Abstract: Generating an optimized supplier allocation plan includes identifying parts and suppliers associated with an allocation problem, where each supplier can supply at least one part. One or more objective functions are selected. Each objective function has part variables, and each part variable represents a quantity of a part to be procured from a supplier. At least one constraint constraining at least one part variable is received. The one or more objective functions are optimized with respect to the at least one constraint to yield a value for each part variable. A quantity of each part to be procured from at least one supplier is determined according to the values to generate the optimized supplier allocation plan.

Abstract: A method of controlling noise noticeable within an elevator car (22) includes intentionally introducing noise into the elevator car (22) at a noise level that depends on the position of the car within a hoistway (24). A disclosed example includes using existing elevator system components for generating compensating noise at different levels corresponding to different positions of the car within the hoistway. One disclosed example includes increasing introduced noise as the car descends further away from a machine responsible for moving the car. The introduced noise reduces or eliminates changes in noticeable noise within the elevator car as the car moves relative to the machine. The disclosed examples have particular usefulness in machine roomless elevator systems although they are not necessarily limited to such systems.

Abstract: A method of computer-based simulation of a cooling system includes receiving configuration data for a heat exchanger of the cooling system, customizing the configuration data for the heat exchanger; simulating cooling system performance by processing the customized configuration data through a model of the cooling system, and generating simulated cooling system performance data, based on the simulating, for evaluating operation of the cooling system.

Abstract: The invention provides for methods of modulating a population of myeloid-derived suppressor cells (MDSCs) in a subject, for treating an autoimmune disease, and also treating cancer in a subject in need thereof. The methods comprise administering to the subject a therapeutically effective amount of an agent that modulates the Tim-3 pathway. The Tim-3 pathway can be activated by a Tim-3 ligand, galectin-9, whereby MDSCs are expanded, or inhibited by an antibody to Tim-3, wherein the expansion of MDSCs is inhibited.

Abstract: The inference of a dependency graph that represents a graph of solves that leads from input model parameter(s) to output model parameters using analytics. In one embodiment, the dependency graph is part of visually driven analytics in which the output model parameter(s) are used to formulate data-drive scenes. As the identity of the input and/or output model parameter(s) change, or as the analytics themselves change, the dependency graph may also change. This might trigger a resolve of the analytics. In one embodiment, the intermediate parameters involved in the dependency graph may be viewed and evaluated by the user.

Abstract: The present invention relates to droplet-based particle sorting. According to one embodiment, a droplet microactuator is provided and includes: (a) a suspension of particles; and (b) electrodes arranged for conducting droplet operations using droplets comprising particles. A method of transporting a particle is also provided, wherein the method includes providing a droplet comprising the particle and transporting the droplet on a droplet microactuator.

Abstract: The present invention provides a method of producing xylose from lignocellulosic feedstock. The method comprises disrupting lignocellulosic feedstock; leaching the lignocellulosic feedstock by contacting the feedstock with at least one aqueous solution for a period greater than about 2 minutes to produce a leached feedstock and a leachate; removing the leachate from the leached feedstock; acidifying the leached feedstock to a pH between about 0.5 and about 3 to produce an acidified feedstock, and; reacting the acidified feedstock under conditions which disrupt fiber structure and hydrolyze a portion of hemicellulose and cellulose of the acidified feedstock, to produce a composition comprising xylose and a pretreated feedstock. The xylose may be purified from the pretreated feedstock or it may be converted to ethanol with the pretreated feedstock.

Abstract: A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.

Abstract: A computer-implemented method, system, and computer program product for performing object collocation on a computer system are provided. The method includes analyzing a sequence of computer instructions for object allocations and uses of the allocated objects. The method further includes creating an allocation interference graph of object allocation nodes with edges indicating pairs of allocations to be omitted from collocation. The method also includes coloring the allocation interference graph such that adjacent nodes are assigned different colors, and creating an object allocation at a program point prior to allocations of a selected color from the allocation interference graph. The method additionally includes storing an address associated with the created object allocation in a collocation pointer, and replacing a use of each allocation of the selected color with a use of the collocation pointer to collocate multiple objects.

