Patents by Inventor Toshinori Nakayama

Toshinori Nakayama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11262680
    Abstract: The fixing device having a long durability life includes a first member, a heater, and a second member, the heater including a base material, an intermediate layer on the base material, and a surface layer on the intermediate layer, which includes a diamond-like carbon film, the base material containing at least one compound selected from the group consisting of aluminum nitride, aluminum oxide, and silicon nitride, and the intermediate layer has a ratio of [(Si)+(C)]/A of 0.8 or more, and a ratio of (Si)/(C) of more than 1.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: March 1, 2022
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Hirotaka Fukushima, Junzo Kobayashi, Toshinori Nakayama, Shigeru Tanaka
  • Publication number: 20210325806
    Abstract: The fixing device having a long durability life includes a first member, a heater, and a second member, the heater including a base material, an intermediate layer on the base material, and a surface layer on the intermediate layer, which includes a diamond-like carbon film, the base material containing at least one compound selected from the group consisting of aluminum nitride, aluminum oxide, and silicon nitride, and the intermediate layer has a ratio of [(Si)+(C)]/A of 0.8 or more, and a ratio of (Si)/(C) of more than 1.
    Type: Application
    Filed: April 9, 2021
    Publication date: October 21, 2021
    Inventors: Hirotaka Fukushima, Junzo Kobayashi, Toshinori Nakayama, Shigeru Tanaka
  • Patent number: 10865247
    Abstract: The present invention provides an antibody that specifically binds to human CD69, has an activity to suppress allergic inflammation, and has cross-reactivity with mouse CD69. In addition, the present invention provides an antibody having high binding affinity for human CD69 and an activity to suppress allergic inflammations. The antibody of the present invention can be a human antibody.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: December 15, 2020
    Assignees: GeneFrontier Corporation, National University Corporation Chiba University
    Inventors: Kanehisa Kojoh, Akira Miyakoshi, Shizue Katoh, Kumiko Tsuihiji, Yuki Hayami, Mikiko Nakamura, Toshinori Nakayama, Chiaki Iwamura
  • Publication number: 20200199235
    Abstract: The present invention provides an antibody that specifically binds to human CD69, has an activity to suppress allergic inflammation, and has cross-reactivity with mouse CD69. In addition, the present invention provides an antibody having high binding affinity for human CD69 and an activity to suppress allergic inflammations. The antibody of the present invention can be a human antibody.
    Type: Application
    Filed: February 20, 2020
    Publication date: June 25, 2020
    Applicants: GeneFrontier Corporation, National University Corporation Chiba University
    Inventors: Kanehisa Kojoh, Akira Miyakoshi, Shizue Katoh, Kumiko Tsuihiji, Yuki Hayami, Mikiko Nakamura, Toshinori Nakayama, Chiaki Iwamura
  • Publication number: 20200055940
    Abstract: It is an object to provide effective means for preventing and/or treating fulminant acute pneumonia. Provided are a pharmaceutical agent or pharmaceutical composition to be used for preventing and/or treating fulminant acute pneumonia, containing a CD69 antagonist, such as an antibody that specifically recognizes CD69 (anti-CD69 antibody), an agent for suppressing intra-alveolar neutrophil aggregation, containing a CD69 antagonist, such as an antibody that specifically recognizes CD69 (anti-CD69 antibody), an agent for suppressing pulmonary neutrophil infiltration, containing a CD69 antagonist, such as an antibody that specifically recognizes CD69 (anti-CD69 antibody), and a method of preventing and/or treating fulminant acute pneumonia, including administering a CD69 antagonist, such as an antibody that specifically recognizes CD69 (anti-CD69 antibody).
    Type: Application
    Filed: October 20, 2017
    Publication date: February 20, 2020
    Inventors: Akihiro HASEGAWA, Hidetaka OGINO, Toshinori NAKAYAMA
  • Patent number: 10513561
    Abstract: The present invention provides an anti-Myl9 antibody or a Myl9 binding fragment thereof that binds to Myl9 and may inhibit the interaction between Myl9 and CD69 in humans, as well as a pharmaceutical composition comprising the same. A mouse anti-human/mouse Myl9 monoclonal antibody having binding affinity against Myl9 was obtained, and the sequence for the complementarity determining region (CDR) of said mouse anti-human/mouse Myl9 monoclonal antibody was identified. Accordingly, a humanized antibody comprising the CDR sequence of said mouse anti-human/mouse Myl9 monoclonal antibody in the variable region of heavy and light chains was produced.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: December 24, 2019
    Assignees: National University Corporation Chiba University, Eisai R&D Management Co., Ltd.
