Abstract: The invention relates to a pharmaceutical composition comprising an SGLT2 inhibitor, a DPPIV inhibitor and a third antidiabetic agent which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.

Abstract: In some embodiments, an electronic device presents user interfaces for browsing and presenting content. In some embodiments, the electronic device presents representations of recommended items of content that include representations of content items the user is entitled to access without including representations of content items the user is not entitled to access.

Abstract: A method for detecting in-vivo properties of a biosensor. In the inventive method, a sensitivity-to-admittance relation is provided and a raw current in the biosensor is measured. An in-vivo current response is also measured at first and second operating points. A time constant ? is determined by the electrical capacitance C of the working electrode and the electrical resistance RM of the membrane by ?=RM·C. The first and second operating points are selected below and above ?, respectively. An analyte value in a sample of a body fluid is determined by using the raw current and compensating sensitivity drift in the biosensor, which in turn is compensated by using the measured value for the raw current and a corrected value for the sensitivity. The failsafe operation of the biosensor is monitored by using the in-vivo current response measured at the first and second operating points.

Abstract: The present invention relates to certain SGLT-2 inhibitors for treating, preventing, protecting against and/or delaying the progression of chronic kidney disease in patients, for example patients with prediabetes, type 1 or type 2 diabetes mellitus.

Abstract: In some embodiments, an electronic device receives, via one or more input devices, an input corresponding to a request to display a user interface associated with a first respective content mix, wherein the first respective content mix is associated with a first respective time period. In some embodiments in response to receiving the input corresponding to the request to display the user interface associated with the first respective content mix, the electronic device displays, via a display, the user interface. In some embodiments, the user interface includes a plurality of representations of content items including visual indications of amounts of consumption, of a first consumption metric type, by a user during the first respective time period, and a plurality of representations of content creators including visual indications of consumption, of a second consumption metric type, by the user during the first respective time period.

Abstract: A liquid filter device may include a filter housing and a ring filter element arranged in the filter housing. The filter housing may include a filter housing cover and a filter housing pot connectable tightly therewith via a housing seal. A discharge channel, a central clean channel, and a vent channel may be disposed in the filter housing pot. The ring filter element may include an upper end plate, a lower end plate, and a pleated star. When the liquid filter device is in an operating state, a pin arranged on the lower end plate may be disposed in and seal the discharge channel via a first seal, a second seal arranged on the lower end plate may be disposed against a surface of the clean channel, and a third seal arranged on the upper end plate may be disposed against a surface of the vent channel.

Abstract: The invention relates to a method for creating manufacturing data for manufacturing an orthopedic product for a body part of a patient, the method comprising the following steps: providing a digital three-dimensional body part model of the relevant body part for which the orthopedic product is destined to an electronic data processing apparatus, the three-dimensional body part model being based on external body part data acquired from the body part of the patient; identifying at least one rigid body part region in the provided body part model by means of the electronic data processing apparatus, with the remaining region situated outside of the rigid body part region being identified as a yielding body part region on the basis of the identified rigid body part region; creating a reduced three-dimensional body part model by means of the electronic data processing apparatus on the basis of the provided three-dimensional body part model, the identified rigid body part regions and a reduction metric applied in

Abstract: The present disclosure provides methods of treating a subject having a proliferative disease or an autoimmune disorder with a combination of (a) a first multispecific binding molecule (MBM) that binds specifically to (i) human CD2 and (ii) a human tumor-associated antigen and/or a human tumor microenvironment antigen, and (b) a second multispecific binding molecule that binds specifically to (i) a component of a human T-cell receptor (TCR) complex or a secondary T-cell signaling molecule and (ii) a human tumor-associated antigen and/or human tumor microenvironment antigen. The disclosure further provides MBMs and combinations of MBMs that can be used in the methods of the disclosure.

Abstract: A method for planning a target trajectory for an autonomously operated vehicle to be travelled along involves determining a discrete set of trajectories as candidates for the target trajectory. Each of the trajectories is composed of a plurality of trajectory sections arranged in a row. The planning is based on a selection of one of the trajectories as a target trajectory. The selection is based on evaluation of the trajectories together with predefined cost functions and an identification of the trajectory evaluated as being the most cost effective. An array of sub-trajectories, each having the same location specifications and different dynamics specifications, is associated with each trajectory section, and costs in accordance with the predefined cost functions are associated with the sub-trajectories.

