Abstract: Disclosed medical data processing method for planning an external ventricle drainage placement, wherein the method comprises executing, on at least one processor (3) of at least one computer (2), the following steps: a) patient image data describing at least one image of an anatomical structure of a patient is acquired (S1); b) atlas data describing a model of the anatomical structure is acquired (S2); c) mapping data describing a mapping of the patient image data to the atlas data is determined (S3); d) spatial relationship data is acquired (S4) which describes a predetermined spatial relationship between at least one potential trajectory for placing the external ventricle drainage in the anatomical structure on the one hand and a surface of the anatomical structure on the other hand; e) entry point data is determined (S5) which describes the position of an entry point (13) of the external ventricle drainage on the surface of the anatomical structure based on the mapping data and the spatial relationship dat

Abstract: A cochlear implant including a cochlear lead, an antenna, a stimulation processor, and a magnet apparatus, associated with the antenna, including a case defining a central axis, a magnet frame within the case and rotatable about the central axis of the case, and a plurality of elongate diametrically magnetized magnets that are located in the magnet frame, the magnets defining a longitudinal axis and a N-S direction and being freely rotatable about the longitudinal axis relative to the magnet frame.

Abstract: A holding device for an injection valve of an exhaust-gas burner of a motor vehicle includes a receiving section and a cooling-water jacket. The receiving section is shaped such that it can receive a front end of the injection valve. The cooling-water jacket extends around the receiving section and is shaped such that, after the holding device has been mounted on the exhaust-gas burner, the cooling-water jacket, together with a corresponding cooling-water jacket of the exhaust-gas burner, forms a cooling-water chamber of the exhaust-gas burner.

Abstract: The present disclosure provides a Peripheral Component Interconnect Express (PCIe) controller for a PCIe endpoint device. The PCIe controller includes: a PCIe link interface configured to receive an interrupt request message, wherein the interrupt request message is a message write transaction PCIe transport layer packet (TLP) including an address associated with the PCIe endpoint device and a data value including interrupt information; an interrupt request trigger register configured to receive the data value; a plurality of interrupt lines; and a decode logic circuit connected to the interrupt request trigger register and the plurality of interrupt lines, the decode logic circuit configured to automatically decode a plurality of data bits of the data value when received in the interrupt request trigger register and generate an interrupt signal and provide the interrupt signal on one of the plurality of interrupt lines to an interrupt handling circuit.

Abstract: The invention relates to the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia using a SGLT-2 inhibitor. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.

Abstract: Provided is a method for controlling a wind power installation, the wind power installation having a generator for the generation of electric current, the generator having an air gap with a variable air gap thickness, the wind power installation being controlled in a part load range by means of a control regulation, the wind power installation being controlled in a manner which is dependent on the air gap thickness, the control regulation being selected or set in a manner which is dependent on the air gap width.

Abstract: An electrode lead for a cochlear implant system may include a tube having an interior volume and an outer peripheral surface; a plurality of stimulating electrodes disposed on a distal portion of the electrode lead; a ground electrode disposed on a proximal portion of the electrode lead for providing a current return path for stimulation current generated by the plurality of stimulation electrodes, wherein the ground electrode is ring-shaped and is fixed on and around the outer peripheral surface of the tube; and a ground wire extending within the interior volume of the tube to the ground electrode and being electrically connected to the ground electrode through an opening in a wall of the tube.

Abstract: A method of forming an electrode array from an electrode array blank that includes a flexible body and a plurality of electrically conductive contacts. The method includes the steps of forming a first window in the flexible body that extends through the exterior of the flexible body to a first one of the electrically conductive contacts, the first window defining a first window perimetric center, and forming a second window in the flexible body that extends through the exterior of the flexible body to a second one of the electrically conductive contacts, the second window defining a second window perimetric center that is perimetrically offset from the first window perimetric center when the flexible body is straight and not twisted around the longitudinal axis of the flexible body.

Abstract: The present invention relates to methods for treating or preventing chronic kidney disease and cardiovascular disease in patients with chronic kidney disease comprising administering empagliflozin to the patient.

Abstract: An exhaust gas system for an internal combustion engine of a single-track vehicle can be arranged on an exhaust gas outlet of a cylinder head. A first lambda probe close to the cylinder head is provided in the exhaust gas system and is arranged before an exhaust gas cleaning system in the flow direction of an exhaust gas. A second lambda probe is provided in the exhaust gas system after the exhaust gas cleaning system in the flow direction of the exhaust gas. The second lambda probe is arranged at a maximum distance away from the exhaust gas cleaning system equal to four times the diameter of the exhaust gas cleaning system. As a result of the design, the lambda probe is arranged in the non-visible region of the single-track vehicle, while simultaneously examining the quality of the exhaust gas cleaning.

