Patents by Inventor Toshio Shinohara

Toshio Shinohara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4349682
    Abstract: The invention provides a novel compound 2-(3-trimethylsilylpropyl)benzothiazole having remarkable anti-tumor effects or, in particular, inhibiting growth of melanoma cells in test animals. The compound is synthesized by the ring-closing intramolecular dehydration condensation of 2-mercapto-(.gamma.-trimethylsilyl)butyroanilide which in turn is obtained by the dehydrochlorination condensation of 2-aminothiophenol and .gamma.-trimethylsilylbutyryl chloride in a polar solvent in the presence of an acid acceptor.
    Type: Grant
    Filed: September 11, 1980
    Date of Patent: September 14, 1982
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Shigeshi Toyoshima, Ryuichi Sato, Koichi Ito, Toshio Shinohara, Yasushi Yamamoto
  • Patent number: 4336251
    Abstract: A novel medicament which is effective as an antihypertensive agent is proposed which contains, as its effective ingredient, an organosilicon compound represented by the general formulaR.sub.3 Si(CH.sub.2).sub.n COOH,where R denotes an alkyl group having from 1 to 6 carbon atoms and n is an integer from 1 to 5 inclusive, or a therapeutically acceptable salt thereof such as a salt with an alkali metal, e.g. sodium or potassium. The effectiveness of the compound, for example, 3-trimethylsilyl butyric acid as well as the sodium and potassium salts thereof is established by the animal test undertaken with hypertensive rats.
    Type: Grant
    Filed: August 15, 1980
    Date of Patent: June 22, 1982
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Shigeshi Toyoshima, Ryuichi Sato, Koichi Ito, Toshio Shinohara, Yasushi Yamamoto, Shoji Ichinohe
  • Patent number: 4328216
    Abstract: The invention provides a novel anti-tumor agent highly effective for inhibiting growth of several tumor or cancer cells with low toxicity. The active ingredient contained in the anti-tumor agent is an .omega.-triorganosilyl-substituted linear alkanoic acid anilide which is a hitherto unknown novel compound prepared by the reaction of corresponding acid chloride and aniline.
    Type: Grant
    Filed: December 10, 1979
    Date of Patent: May 4, 1982
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Shigeshi Toyoshima, Ryuichi Sato, Koichi Ito, Toshio Shinohara, Yasushi Yamamoto, Shoji Ichinohe
  • Patent number: 4320172
    Abstract: The invention provides a novel in-process release paper, i.e. a release paper used as a backing paper in the manufacturing of, e.g. a synthetic leather with a polyurethane resin. The releasing resin composition with which the release paper is coated is novel as comprising (a) a base resin selected from the group consisting of alkyd resins and acrylic resins modified with an organopolysiloxane, of which from 15 to 50% by moles of the organic groups directly bonded to the silicon atoms in a molecule are phenyl groups, having at least one hydroxy-substituted organic group directly bonded to the silicon atom in a molecule, (b) an alkanol-modified amino resin and (c) an acidic catalyst. The inventive in-process release paper is very superior to the conventional ones in the very much reduced peeling resistance, increased surface gloss and durability in repeated use.
    Type: Grant
    Filed: July 1, 1980
    Date of Patent: March 16, 1982
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Minoru Takamizawa, Toshio Shinohara, Yasushi Yamamoto, Tasuku Tanino, Kiyoyuki Takano, Fumiaki Mori
  • Patent number: 4278666
    Abstract: The invention provides a novel class of organosilicon compounds and a method for the preparation thereof as well as an anti-tumor agent containing the compound having very remarkable anti-tumor activity but with very low toxicity. The inventive compound is a (trihydrocarbylsilylmethyloxyimino)alkane, which is a silicon-containing oxime compound hitherto not described in any prior art literatures, represented by the general formula R.sup.1.sub.3 Si--CH.sub.2 --O--N.dbd.Y, R.sup.1 is a substituted or unsubstituted monovalent hydrocarbon group having from 1 to 10 carbon atoms and Y is a divalent hydrocarbon group denoted by .dbd.CR.sup.2 R.sup.3 or .dbd.CR.sup.4, R.sup.2 and R.sup.3, which may be identical or different, having the same meaning as R.sup.1 defined above and R.sup.4 being an alkylene group to form a ring structure jointly with the carbon atom directly bonded to the nitrogen atom.
