Abstract: A method of treating cancer, inflammatory disease, and autoimmune disease by administering to a subject in need thereof an effective amount of one or more 1,5-dipenylpenta-1,4-dien-3-one compounds. The compounds feature either or both of the phenyl rings being substituted with hydroxyl, diethyl(2-alkoxyethyl)amine, 1-(2-alkoxyethyl)piperidine, sulfonate, phosphinate, or phosphate.

Abstract: An object of the present invention is to efficiently improve uniformity of energy lines to be irradiated.

Abstract: An object of the present invention is to efficiently improve uniformity of energy lines to be irradiated.

Abstract: The device has a target supply unit 4a for supplying a target 2a to a chamber 3a, a target monitor 5a for monitoring the target 2a present inside the chamber 3a, a laser light irradiator 6a for irradiating the target 2a present inside the chamber 3a, with laser light 8a, and a controller 7a. The target supply unit 4a emits the target 2a at a timing for emitting, that is controlled by the controller 7a, into a preset emission direction 3d inside the chamber 3a, and the controller 7a calculates an irradiation point 4d with the laser light 8a, calculates a timing for arriving of the target 2a at the irradiation point 4d, and makes the laser light irradiator 6a irradiate the target with the laser light, based on the irradiation point 4d and the timing for arriving.

Abstract: A target shell monitoring device 4 that monitors an attitude and a position of the target shell Tg1, a compression laser output device 5a that irradiates the target shell Tg1 with a compression laser light LS1, and a heating laser output device 6 that irradiates the target shell Tg1 with a heating laser light LS3 following the compression laser light LS1 are provided. The target shell Tg1 has a hollow spherical shell shape, includes an approximately spherical space Sp on an inner side thereof, includes at least one through hole H1 connecting an outer side thereof and the space Sp, and includes, on an outer surface Sf1 thereof, irradiation areas Ar1 and Ar2 to be irradiated with compression laser lights.

Abstract: A laser device 1 demultiplexes seed light L0 into a plurality of beams of laser light L1 and then continuously optically amplifies the plurality of beams of the laser light L1 with an amplifier 14. Therefore, its amplification factor can be set higher than that in the case of amplifying pulsed laser light. When producing multiplexed light L3 by multiplexing the beams of the amplified laser light L1 with a diffraction grating 16, respective phases of the beams of the laser light L1 are controlled such that an output peak of the multiplexed light L3 repeatedly appears at a converging position P1 at a predetermined time interval. This produces pulsed laser light at the converging position P1 from a plurality of beams of laser light L2 amplified at a high amplification factor. Hence, this laser device 1 can produce pulsed laser light with a high output.

Abstract: A laser device 1 demultiplexes seed light L0 into a plurality of beams of laser light L1 and then continuously optically amplifies the plurality of beams of the laser light L1 with an amplifier 14. Therefore, its amplification factor can be set higher than that in the case of amplifying pulsed laser light. When producing multiplexed light L3 by multiplexing the beams of the amplified laser light L1 with a diffraction grating 16, respective phases of the beams of the laser light L1 are controlled such that an output peak of the multiplexed light L3 repeatedly appears at a converging position P1 at a predetermined time interval. This produces pulsed laser light at the converging position P1 from a plurality of beams of laser light L2 amplified at a high amplification factor. Hence, this laser device 1 can produce pulsed laser light with a high output.

Abstract: A method of treating cancer, inflammatory disease, and autoimmune disease by administering to a subject in need thereof an effective amount of one or more 1,5-dipenylpenta-1,4-dien-3-one compounds. The compounds feature either or both of the phenyl rings being substituted with hydroxyl, diethyl(2-alkoxyethyl)amine, 1-(2-alkoxyethyl)piperidine, sulfonate, phosphinate, or phosphate.

Abstract: This invention relates to compounds of Formula (I), (II), or (III) as shown in the specification, which contain a 1,5-diphenylpenta-1,4-dien-3-one backbone. These compounds can be used to treat cancer, inflammatory disease, or autoimmune disease.

Abstract: A radiation generating apparatus comprises a fuel storage unit 20 for storing a mixed liquid 61, a pressure application unit 10 for applying a pressure to the mixed liquid 61, a jet formation unit 30 for forming a jet 61a of the mixed liquid 61, a reaction unit 44 for forming the jet 61a of the mixed liquid 61 therein, a pressure adjustment unit 41 for setting a pressure in the reaction unit 44 lower than an internal pressure of the jet formation unit 30, and a light source unit 45 for irradiating a particle group 63a with laser light L1.

