Abstract: A pressing rotatable member for use with an image heating apparatus including a base layer; and a porous elastic layer provided on the base layer, wherein the elastic layer has a thermal conductivity in an axial direction thereof and a thermal conductivity in a circumferential direction thereof which are not less than 6-times and not more than 900-times a thermal conductivity in a thickness direction thereof.

Abstract: In an image heating apparatus including heat generating members arranged along a longitudinal direction of a belt, when an image heating operation is performed on a recording material having a width which is smaller than a maximum width of the recording material usable in the image heating apparatus, the heat generating member positioned within an area corresponding to a non passing portion of the recording material is actuated together with the heat generating member positioned within an area corresponding to a non passing portion of the recording material.

Abstract: A heater includes: a substrate; a first electrical contact; second electrical contacts; first electrode portions and second electrode portions; heat generating portions; a first electroconductive line portion electrically connecting the first electrical contact and the first electrode portions; and a second electroconductive line portion electrically connecting one of the second electrical contacts and a part of the second electrode portions. A cross-sectional area of a portion, of the first electroconductive line portion, into which all of currents flowing through the first electrode portions merge when the currents flow from the first electrode portions toward the first electrical contact is larger than a cross-sectional area of a portion, of the second electroconductive line portion, into which all of currents flowing through the part of the second electrode portions merge when the currents flow from the part of the second electrode portions toward the one of second electrical contacts.

Abstract: A heater includes a substrate; a first electrical contact a plurality of second electrical contacts an electroconductive line portion electrically connected with the first electrical contact; a plurality of electrode portions including first electrode portions electrically connected with the first electrical contact through the electroconductive line portion and second electrode portions electrically connected with the second electrical contacts; and a plurality of heat generating portions provided between adjacent ones of the electrode portions. A cross-section of the electroconductive line portion in a side closer to the first electrical contact than the plurality of heat generating portions are with respect to the longitudinal direction is larger than a cross-section of a predetermined electrode portion, between adjacent heat generating portions, of the plurality of electrode portions.

Abstract: [Problem] The present invention provides a novel pathological marker of angiitis which serves as an alternative to MPO-ANCAs. [Means for Solution] According to one embodiment of the present invention, a method for testing angiitis which includes a step of detecting an antibody specifically recognizing a moesin in a biological sample is provided. In addition, according to another embodiment of the present invention, a reagent for testing angiitis which contains a substance that detects an antibody specifically recognizing a moesin in a biological sample is provided.

Abstract: A fixing member used for fixing a toner image on a recording material includes: a base layer; and a porous elastic layer provided on the base layer and containing a needle-like filler. The elastic layer has a thermal conductivity with respect to a longitudinal direction thereof in a first region where the elastic layer is contactable to the recording material on the fixing member, and the thermal conductivity is 6 times to 900 times a thermal conductivity with respect to a thickness direction in the first region. The elastic layer has a thermal conductivity with respect to the thickness direction thereof in a second region outside the first region with respect to the longitudinal direction, and the thermal conductivity with respect to the thickness direction in the second region is larger than the thermal conductivity with respect to the thickness direction in the first region.

Abstract: A fixing device includes a rotatable heating member and a rotatable pressing member which are configured to fix a toner image on a recording material in a nip therebetween; and a heating mechanism configured to selectively heat regions of the rotatable heating member depending on sizes of the recording material when the sizes are predetermined ones of all sizes usable in the fixing device. The rotatable pressing member includes a base layer and a porous elastic layer provided on the base layer and containing a needle-like filler. The elastic layer having a thermal conductivity, with respect to a longitudinal direction thereof, which is 6 times to 900 times a thermal conductivity with respect to a thickness direction thereof.

Abstract: An elastic layer includes a needle-shaped filler and a void and has a porosity of 20 vol % or more and 60 vol % or less. The elastic layer contains a first area and a second area. The first area extends from a surface of the elastic layer opposite to a surface facing the mandrel toward the mandrel and has a thickness of 30% of the thickness of the elastic layer. The second area is a central area in a thickness direction of the elastic layer and has a thickness of 40% of the thickness of the elastic layer. The needle-shaped filler in the second area has an orientation degree of 50% or lower. The needle-shaped filler in the first area has an orientation degree higher than that of the needle-shaped filler in the second area.

Abstract: An image heating apparatus includes: an electric energy supplying portion, an endless belt and a heater. The heater includes a substrate, electrode portions including first electrode portions and second electrode portions, a plurality of heat generating portions, and a connecting circuit. The electric energy supplying portion supplies electric energy to the first heat generating portions when a sheet having a predetermined width is heated, and supplies electric energy to the first heat generating portions and the second heat generating portions when a sheet having a width broader than the predetermined width is heated. The connecting circuit includes a single interrupting element configured to interrupt electric energy supply from the electric energy supplying portion to the heater. The interrupting element is provided so as to establish a positional relationship that the interrupting element opposes the first heat generating portions with respect to a longitudinal direction of the substrate.

Abstract: A heater usable with an image heating apparatus includes contacts including at least one first contact provided on a substrate and connectable with a first terminal, and second contacts provided on the substrate and connectable with a second terminal; electrodes arranged in a longitudinal direction of the substrate with predetermined gaps; electroconductive lines connecting the electrodes with respective ones of the contacts such that the electrode connected with the first contact and the electrode connected with the second contacts are alternately arranged in the longitudinal direction of the substrate; and heat generating portions, provided between adjacent electrodes, respectively, for generating heat by electric power supply between adjacent electrodes, wherein all of the first contacts are provided in one end portion of the substrate with respect to the longitudinal direction, and all of the second contacts are provided in the other end portion with respect to the longitudinal direction.