Abstract: An optically intelligent image sensing device is provided. By applying different potentials across different electrode sections in the image sensing device, the electric field profiles of the corresponding liquid crystal layer sections bend the lights passing through the liquid crystal layer sections in a predetermined manner. In one embodiment, all of a certain color light entering the image sensing device can be bent towards a color filter for the specific color, thereby entering the light sensor for the specific color light. Accordingly, the optically intelligent image sensing device has improved optical efficiency. An arrangement for an array of different electrode and light sensing sections in the image sensing device is also provided as an example for how each electrode may be connected to the optically intelligent image sensing device control signals. An example using the present optically intelligent image sensing device to improve the optical efficiency of an image capturing device is also described.

Abstract: The present invention includes compositions relating to the setting of fluids or slurries in a wellbore. In one embodiment, a sealant composition having a fluid component and a polymeric additive component can be subjected to ionizing radiation. The ionizing radiation can cause bonding between polymeric additive components and create a polymer matrix within the sealant composition that increases the mechanical strength of the sealant composition.

Abstract: The present invention relates to compositions useful for isolating a portion of a wellbore. In one embodiment, a composition includes a sealant composition containing a wellbore treatment fluid and a set modifier component. The sealant composition can be placed into the wellbore and subjected to ionizing radiation that alters the set modifier component, triggering the setting of the sealant composition.

Abstract: Fullerenes, when irradiated with electromagnetic radiation, generate acoustic waves. A photoacoustic tomography method using a material comprising fullerenes is disclosed that includes irradiating the material with a radiation beam such as a laser. The resultant photoacoustic effect produced by the material is detected by at least one detector. A photoacoustic tomography system using a material comprising fullerenes is also described.

Abstract: A working end of a catheter includes at least one therapeutic element, such as a resistive heating element, usable to deliver energy for ligating, or reducing the diameter of, a hollow anatomical structure. In certain examples, the catheter includes a lumen to accommodate a guide wire or to allow fluid delivery. In certain embodiments, a balloon is inflated to place resistive element(s) into apposition with a hollow anatomical structure and to occlude the structure. Indexing devices and methods are also disclosed for successively treating portions of the hollow anatomical structure. In certain examples, marks along the catheter shaft provide visual verification to the physician of the relative position of the therapeutic element of the catheter. Embodiments of indexing devices may include pairs of rings and/or hinged arms that move a catheter a desired indexed position between successive treatments.

Abstract: The present invention relates to methods useful for isolating a portion of a wellbore. In one embodiment, a method includes preparing a sealant composition containing a set modifier component. The sealant composition is placed into the wellbore and is subjected to ionizing radiation that alters the set modifier component, triggering the thickening of the sealant composition.

Abstract: The present disclosure is directed to a system and method for sonically activating cement slurries. In some implementations, a method of treating a subterranean formation includes positioning a settable composition including a capsule in a wellbore. The capsule is used to increase a setting rate in response to at least sonic signals. A sonic signal is transmitted to at least a portion of the settable composition to release an activator from the capsule.

Abstract: The present invention includes methods relating to the setting of fluids or slurries in a wellbore. In one embodiment, a method of isolating a portion a wellbore by preparing a sealant composition comprising a fluid component and a polymeric additive component, placing the sealant composition into a wellbore and subjecting the sealant composition to ionizing radiation. The ionizing radiation can cause bonding between polymeric additive components and create a polymer matrix within the sealant composition that increases the mechanical strength of the sealant composition.

Abstract: The present disclosure is directed to a system and method for sonically activating cement slurries. In some implementations, a composition for treating a subterranean formation includes a settable composition and an activator. The activator is released in response to a sonic signal to initiate setting of the settable composition.

Abstract: An aircraft component having an external surface includes an improved lightning strike protection surface film disposed on or proximate to the external surface. The surface film includes a preform that includes a substrate having a first areal weight density and a plurality of spaced carbon nanotubes grown on the substrate, the nanotubes having a second areal weight density. The sum of the first areal weight density and the second areal weight density is less than about 500 grams per square meter, and the preform has a surface resistance less than about 1 ohm/square.

Abstract: A synchronization framework is provided for synchronizing data groups between a server and clients that may go off-line. The framework includes a client sync provider component that interfaces to client storage in a storage format independent way, a sync agent component that collects synchronization metadata maintained by the clients and uploads and/or downloads changes to the data groups to and/or from server storage and a server sync provider component that interfaces via sync adapters to server storage independently of storage format. The framework provides default building blocks for building off-line synchronizing applications that behave according to default application synchronization scenarios, and also enables custom building blocks for custom off-line application synchronization scenarios.