Abstract: The present invention relates to a phosphomimetic RAGE protein comprising an amino acid sequence that is at least 90% identical to a native mammalian RAGE isoform or fragment thereof wherein at least one serine present in the cytoplasmatic tail of the mammalian RAGE isoform is replaced by a phosphomimetic structure. The invention further relates to a polynucleotide encoding phosphomimetic RAGE protein and a vector comprising the polynucleotide. Finally, the invention relates to a composition comprising carrier and an active pharmaceutical ingredient, selected from the RAGE protein the vector for use in the treatment or prevention of a disease in a patient, wherein the disease is preferably selected from a disease initiated by impaired DNA repair, a disease initiated by increased DNA damage or a disease initiated by increased senescence.

Abstract: Dynamic erasure coding for computing and data storage systems. A method embodiment commences upon accessing a set of fault tolerance policy attributes associated with the computing and data storage system. The topology of the system is analyzed to form mappings between the computing nodes of the system and the availability domains of the system. Based on the fault tolerance policy attributes, the topology, and the generated mapping, a plurality of feasible erasure coding configurations are generated. The feasible erasure coding configurations are scored. One or more high-scoring feasible erasure coding configurations are selected and deployed to the computing and data storage system. The method is repeated when there is a change in the fault tolerance policy attributes or in the topology. Depending on the topology and/or the nature of a change in the topology, more than one erasure coding configurations can be deployed onto the computing and data storage system.

Abstract: Various embodiments described herein relate to an intelligent warning system in a communication service. One embodiment of the present invention analyzes a user's biometric signals and image data of one of the user's in a communication session to determine a distress level. In addition, location data indicating the user's velocity and direction can be used to determine a distress level. If the biometric signals or the image data indicate a distress level that meets or exceeds a threshold level, a notification is automatically sent to a remote user. This can allow a remote user to render assistance to a user in distress, even when the user is unable to communicate one or more conditions.

Abstract: Systems for ad-hoc analysis of metadata in distributed data storage systems. A distributed storage system comprises computing nodes and a storage pool that is accessible by computing nodes. The storage pool comprises stored information and respective metadata that describes the stored information. Instances of a metadata search engine are installed on the computing nodes such that the metadata search engines have access to both local data stored in the storage pool as well as to networked storage in the storage pool. A user defines metadata management application extensions for extending the metadata search engine using computer programming languages. When executed by the metadata search engine, the extensions perform user-defined functions. A metadata analysis command is associated with the user-defined function and the metadata analysis command is launched from within the metadata search engine to perform the user-defined function over metadata stored in the system.

Abstract: Systems for high-performance computing. A method operates in a distributed storage cluster platform that has a storage pool and computing nodes that concurrently execute foreground tasks and background tasks. A uses interacts with a user interface to input specifications of background task time windows. Background tasks that run within the time frame of a background task time window are permitted to be scheduled at a relatively higher resource usage rate that consumes relatively higher cluster resources than do background task tasks that run outside of the background task time window. When the background task time window closes, the relatively higher resource usage rate of the running cluster background tasks is reduced to a relatively lower resource usage rate. Background tasks can self-observe the background task time windows and/or can be controlled by messages received from a virtualized controller that is designated to perform cluster-wide observations and to make cluster-wide determinations.

Abstract: Various embodiments described herein relate to an intelligent warning system in a communication service. One embodiment of the present invention analyzes a user's biometric signals and image data of one of the user's in a communication session to determine a distress level. In addition, location data indicating the user's velocity and direction can be used to determine a distress level. If the biometric signals or the image data indicate a distress level that meets or exceeds a threshold level, a notification is automatically sent to a remote user. This can allow a remote user to render assistance to a user in distress, even when the user is unable to communicate one or more conditions.

Abstract: Dynamic erasure coding for computing and data storage systems. A method embodiment commences upon accessing a set of fault tolerance policy attributes associated with the computing and data storage system. The topology of the system is analyzed to form mappings between the computing nodes of the system and the availability domains of the system. Based on the fault tolerance policy attributes, the topology, and the generated mapping, a plurality of feasible erasure coding configurations are generated. The feasible erasure coding configurations are scored. One or more high-scoring feasible erasure coding configurations are selected and deployed to the computing and data storage system. The method is repeated when there is a change in the fault tolerance policy attributes or in the topology. Depending on the topology and/or the nature of a change in the topology, more than one erasure coding configurations can be deployed onto the computing and data storage system.

Abstract: Various embodiments described herein relate to an intelligent warning system in a communication service. One embodiment of the present invention analyzes a user's biometric signals and image data of one of the user's in a communication session to determine a distress level. In addition, location data indicating the user's velocity and direction can be used to determine a distress level. If the biometric signals or the image data indicate a distress level that meets or exceeds a threshold level, a notification is automatically sent to a remote user. This can allow a remote user to render assistance to a user in distress, even when the user is unable to communicate one or more conditions.

Abstract: Various embodiments described herein relate to coupling textual and emotional communication in a communication service. One embodiment captures an image from a user of an application. Next, an expression is determined from the image. The application then identifies a graphical expression which corresponds to the graphical expression. Finally, the application displays the graphical expression. This can be done for example via a WI-FI network, a cellular network, or other mode of peer-to-peer or server-based communication scheme. The present invention also provides a keyboard service.

