Patents by Inventor Vasulinga Ravikumar

Vasulinga Ravikumar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Supports for oligomer synthesis
    Patent number: 8541599
    Abstract: Universal linkers, their facile processes of manufacture and methods of using the same are provided.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: September 24, 2013
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Andrei P. Guzaev, Zhiwei Wang, Raju K. Kumar
  • SUPPORTS FOR OLIGOMER SYNTHESIS
    Publication number: 20120165547
    Abstract: Universal linkers, their facile processes of manufacture and methods of using the same are provided.
    Type: Application
    Filed: March 7, 2012
    Publication date: June 28, 2012
    Applicant: ISIS PHARMACEUTICALS, INC.
    Inventors: VASULINGA RAVIKUMAR, MUTHIAH MANOHARAN, ANDREI P. GUZAEV, ZHIWEI WANG, RAJU KRISHNA KUMAR
  • Supports for oligomer synthesis
    Patent number: 8153725
    Abstract: Universal linkers, their facile processes of manufacture and methods of using the same are provided.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: April 10, 2012
    Assignee: Isis Pharmaceuticals, Inc
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Andrei P. Guzaev, Zhiwei Wang, Raju K. Kumar
  • Process for the synthesis of 2?-O-substituted purine nulceosides
    Patent number: 7820810
    Abstract: The present invention provides an improved process for the synthesis of 2?-O-substituted purine nucleosides. The process includes anhydro or thioanhydro ring opening of a selected 8,2?-cyclopurine nucleoside with a weak nucleophile in the presence of a Lewis acid ester, followed by reduction to afford the desired 2?-O-substituted purine nucleoside.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: October 26, 2010
    Assignee: Isis Pharmaceuticals, Inc.
    Inventor: Vasulinga Ravikumar
  • SUPPORTS FOR OLIGOMER SYNTHESIS
    Publication number: 20100234528
    Abstract: Universal linkers, their facile processes of manufacture and methods of using the same are provided.
    Type: Application
    Filed: March 19, 2010
    Publication date: September 16, 2010
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Andrei P. Guzaev, Zhiwei Wang, Raju Krishna Kumar
  • Synthesis of sulfurized oligonucleotides
    Patent number: 7723511
    Abstract: Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: May 25, 2010
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga Ravikumar, Zacharia S. Cheruvallath
  • Supports for oligomer synthesis
    Patent number: 7718810
    Abstract: Universal linkers, their facile processes of manufacture and methods of using the same are provided.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: May 18, 2010
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Andrei P. Guzaev, Zhiwei Wang, Raju K. Kumar
  • Polymeric beads for oligomer synthesis
    Patent number: 7700706
    Abstract: The present invention provides solid support media for use in oligomer synthesis, methods of producing the media, and methods of using the media. In some embodiments, the processes of the invention comprise (a) providing an organic phase comprising an olefin monomer, a cross-linker, a functionalizing reagent and an initiator; and (b) contacting the organic phase with an aqueous phase under conditions of time and temperature effective to form the polymeric bead.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: April 20, 2010
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Raju K. Kumar, Kenjirou Mori, Tatsuya Konishi, Ayako Matsunawa, Takeo Matsumura, Cheiko Kitaura, Gang Zhao
  • POLYMERIC BEADS FOR OLIGOMER SYNTHESIS
    Publication number: 20090286085
    Abstract: The present invention provides solid support media for use in oligomer synthesis, methods of producing the media, and methods of using the media. In some embodiments, the processes of the invention comprise (a) providing an organic phase comprising an olefin monomer, a cross-linker, a functionalizing reagent and an initiator; and (b) contacting the organic phase with an aqueous phase under conditions of time and temperature effective to form the polymeric bead.
    Type: Application
    Filed: July 28, 2009
    Publication date: November 19, 2009
    Applicants: Isis Pharmaceuticals, Inc., Nitto-Denko
    Inventors: Vasulinga Ravikumar, Raju K. Kumar, Kenjirou Mori, Tatsuya Konishi, Ayako Matsunawa, Takeo Matsumura, Cheiko Kitaura, Gang Zhao
  • Supports for oligomer synthesis
    Patent number: 7576119
    Abstract: Universal linkers, their facile processes of manufacture and methods of using the same are provided.
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: August 18, 2009
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Andrei P. Guzaev, Zhiwei Wang, Raju K. Kumar
  • SUPPORTS FOR OLIGOMER SYNTHESIS
    Publication number: 20090131682
    Abstract: Universal linkers, their facile processes of manufacture and methods of using the same are provided.