Abstract: A heater usable with an image heating apparatus including first and second terminals includes electrodes including first and second electrodes connectable the first and second terminals, respectively, the first electrodes and the second electrodes extend longitudinally; heat generating portions between adjacent electrodes; a first electric line connected with the first electrodes, the first line being extending with a gap between the heat generating portions, a second electric line connected with the second electrode connected with the heat generating portions in a first heat generating region, a third electric line connected with the second electrode connected with the heat generating portions in a second heat generating region, the second electric line being extended adjacent to the second electric line, wherein a gap between the second and third electric lines in the widthwise direction is smaller than the gap between the first and second electrodes in the widthwise direction.

Abstract: A heater usable with an image heating apparatus including first and second terminals includes a first connector connectable with the first terminal; a second connector connectable with the second terminal and positioned with a gap from the first connector in a longitudinal direction of the substrate; a third connector connectable with the second terminal; a fourth connector connectable with the second terminal and positioned with a gap from the third connector in the widthwise; heat generators arranged in the longitudinal direction, the heat generators including at least one heat generator activatable by the first connector and the second connector, at least one heat generator activatable by the first connector and the third connector, and at least one heat generator activatable by the first connector and the fourth connector; a gap between the third connector and the fourth connector in the widthwise direction is smaller than a gap between the first connector and the second connector in the longitudinal dire

Abstract: A heater usable with an image heating apparatus including first and second terminals, a connector, and an endless heating belt, the heater including at least one first contact provided on a substrate and connectable with the first terminal through the connector; second contacts provided on the substrate and connectable with the second terminal through the connector; electrodes including a first electrode connected with the first contact and second electrodes connected with the second contacts, the first electrodes and the second electrodes being arranged alternately with predetermined gaps in a longitudinal direction of the substrate; and a plurality of heat generating portions provided between adjacent electrodes so as to connect between adjacent electrodes, the heat generating portions being capable of generating heat by the electric power supply between adjacent electrodes; wherein the first contact and the second contacts are all disposed in one longitudinal end portion side of the substrate.

Abstract: An image heating apparatus includes an endless belt configured to heat an image on a sheet at a nip potion, a heat generation device configured to cause the belt to generate heat, a nip forming member configured to form the nip portion between the nip forming member and the belt, and a pressing roller configured to press an inner surface of the belt toward the nip forming member, the pressing roller including an elastic porous layer containing a plurality of filler particles, wherein a thermal conductivity of the elastic porous layer in an axial direction of the pressing roller is in a range of 6 times to 900 times a thermal conductivity of the elastic porous layer in a radial direction of the pressing roller.

Abstract: To provide a method of efficiently delivering cells having an anti-tumor activity to tumor tissues to evoke a stronger anti-tumor reaction, and a method of providing a more effective tumor regression effect, both in a cellular immunotherapy for cancer utilizing cells having an anti-tumor activity or antigen presenting cells for activating cells capable of exhibiting an anti-tumor activity. Provided are: a method of treating head and neck cancer, comprising administering an anti-cancer cell composition containing NKT cells activated in vitro with an NKT cell ligand into the tumor-feeding artery, and administering an NKT cell-stimulating agent containing antigen presenting cells treated with an NKT cell ligand through the upper respiratory tract mucous membrane; a use, in anti-cancer treatment of head and neck region, of the anti-cancer cell composition and the NKT cell-stimulating agent; a kit comprising the anti-cancer cell composition and the NKT cell-stimulating agent; and the anti-cancer cell composition.

Abstract: An image heating apparatus includes an endless belt configured to heat an image on a sheet at a nip potion, a heat generation device configured to cause the belt to generate heat, a nip forming member configured to form the nip portion between the nip forming member and the belt, and a pressing roller configured to press an inner surface of the belt toward the nip forming member, the pressing roller including an elastic porous layer containing a plurality of filler particles, wherein a thermal conductivity of the elastic porous layer in an axial direction of the pressing roller is in a range of 6 times to 900 times a thermal conductivity of the elastic porous layer in a radial direction of the pressing roller.

Abstract: The present invention provides an antibody that specifically binds to human CD69, has an activity to suppress allergic inflammation, and has cross-reactivity with mouse CD69. In addition, the present invention provides an antibody having high binding affinity for human CD69 and an activity to suppress allergic inflammations. The antibody of the present invention can be a human antibody.

Abstract: An image forming portion of an image forming apparatus is configured to form a toner image on a recording medium such that a relationship of M???L/(30?3) is satisfied, where a volume average particle size of toner is L (?m), density of the toners is ? (g/cm3), and a maximum toner laid quantity per unit area of a single color toner image on a recording medium is M (mg/cm2). The toner image formed by the image forming portion is fixed on the recording medium by a fixing nip portion by being heated and applied a force in a direction of a plane of the recording medium.

Abstract: A pressing rotatable member for use with an image heating apparatus including a base layer; and a porous elastic layer provided on the base layer, wherein the elastic layer has a thermal conductivity in an axial direction thereof and a thermal conductivity in a circumferential direction thereof which are not less than 6-times and not more than 900-times a thermal conductivity in a thickness direction thereof.

Abstract: In an image heating apparatus including heat generating members arranged along a longitudinal direction of a belt, when an image heating operation is performed on a recording material having a width which is smaller than a maximum width of the recording material usable in the image heating apparatus, the heat generating member positioned within an area corresponding to a non passing portion of the recording material is actuated together with the heat generating member positioned within an area corresponding to a non passing portion of the recording material.