a pharmaceutical combination composition and drug combinations for the prevention and/or treatment of dyslipidemic conditions such as atherosclerosis, hypercholesterolemia, low HDL blood disease in mammals including humans. A pharmaceutical composition for the prevention and/or treatment of dyslipidemia, etc. which comprises (a) a compound represented by the general formula (1) (in the formula, each symbol is the same as defined in the specification) or a salt thereof or a solvate thereof and (b) a cholesterol absorption inhibitor.

Abstract: This surface fastener has a substrate portion and a plurality of engaging elements, each of the engaging elements being provided with a stem portion standing from the substrate portion and a hook portion extending in the fastener width direction from the stem portion. The engaging element has a narrow width tip end portion provided with at least a hook portion and an enlarged width portion provided with only the stem portion, separated by a reference surface along the fastener length and height directions as a boundary. This makes an undercut hardly formable in the molding of the engaging element, and deficiencies such as deformation and the like of the engaging element can be prevented. Further, the strength of the stem portion can be increased, and a damage which a loop-shaped engaging element and the engaging element receive when the loop-shaped engaging element is attached or pulled out can be reduced.

Abstract: An FGF21 production promoting agent containing, as an active ingredient, a compound represented by the following formula (1): wherein each of R1 and R2, which may be identical to or different from each other, represents, for example, a hydrogen atom; each of R3a, R3b, R4a, and R4b, which may be identical to or different from one another, represents, for example, a hydrogen atom or a halogen atom, or R3a and R3b or R4a and R4b may bond together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N—R5 (R5 represents, for example, a hydrogen atom or a C1-4 alkyl group); Y represents, for example, an oxygen atom, an S(O)l group (l is a number of from 0 to 2), or a carbonyl group; Z represents CH or N; n is a number of from 1 to 6; and m is a number from 2 to 6, a salt of the compound, or a solvate of the compound or the salt.

Abstract: This invention provides a combination-drug composition and a combination use of pharmaceuticals for preventing and/or treating dyslipidemia states, such as hyper-LDL cholesterolemia, in mammals, including humans. This invention pertains to a drug composition for preventing and/or treating dyslipidemia and the like, said drug composition comprising the following: (R)-2-[3-[[N-(benzoxazole-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy]butyric acid, a salt thereof, or a solvate of either; and an omega-3 fatty acid or an ester derivative of an ?-3 fatty acid.

Abstract: The present invention provides a compound useful in the prevention and treatment of nonalcoholic fatty liver disease. The invention relates to a drug for the prevention and/or treatment of nonalcoholic fatty liver disease, the drug having as an active ingredient (R)-2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy]butyric acid, a salt thereof, or a solvate of these.

Abstract: The present invention addresses the problem of providing a pharmaceutical combination composition and drug combinations for the prevention and/or treatment of dyslipidemic conditions such as atherosclerosis, hypercholesterolemia, low HDL blood disease in mammals including humans. A pharmaceutical composition for the prevention and/or treatment of dyslipidemia, etc. which comprises (a) a compound represented by the general formula (1) (in the formula, each symbol is the same as defined in the specification) or a salt thereof or a solvate thereof and (b) a cholesterol absorption inhibitor.

Abstract: The present invention provides a therapeutic agent for hyperlipidemia having an excellent effect of lowering the cholesterol and triglyceride level in blood plasma. The present invention relates to a prophylactic and/or therapeutic agent for hyperlipidemia, a prophylactic and/or therapeutic agent for obesity or diabetes mellitus, and a prophylactic and/or therapeutic agent for metabolic syndrome, each agent including a compound represented by the formula (1), or a salt thereof, and a statin, particularly pitavastatin, in combination.

Abstract: An FGF21 production promoting agent containing, as an active ingredient, a compound represented by the following formula (1): wherein each of R1 and R2, which may be identical to or different from each other, represents, for example, a hydrogen atom; each of R3a, R3b, R4a, and R4b, which may be identical to or different from one another, represents, for example, a hydrogen atom or a halogen atom, or R3a and R3b or R4a and R4b may bond together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N—R5 (R5 represents, for example, a hydrogen atom or a C1-4 alkyl group); Y represents, for example, an oxygen atom, an S(O)l group (l is a number of from 0 to 2), or a carbonyl group; Z represents CH or N; n is a number of from 1 to 6; and m is a number from 2 to 6, a salt of the compound, or a solvate of the compound or the salt.

Abstract: The present invention provides a therapeutic agent for hyperlipidemia having an excellent effect of lowering the cholesterol and triglyceride level in blood plasma.

Abstract: In an electric working machine, a scroll portion is provided at one of left and right sides of a machine body, and a relay member functioning as a power switch in which a power on/off key is removably inserted is provided at the other side of the machine body. The relay member is provided between a motor-driving battery and a control section so that the battery and control section can be electrically connected with each other by insertion, in the relay member, of the power on/off key and disconnected from each other by removal, from the relay member, of the power on/off key.

Abstract: The present invention relates to a composition for prevention and treatment of kidney diseases comprising one or more effective component(s) of a PAR-2 activating agent which is able to activate PAR-2 and a pharmaceutically acceptable carrier. The present invention further relates to a method for prevention and treatment of kidney diseases comprising administration of a composition for prevention and treatment of kidney diseases containing a PAR-2 activating agent which is able to activate PAR-2 to patients suffering from kidney diseases, and also relates to the use of a PAR-2 activating agent which is able to activate PAR-2 for the manufacture of a composition for prevention and treatment of kidney diseases. The present invention furthermore relates to a method for screening an effective ingredient for prevention and treatment of kidney diseases comprising screening of the activating action of the test substance to PAR-2.

