Abstract: Our high phase sensitivity wide-field phase cancellation interferometry system allows single-shot, label-free optical sensing of neural action potentials via imaging of optical path length changes. Single-shot sensing and monitoring of single neurons within a neural network should lead to a more comprehensive understanding neural network processing, which is beneficial for the advancement in the field of neuroscience as well as its biomedical applications and impact. Our system cancels the phase profile of the resting neuron from the phase profile of the spiking neuron, improving the sensitivity by two orders of magnitude. Using a detector with an extremely large well depth and an appropriately biased interferometer increases the sensitivity by another order of magnitude, yielding a measurement that is three orders of magnitude more sensitive than those possible with other microscopes.

Abstract: One or more techniques and/or computing devices are provided for automatic switchover implementation. For example, a first storage controller, of a first storage cluster, may have a disaster recovery relationship with a second storage controller of a second storage cluster. In the event the first storage controller fails, the second storage controller may automatically switchover operation from the first storage controller to the second storage controller for providing clients with failover access to data previously accessible to the clients through the first storage controller. The second storage controller may detect, cross-cluster, a failure of the first storage controller utilizing remote direct memory access (RDMA) read operations to access heartbeat information, heartbeat information stored within a disk mailbox, and/or service processor traps.

Abstract: A phosphoinositide 3-kinase inhibitor for use in the treatment of pancreatic cancer and a method for treatment of pancreatic cancer including administration of an phosphoinositide 3-kinase inhibitor an Src inhibitor to a human subject in need thereof. There is also provided a pharmaceutical composition comprising a phosphoinositide 3-kinase inhibitor and an Src inhibitor.

Abstract: Methods, non-transitory machine readable media, and computing devices that manage data storage fabric health are disclosed. With this technology, a network model is applied to network data determined from monitored network traffic exchanged between storage nodes and via network connections over a cluster fabric to generate a health score for the cluster fabric. A cause of health degradation in the cluster fabric is determined based on an analysis of the network data, when the health score indicates that health of the cluster fabric is degrading. A corrective action is automatically initiated based on the cause of health degradation in the cluster fabric. With this technology, cluster fabrics in data storage networks are more effectively monitored for health degradation and, advantageously, corrective actions can be preemptively initiated to improve performance.

Abstract: Our high phase sensitivity wide-field phase cancellation interferometry system allows single-shot, label-free optical sensing of neural action potentials via imaging of optical path length changes. Single-shot sensing and monitoring of single neurons within a neural network should lead to a more comprehensive understanding neural network processing, which is beneficial for the advancement in the field of neuroscience as well as its biomedical applications and impact. Our system cancels the phase profile of the resting neuron from the phase profile of the spiking neuron, improving the sensitivity by two orders of magnitude. Using a detector with an extremely large well depth and an appropriately biased interferometer increases the sensitivity by another order of magnitude, yielding a measurement that is three orders of magnitude more sensitive than those possible with other microscopes.

Abstract: An apparatus for the production of red wine is provided. This compact device is suitable for home and hobby use. The fermenting wine is contained inside a single-use plastic bag, eliminating cleaning. A reusable rubber bladder is inflated periodically to squeeze the cap and disperse it. At the conclusion of the fermentation, a perforated device is inserted into the fermentation bag and pneumatic bladders are sequentially inflated to press out the wine while retaining the waste skins and seeds.

Abstract: A system is provided for dispensing and storing liquid, such as wine. The system may include a dip tube coupled to a flexible bladder in an airtight manner. The dip tube may include a dip tube head and a perforated dip tube extension extending from the dip tube head into the contents of the flexible bladder.

Abstract: System, method and computer program product of assessing the likelihood of response to cardiac resynchronization therapy (CRT) for a patient. ECG data is obtained from the patient and is analyzed to detect abnormal QRS peaks. A likelihood of the patient responding to CRT is determined based on the number of abnormal QRS peaks detected. An indication of whether the patient is a candidate for CRT can be provided based on the determined likelihood of CRT response. This indication can be used to guide treatment for the patient.

Abstract: One or more techniques and/or devices are provided for storage virtual machine relocation (e.g., ownership change) between storage clusters. For example, operational statistics of a first storage cluster and a second storage cluster may be evaluated to identify a set of load balancing metrics. Ownership of one or more storage aggregates and/or one or more storage virtual machines may be changed (e.g., permanently changed for load balancing purposes or temporarily changed for disaster recovery purposes) between the first storage cluster and the second storage cluster utilizing zero-copy ownership change operations based upon the set of load balancing metrics. For example, if the first storage cluster is experiencing a relatively heavier load of client I/O operations and the second storage cluster has available resources, ownership of a storage aggregate and a storage virtual machine may be switched from the first storage cluster to the second storage cluster for load balancing.

Abstract: A method, non-transitory computer readable medium and local storage node computing device that establishes a first connection between a first endpoint in a kernel of an operating system and a second endpoint. A proxy application in a user space is invoked and a second connection is established from the operating system kernel to the proxy application. The proxy application is linked to a secure protocol implementation. Handshake messages are proxied between the second endpoint and the proxy application using the first and second connections. Security parameters for the first connection and determined from the handshake messages are sent from the proxy application to the operating system kernel via the second connection. Data is exchanged between the first endpoint in the operating system kernel and the second endpoint using the first connection and the security parameters.

