Patents by Inventor Tushar Kshirsagar

Tushar Kshirsagar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxime substituted imidazoquinolines
    Patent number: 7897767
    Abstract: Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: March 1, 2011
    Assignee: 3M Innovative Properties Company
    Inventors: Tushar A. Kshirsagar, Gregory D. Lundquist, David T. Amos, Joseph F. Dellaria, Jr., Bernhard M. Zimmermann, Philip D. Heppner
  • Piperazine, [1,4]Diazepane, [1,4]Diazocane, and [1,5]Diazocane fused imidazo ring compounds
    Patent number: 7888349
    Abstract: Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds (i.e., imidazoquinolines, tetrahydroimidazoquinolines, imidazonaphthyridines, tetrahydroimidazonaphthyridines, and imidazopyridines), pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: February 15, 2011
    Assignee: 3M Innovative Properties Company
    Inventors: Tushar A. Kshirsagar, George W. Griesgraber, Azim A. Celebi, Philip D. Heppner
  • Pyrazolopyridines and analogs thereof
    Patent number: 7879849
    Abstract: Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Grant
    Filed: June 8, 2009
    Date of Patent: February 1, 2011
    Assignee: 3M Innovative Properties Company
    Inventors: David S. Hays, Michael E. Danielson, John F. Gerster, Shri Niwas, Ryan B. Prince, Tushar A. Kshirsagar, Philip D. Heppner, William H. Moser, Joan T. Moseman, Matthew R. Radmer, Maureen A. Kavanagh, Sarah A. Strong, Jason D. Bonk
  • Amide and Carbamate Derivatives of N-{2-[4-Amino-2- (Ethoxymethyl)-1H-Imidazo[4,5-c] Quinolin-1-Yl]-1,1-Dimethylethyl} Methanesulfonamide and Methods
    Publication number: 20100317684
    Abstract: Amide and carbamate derivatives N-{2-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide, pharmaceutical compositions containing these compounds, methods of making the compounds, and methods of use of these compounds in modulating the immune system, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Application
    Filed: September 8, 2006
    Publication date: December 16, 2010
    Applicant: Coley Pharmaceutical Group, Inc.
    Inventors: Tushar A. Kshirsagar, Shri Niwas, Bryon A. Merrill
  • PROCESS FOR LIMITING THE GROWTH OF MICROORGANISMS
    Publication number: 20100247592
    Abstract: A process for limiting the growth of microorganisms comprises (a) providing an antimicrobial agent comprising fine-nanoscale gold on a support medium comprising nanoparticulate titania, the fine-nanoscale gold having been deposited on the support medium by physical vapor deposition; and (b) contacting at least one microorganism with the antimicrobial agent.
    Type: Application
    Filed: October 1, 2008
    Publication date: September 30, 2010
    Inventors: Manjiri T. Kshirsagar, Tushar A. Kshirsagar, Thomas E. Wood
  • MICROORGANISM CONCENTRATION PROCESS
    Publication number: 20100248214
    Abstract: A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a particulate concentration agent that comprises gamma-FeO(OH); (b) providing a fluid sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the concentration agent is dispersed in the sample and at least a portion of the at least one microorganism strain is bound to or captured by the concentration agent.
    Type: Application
    Filed: October 2, 2008
    Publication date: September 30, 2010
    Inventors: Manjiri T. Kshirsagar, Tushar A. Kshirsagar, Thomas E. Wood
  • MICROORGANISM CONCENTRATION PROCESS AND AGENT
    Publication number: 20100209961
    Abstract: A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration agent that comprises diatomaceous earth bearing, on at least a portion of its surface, a surface treatment comprising a surface modifier comprising titanium dioxide, fine-nanoscale gold or platinum, or a combination thereof; (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration agent.
    Type: Application
    Filed: October 2, 2008
    Publication date: August 19, 2010
    Inventors: Manjiri T. Kshirsagar, Tushar A. Kshirsagar, Thomas E. Wood
  • MICROORGANISM CONCENTRATION PROCESS
    Publication number: 20100190171
    Abstract: A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration agent that comprises an amorphous metal silicate and that has a surface composition having a metal atom to silicon atom ratio of less than or equal to about 0.5, as determined by X-ray photoelectron spectroscopy (XPS); (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration agent.
    Type: Application
    Filed: October 2, 2008
    Publication date: July 29, 2010
    Inventors: Manjiri T. Kshirsagar, Tushar A. Kshirsagar, Thomas E. Wood
  • IMMUNE RESPONSE MODIFIER COMPOSITIONS AND METHODS
    Publication number: 20100158928
    Abstract: The present invention provides an immune response modifier (IRM) composition that includes an IRM moiety and a second active moiety covalently linked to the IRM moiety, wherein the covalent link comprises a labile bond directly attached to the IRM moiety.
    Type: Application
    Filed: December 20, 2007
    Publication date: June 24, 2010
    Inventors: Doris Stoermer, George W. Griesgraber, Tushar A. Kshirsagar
  • Oxime and Hydroxylamine Substituted Imidazo[4,5-c] Ring Compounds and Methods
    Publication number: 20100069427
    Abstract: Imidazo[4,5-c] ring compounds, (e.g. imidazo[4,5-c]pyridines, imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydro imidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridine, and 6,7,8,9-tetrahydro imidazo[4,5-c]naphthyridine compounds) having an oxime or hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: February 10, 2006
    Publication date: March 18, 2010
    Applicant: COLEY PHARMACEUTICAL GROUP, INC.