Abstract: A method for operating an assistance system for automated driving operation of a vehicle involves continuously determining an emergency trajectory along which the vehicle is brought to a standstill in a longitudinally and transversely controlled manner after activation of an emergency operation of the vehicle. In the event of an imminent or already initiated lane change of the vehicle from a starting lane to a target lane according to a determined standard trajectory, a decision is made as to whether the vehicle should be brought to a standstill in the starting lane or in the target lane when emergency operation is activated. This decision depends on the position of the vehicle on the standard trajectory.

Abstract: A method for operating an assistance system for automated driving operation of a vehicle involves continuously determining an emergency trajectory along which the vehicle is brought to a standstill in a longitudinally and transversely controlled manner after activation of an emergency operation of the vehicle. In the event of an imminent or already initiated lane change of the vehicle from a starting lane to a target lane according to a determined standard trajectory, a decision is made as to whether the vehicle should be brought to a standstill in the starting lane or in the target lane when emergency operation is activated. This decision depends on the position of the vehicle on the standard trajectory.

Abstract: A cochlear implant including a cochlear lead, an antenna, a stimulation processor, and a magnet apparatus, associated with the antenna, including a case defining a central axis, a magnet frame within the case and rotatable about the central axis of the case, and a plurality of elongate diametrically magnetized magnets that are located in the magnet frame, the magnets defining a longitudinal axis and a N-S direction and being freely rotatable about the longitudinal axis relative to the magnet frame.

Abstract: A nozzle is provided for cleaning the interior of pipes that is capable of cutting through obstructions disposed in the interior of pipes. The nozzle comprises a three-dimensional (3-D) fluid mechanics comprising a 3-D redirection configuration that redirects high-pressure fluid received in the nozzle from a fluid source onto multiple pathways, or channels, toward rearwardly-facing jet outlets. The 3-D fluid redirection configuration redirects the water in a manner that reduces or eliminates vibrations in the nozzle that can degrade performance and cause other problems.

Abstract: A prosthesis socket having an open proximal end for accommodating an amputation stump, an inner wall and an outer wall, at least one hollow space being located between the inner wall and the outer wall and at least one internal element extending through said hollow space, the at least one internal element being integrally formed with the inner wall and/or the outer wall.

Abstract: An exhaust-gas burner for an exhaust-gas system of a motor vehicle includes a combustion chamber, which is surrounded by an outer wall, for a channel section in an exhaust-gas system. A dosing unit is provided for the controlled feed of a fuel into the combustion chamber. An ignition unit is provided for the ignition of a combustible mixture in the combustion chamber. A cooling circuit is provided for the exchange of heat with the dosing unit, and is arranged within the outer wall of the exhaust-gas burner.

Abstract: The invention relates to a method for creating manufacturing data for manufacturing an orthopedic product for a body part of a patient, the method comprising the following steps: providing a digital three-dimensional body part model of the relevant body part for which the orthopedic product is destined to an electronic data processing apparatus, the three-dimensional body part model being based on external body part data acquired from the body part of the patient; identifying at least one rigid body part region in the provided body part model by means of the electronic data processing apparatus, with the remaining region situated outside of the rigid body part region being identified as a yielding body part region on the basis of the identified rigid body part region; creating a reduced three-dimensional body part model by means of the electronic data processing apparatus on the basis of the provided three-dimensional body part model, the identified rigid body part regions and a reduction metric applied in

Abstract: A message processing component may include an execution unit configurable to execute a set of tasks associated with one or more communication network messages. The set of tasks may include at least one of a message evaluation task or a cryptography task. The execution unit may be configured to provide functional safety in association with executing the set of tasks. The execution unit includes a set of time-multiplexed partitions. Each partition in the set of time-multiplexed partitions may be configurable to execute only one task included in the set of tasks. The message processing component may include an interface to one or more hardware accelerators available for use in association with the execution of the set of tasks. Only one partition, of the set of time-multiplexed partitions, may have access to the one or more hardware accelerators at a time.

Abstract: An exhaust-gas tract for a motor vehicle has an exhaust-gas burner that includes an air inlet connection for the introduction of air into the exhaust-gas burner. The air inlet connection has a connection piece in which a check valve for the closure of the connection piece is arranged. The air inlet connection has an air inlet flange which connects the connection piece to a combustion chamber of the exhaust-gas burner and which seals off the combustion chamber. A motor vehicle incorporates the exhaust-gas tract.