Abstract: A laser device including a plurality of oscillating means for oscillating a plurality of laser lights being continuous lights and having frequencies different from each other, respectively, multiplexing means for multiplexing, after amplifying or without amplifying, the respective laser lights oscillated from the respective oscillating means at a predetermined position to generate a multiplexed light, and phase control means for controlling the phase of each of the laser lights so that a peak in output of the multiplexed light repeatedly appears at predetermined time intervals at the predetermined position (so that the same pulse temporal waveform repeatedly appears at predetermined time intervals).

Abstract: A check valve in the three-way stopcock unit includes: a first housing having a valve seat in which an opening is provided; a second housing inserted into the first housing; and a valve element held between the valve seat of the first housing and an opening end portion of the second housing. The valve element has a substantially U-shaped cut line formed outside of an outer rim portion of the opening provided in the valve seat of the first housing, and inside of an inner rim portion of the second housing. A portion inside of the cut line is used as a switching valve, and the valve seat of the first housing and the opening end portion of the second housing are closed in a liquid-tight state at a portion outside of the cut line.

Abstract: An object is to be capable of inducing a nuclear fusion reaction at a relatively high efficiency and downsize a device. A nuclear fusion device 1 of the present invention includes a nuclear fusion target 7 including a target substrate 7a containing deuterium or tritium and a thin-film layer 7b containing deuterium or tritium stacked on the target substrate 7a, a vacuum container 5 for storing the nuclear fusion target 7, and a laser unit 3 for irradiating two successive first and second pulsed laser lights P1, P2 toward the thin-film layer 7b of the nuclear fusion target 7, and the intensity of the first pulsed laser light P1 is set to a value that is smaller than that of the second pulsed laser light P2 and allows peeling of the thin-film layer 7b from the target substrate 7a.

Abstract: An object of the present invention is to efficiently improve uniformity of energy lines to be irradiated.

Abstract: This invention relates to compounds of Formula (I), (II), or (III) as shown in the specification, which contain a 1,5-diphenylpenta-1,4-dien-3-one backbone. These compounds can be used to treat cancer, inflammatory disease, or autoimmune disease.

Abstract: A solid-state laser apparatus 1 bounces laser light L2 between an end mirror 3 and an output mirror 4 via a slab-type solid-state laser medium 2 excited by excitation light L1 to thereby amplify and output the laser light L2. The solid-state laser medium 2 includes incident/exit end faces 2a, 2b on and from which the laser light L2 is made incident and exits, and reflecting end faces 2c, 2d which reflect the laser light L2 so that the incident laser light L2 propagates in a zigzag manner. The incident/exit end face 2a is made incident with the excitation light L1 so that the excitation light L1 propagates along substantially the same propagation path as that of the laser light L2 within the solid-state laser medium 2. Accordingly, a solid-state laser apparatus which can improve the coupling efficiency between the excitation light and the laser light is realized.

Abstract: An illumination device includes: a light emitting element to be a light source; a light amount detecting means for detecting the amount of light emitted by the light emitting element; a light emitting element drive means for controlling drive current supplied to the light emitting element so that the difference between the light mount detected by the light amount detecting means and a light amount target value becomes small; a junction temperature detecting means for calculating junction temperature of the light emitting element; and a setting means for setting the light amount target value in accordance with the junction temperature detected by the junction temperature detecting means.

Abstract: A method and apparatus for optimizing picture quality of a video signal. The method includes displaying a user menu having a plurality of choices of video labels; receiving a choice of video label from the plurality via an input from a user; translating the video label into a label code; receiving at least a first video processing parameter from a look-up table corresponding to the label code; and configuring a video processor according to the first video processing parameter.

Abstract: The present invention relates to a solid-state laser module, and so on, having a structure for enabling optical output of high quality to be obtained. The solid-state laser module includes a vacuum container with windows, and a heat sink, a solid-state laser medium, and a pair of transparent members are housed in the vacuum container in an integrally assembled state. The solid-state laser medium and the pair of transparent members respectively have disk shapes, and the pair of transparent members sandwich the solid-state laser medium. The thermal conductivity of each of the pair of transparent members is higher than the thermal conductivity of the solid-state laser medium.

Abstract: The present invention provides methods for screening compounds which inhibit activation of a member of the IL-6 signaling pathways, comprising: (a) a positive screening step using a cell capable of being killed by IL-6 stimulation to select compounds which inhibit death of the cell when it is stimulated by IL-6; and then (b) a biochemical screening step to further select compounds which inhibit activation of a member of the IL-6 signaling pathways by a biochemical means from the compounds selected in step (a). The present invention also provides compounds which inhibit activation of a member of the IL-6 signaling pathways identified using said methods.