    Inventors: Toshinori Nakayama, Motoko Kimura, Koji Hayashizaki, Toshifumi Hirayama, Jungo Kakuta, Yoshimasa Sakamoto, Ryu Gejima, Daisuke Tokita, Kenzo Muramoto, Toshio Imai
  • Patent number: 10449252
    Abstract: A method of treating or reducing at least one inflammatory condition or the susceptibility to at least one inflammatory condition is provided involving administering at least one CD69 antagonist to a subject, wherein the subject has been diagnosed with at least one inflammatory condition, or a susceptibility to the same. CD69 antagonists can include one or more of an anti-CD69 antibody, an anti-CD69 aptamer, a CD69 mRNA antagonist, and a small molecule pharmaceutical.
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: October 22, 2019
    Assignees: National University Corporation Chiba University, National University Corporation Yamaguchi University
    Inventors: Toshinori Nakayama, Akihiro Hasegawa, Mutsunori Shirai
  • Patent number: 10379464
    Abstract: Provided is an endless belt-shaped electrophotographic member having a superior durability. The member comprises an endless belt-shaped substrate and a surface layer, the surface layer comprising an ionizing radiation crosslinked product of a tetrafluoroethylene-perfluoroalkyl vinyl ether copolymer (PFA), the surface layer is formed by irradiation of electron beam to a resin layer, the resin layer comprising the PFA, the surface layer has a universal hardness HU at 200° C. of 18 N/mm2?HU?40 N/mm2, and when a degree of orientation of the PFA in the resin layer in a direction orthogonal to the circumferential direction of the substrate is defined as Ri, and a degree of orientation of the crosslinked PFA in the surface layer in the direction orthogonal to the circumferential direction of the substrate is defined as Rf, Ri and Rf satisfy a relationship represented by expression (1): Ri×0.8?Rf?Ri??(1).
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: August 13, 2019
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Hiroki Muramatsu, Toshinori Nakayama, Kota Arimoto, Masayuki Tamaki, Yusuke Yamaguchi, Ryo Yashiro, Matsutaka Maeda, Yuji Kitano, Yoshihito Oshima
  • Publication number: 20190233521
    Abstract: The present invention provides an antibody that specifically binds to human CD69, has an activity to suppress allergic inflammation, and has cross-reactivity with mouse CD69. In addition, the present invention provides an antibody having high binding affinity for human CD69 and an activity to suppress allergic inflammations. The antibody of the present invention can be a human antibody.
    Type: Application
    Filed: October 5, 2018
    Publication date: August 1, 2019
    Applicants: GeneFrontier Corporation, National University Corporation Chiba University
    Inventors: Kanehisa KOJOH, Akira MIYAKOSHI, Shizue KATOH, Kumiko TSUIHIJI, Yuki HAYAMI, Mikiko NAKAMURA, Toshinori NAKAYAMA, Chiaki IWAMURA
  • Patent number: 10303093
    Abstract: An image forming apparatus has an image forming portion, and a fixing portion including a first rotatable member and a second rotatable member that form a nip, and a detecting portion configured to detect a temperature of the first rotatable member. An acquiring portion acquires a rotation time of the first rotatable member, and a notifying portion provides a notification prompting exchange of the first rotatable member on the basis of an accumulated value of the rotation time of the first rotatable member acquired by the acquiring portion, the rotation time being subjected to weighting on the basis of the temperature of the first rotatable member detected by the detecting portion.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: May 28, 2019
    Assignee: Canon Kabushiki Kaisha
    Inventors: Masayuki Tamaki, Toshinori Nakayama
  • Publication number: 20190002543
    Abstract: Provided is a means for inhibiting a function of CD69, whereby allowing suppression of an inflammatory response. That is, provided are: a composition for treating an inflammatory disease which includes an antibody that specifically recognizes a myosin regulatory light chain polypeptide (hereinafter abbreviated as Myl), preferably Myl9, Myl12a, and Myl12b, and inhibits a result of an effect of coexistence of Myl with CD69; a method of treating an inflammatory disease, including administering, to a subject diagnosed as having an inflammatory disease, a therapeutically effective amount of the antibody; and a method of identifying a compound that inhibits a result of an effect of coexistence of Myl with CD69, and a method of identifying a candidate compound for treating an inflammatory disease, including selecting a compound that inhibits the result.
