Abstract: To provide a method of efficiently delivering cells having an anti-tumor activity to tumor tissues to evoke a stronger anti-tumor reaction, and a method of providing a more effective tumor regression effect, both in a cellular immunotherapy for cancer utilizing cells having an anti-tumor activity or antigen presenting cells for activating cells capable of exhibiting an anti-tumor activity. Provided are: a method of treating head and neck cancer, comprising administering an anti-cancer cell composition containing NKT cells activated in vitro with an NKT cell ligand into the tumor-feeding artery, and administering an NKT cell-stimulating agent containing antigen presenting cells treated with an NKT cell ligand through the upper respiratory tract mucous membrane; a use, in anti-cancer treatment of head and neck region, of the anti-cancer cell composition and the NKT cell-stimulating agent; a kit comprising the anti-cancer cell composition and the NKT cell-stimulating agent; and the anti-cancer cell composition.

Abstract: The present invention provides an agent for promoting human Th1 cell differentiation and an agent for suppressing human Th2 cell differentiation, comprising lipoarabinomannans and/or lipomannans derived from BCG cell bodies. The agent of the present invention is useful as a prophylactic/therapeutic agent for cancers and the like, and also as a therapeutic agent for allergic diseases such as pollinosis.

Abstract: An image heating apparatus includes a heating rotatable member for heating, in a nip, an image on a recording material; a heater for heating the image heating member; a cooling device for cooling the image heating member, wherein when a target temperature of the image heating member is changed to a low temperature which is lower than the target temperature, the apparatus is operable in a mode wherein a temperature of the image heating member is lowered by the cooling device to a transition temperature which is lower than the low temperature, and then, the temperature of the image heating member is raised by the heater to the low temperature.

Abstract: An imageable rodent model for asthma is described. The invention provides a rodent model for asthma wherein a rodent is provided with fluorescently labeled lymphocytes sensitized to an allergen which can be monitored after inducing an asthmatic response by the allergen. Methods to monitor trafficking of the fluorescently labeled cells in the rodent model for asthma are provided. Methods to determine the effectiveness of candidate drugs that regulate asthmatic responses using the rodent asthma model are also provided.

Abstract: An image forming apparatus includes a rotatable image heating member for heating a toner image on a recording material in a nip; a rotatable pressing member for pressing against the image heating member to form the nip; a moving mechanism for relative movement between the heating member and the pressing member toward and away from each other; a temperature detecting member for detecting a temperature of the pressing member; cooling means for cooling the pressing member; rotational speed changing means for changing a rotational speed of the pressing member; and an executing portion for executing, when the temperature of the pressing member reaches an upper limit temperature during execution of an image formation job of continuously forming the images, a cooling mode for cooling the pressing member by the cooling means in a state that the pressing member and the heating member are spaced from each other while rotating the pressing member at a second rotational speed higher than a first rotational speed which is

Abstract: An image heating apparatus includes a heating rotatable member for heating, in a nip, an image on a recording material; a heater for heating the image heating member; a cooling device for cooling the image heating member, wherein when a target temperature of the image heating member is changed to a low temperature which is lower than the target temperature, the apparatus is operable in a mode wherein a temperature of the image heating member is lowered by the cooling device to a transition temperature which is lower than the low temperature, and then, the temperature of the image heating member is raised by the heater to the low temperature.

Abstract: An image heating apparatus includes a heating rotatable member for heating, in a nip, an image on a recording material; a heater for heating the image heating member; a cooling device for cooling the image heating member, wherein when a target temperature of the image heating member is changed to a low temperature which is lower than the target temperature, the apparatus is operable in a mode wherein a temperature of the image heating member is lowered by the cooling device to a transition temperature which is lower than the low temperature, and then, the temperature of the image heating member is raised by the heater to the low temperature.

Abstract: An image heating apparatus includes a first image heating device for heating a toner image on a recording material. A first temperature detector is provided for detecting a temperature of the first image heating device. A second image heating device is also provided for heating the toner image on the recording material heated by the first image heating device, and a second temperature detecting device is provided for detecting a temperature of the second image heating device. Still further, a controller is provided for changing a number of recording materials passing through the first image heating device and the second image heating device per unit time on the basis of the detected temperature by the first image heating device and a detected temperature by the second image heating device.

Abstract: An image forming apparatus capable of executing a mode for decelerating a rotation speed of a fixing member and a pressure member between sheets in a continuous print than that during a fixing operation.

Abstract: An image heating device has a heating roller, an endless belt forming a nip with the heating roller and a pressure pad pressing the belt into the nip, the device has a supplying and connection unit to supply a lubricant onto the inner surface of a pressure belt before the pressure pad and to collect the supplied lubricant from the pressure belt before a steering roller.