Abstract: An adjustable neck for a vent cap includes a housing having a mount and a cylindrical body, where the cylindrical body includes an inner surface. The adjustable neck also includes adjustable straps arranged to form an adjustable inner diametrical surface disposed radially inward from the cylindrical body of the housing, relative to a central axis of the adjustable neck. The adjustable inner diametrical surface is configured to engage an outer pipe surface. The adjustable straps are coupled to the inner surface of the cylindrical body. The adjustable neck also includes legs coupled to the adjustable straps and to the mount, where the cylindrical body is configured to be rotated relative to the mount and the legs to adjust a dimension of the adjustable inner diametrical surface to correspond to the outer pipe surface.

Abstract: One or more techniques and/or devices are provided for storage virtual machine relocation (e.g., ownership change) between storage clusters. For example, operational statistics of a first storage cluster and a second storage cluster may be evaluated to identify a set of load balancing metrics. Ownership of one or more storage aggregates and/or one or more storage virtual machines may be changed (e.g., permanently changed for load balancing purposes or temporarily changed for disaster recovery purposes) between the first storage cluster and the second storage cluster utilizing zero-copy ownership change operations based upon the set of load balancing metrics. For example, if the first storage cluster is experiencing a relatively heavier load of client I/O operations and the second storage cluster has available resources, ownership of a storage aggregate and a storage virtual machine may be switched from the first storage cluster to the second storage cluster for load balancing.

Abstract: Extendable armrest assembly for passenger chair structures, the armrest assembly including a primary armrest configured to pivotably couple to a passenger chair structure, and a secondary armrest disposed beneath, aligned with, and coupled to the primary armrest, where the secondary armrest can be moved from a first stowed position aligned with and beneath the primary armrest and a second extended position in which a portion of surface of the secondary armrest surface is exposed and accessible for use by a passenger seated in the passenger chair structure.

Abstract: Extendable armrest assembly for passenger chair structures, the armrest assembly including a primary armrest configured to pivotably couple to a passenger chair structure, and a secondary armrest disposed beneath, aligned with, and coupled to the primary armrest, where the secondary armrest can be moved from a first stowed position aligned with and beneath the primary armrest and a second extended position in which a portion of surface of the secondary armrest surface is exposed and accessible for use by a passenger seated in the passenger chair structure.

Abstract: Systems, methods, and devices are provided for mixing very small volumes of liquids, creams, and ointments. The system includes a mixing apparatus and a flexible tube in ingredients can be added to a base formulation via a connector. The mixing apparatus can mix the contents of the tube non-invasively.

Abstract: Embodiments of the present disclosure relate to a substrate transfer device having a contactless latch and contactless coupling providing the ability to lock and unlock the substrate transfer device at atmospheric and vacuum pressure with without particle generation at a base of the substrate transfer device, the contactless latch, and the contactless coupling. The substrate transfer device includes a lid having one or more lid grooves, a base having one or more base grooves, and a rotation member rotatably coupled to the lid. Each flange of one or more flanges of the substrate transfer device is rotatable in aligned lid grooves and base grooves, and each flange of the one or more flanges has an arm with a ferromagnetic material coupled thereto. The base is coupled to the lid when the ferromagnetic material of the arm is aligned and spaced from a magnetic material of a slot of the one or more base grooves.

Abstract: A system is provided for dispensing and storing liquid, such as wine. The system may include a dip tube coupled to a flexible bladder in an airtight manner. The dip tube may include a dip tube head and a perforated dip tube extension extending from the dip tube head into the contents of the flexible bladder.

Abstract: One or more techniques and/or computing devices are provided for communicating storage controller failures utilizing service processor traps. A first storage controller, of a first storage cluster, has a disaster recovery relationship with a second storage controller of a second storage cluster. The first storage controller comprise a first service processor configured to monitor health of the first storage controller. Responsive to identifying a failure of the first storage controller, the first service processor uses stored communication configuration of a second service processor of the second storage controller to send a service processor trap to the second service processor. In this way, the second service processor initiates a switchover operation by the second storage controller to provide clients with failover access to data previously available through the first storage controller before the failure.

Abstract: The present disclosure relates to processes for inverting oligonucleotide probes in an in situ synthesized array. These processes can be used to reverse the orientation of probes with respect to the substrate from 3?-bound to 5?-bound. These processes can also be used to reduce or eliminate the presence of truncated probe sequences from an in situ synthesized array.

Abstract: Methods, non-transitory machine readable media, and computing devices that manage data storage fabric health are disclosed. With this technology, a network model is applied to network data determined from monitored network traffic exchanged between storage nodes and via network connections over a cluster fabric to generate a health score for the cluster fabric. A cause of health degradation in the cluster fabric is determined based on an analysis of the network data, when the health score indicates that health of the cluster fabric is degrading. A corrective action is automatically initiated based on the cause of health degradation in the cluster fabric. With this technology, cluster fabrics in data storage networks are more effectively monitored for health degradation and, advantageously, corrective actions can be preemptively initiated to improve performance.