Patents by Inventor Vasulinga Ravikumar

Vasulinga Ravikumar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of synthesizing phosphorothioate oligonucleotides
    Patent number: 6403781
    Abstract: This invention presents novel methods for synthesizing phosphorothioate oligonucleotides, using support-bound phosphoramidites. Novel intermediates useful in the methods are also provided.
    Type: Grant
    Filed: January 8, 2001
    Date of Patent: June 11, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga Ravikumar
  • Synthesis of oligonucleotides
    Patent number: 6294664
    Abstract: Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes. Intermediates having structure (I) are prepared in accordance with preferred embodiments.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: September 25, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Douglas L. Cole
  • Synthesis of oligonucleotides
    Publication number: 20010018510
    Abstract: Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes.
    Type: Application
    Filed: April 2, 2001
    Publication date: August 30, 2001
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Douglas L. Cole
  • Method of synthesizing phosphorothioate oligonucleotides
    Publication number: 20010003132
    Abstract: This invention presents novel methods for synthesizing phosphorothioate oligonucleotides, using support-bound phosphoramidites. Novel intermediates useful in the methods are also provided.
    Type: Application
    Filed: January 8, 2001
    Publication date: June 7, 2001
    Inventors: Douglas L. Cole, Vasulinga Ravikumar
  • Synthesis of oligonucleotides
    Patent number: 6211350
    Abstract: Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes. Intermediates having structure are prepared in accord with preferred embodiments.
    Type: Grant
    Filed: September 14, 1999
    Date of Patent: April 3, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Douglas L. Cole
  • Method of synthesizing phosphorothioate oligonucleotides
    Patent number: 6172217
    Abstract: This invention presents novel methods for synthesizing phosphorothioate oligonucleotides, using support-bound phosphoramiditese. Novel intermediates useful in the methods are also provided.
    Type: Grant
    Filed: December 27, 1996
    Date of Patent: January 9, 2001
    Assignee: ISIS Pharmaceuticals Inc.
    Inventors: Douglas L. Cole, Vasulinga Ravikumar
  • Processes and intermediates for phosphorous-containing covalent linkages
    Patent number: 6124450
    Abstract: Synthetic processes are provided wherein substituted silylalkyl phosphoramidites serve as coupling reagents for preparing phosphate, phosphorothioate, and other phosphorous-containing covalent linkages. Also provided are synthetic intermediates useful in such processes.
    Type: Grant
    Filed: July 27, 1998
    Date of Patent: September 26, 2000
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Dennis Mulvey, Douglas L. Cole, Phillip Dan Cook
  • Lactam nucleic acids
    Patent number: 6084082
    Abstract: Novel .beta.-lactam monomers bearing various functional groups are prepared. The novel .beta.-lactam monomers can be joined into oligomeric compounds such as via preferred phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen bonding. The oligomeric compounds are useful as diagnostic and research reagents.
    Type: Grant
    Filed: October 15, 1998
    Date of Patent: July 4, 2000
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Venkatraman Mohan
  • Synthesis of oligonucleotides
    Patent number: 6001982
    Abstract: Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes. Intermediates having structure ##STR1## are prepared in accord with preferred embodiments.
    Type: Grant
    Filed: July 31, 1996
    Date of Patent: December 14, 1999
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Douglas L. Cole
  • Method for the synthesis of nucleotide or oligonucleotide phosphoramidites
    Patent number: 5955600
    Abstract: This invention presents novel methods for recovery of phosphoramidites from the waste products of oligonucleotide synthesis. The methods include reacting a tribromophenoxydichlorophosphorane with a H-phosphonate in the presence of an amine.
    Type: Grant
    Filed: December 27, 1996
    Date of Patent: September 21, 1999
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Richard H. Griffey, Douglas L. Cole, Vasulinga Ravikumar
  • Lactam nucleic acids
    Patent number: 5866691
    Abstract: Novel .beta.-lactam monomers bearing various functional groups are prepared. The novel .beta.-lactam monomers can be joined into oligomeric compounds such as via preferred phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen bonding. The oligomeric compounds are useful as diagnostic and research reagents.
    Type: Grant
    Filed: July 19, 1996
    Date of Patent: February 2, 1999
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Venkatraman Mohan
  • Monomeric and dimeric nucleosides with silyl-containing diamino phosphorous linkages
    Patent number: 5847106
    Abstract: Synthetic processes are provided wherein substituted silylalkyl phosphoramidites serve as coupling reagents for preparing phosphate, phosphorothioate, and other phosphorous-containing covalent linkages. Also provided are synthetic intermediates useful in such processes. h processes.
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: December 8, 1998
    Assignee: ISIS Pharmaceuticals Inc.
    Inventors: Vasulinga Ravikumar, Dennis Mulvey, Douglas L. Cole, Phillip Dan Cook
  • Use of carbocation scavenger during oligonucleotide synthesis
    Patent number: 5714597
    Abstract: During the synthesis of oligonucleotides and phosphate linked oligomers, a carbocation scavenging agent is employed to increase the overall yield. The carbocation scavenging agent is used in conjunction with an acidic solution employed during the deprotection step.
    Type: Grant
    Filed: March 8, 1996
    Date of Patent: February 3, 1998
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Mark Andrade, Dennis Mulvey, Douglas L. Cole
  • Trisubstituted .beta.-lactams and oligo .beta.-lactamamides
    Patent number: 5629152
    Abstract: Novel .beta.-lactam monomers bearing various functional groups are prepared. The novel .beta.-lactam monomers can be joined into oligomeric compounds via standard peptide linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen bonding. The oligomeric compounds are useful as diagnostic and research reagents.
    Type: Grant
    Filed: August 1, 1994
    Date of Patent: May 13, 1997
    Assignee: Isis Pharmaceuticals, Inc.
    Inventor: Vasulinga Ravikumar
  • Synthesis of oligonucleotides
    Patent number: 5571902
    Abstract: Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes. Intermediates having structure ##STR1## are prepared in accord with preferred embodiments.
    Type: Grant
    Filed: May 26, 1994
    Date of Patent: November 5, 1996
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Douglas L. Cole
  • Lactam nucleic acids
    Patent number: 5554746
    Abstract: Novel .beta.-lactam monomers bearing various functional groups are prepared. The novel .beta.-lactam monomers can be joined into oligomeric compounds such as via preferred phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen bonding. The oligomeric compounds are useful as diagnostic and research reagents.
    Type: Grant
    Filed: May 16, 1994
    Date of Patent: September 10, 1996
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Venkatraman Mohan
  • Carbocation scavenging during oligonucleotide synthesis
    Patent number: 5510476
    Abstract: During the synthesis of oligonucleotides and phosphate linked oligomers, a carbocation scavenging agent is employed to increase the overall yield. The carbocation scavenging agent is used in conjunction with an acidic solution employed during the deprotection step.
    Type: Grant
    Filed: July 7, 1994
    Date of Patent: April 23, 1996
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Mark Andrade, Dennis Mulvey, Douglas L. Cole