Patents by Inventor Vasulinga Ravikumar

Vasulinga Ravikumar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligomeric compounds having modified phosphate groups
    Publication number: 20060003952
    Abstract: Oligomeric compounds having at least one phosphorothioate monoester are provided having increased nuclease resistance and binding affinity to a complementary strand of nucleic acid. Such oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions responsive to oligonucleotide therapeutics.
    Type: Application
    Filed: April 9, 2003
    Publication date: January 5, 2006
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Thazha Prakash, Balkrishen Bhat
  • Deprotection of phosphorus in oligonucleotide synthesis
    Patent number: 6967247
    Abstract: A process for removing a phosphorus protecting group from a protected phosphate triester or phosphorothioate triester includes contacting a protected phosphate or phosphorothioate triester with a thiol compound that is not offensive to the olfactory senses.
    Type: Grant
    Filed: July 24, 2002
    Date of Patent: November 22, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventor: Vasulinga Ravikumar
  • Supports for oligomer synthesis
    Publication number: 20050208588
    Abstract: Universal linkers, their facile processes of manufacture and methods of using the same are provided.
    Type: Application
    Filed: November 15, 2004
    Publication date: September 22, 2005
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Andrei Guzaev, Zhiwei Wang, Raju Kumar
  • Process for the synthesis of oligomeric compounds
    Publication number: 20050182251
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: December 28, 2004
    Publication date: August 18, 2005
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Daniel Capaldi, Achim Krotz, Douglas Cole, Andrei Guzaev
  • Synthesis of sulfurized oligonucleotides
    Publication number: 20050165226
    Abstract: Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.
    Type: Application
    Filed: May 17, 2004
    Publication date: July 28, 2005
    Inventors: Douglas Cole, Vasulinga Ravikumar, Zacharia Cheruvallath
  • Process for the synthesis of oligomeric compounds
    Publication number: 20050137391
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: September 14, 2004
    Publication date: June 23, 2005
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Daniel Capaldi, Achim Krotz, Douglas Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Publication number: 20050137390
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: December 28, 2004
    Publication date: June 23, 2005
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Daniel Capaldi, Achim Krotz, Douglas Cole, Andrei Guzaev
  • Synthesis of oligonucleotides
    Patent number: 6870039
    Abstract: Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes. Intermediates having structure are prepared in accord with preferred embodiments.
    Type: Grant
    Filed: September 19, 2003
    Date of Patent: March 22, 2005
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Douglas L. Cole
  • Diribonucleoside Phosphoramidites
    Patent number: 6780989
    Abstract: This invention presents novel methods for synthesizing phosphorothioate oligonucleotides, using support-bound phosphoramidites. Novel intermediates useful in the methods are also provided.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: August 24, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga Ravikumar
  • Synthesis of oligonucleotides
    Publication number: 20040063925
    Abstract: Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes.
    Type: Application
    Filed: September 19, 2003
    Publication date: April 1, 2004
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Douglas L. Cole
  • Deprotection of phosphorus in oligonucleotide synthesis
    Publication number: 20040024194
    Abstract: A process for removing a phosphorus protecting group from a protected phosphate triester or phosphorothioate triester includes contacting a protected phosphate or phosphorothioate triester with a thiol compound that is not offensive to the olfactory senses.
    Type: Application
    Filed: July 24, 2002
    Publication date: February 5, 2004
    Inventor: Vasulinga Ravikumar
  • Synthesis of oligonucleotides
    Patent number: 6646114
    Abstract: Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes. Intermediates having structure are prepared in accord with preferred embodiments.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: November 11, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Douglas L. Cole
  • Phosphorothioate monoester modified oligomers
    Publication number: 20030190626
    Abstract: Oligomeric compounds having at least one phosphorothioate monoester are provided having increased nuclease resistance and binding affinity to a complementary strand of nucleic acid. Such oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions responsive to oligonucleotide therapeutics.
    Type: Application
    Filed: April 9, 2002
    Publication date: October 9, 2003
    Inventor: Vasulinga Ravikumar
  • Method of synthesizing phosphorothioate oligonucleotides
    Publication number: 20030114662
    Abstract: This invention presents novel methods for synthesizing phosphorothioate oligonucleotides, using support-bound phosphoramidites. Novel intermediates useful in the methods are also provided.
    Type: Application
    Filed: January 17, 2003
    Publication date: June 19, 2003
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga Ravikumar
  • Synthesis of oligonucleotides
    Publication number: 20030069412
    Abstract: Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes.
    Type: Application
    Filed: October 11, 2002
    Publication date: April 10, 2003
    Inventors: Vasulinga Ravikumar, Douglas L. Cole
  • Method for the synthesis of nucleotide of oligonucleotide phosphoramidites
    Publication number: 20030013864
    Abstract: This invention presents novel methods for recovery of phosphoramidites from the waste products of oligonucleotide synthesis. The methods include reacting a tribromophenoxydichlorophosphorane with an H-phosphonate in the presence of an amine.
    Type: Application
    Filed: August 29, 2002
    Publication date: January 16, 2003
    Inventors: Richard H. Griffey, Douglas L. Cole, Vasulinga Ravikumar
  • Synthesis of oligonucleotides
    Patent number: 6486312
    Abstract: Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes. Intermediates having structure are prepared in accord with preferred embodiments.
    Type: Grant
    Filed: April 2, 2001
    Date of Patent: November 26, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Douglas L. Cole
  • Compounds for the synthesis of nucleotide or oligonucleotide phosphoramidites
    Patent number: 6458941
    Abstract: This invention presents novel methods for recovery of phophoramidites from the waste products of oligonucleotide synthesis. The methods include reacting a tribromophenoxydichlorophosphorane with an H-phosphonate in the presence of an amine.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: October 1, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Richard H. Griffey, Douglas L. Cole, Vasulinga Ravikumar
  • Method of synthesizing phosphorothioate oligonucleotides
    Publication number: 20020128466
    Abstract: This invention presents novel methods for synthesizing phosphorothioate oligonucleotides, using support-bound phosphoramidites. Novel intermediates useful in the methods are also provided.
    Type: Application
    Filed: February 6, 2002
    Publication date: September 12, 2002
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga Ravikumar
  • Compounds for the Synthesis of Nucleotide or oligonucleotide phosphoramidites
    Patent number: 6441150
    Abstract: This invention presents novel methods for recovery of phosphoramidites from the waste products of oligonucleotide synthesis. The methods include reacting a tribromophenoxydichlorophosphorane with an H-phosphonate in the presence of an amine.
    Type: Grant
    Filed: August 23, 1999
    Date of Patent: August 27, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Richard H. Griffey, Douglas L. Cole, Vasulinga Ravikumar