    Type: Application
    Filed: July 17, 2008
    Publication date: May 21, 2009
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Andrei P. Guzaev, Zhiwei Wang, Raju Krishna Kumar
  • PROCESS FOR THE SYNTHESIS OF 2'-O-SUBSTITUTED PURINES
    Publication number: 20080234475
    Abstract: The present invention provides an improved process for the synthesis of 2?-O-substituted purine nucleosides. The process includes anhydro or thioanhydro ring opening of a selected 8,2?-cyclopurine nucleoside with a weak nucleophile in the presence of a Lewis acid ester, followed by reduction to afford the desired 2?-O-substituted purine nucleoside.
    Type: Application
    Filed: March 19, 2008
    Publication date: September 25, 2008
    Inventor: Vasulinga Ravikumar
  • POLYMERIC BEADS FOR OLIGOMER SYNTHESIS
    Publication number: 20080097028
    Abstract: The present invention provides solid support media for use in oligomer synthesis, methods of producing the media, and methods of using the media. In some embodiments, the processes of the invention comprise (a) providing an organic phase comprising an olefin monomer, a cross-linker, a functionalizing reagent and an initiator; and (b) contacting the organic phase with an aqueous phase under conditions of time and temperature effective to form the polymeric bead.
    Type: Application
    Filed: December 17, 2007
    Publication date: April 24, 2008
    Applicants: lsis Pharmaceuticals, Inc., Nitto-Denko
    Inventors: Vasulinga Ravikumar, Raju Kumar, Kenjirou Mori, Tatsuya Konishi, Ayako Matsunawa, Takeo Matsumura, Cheiko Kitaura, Gang Zhao
  • Polymeric beads for oligomer synthesis
    Patent number: 7348391
    Abstract: The present invention provides solid support media for use in oligomer synthesis, methods of producing the media, and methods of using the media. In some embodiments, the processes of the invention comprise (a) providing an organic phase comprising an olefin monomer, a cross-linker, a functionalizing reagent and an initiator; and (b) contacting the organic phase with an aqueous phase under conditions of time and temperature effective to form the polymeric bead.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: March 25, 2008
    Assignees: Isis Pharmaceuticals, Inc., Nitto Denko Corporation
    Inventors: Vasulinga Ravikumar, Raju K. Kumar, Kenjirou Mori, Tatsuya Konishi, Ayako Matsunawa, Takeo Matsumura, Cheiko Kitaura, Gang Zhao
  • SUPPORTS FOR OLIGOMER SYNTHESIS
    Publication number: 20080021224
    Abstract: Universal linkers, their facile processes of manufacture and methods of using the same are provided.
    Type: Application
    Filed: January 11, 2007
    Publication date: January 24, 2008
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Andrei Guzaev, Zhiwei Wang, Raju Kumar
  • PROCESS FOR THE SYNTHESIS OF OLIGOMERIC COMPOUNDS
    Publication number: 20070265435
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: April 5, 2007
    Publication date: November 15, 2007
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Daniel Capaldi, Achim Krotz, Douglas Cole, Andrei Guzaev
  • Supports for oligomer synthesis
    Patent number: 7202264
    Abstract: Universal linkers, their facile processes of manufacture and methods of using the same are provided.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: April 10, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Andrei P. Guzaev, Zhiwei Wang, Raju Krishna Kumar
  • Process for the synthesis of oligomeric compounds
    Patent number: 7186822
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: December 28, 2004
    Date of Patent: March 6, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei P. Guzaev
  • Polymeric beads for oligomer synthesis
    Publication number: 20060051800
    Abstract: The present invention provides solid support media for use in oligomer synthesis, methods of producing the media, and methods of using the media. In some embodiments, the processes of the invention comprise (a) providing an organic phase comprising an olefin monomer, a cross-linker, a functionalizing reagent and an initiator; and (b) contacting the organic phase with an aqueous phase under conditions of time and temperature effective to form the polymeric bead.
    Type: Application
    Filed: September 2, 2005
    Publication date: March 9, 2006
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Raju Kumar, Kenjirou Mori, Tatsuya Konishi, Ayako Matsunawa, Takeo Matsumura, Cheiko Kitaura, Gang Zhao
  • Methods for preparing oligonucleotides having chiral phosphorothioate linkages
    Publication number: 20060041115
    Abstract: Methods are provided for preparing internucleotide phosphorothioate linkages that are enriched in the Sp or Rp enantiomer comprising coupling a synthon with a 2?-substituted nucleoside in the presence of coupling agent that is selected to enhance either the Rp or Spenantiomer according to its pKa.
    Type: Application
    Filed: March 15, 2005
    Publication date: February 23, 2006
    Inventor: Vasulinga Ravikumar