Abstract: An approach to identify and evaluate potential insecticide targets using publicly available genome (DNA) sequence information for arthropod disease vector is provided. The utility of this approach is demonstrated by first determining the molecular and pharmacological properties of two different dopamine (neurotransmitter) receptors identified in the genome of the yellow fever- and dengue-transmitting mosquito, Aedes aegypti. Next, different chemistries were tested for their ability to interact with one of these dopamine receptors in a chemical compound screen, and “hit” compounds were identified. Finally, it is shown that some of these chemistries, are selective for the mosquito over the human dopamine receptor and that these chemistries caused significant mortality in mosquito larvae 24 hours after exposure.

Abstract: The multi-functional vehicular ramp is an accessory that attaches to a trailer hitch of a pickup truck and which include foldable ramp members that fold down to enable ATVs or other wheeled objects to drive up onto a bed of a pickup truck for transport, and wherein the foldable ramp members can fold up to secure said wheeled object to said pickup truck bed. The multi-functional vehicular ramp can also adapt to attach wheels thereon for use as a trailer to be towed via one of a multitude of adaptors behind a truck or other motor-powered vehicle. The multi-functional vehicular ramp may also be adaptively used to suspend an object above the ground by extending the foldable ramp members upwardly and connection there between via a suspension member. The multi-functional vehicular ramp may also adapt for use as a workbench or as a picnic table.

Abstract: A system for simultaneous transmission (1) of Morse signaling over a radio communication using digital technology, comprising a signal generator (2) with at least one digital modulation which includes at least one amplitude modulation component; a Morse code generator (3) that generates Morse tones in analog form; and a first attenuator module (4), controlled by the Morse code generator (4). In this way, a signal with digital modulation generated by the signal generator (2) is attenuated in amplitude by the first attenuator module (4), the amplitude attenuation being the function of the amplitude of the waveform generated by the Morse code generator (3). In this way the transmission of information by digital modulation is simultaneous with the transmission of the Morse code by analog amplitude modulation (AM), using one single radiofrequency (RF) carrier signal and without service interruption or information loss.

Abstract: The objective of this invention is to enable a rapid construction of affordable, disaster-resistant real estate structures. Inventors present a building block construction of an ornamental shape and design as described herein, a corresponding interlock system, and a method of assembling novel structural elements and elements of known design into a cohesive building structure. The novel construction blocks, interlocks and panels form a cooperatively organized communicating chamber for receiving a cement-based substance, for example a cement-based concrete or mortar mixture, hence comprising a monolithic building structure.

Abstract: The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.

Abstract: Provided are compounds having an inhibitory effect on Mixed Lineage Kinases, having a structural Formula, Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment of neuropsychiatric disorders which comprise the inhibition of Mixed Lineage Kinases.

Abstract: The present disclosure includes a pulse oximeter attachment having an accessible memory. In one embodiment, the pulse oximeter attachment stores calibration data, such as, for example, calibration data associated with a type of a sensor, a calibration curve, or the like. The calibration data is used to calculate physiological parameters of pulsing blood.

Abstract: The present invention relates to an isolated strain of Bacillus subtilis (IAB/BS/03) deposited at the DSM German Type Culture Collection under Access No DSM 24682, or a mutant of said strain, and also deposited at the Spanish type culture collection under Access number CECT 7254, the property of the company filing the patent, in which said strain and/or the mutant thereof exhibits antifungal and antibacterial activity, with a profile of action different from that of other strains of Bacillus subtilis and with much greater potency in terms of the capacity thereof to act as a field biological control agent. The invention also includes methods for preventing and treating fungal and bacterial diseases in plants using said bacterial strains or supernatants containing antibiotics or pure antibiotics obtained from said bacterial strains, in which said antibiotics are contained in a composition.

Abstract: Provided are compounds having an inhibitory effect on kinases including Mixed Lineage Kinases. Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment of neuropsychiatric disorders that comprise the inhibition of Mixed Lineage Kinases.

Abstract: A mobile device and peripheral hardware case and holder comprises a panel section for attachment to the rear of peripheral hardware, such as a battery pack or amplifier. The panel member includes edges which slide in to rails of a mobile device case, which holds a mobile device, such as a cell phone or music player. The rails of the case include a stop for holding the panel section in an installed position, and a corresponding locking arrangement biases the holder in a locked position. When assembled, the holder preserves the connections of the mobile device and peripheral hardware in proximity to each other.

Abstract: Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their therapeutic. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and pharmaceutical compositions.

Abstract: Electronic components are often assembled using robotic equipment, such as pick-and-place machines, that is not optimized for components such as ultra-thin semiconductor bare dice. Selective laser-assisted die transfer is described based on the unique blistering behavior of a multilayer dynamic release layer when irradiated by low energy focused laser pulse(s) in which the blister creates translation of the article being placed. Accurate placement results are provided with negligible lateral and angular displacement.

Abstract: The present invention is directed to a system and method which allows a prospective insured to make an informed decision on healthcare insurance or a specific health care management decision by using a current medical profile to assist in their selection. Based on past medical care, as obtained from payor data, a number of different plans, each having different providers, different deductibles, different maximums, different reimbursement policies, etc., a person can make an informed decision. When a family has different payors for different family members, a proper blend of payors can be more easily selected since the payors (or a single payor) has a medical profile of each family member and also has information on providers in the network, prescription policies, deductibles, maximums, etc.

Abstract: A threat detection system includes a facility including at least three separate rooms located in the facility and a positive pressure zone located external to the facility. A ventilation system is coupled to the at least three separate rooms. A first room is located in the facility, wherein the first room includes a first room pressure zone that is negative with respect to the positive pressure zone external to the facility. A second room is located in the facility and connected to the first room, wherein the second room includes a second room pressure zone that is negative with respect to the first room pressure zone.

Abstract: A method for fabricating a re-built wafer which comprises chips having connection pads, comprising: fabricating a first wafer of chips, production on this wafer of a stack of at least one layer of redistribution of the pads of the chips on conductive tracks designed for the interconnection of the chips, this stack being designated the main RDL layer, cutting this wafer in order to obtain individual chips each furnished with their RDL layer, transferring the individual chips with their RDL layer to a sufficiently rigid support to remain flat during the following steps, which support is furnished with an adhesive layer, with the RDL layer on the adhesive layer, depositing a resin in order to encapsulate the chips, polymerizing the resin, removing the rigid support, depositing a single redistribution layer called a mini RDL in order to connect the conductive tracks of the main RDL layer up to interconnection contacts, through apertures made in the adhesive layer, the wafer comprising the polymerized resin, the c

Abstract: The present invention is directed to a system and method which allows a prospective insured to make an informed decision on healthcare insurance or a specific health care management decision by using a current medical profile to assist in their selection. Based on past medical care, as obtained from payor data, a number of different plans, each having different providers, different deductibles, different maximums, different reimbursement policies, etc., a person can make an informed decision. When a family has different payors for different family members, a proper blend of payors can be more easily selected since the payors (or a single payor) has a medical profile of each family member and also has information on providers in the network, prescription policies, deductibles, maximums, etc.

Abstract: Trampolines and trampoline frames configured to support a rebounding mat that extends from a horizontal plane into a vertical plane that is below the horizontal plane. The trampoline includes a horizontal frame that connects to a first portion of the rebounding mat to hold the mat in a substantially horizontal plane and a vertical frame that connects to a second portion of the rebounding mat to hold the mat in a substantially vertical plane that extends downward from the horizontal plane.