Abstract: The present invention provides a pharmaceutical composition by a novel action mechanism without serious side effects for delayed hypersensitivity and a screening method of the same. The invention also provides a novel assay method of inhibitors/suppressive agents of PAR-2. The invention relates to a pharmaceutical composition for delayed hypersensitivity containing one or two or more active ingredients selected from the group consisting of inhibitors of PAR-2 and suppressive agents of PAR-2 gene expression and a pharmaceutically acceptable carrier, and to a method for screening active ingredients for pharmaceutical composition for delayed hypersensitivity by contacting a subject substance with cells expressing PAR-2 and by determining expression or activity of PAR-2. The invention also relates to a method for detecting or quantifying actions of the subject substance for PAR-2 using cells expressing PAR-2 in a culture containing inositol.

Abstract: An abrasive substrate is removably provided between a head portion and an abrasive member in a carry type abrasive machine. The abrasive substrate is constituted by a single synthetic resin molded member formed of the same material, and a hardness in a peripheral portion is set to be lower than that in a central portion excluding the peripheral edge portion. A difference in the hardness between the central portion and the peripheral portion is regulated by a concavo-convex surface formed on a surface at the fixing side to the head portion of the carry type abrasive machine. It is desirable that the concavo-convex surface should be constituted by a plurality of rib-shaped projections formed on the same plane. The abrasive substrate of the carry type abrasive machine can be manufactured inexpensively and can carry out a reliable and stable abrasion work.

Abstract: Both sides of a fastener chain may be reinforced and an attachment object such as a bag or a case may be mounted in a stabilized condition. A reinforcement member, which is molded of thermoplastic resin, thermoplastic elastomer or synthetic rubber in the form of a turned-down U shape in its cross section and has an appropriate plasticity and flexibility, is bonded along both outer sides of a fastener chain with a thermal welding resin film. The reinforcement member has a mounting groove which enables a cloth of the attachment object such as the bag or the case to be mounted and further contains a concave groove for a sewing thread, provided in the surface thereof. The cloth of the attachment object is inserted into the mounting groove and sewed along the concave groove with a sewing thread. Consequently, the reinforcement member can be mounted simply in a stabilized condition and can ensure a long term use.

Abstract: A stretchable warp knitted fabric comprising warp knitting yarns, first weft in-laid yarns and second weft in-laid yarns, and stretchable warp in-laid yarns. The second weft in-laid yarns consist of a plurality of at least non-stretchable yarns, and said second weft in-laid yarns run sequentially and separately in the course direction on different wale regions of the same course with having an arbitrary length respectively, while crossing the first weft in-laid yarns between courses. Consequently, even when pulled in a longitudinal direction, because the separate second weft in-laid yarns influence each other independently, the fabric does not have a great amount of ruffling in a width direction thereof and thus the a flat surface is maintained wherein there is no narrowing in the middle of the longitudinal direction.

Abstract: In an engine generator, a pair of wall plate members are opposed to each other at a distance. Accommodated between the wall plate members are an engine having a crankshaft perpendicular to the wall plate members; an outer-rotor type generator also serving as a flywheel and connected directly to the crankshaft; an intake system device disposed on one side of the engine in a plane perpendicular to an axis of the crankshaft; and an exhaust system device disposed on the other side of the engine in the plane. Thus, the engine generator can be accommodated in a limited space.

Abstract: In an electric lawn mower, a rechargeable battery and an electric motor activatable by the battery are mounted in a machine body section, and a cutter blade is provided within a cutter housing and rotatable via the electric motor to cut grass. Cover member collectively covers the battery and electric motor. The cover member is shaped to progressively slant upward in a front-to-rear direction of the machine body section, and the cover member has an opening formed in its lower front end portion and an air vent formed in its rear end portion to thereby permit ventilation from the opening to the air vent such that the battery and electric motor can be cooled by air flows.

Abstract: The present invention relates to a composition for prevention and treatment of kidney diseases comprising one or more effective component(s) of a PAR-2 activating agent which is able to activate PAR-2 and a pharmaceutically acceptable carrier. The present invention further relates to a method for prevention and treatment of kidney diseases comprising administration of a composition for prevention and treatment of kidney diseases containing a PAR-2 activating agent which is able to activate PAR-2 to patients suffering from kidney diseases, and also relates to the use of a PAR-2 activating agent which is able to activate PAR-2 for the manufacture of a composition for prevention and treatment of kidney diseases. The present invention furthermore relates to a method for screening an effective ingredient for prevention and treatment of kidney diseases comprising screening of the activating action of the test substance to PAR-2.

Abstract: An abrasive substrate is removably provided between a head portion and an abrasive member in a carry type abrasive machine. The abrasive substrate is constituted by a single synthetic resin molded member formed of the same material, and a hardness in a peripheral portion is set to be lower than that in a central portion excluding the peripheral edge portion. A difference in the hardness between the central portion and the peripheral portion is regulated by a concavo-convex surface formed on a surface at the fixing side to the head portion of the carry type abrasive machine. It is desirable that the concavo-convex surface should be constituted by a plurality of rib-shaped projections formed on the same plane. The abrasive substrate of the carry type abrasive machine can be manufactured inexpensively and can carry out a reliable and stable abrasion work.