    Type: Application
    Filed: September 6, 2018
    Publication date: January 3, 2019
    Applicant: National University Corporation Chiba University
    Inventors: Toshinori Nakayama, Hiroyuki Hosokawa, Koji Tokoyoda, Koji Hayashizaki, Akane Suzuki
  • Publication number: 20190002588
    Abstract: The present invention provides an anti-Myl9 antibody or a Myl9 binding fragment thereof that binds to Myl9 and may inhibit the interaction between Myl9 and CD69 in humans, as well as a pharmaceutical composition comprising the same. A mouse anti-human/mouse Myl9 monoclonal antibody having binding affinity against Myl9 was obtained, and the sequence for the complementarity determining region (CDR) of said mouse anti-human/mouse Myl9 monoclonal antibody was identified. Accordingly, a humanized antibody comprising the CDR sequence of said mouse anti-human/mouse Myl9 monoclonal antibody in the variable region of heavy and light chains was produced.
    Type: Application
    Filed: January 11, 2017
    Publication date: January 3, 2019
    Inventors: Toshinori Nakayama, Motoko Kimura, Koji Hayashizaki, Toshifumi Hirayama, Jungo Kakuta, Yoshimasa Sakamoto, Ryu Gejima, Daisuke Tokita, Kenzo Muramoto, Toshio Imai
  • Patent number: 10100107
    Abstract: Provided is a means for inhibiting a function of CD69, whereby allowing suppression of an inflammatory response. That is, provided are: a composition for treating an inflammatory disease which includes an antibody that specifically recognizes a myosin regulatory light chain polypeptide (hereinafter abbreviated as Myl), preferably Myl9, Myl12a, and Myl12b, and inhibits a result of an effect of coexistence of Myl with CD69; a method of treating an inflammatory disease, including administering, to a subject diagnosed as having an inflammatory disease, a therapeutically effective amount of the antibody; and a method of identifying a compound that inhibits a result of an effect of coexistence of Myl with CD69, and a method of identifying a candidate compound for treating an inflammatory disease, including selecting a compound that inhibits the result.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: October 16, 2018
    Assignee: National University Corporation Chiba University
    Inventors: Toshinori Nakayama, Hiroyuki Hosokawa, Koji Tokoyoda, Koji Hayashizaki, Akane Suzuki
  • Publication number: 20180046117
    Abstract: Provided is an endless belt-shaped electrophotographic member having a superior durability. The member comprises an endless belt-shaped substrate and a surface layer, the surface layer comprising an ionizing radiation crosslinked product of a tetrafluoroethylene-perfluoroalkyl vinyl ether copolymer (PFA), the surface layer is formed by irradiation of electron beam to a resin layer, the resin layer comprising the PFA, the surface layer has a universal hardness HU at 200° C. of 18 N/mm2?HU?40 N/mm2, and when a degree of orientation of the PFA in the resin layer in a direction orthogonal to the circumferential direction of the substrate is defined as Ri, and a degree of orientation of the crosslinked PFA in the surface layer in the direction orthogonal to the circumferential direction of the substrate is defined as Rf, Ri and Rf satisfy a relationship represented by expression (1): Ri×0.8?Rf?Ri??(1).
    Type: Application
    Filed: August 7, 2017
    Publication date: February 15, 2018
    Inventors: Hiroki Muramatsu, Toshinori Nakayama, Kota Arimoto, Masayuki Tamaki, Yusuke Yamaguchi, Ryo Yashiro, Matsutaka Maeda, Yuji Kitano, Yoshihito Oshima
  • Publication number: 20170334982
    Abstract: Provided is a means for inhibiting a function of CD69, whereby allowing suppression of an inflammatory response. That is, provided are: a composition for treating an inflammatory disease which includes an antibody that specifically recognizes a myosin regulatory light chain polypeptide (hereinafter abbreviated as Myl), preferably Myl9, Myl12a, and Myl12b, and inhibits a result of an effect of coexistence of Myl with CD69; a method of treating an inflammatory disease, including administering, to a subject diagnosed as having an inflammatory disease, a therapeutically effective amount of the antibody; and a method of identifying a compound that inhibits a result of an effect of coexistence of Myl with CD69, and a method of identifying a candidate compound for treating an inflammatory disease, including selecting a compound that inhibits the result.