Abstract: An optoelectronic device, in particular a display device, comprises: at least one optoelectronic light source, an at least partially transparent front layer, an at least partially transparent support layer, wherein the light source is arranged between the front layer and the support layer, wherein a front side of the light source faces the front layer and a rear side of the light source faces the support layer, and wherein a limiting device is provided in a circumferential direction around the light source, wherein the limiting device limits a spatial region, in which the light source emits light such that total internal reflection of the emitted light, in particular at an interface between the front layer and the outside, is avoided or at least reduced.

Abstract: The present invention relates to a nucleic acid molecule comprising a low repetitive nucleotide sequence encoding a proline/alanine-rich amino acid repeat sequence. The encoded polypeptide comprises a repetitive amino acid sequence that forms a random coil. The nucleic acid molecule comprising said low repetitive nucleotide sequences can further comprise a nucleotide sequence encoding a biologically or pharmacologically active protein. Further, the present invention provides for selection means and methods to identify said nucleic acid molecule comprising said low repetitive nucleotide sequence. The present invention also relates to a method for preparing said nucleic acid molecules. Also provided herein are methods for preparing the encoded polypeptide or drug conjugates with the encoded polypeptide using the herein provided nucleic acid molecules. The drug conjugate may comprise a biologically or pharmacologically active protein or a small molecule drug.

Abstract: An optoelectronic device, in particular an at least semi-transparent pane for example for a vehicle, comprises: a cover layer, a carrier layer, an intermediate layer between the cover layer and the carrier layer, wherein at least one and preferably a plurality of optoelectronic light sources, in particular ?LEDS, is arranged on at least one surface of the intermediate layer and/or is at least partially embedded in the intermediate layer, wherein the intermediate layer is adapted such that light emitted by the optoelectronic light sources at least partially spreads in and along the intermediate layer and exits the intermediate layer within and/or at a pre-set distance to the respective optoelectronic light source in a direction through the cover layer and/or through the carrier layer.

Abstract: The present invention relates to certain SGLT-2 inhibitors for treating, preventing, protecting against and/or delaying the progression of chronic kidney disease in patients, for example patients with prediabetes, type 1 or type 2 diabetes mellitus.

Abstract: The invention relates to methods for producing coloured materials with the use of metal nanoparticles of gold, copper or silver, to said coloured materials, and to the uses of same in various applications.

Abstract: A method for operating an optoelectronic semiconductor device. The semiconductor device includes a first optoelectronic semiconductor chip for generating, for example, blue light, an optional second optoelectronic semiconductor chip for generating, for example, green light, and a third optoelectronic semiconductor chip for generating, for example, red light. The semiconductor device also includes a driver unit which supplies the semiconductor chips with current during operation. The third semiconductor chip is operated on the basis of a temperature-brightness characteristic curve stored in the driver unit. The temperature-brightness characteristic curve is configured for a minimum color location deviation over an intended operating temperature range, relative to at least one reference color location.

Abstract: The present invention relates to methods for preventing or treating acute or chronic heart failure and for reducing the risk of cardiovascular death, hospitalization for heart failure and other conditions in patients with preserved or reduced ejection fraction by administering empagliflozin to the patient.

Abstract: Methods and compositions for producing mature myotubes are provided herein. In some instances, the method involves contacting a myoblast in an in vitro culture with a compound, wherein the contacting the myoblast in the in vitro culture with the compound results in generation of mature myotubes or myotube-like cells. In some cases, methods of treatment are provided involving treating a subject with a compound such as a Chk1 inhibitor in order to treat muscle deficiency. The compound may be administered as a stand-alone therapy or in combination with a cell therapy, such as introduction of muscle precursor cells such as satellite cells or myoblasts. Methods for identifying compounds that induce formation of mature myotubes or myotube-like cells from myoblasts are also provided herein, as well as methods of using the identified compounds to treat subjects.

Abstract: A measuring system and an associated measuring method for measuring a stator of a gearless wind power installation, wherein the measuring system has an air gap measuring unit and a position determination unit, wherein the air gap measuring unit has a holding apparatus and a distance sensor, wherein the holding apparatus is set up to mount the air gap measuring unit on a rotor of the wind power installation, wherein the distance sensor is set up to provide a signal which is indicative of an extent of an air gap between the stator and the rotor, wherein the position determination unit is set up to be mounted on the rotor of the wind power installation and to capture the signal from the distance sensor during a rotation of the rotor at a plurality of revolution positions. The measuring system and the associated measuring method make it possible to measure a stator in a simplified manner.

Abstract: In some embodiments, an electronic device presents user interfaces for browsing and presenting content. In some embodiments, the electronic device presents representations of recommended items of content that include representations of content items the user is entitled to access without including representations of content items the user is not entitled to access.