Abstract: A novel peptide nucleic acid (PNA) oligomer capable of forming a PNA/DNA/PNA triplex when binding to its target genomic DNA is described. An PNA oligomer directed to C-Myc oncogene was capable of binding the target DNA and effectively inhibit the transcription of the gene both in vitro as well as in vivo without causing any toxicity. Methods of making and using the novel PNA oligomer for targeting other genomic DNA are described.

Abstract: A fuel pump brushless direct current motor (100), comprising: a housing assembly (1), a stator assembly (2), and a rotor assembly (3). The rotor assembly (3) includes a shaft (4), a pair of magnets (5), a sleeve ring (6) and an over molding structure (7), the sleeve ring (6) is provided over the pair of magnet (5) for shielding the pair of magnets (5) thereby preventing wear and tear of the pair of magnets (5), and the shaft (4), the pair of magnets (5), sleeve ring (6) are over molded via the over molding structure (7) for providing a protection from the set of external factors. The rotor assembly (3) include a slotted spring pin (10) for increasing torque strength and extending a cyclic life and said slotted spring pin (10) facilitates in reinforcing a drive dog area (11), thereby providing strength to the drive dog area (11).

Abstract: Systems and methods for bias testing and remediation are disclosed. Decentralized Web Application Testing Systems use a Holochain framework to distribute testing workloads across Full Nodes and Lightning Nodes. A Holochain Node Management Application for configuring nodes, a UI Application creates test cases, and a Version Management System tracks changes. Test results are stored and analyzed in a Test Result Store, with a Bias Intelligence module detecting biases and generating additional test cases. A Consensus Algorithm validates test cases through decentralized nomination. An AI-Driven Defect Remediation System automates defect detection, root cause analysis, and remediation using AI modules. Machine learning algorithms identify patterns and anomalies, while NLP techniques generate code fixes. Predictive maintenance monitors application performance to preemptively address issues. A feedback loop mechanism continuously improves AI models through reinforcement learning.

Abstract: Systems and methods for bias testing and remediation are disclosed. Decentralized Web Application Testing Systems use a Holochain framework to distribute testing workloads across Full Nodes and Lightning Nodes. A Holochain Node Management Application for configuring nodes, a UI Application creates test cases, and a Version Management System tracks changes. Test results are stored and analyzed in a Test Result Store, with a Bias Intelligence module detecting biases and generating additional test cases. A Consensus Algorithm validates test cases through decentralized nomination. An AI-Driven Defect Remediation System automates defect detection, root cause analysis, and remediation using AI modules. Machine learning algorithms identify patterns and anomalies, while NLP techniques generate code fixes. Predictive maintenance monitors application performance to preemptively address issues. A feedback loop mechanism continuously improves AI models through reinforcement learning.

Abstract: A system (106) and method (400) for intent-based orchestration of graphics processing unit (GPU) resources are disclosed. The method (400) involves receiving one or more high-level intents from one or more users (102), wherein the one or more high-level intents indicate the GPU-resource requirement of the one or more users (102). The one or more high-level intents are interpreted to derive contextual meaning associated with user-defined requirements. Based on the interpreted intents, the one or more high-level intents are translated into a predefined one or more GPU resources (210). The translated one or more GPU resources (210) are then provisioned in isolated manner to fulfil the GPU-resource requirement of the one or more users (102) such that intent-based orchestration of the GPU resources is achieved.

Abstract: The present disclosure relates to method and apparatus for dynamically selecting a port of an Embedded Universal Integrated Circuit Card (eUICC) supporting Multiple Enabled Profiles (MEP) mode in a device. The method includes: receiving a request to activate a profile from a plurality of profiles stored in the eUICC; monitoring ongoing communication on one or more active ports of the eUICC; and selecting a port from the one or more active ports of the eUICC based on the ongoing communication to activate the profile. The method provides effective and efficient profiles management within the eUICCs by introducing dynamic port selection and robust error handling mechanisms. This ensures greater flexibility and reliability in profile activation and deactivation processes, even in the event of malfunctions or communication failures.

