Abstract: A cell stethoscope 1 comprises a sample image input section 31 for inputting image information of a cell, an image display part 50 for displaying the image information to an observer, an area designation part 40 for designating a fixed area included in the image information in response to an operation carried out by the observer according to the image information displayed by the image display part 50, a frequency conversion section 32 for frequency-converting vibration information of the cell in the fixed area designated by the area designation part 40 into sound information, and a sound output part 60 for outputting the sound information frequency-converted by the frequency conversion section 32 to the observer.

Abstract: The present invention provides a method for determining differentiation level of pluripotent stem cell, comprising a step of determining a flatness of cultured pluripotent stem cell, wherein the flatness is an indication.

Abstract: This blood examination apparatus examines cancer cells mixed in an examination object which is flowing blood, and includes: a flow cell through which the examination object is made to flow; an imaging optical system which light output from the examination object in an examination region in the flow cell enters, the imaging optical system forming an image of the light on a first image plane; a first Fourier transformation optical system which optically two-dimensionally Fourier-transforms the image formed on the first image plane by the imaging optical system to form the Fourier-transformed image on a second image plane; a spatial light filter which selectively allows a portion in a certain range around an optical axis of the first Fourier transformation optical system of the image formed on the second image plane by the first Fourier transformation optical system to pass through; and a second Fourier transformation optical system which optically two-dimensionally Fourier-transforms the portion which has passe

Abstract: The present invention relates to a full-field reflection phase microscope. In a preferred embodiment, the invention can combine low-coherence interferometry and off-axis digital holographic microscopy (DHM). The reflection-based DHM provides highly sensitive and a single-shot imaging of cellular dynamics while the use of low coherence source provides a depth-selective measurement. A preferred embodiment of the system uses a diffraction grating in the reference arm to generate an interference image of uniform contrast over the entire field-of-view albeit low-coherence light source. With improved path-length sensitivity, the present invention is suitable for full-field measurement of membrane dynamics in live cells with sub-nanometer-scale sensitivity.

Abstract: An optical property measurement apparatus includes a light source unit, a first optical coupler, a second optical coupler, a lens, a lens, a phase modulation unit, a drive unit, an optical path length difference adjustment unit, a control unit, a light receiving unit, a synchronization detection unit, and a measurement unit. The phase modulation unit carries out phase modulation with a frequency f. The synchronization detection unit outputs a first signal having a value corresponding to a magnitude of a component of the frequency f included in an electrical signal output from the light receiving unit, and also outputs a second signal having a value corresponding to a magnitude of a component of the frequency 2f included in the electrical signal. The control unit controls the optical path length difference adjusted by the optical path length difference adjustment unit to be a predetermined value based on the first signal or the second signal output from the synchronization detection unit.

Abstract: An interference measuring device comprises light sources lenses, an aperture, an optical multiplexer, an optical branching filter, a half mirror, an imaging unit, an analyzing unit, a light receiving unit, a displacement detecting unit, a piezoelectric actuator, a drive unit, a mirror, a stage, a drive unit, and a control unit. According to a result of optical path length difference detection by the displacement detecting unit, the control unit controls optical path length difference adjusting operations by the piezoelectric actuator and stage through the drive units such that the optical path length difference becomes a plurality of target values in sequence. The control unit subjects the moving operation by the piezoelectric actuator to a feedback control such that the optical path length difference becomes each of the target values upon the moving operation by the stage as well.

Abstract: A cell stethoscope 1 comprises a sample image input section 31 for inputting image information of a cell, an image display part 50 for displaying the image information to an observer, an area designation part 40 for designating a fixed area included in the image information in response to an operation carried out by the observer according to the image information displayed by the image display part 50, a frequency conversion section 32 for frequency-converting vibration information of the cell in the fixed area designated by the area designation part 40 into sound information, and a sound output part 60 for outputting the sound information frequency-converted by the frequency conversion section 32 to the observer.