    Type: Grant
    Filed: February 26, 1980
    Date of Patent: July 14, 1981
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Shigeshi Toyoshima, Ryuichi Sato, Koichi Ito, Toshio Shinohara, Yasushi Yamamoto
  • Patent number: 4267172
    Abstract: The present invention presents a novel class of compounds bis(triorganosilylalkyl) phosphites, e.g. bis(trimethylsilylmethyl) phosphite. The compound is readily prepared by the reaction of a corresponding triorganosilyl alkanol with phosphorus trichloride or by the partial hydrolysis of a corresponding tris(triorganosilylalkyl) phosphite with an equimolar amount of water followed by distillation of the reaction mixture.The compound has a remarkable anti-transplanted tumor effectiveness as established by the test with mice as the test animals for preventing the growth of Ehrlich's cancer cells and Sarcoma 180 cells. The compound has very low toxicity when orally administrated.
    Type: Grant
    Filed: September 25, 1979
    Date of Patent: May 12, 1981
    Assignee: Shin-Etsu Chemical Co. Ltd.
    Inventors: Shigeshi Toyoshima, Ryuichi Sato, Koichi Ito, Toshio Shinohara, Masatoshi Arai
  • Patent number: 4257868
    Abstract: In an automatic serum applicator so adapted as to insert blade tips of a serum applicating member into sera filled in sample trays for applying sera to said blade tips and place said blade tips onto carrier to apply said sera, an automatic applicator with serum drying-preventive mechanism adapted in such a manner that a water-absorptive sheet impregnated with water is placed in a case for accommodating sample trays, a lid covering said case is arranged in a freely openable-closable condition and said lid is opened only when the serum is to be applied to the applicating member, thereby preventing sera contained in sample trays from being dried.
    Type: Grant
    Filed: March 26, 1980
    Date of Patent: March 24, 1981
    Assignee: Olympus Optical Co., Ltd.
    Inventors: Heihachi Arima, Toshio Shinohara
  • Patent number: 4234023
    Abstract: A liquid feeder comprises a liquid suction and delivery pump which withdraws a liquid such as a culture solution, buffer solution, enzyme solution or the like which is retained in a liquid storage container as refrigerated or at a reduced temperature and delivers it through a flexible tube for injection into a culture vessel located within an incubator. The tube is inserted into an inner pipe and is sealingly secured thereto. The inner pipe is detachably and hermetically mounted in an outer pipe which extends through and is secured to a wall forming an environment isolating layer of the incubator. An eccentric crankpin which is driven by a motor is connected through a link with another crankpin having a greater eccentricity, the latter crankpin being driven for rotation to cause a reciprocatory rotating motion of a driven shaft about its own axis through an angular extent of less than 180.degree..
    Type: Grant
    Filed: December 26, 1978
    Date of Patent: November 18, 1980
    Assignee: Olympus Optical Co., Ltd.
    Inventors: Shinroku Sogi, Makoto Yoshinaga, Toshio Shinohara, Takayuki Aihara, Ikuo Tawara
  • Patent number: 4231403
    Abstract: A liquid feeder comprises a motor which drives a cam causing a vertical motion of a drive shaft which is also angularly driven by a cam groove, the drive shaft being effective to cause a three dimensional motion of the discharge port of a single liquid supply tube for injection into a pair of vessels.
    Type: Grant
    Filed: December 26, 1978
    Date of Patent: November 4, 1980
    Assignee: Olympus Optical Co., Ltd.
    Inventors: Shinroku Sogi, Makoto Yoshinaga, Toshio Shinohara, Takayuki Aihara, Ikuo Tawara
  • Patent number: 4210724
    Abstract: An apparatus for liquid disposal and distribution in automatic culture system comprises a first turntable carrying a plurality of culture vessels disposed in an array on a common circle thereon, and a second turntable carrying a plurality of centrifuge tubes disposed in an array on a common circle thereof. The apparatus comprises a pipette holding arm which is disposed so that its free end is angularly movable between one of the culture vessels and one of the centrifuge tubes. The free end of the arm has attached thereto a tapered cylinder which detachably receives a pipette. A fixed displacement pump is connected with the cylinder, which is movable along the path of rotation, along which are disposed a pipette holder, a pipette remover and a liquid disposal pot. The apparatus also comprises a rotary and elevating mechanism associated with the arm.