Abstract: An image heating apparatus includes a heating rotatable member for heating an image on a recording material in a nip, a nip forming member for cooperating with the heating rotatable member to form the nip, and a rubbing rotatable member. The rubbing rotatable member rubs, by its rotation, the heating rotatable member. The rubbing rotatable member has an elastic layer to provide a microhardness [GPa] of not less than 0.03 and not more than 1.0.

Abstract: A semiconductor device includes a first semiconductor package, in which a first semiconductor chip is mounted and a second semiconductor package, in which a second semiconductor chip is mounted and which is supported above the first semiconductor package so as to extend off the first semiconductor package.

Abstract: An image heating apparatus includes a heating rotatable member for heating an image on a recording material in a nip; a nip forming member for cooperating with said heating rotatable member to form the nip; a rubbing rotatable member having a rubbing material for rubbing said heating rotatable member; the following is satisfied: 7×10?3?(P/?H tan ?) (|V?v|/V)?68×10?3 where P: load [N] by said rubbing member to said heating rotatable member, V: peripheral speed of said heating rotatable member [mm/sec], v: peripheral speed [mm/sec] the of said rubbing member, h: microhardness [GPa] of said heating rotatable member, and ?: a half-apex-angle [°] of said rubbing material.

Abstract: The present invention provides an agent for promoting human Th1 cell differentiation and an agent for suppressing human Th2 cell differentiation, comprising lipoarabinomannans and/or lipomannans derived from BCG cell bodies. The agent of the present invention is useful as a prophylactic/therapeutic agent for cancers and the like, and also as a therapeutic agent for allergic diseases such as pollinosis.

Abstract: An image heating apparatus including a plurality of image heating devices, each of the plurality of image heating devices having: an image heating member that heats an image on a recording material; and a separation member that separates the recording material from the image heating member, wherein the recording material is caused to first pass through the image heating device on an upstream side with respect to a conveying direction of the recording material and then pass through the image heating device on a downstream side, and wherein the separation member of the image heating device on the upstream side and the separation member of the image heating device on the downstream side are different from each other.

Abstract: An image heating apparatus includes a heating rotatable member for heating an image on a recording material in a nip; a nip forming member for cooperating with said heating rotatable member to form the nip; a rubbing rotatable member having a rubbing material for rubbing said heating rotatable member; the following is satisfied: 7×10?3?(P/?H tan ?) (|V?v|/V)?68×10?3 where P: load [N] by said rubbing member to said heating rotatable member, V: peripheral speed of said heating rotatable member [mm/sec], v: peripheral speed [mm/sec] the of said rubbing member, h: microhardness [GPa] of said heating rotatable member, and ?: a half-apex-angle [°] of said rubbing material.

Abstract: An image heating apparatus includes a heating rotatable member for heating an image on a recording material in a nip; a nip forming member for cooperating with said heating rotatable member to form the nip; a rubbing rotatable member for rubbing, by its rotation, said heating rotatable member; wherein said rubbing rotatable member has an elastic layer to provide a microhardness the GPa] of not less than 0.03 and not more than 1.0.

Abstract: An image heating apparatus includes first image heating means for heating a toner image on a recording material; first temperature detecting means for detecting a temperature of the first image heating means; second image heating means for heating the toner image on the recording material heated by the first image heating means; a second temperature detecting means for detecting a temperature of the second image heating means; changing means for changing a number of recording materials passing through the first image heating means and the second image heating means per unit time on the basis of the detected temperature by the first image heating means and a detected temperature by the second image heating means.

Abstract: An image heating apparatus including a plurality of image heating devices, each of the plurality of image heating devices having: an image heating member that heats an image on a recording material; and a separation member that separates the recording material from the image heating member, wherein the recording material is caused to first pass through the image heating device on an upstream side with respect to a conveying direction of the recording material and then pass through the image heating device on a downstream side, and wherein the separation member of the image heating device on the upstream side and the separation member of the image heating device on the downstream side are different from each other.

Abstract: An image heating apparatus includes a first image heating device for heating a toner image on a recording material. A first temperature detector is provided for detecting a temperature of the first image heating device. A second image heating device is also provided for heating the toner image on the recording material heated by the first image heating device, and a second temperature detecting device is provided for detecting a temperature of the second image heating device. Still further, a controller is provided for changing a number of recording materials passing through the first image heating device and the second image heating device per unit time on the basis of the detected temperature by the first image heating device and a detected temperature by the second image heating device.