    Type: Application
    Filed: August 3, 2017
    Publication date: November 23, 2017
    Applicant: National University Corporation Chiba University
    Inventors: Toshinori Nakayama, Hiroyuki Hosokawa, Koji Tokoyoda, Koji Hayashizaki, Akane Suzuki
  • Patent number: 9758574
    Abstract: Provided is a means for inhibiting a function of CD69, whereby allowing suppression of an inflammatory response. That is, provided are: a composition for treating an inflammatory disease which includes an antibody that specifically recognizes a myosin regulatory light chain polypeptide (hereinafter abbreviated as Myl), preferably Myl9, Myl12a, and Myl12b, and inhibits a result of an effect of coexistence of Myl with CD69; a method of treating an inflammatory disease, including administering, to a subject diagnosed as having an inflammatory disease, a therapeutically effective amount of the antibody; and a method of identifying a compound that inhibits a result of an effect of coexistence of Myl with CD69, and a method of identifying a candidate compound for treating an inflammatory disease, including selecting a compound that inhibits the result.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: September 12, 2017
    Assignee: National University Corporation Chiba University
    Inventors: Toshinori Nakayama, Hiroyuki Hosokawa, Koji Tokoyoda, Koji Hayashizaki, Akane Suzuki
  • Patent number: 9671731
    Abstract: A fixing member is provided, including a release layer containing a tetrafluoroethylene-perfluoroalkyl vinyl ether copolymer (PFA), wherein a content of the perfluoroalkyl vinyl ether (PAVE) based on all PFAs in the release layer is 3.0 mol % or more and 5.8 mol % or less, and an elastic layer having an indentation elastic modulus EITs at a surface thereof and an indentation elastic modulus EITc at a position in a depth of 50 ?m from the surface, EITs and EITc being measured at a temperature of 150° C., and EITs is larger than EITc and EITc being 17 MPa or more and 24 MPa or less.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: June 6, 2017
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Katsuhisa Matsunaka, Yoshihito Oshima, Toshinori Nakayama, Yasuhiro Miyahara
  • Patent number: 9606486
    Abstract: An elastic layer includes a needle-shaped filler and a void and has a porosity of 20 vol % or more and 60 vol % or less. The elastic layer contains a first area and a second area. The first area extends from a surface of the elastic layer opposite to a surface facing the mandrel toward the mandrel and has a thickness of 30% of the thickness of the elastic layer. The second area is a central area in a thickness direction of the elastic layer and has a thickness of 40% of the thickness of the elastic layer. The needle-shaped filler in the second area has an orientation degree of 50% or lower. The needle-shaped filler in the first area has an orientation degree higher than that of the needle-shaped filler in the second area.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: March 28, 2017
    Assignee: Canon Kabushiki Kaisha
    Inventors: Yutaka Arai, Takeshi Suzuki, Jun Miura, Shigeaki Takada, Toshinori Nakayama, Naoki Akiyama, Daigo Matsuura, Yasuhiro Miyahara, Akeshi Asaka, Shuichi Tamura, Katsuhisa Matsunaka, Shinsuke Takahashi, Hiroto Sugimoto
  • Patent number: 9596718
    Abstract: A heater usable with an image heating apparatus includes contacts including at least one first contact provided on a substrate and connectable with a first terminal, and second contacts provided on the substrate and connectable with a second terminal; electrodes arranged in a longitudinal direction of the substrate with predetermined gaps; electroconductive lines connecting the electrodes with respective ones of the contacts such that the electrode connected with the first contact and the electrode connected with the second contacts are alternately arranged in the longitudinal direction of the substrate; and heat generating portions, provided between adjacent electrodes, respectively, for generating heat by electric power supply between adjacent electrodes, wherein all of the first contacts are provided in one end portion of the substrate with respect to the longitudinal direction, and all of the second contacts are provided in the other end portion with respect to the longitudinal direction.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: March 14, 2017
    Assignee: CANON KABUSHIKI KAISHA
    Inventor: Toshinori Nakayama
  • Patent number: 9594334
    Abstract: A heater usable with an image heating apparatus includes first and second terminals, a connector, and an endless heating belt. At least one first contact is provided on a substrate and connectable with the first terminal through the connector, and second contacts are provided on the substrate and connectable with the second terminal through the connector. The heater also includes electrodes, including a first electrode connected with the first contact and second electrodes connected with the second contacts, the first electrodes and the second electrodes being arranged alternately with predetermined gaps in a longitudinal direction of the substrate. A plurality of heat generating portions are provided between adjacent electrodes so as to connect between adjacent electrodes, and are capable of generating heat by the electric power supply between adjacent electrodes. The first contact and the second contacts are all disposed in one longitudinal end portion side of the substrate.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: March 14, 2017
    Assignee: CANON KABUSHIKI KAISHA
    Inventor: Toshinori Nakayama