Abstract: The present invention provides a method for fixing carbon dioxide gas as a carbonyl compound represented by formula (3) as depicted by FIG. 1 and comprising, purging of carbon dioxide in a solution of a nucleophile represented by the formula (1) in presence of a solvent at a temperature ranging from ?40 Degree Celsius to 35 Degree Celsius, followed by adding a reagent at temperature ranging from ?40 degree to 35 degree and thereafter adding another nucleophile represented by the formula (2) to obtain carbonyl compound represented by formula (3). The present invention can be advantageously used to obtain commercially important carbonyl compounds and clean unwanted carbon dioxide gas from the atmosphere and industrial effluents.

Abstract: Techniques are described herein for, among other things, selecting and/or modifying a portion of online content based on an emotional state of a user. The user's emotional state is determined based on the user's online activity. A portion or portions of online content are selected and/or modified for provision to the user based on the user's emotional state. A portion of online content may be modified in any of a variety of ways. For example, a color that is included in a portion of online content may be replaced with a different color. In another example, a color filter may be applied to the portion of online content. In yet another example, visual attribute(s) of the portion of online content may be modified. Examples of a visual attribute include, but are not limited to, hue, brightness, contrast, and saturation.

Abstract: Techniques for performing compression operations on persistently-stored data blocks during read/write commands. A method embodiment performs in-line data compression operations over data blocks referenced by a caller. The in-line data compression operations are performed during execution of a storage input-output (I/O) command, between the event of receipt of the storage I/O command and the event of returning status of the storage I/O command. The storage I/O operation is associated with at least one data group comprising one or more data blocks that are identified by the caller. Upon receipt of the storage I/O command, one or more compression rules are applied to the data blocks to determine one or more compression parameters, which compression parameters are used to form specific compression operations that are performed over at least a portion of the data group. The status pertaining to the execution of the storage I/O operation is returned to the caller.

Abstract: Systems and methods for scheduling storage management tasks over predicted user tasks in a distributed storage system. A method commences upon receiving a set of historical stimulus records that characterize management tasks that are run in the storage system. A corresponding set of historical response records comprising system metrics associated with execution of the system tasks is also received. A learning model is formed from the stimulus records and the response records and formatted to be used as a predictor. A set of forecasted user tasks is input as new stimulus records to the predictor to determine a set of forecasted system metrics that would result from running the forecasted user tasks. Management tasks are selected so as not to impact the forecasted user tasks. Management tasks can be selected based on non-contentions resource usage between historical management task resource usage and predictions of resource usage by the user tasks.

Abstract: Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Abstract: Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Abstract: A fuel tank isolation valve 10, wherein, the shaft 18 is assembled coaxially inside hole 42 of moving plunger 46 of seal sub assembly 16 and then flow limiter 22 is guided over the shaft 18 through guiding hole 34 to maintain sealing seat 36 in parallel with respect to the sealing surface 38 of rubber seal 44 and avoid misalignment of flow limiter 22 with respect to sealing surface 38 during and after the operation; the sealing seat 36 of flow limiter 22 on the sealing surface 38 of the rubber seal 44 fixed into moving plunger 46 of seal sub assembly 16 performs the over pressure relief function; the sealing surface 40 of rubber seal 44 fixed into moving plunger 46 of seal sub-assembly 16 is resting on surface 48 of nozzle body 20 to perform over vacuum relief function; and the rubber seal 44 assist both over pressure relief (OPR) and over vacuum relief (OVR) function.

Abstract: Techniques for performing compression operations on persistently-stored data blocks during read/write commands. A method embodiment performs in-line data compression operations over data blocks referenced by a caller. The in-line data compression operations are performed during execution of a storage input-output (I/O) command, between the event of receipt of the storage I/O command and the event of returning status of the storage I/O command. The storage I/O operation is associated with at least one data group comprising one or more data blocks that are identified by the caller. Upon receipt of the storage I/O command, one or more compression rules are applied to the data blocks to determine one or more compression parameters, which compression parameters are used to form specific compression operations that are performed over at least a portion of the data group. The status pertaining to the execution of the storage I/O operation is returned to the caller.

Abstract: Methods and systems for checking the integrity of a system on chip (SOC) are described. The SOC can include a controller and one or more registers. Register value(s) from the register(s) can be obtained at a first time to generate a first set of register values. Process(es) of the SOC are executed at a second time after the first time. Register values can again be obtained from the registers at a third time after the second time to generate a second set of register values. The first set of register values can be compared with the second set of register values. Based on the comparison, an operating mode of the SOC can be adjusted. The SOC integrity verification system and method can be used in safety and/or monitoring application(s), such as ASIL applications. For example, the system and method can be used in partial or fully autonomous (self-driving) automotive systems.

Abstract: A mechanism is described for facilitating smart monitoring of body dimensions according to one embodiment. A method of embodiments, as described herein, includes receiving a first request to take a first picture of a user, wherein the first picture is taken at a first point in time using a depth-sensing camera; automatically computing first body dimensions relating to a body of the user based on at least one of a first image of the body and first depth information relating to one or more parts of the body, wherein the first image and the first depth information are obtained from the first picture; generate a first three-dimensional (3D) model of the body based on the first body dimensions; and communicating at least one of the first 3D model and the first body dimensions to a display device, wherein the display device to display at least one of the first 3D model and the first body dimensions.

Abstract: There is provided a nanofibrous filter comprising a substrate and self-assembled nanofibers deposited on the substrate. The self-assembled nanofibers comprise ?-conjugated molecules self-assembled by non-covalent interactions, wherein the ?-conjugated molecules are phthalocyanine derivative molecules or diketopyrrolopyrrole derivative molecules. There is also provided a method of preparing the nanofibrous filter.