    Type: Grant
    Filed: March 20, 1978
    Date of Patent: July 1, 1980
    Assignee: Olympus Optical Co., Ltd.
    Inventors: Shinroku Sogi, Makoto Yoshinaga, Toshio Shinohara, Takayuki Aihara, Ikuo Tawara
  • Patent number: 4208484
    Abstract: An apparatus for handling a centrifuge tube in an automatic culture system includes a centrifuge, above which is disposed a centrifuge tube carrying turntable which is intermittently driven through a given angular increment. Disposed at an equal spacing on and around the periphery of the turntable are centrifuge tube holder mechanisms each carrying a centrifuge tube holder.
    Type: Grant
    Filed: March 13, 1978
    Date of Patent: June 17, 1980
    Assignee: Olympus Optical Co., Ltd.
    Inventors: Shinroku Sogi, Makoto Yoshinaga, Toshio Shinohara, Takayuki Aihara, Ikuo Tawara
  • Patent number: 4198483
    Abstract: A pipette exchange apparatus for use in a system for automatically culturing a biotissue or a cell includes a pipette mounting device for mounting a dividing and injecting means, a pipette supply device and a pipette feeding device.
    Type: Grant
    Filed: March 15, 1978
    Date of Patent: April 15, 1980
    Assignee: Olympus Optical Company, Limited
    Inventors: Shinroku Sogi, Makoto Yoshinaga, Toshio Shinohara, Ikuo Tawara
  • Patent number: 4198284
    Abstract: An electrophoretic apparatus comprising a pair of endless belts for conveying a film into and out of the apparatus, filter paper supports on which edge portions of filter paper sheets are placed and filter paper retainers arranged above the filter paper supports. The electrophoretic apparatus is arranged that, after the film is conveyed into the apparatus by means of endless belts, the film is moved upward by moving the filter paper supports upward and thereby holding the edge portions of film between the filter paper supports and filter paper retainers, edge portions of film are pulled in the direction opposite to each other and, then, the film is energized, the electrophoretic apparatus being thereby arranged that the film is energized in the state that it is free from slack so that favorable fractionated patters are obtained.
    Type: Grant
    Filed: April 23, 1979
    Date of Patent: April 15, 1980
    Assignee: Olympus Optical Co., Ltd.
    Inventors: Toshio Shinohara, Ryo Fujimori
  • Patent number: 4179339
    Abstract: A liquid feeder comprises a liquid suction and delivery pump which withdraws a liquid such as a culture solution, buffer solution, enzyme solution or the like which is retained in a liquid storage container as refrigerated or at a reduced temperature and delivers it through a flexible tube for injection into a culture vessel located within an incubator. The tube is inserted into an inner pipe and is sealingly secured thereto. The inner pipe is detachably and hermetically mounted in an outer pipe which extends through and is secured to a wall forming an environment isolating layer of the incubator. An eccentric crankpin which is driven by a motor is connected through a link with another crankpin having a greater eccentricity, the latter crankpin being driven for rotation to cause a reciprocatory rotating motion of a driven shaft about its own axis through an angular extent of less than 180.degree..
    Type: Grant
    Filed: February 13, 1978
    Date of Patent: December 18, 1979
    Assignee: Olympus Optical Company, Ltd.
    Inventors: Shinroku Sogi, Makoto Yoshinaga, Toshio Shinohara, Takayuki Aihara, Ikuo Tawara
  • Patent number: 4160699
    Abstract: An automatic culture apparatus includes an airtight casing, a culture vessel platform, a culture observation platform and a separation/distribution work platform disposed in layered configuration with suitable vertical spacings between them. A drive system for the apparatus comprises an opening formed centrally in each of the platforms; a culture vessel carrier for conveying a culture vessel to each of the platforms through the openings; a transfer arm for loading and unloading a culture vessel on or from the carrier and any one of the platforms; a first drive mechanism for operating the carrier and the transfer arm; and a second drive mechanism for driving any one of the platforms. The second drive mechanism is mounted hermetically in the casing.