Abstract: The observation device 1 is to observe the surface or the inside of an observation object 9, that has light sources 11 and 12, lenses 21 to 25, an aperture 31, an optical multiplexer 41, an optical demultiplexer 42, a half mirror 43, an image pickup unit 51, an analyzing unit 52, a display unit 53, a light receiving unit 61, a displacement detecting unit 62, a piezoelectric actuator 71, a drive unit 72, a mirror 73, a stage 81, a drive unit 82, and a control unit 90. The analyzing unit 52 determines a complex amplitude of an interference light figure taken as an image by the image pickup unit 51 with a phase shift technique after an optical path difference is set to each target value in sequence, and determines an amount of change per certain time of a phase component of a reflected light generated on the surface or the inside of the observation object 9 on the basis of an absolute value of an amount of change per certain time of the determined complex amplitude and an absolute value of the complex amplitude.

Abstract: An interference measuring device 1 comprises light sources 11, 12, lenses 21 to 25, an aperture 31, an optical multiplexer 41, an optical branching filter 42, a half mirror 43, an imaging unit 51, an analyzing unit 52, a light receiving unit 61, a displacement detecting unit 62, a piezoelectric actuator 71, a drive unit 72, a mirror 73, a stage 81, a drive unit 82, and a control unit 90. According to a result of optical path length difference detection by the displacement detecting unit 62, the control unit 90 controls optical path length difference adjusting operations by the piezoelectric actuator 71 and stage 81 through the drive units 72 and 82 such that the optical path length difference becomes a plurality of target values in sequence. The control unit 90 subjects the moving operation by the piezoelectric actuator 71 to a feedback control such that the optical path length difference becomes each of the target values upon the moving operation by the stage 81 as well.

Abstract: This blood examination apparatus examines cancer cells mixed in an examination object which is flowing blood, and includes: a flow cell through which the examination object is made to flow; an imaging optical system which light output from the examination object in an examination region in the flow cell enters, the imaging optical system forming an image of the light on a first image plane; a first Fourier transformation optical system which optically two-dimensionally Fourier-transforms the image formed on the first image plane by the imaging optical system to form the Fourier-transformed image on a second image plane; a spatial light filter which selectively allows a portion in a certain range around an optical axis of the first Fourier transformation optical system of the image formed on the second image plane by the first Fourier transformation optical system to pass through; and a second Fourier transformation optical system which optically two-dimensionally Fourier-transforms the portion which has passe

Abstract: An optical property measurement apparatus 1 includes a light source unit 10, a first optical coupler 21, a second optical coupler 22, a lens 31, a lens 32, a phase modulation unit 40, a drive unit 41, an optical path length difference adjustment unit 50, a control unit 51, a light receiving unit 60, a synchronization detection unit 70, and a measurement unit 80. The phase modulation unit 40 carries out phase modulation with a frequency f. The synchronization detection unit 70 outputs a first signal having a value corresponding to a magnitude of a component of the frequency f included in an electrical signal output from the light receiving unit 60, and also outputs a second signal having a value corresponding to a magnitude of a component of the frequency 2f included in the electrical signal.

Abstract: The light irradiation device 1 is provided with a laser light source 10 for generating laser light, a light source for detection light 20 for generating detection light of a predetermined wavelength, an optical fiber 30 having a FBG 32 for inputting laser light on one end face 30a and emitting the light from the other end face 30b to radiate it to an object 3, inputting detection light on the one end face 30a and also reflecting the light of a predetermined wavelength adjacent to the other end face 30b, a light detector 50 for detecting an intensity of detection light reflected by the FBG 32 and emitted from the one end face 30a, and a signal processing unit 60 for detecting an irradiation state of the laser light to the object 3 based on an intensity of the thus detected detection light. The laser light generated from the laser light source 10 is light other than that of a wavelength reflected by the FBG 32.

Abstract: A common key 11 is shared by a controller and an operating terminal. An interface is displayed for entering control signals, and a user enters a control signal 21. A next operating rights code 22 is generated (112) and the common key 11 is used to encrypt a signal 23 that contains the control signal 21, the next operating rights code 22, and the current operating rights code 12 (114). This is then transferred to the controller (115), and the next operating rights code 22 is stored in the operating terminal (112). The controller uses the common key 11 to decrypt the transferred encrypted message 24 (117) and obtains the control signal 21, the current operating rights code 12, and the next operating rights code 22. The current operating rights code 12 is checked to see if it matches an operating rights code registered in the controller (118). If there is a match, the control signal is sent to the control device (19). The next operating rights code 22 is registered in the controller (120).