    Inventors: Tushar A. Kshirsagar, Gregory D. Lundquist, JR., Joseph F. Dellaria, Matthew R. Radmer, Bernhard M. Zimmermann
  • Hydroxylamine substituted imidazoquinolines
    Patent number: 7648997
    Abstract: Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, imidazopyridines) with a hydrox-ylamine substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: January 19, 2010
    Assignee: Coley Pharmaceutical Group, Inc.
    Inventors: Tushar A. Kshirsagar, David T. Amos, Joseph F. Dellaria, Jr., Philip D. Heppner, Scott E. Langer, Bernhard M. Zimmermann
  • PYRAZOLOPYRIDINES AND ANALOGS THEREOF
    Publication number: 20090318435
    Abstract: Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Application
    Filed: June 8, 2009
    Publication date: December 24, 2009
    Inventors: David S. Hays, Michael E. Danielson, John F. Gerster, Shri Niwas, Ryan B. Prince, Tushar A. Kshirsagar, Philip D. Heppner, William H. Moser, Joan T. Moseman, Matthew R. Radmer, Maureen A. Kavanagh, Sarah A. Strong, Jason D. Bonk
  • HYDROXY AND ALKOXY SUBSTITUTED IH-IMIDAZONAPHTHYRIDINES AND METHODS
    Publication number: 20090298821
    Abstract: 1H-Imidazo[4,5-c]naphthyridin-4-amines with a hydroxy, alkoxy, hydroxyalkoxy, or alkoxyalkoxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Application
    Filed: March 14, 2007
    Publication date: December 3, 2009
    Inventors: Tushar A. Kshirsagar, Scott E. Langer
  • Hydroxyalkyl Substituted Imidazonaphthyridines
    Publication number: 20090253695
    Abstract: Certain imidazonaphthyridines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-? biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: February 22, 2006
    Publication date: October 8, 2009
    Applicant: Coley Pharmaceutical Group, Inc,
    Inventors: Tushar A. Kshirsagar, Scott E. Langer, Shri Niwas, George W. Griesgraber, Philip D. Heppner, Kyle J. Lindstrom
  • Aryl substituted imidazoquinolines
    Patent number: 7598382
    Abstract: Aryl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: October 6, 2009
    Assignee: Coley Pharmaceutical Group, Inc.
    Inventors: David S. Hays, Tushar Kshirsagar, Philip D. Heppner, Bryon A. Merrill, Michael E. Danielson, John F. Gerster, Chad A. Haraldson, Sarah Johannessen, Maureen A. Kavanagh, Kyle J. Lindstrom, Michael J. Rice, David J. Squire, Sarah A. Strong, Joshua R. Wurst
  • SUBSTITUTED FUSED[1,2] IMIDAZO[4,5C] RING COMPOUNDS AND METHODS
    Publication number: 20090221551
    Abstract: [1,2]Imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and imidazo[4,5-c]pyridines) substituted with a fused ring containing an oxygen and/or nitrogen atom attached at the 1- and/or 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Application
    Filed: March 14, 2007
    Publication date: September 3, 2009
    Inventors: Tushar A. Kshirsagar, Karl J. Manske, Larry R. Krepski, Joan T. Moseman, George W. Griesgraber, Sarah Johannessen Slania, Philip D. Heppner
  • HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS
    Publication number: 20090221556
    Abstract: 1H-Imidazo[4,5-c]quinolin-4-amines with a hydroxy, alkoxy, hydroxyalkoxy, or alkoxyalkoxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Application
    Filed: November 3, 2006
    Publication date: September 3, 2009
    Inventors: Tushar A. Kshirsagar, Philip D. Heppner, Scott E. Langer
  • Amide and Carbamate Derivatives of Alkyl Substituted N-[4-(4-Amino-1H-Imidazo[4,5-C] Quinolin-1-YL)Butyl]Methanesulfonamides and Methods
    Publication number: 20090176821
    Abstract: Amide and carbamate derivatives of N-[4-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamides with an ethyl, methyl, or n-propyl substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, and methods of use of these compounds in modulating the immune system, for inducing cytokine biosyn-thesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Application
    Filed: September 8, 2006
    Publication date: July 9, 2009
    Applicant: COLEY PHARMACEUTICAL GROUP, INC.
    Inventors: Tushar A. Kshirsagar, Shri Niwas, Bryon A. Merrill
  • Pyrazolopyridines and analogs thereof
    Patent number: 7544697
    Abstract: Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: June 9, 2009
    Assignee: Coley Pharmaceutical Group, Inc.
    Inventors: David S. Hays, Michael E. Danielson, John F. Gerster, Shri Niwas, Ryan B. Prince, Tushar A. Kshirsagar, Philip D. Heppner, William H. Moser, Joan T. Moseman, Matthew R. Radmer, Maureen A. Kavanagh, Sarah A. Strong, Jason D. Bonk
  • HYDROXYLAMINE SUBSTITUTED IMIDAZOQUINOLINES
    Publication number: 20090105295
    Abstract: Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with a hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: November 12, 2004
    Publication date: April 23, 2009
    Applicant: Coley Pharmaceutical Group, Inc.
    Inventors: Tushar A. Kshirsagar, Gregory D. Lundquist, JR., David T. Amos, Joseph F. Dellaria, JR., Bernhard M. Zimmermann, Philip D. Heppner