    Type: Grant
    Filed: November 1, 1977
    Date of Patent: July 10, 1979
    Assignee: Olympus Optical Co., Ltd.
    Inventors: Shinroku Sogi, Makoto Yoshinaga, Toshio Shinohara, Takayuki Aihara, Ikuo Tawara
  • Patent number: 4159039
    Abstract: The invention is to drive an article into an object or extract it therefrom by means of strain energy.The article is provided at its top with an elastic part having a reaction material for giving a tensile strain or a compressive strain to the elastic part via the reaction material in order to accumulate the strain energy in the elastic part.For carrying out the driving operation, the strain energy is abruptly released from the top of the elastic part, otherwise the compressive strain is abruptly released from the bottom of the elastic part. The strain energy is transformed into a kinetic energy and the article is struck on its head by this kinetic energy so that a compressive strain wave is generated in the article being driven.For carrying out the extracting operation, the compressive strain is abruptly released from the top of the elastic part, otherwise the tensile strain is abruptly released from the bottom of the elastic part.
    Type: Grant
    Filed: May 3, 1978
    Date of Patent: June 26, 1979
    Assignee: Nippon Kokan Kabushiki Kaisha
    Inventors: Masami Kasuga, Tetsuzo Hirose, Tsunematsu Yoshida, Toshio Shinohara
  • Patent number: 4154652
    Abstract: Tissues or cells of a living body, especially a human body, are automatically and successively cultivated in a nutrient solution filled culture container disposed in a gas-sealed culture box by detecting, within the culture box, a multiplication condition of the tissues or cells and culture conditions which are represented by temperature, humidity and gaseous atmosphere in the culture box and pH value of the nutrient solution, controlling the culture conditions and apparatus for subculture of the tissues or cells within the culture box in accordance with the information detected.
    Type: Grant
    Filed: June 10, 1976
    Date of Patent: May 15, 1979
    Assignee: Olympus Optical Co., Ltd.
    Inventors: Ichiro Sawamura, Shinroku Sogi, Shin-ichi Kamachi, Makoto Yoshinaga, Atsuo Goto, Masao Izawa, Yoshio Nakajima, Nagahiro Gocho, Toshio Shinohara, Shinichiro Hattori
  • Patent number: 4101194
    Abstract: A screen microscope comprising a projection screen arranged on an arm of the microscope and a plural number of reflecting mirrors arranged in the arm and arranged to project an image of an object obtained by the microscope onto the screen through the reflecting mirrors. The screen microscope is arranged so that the observing direction by the screen is approximately same as the observing direction through an eyepiece.
    Type: Grant
    Filed: July 14, 1976
    Date of Patent: July 18, 1978
    Assignee: Olympus Optical Co., Ltd.
    Inventors: Kensaku Miyazaki, Toshio Shinohara
  • Patent number: 4098749
    Abstract: The present invention relates to an anticorrosion primer coating composition comprising (i) a polyvinyl butyral resin, (ii) an organo functional silane, (iii) at least one member selected from the group consisting of inorganic borate compounds and polyphosphate compounds, and (iv) phosphoric acid.
    Type: Grant
    Filed: March 24, 1977
    Date of Patent: July 4, 1978
    Assignee: Dai Nippon Toryo Co., Ltd.
    Inventors: Minoru Hoshino, Toshio Shinohara, Yukio Kawahara, Katsuji Takase, Toshimoto Tsuji, Jun-ichi Fukuda
  • Patent number: 4096161
    Abstract: Halogenosilanes are prepared from an organohalogenosilane and an organopolysiloxane as the starting materials by subjecting them to an intermolecular redistribution reaction in the presence of a monohydrochloride of a hexaalkylphosphotriamide. The thus prepared halogenosilanes, which are different from the starting halogenosilane reactant, are very useful in the silicone industry.
    Type: Grant
    Filed: November 18, 1976
    Date of Patent: June 20, 1978
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Toshio Shinohara, Masatoshi Arai, Shoji Ichinohe