Abstract: A resource allocation engine distributes host resources, such as CPU cores, dynamically between a set of containers executing in the context of the host operating system. The resource allocation engine sets a lower limit on CPU allocation for each container to prevent the containers from being starved of CPU resources. The resource allocation engine monitors the utilization of the resources allocated to the containers, and redistributes the host resources dynamically among the containers based on the utilization values. Containers having high utilization values are assigned more resources correspondingly, and containers having low utilization values are assigned fewer resources. In some embodiments, the resource allocation engine assigns weights to the containers, and uses the weights to assign CPU resources for an upcoming assignment period. An operating system utility, such as C-groups, is used to implement the resource allocations to the containers for the assignment periods.

Abstract: A genetic sequence-carbohydrate conjugate is disclosed, having a formula (I): wherein GS is a genetic sequence, preferably a peptide nucleic acid or an oligonucleotide such as an mRNA sequence, an siRNA Sequence, or a DNA sequence, optionally wherein each genetic sequence is natural or modified, and the variables are as described herein. Also disclosed are uses for the genetic sequence-carbohydrate conjugates, including as RNA therapeutics targeting the liver and kidneys of a mammal, including a human.

Abstract: A method for controlling characteristics of light emitted from a surgical light includes remotely configuring a surgical light, using a remote computing system communicatively connected to the surgical light, by selecting which of a plurality of characteristics of light emitted from the surgical light are adjustable by operation of a handle assembly of the surgical light. The method includes adjusting, using the handle assembly, at least one characteristic of the plurality of characteristics of the light emitted from the surgical light according to the selection of which of the plurality of characteristics of light emitted from the surgical light are adjustable by operation of the handle assembly.

Abstract: Disclosed is a system and associated methods for generating interactive interfaces that provide targeted visualizations for different amounts of alignment between a target product, service, or company and varying market dynamics in different regions that affect the favorability or acceptance of the target in the different regions. The system receives a request that is directed to the target and a set of regions. The system selects relevant market conditions based on a sector or industry associated with the target, aggregates data directed to each relevant market condition and each region of the set of regions, and determines an alignment amount between the target and different data that is associated with the relevant market conditions in different regions. The system presents an interactive interface that includes a choropleth map spanning the set of regions with each region color-coded according to the determined alignment amount.

Abstract: The present invention discloses a fused heterocyclic compound of formula (I), wherein, R1, Y, Q, A, G, m and E are as defined in the detailed description. The present invention further discloses methods for their preparation and use of the compounds of formula (I) as a pest control agent.

Abstract: A method for generating a stitched image by an electronic device is disclosed. The method comprises: identifying a moving object from a first frame and a second frame among a plurality of frames; normalizing the attributes associated with the moving object from overlapping region of the first frame and the second frame with respect to image capturing device attributes; determining a trajectory, associated with the moving object based on the normalized attributes; stitching the first frame at a first location of the overlapping region where the moving object is present, or stitching the first frame at a second location of the overlapping region where the moving object is not present, wherein the trajectory from the first frame is masked to regenerate a masked portion of the second frame; and generating the stitched image by stitching the first frame with the masked portion of the second frame.

Abstract: Embodiments of the disclosure describe a method for transferring profile information associated with a physical subscriber identity module (pSIM) of a first electronic device to an embedded SIM (eSIM) of a second electronic device. The method includes creating an enhanced feature short message delivery point (EF-SMDP) file directory in a memory associated with the pSIM. The method includes obtaining eSIM identity (EID) and international mobile equipment identity (IMEI) associated with the eSIM by utilizing a first connection. The method includes sending a first request directly to a subscription manager data preparation (SMDP) server. The method includes obtaining an authorization from the SMDP server for the first request, the first electronic device stores the profile information in a virtual Local Profile Assistant (LPA) module. The method includes transferring the profile information from the virtual LPA module to the eSIM over the first connection.

Abstract: Disclosed is a system and associated methods for generating an autonomous bot that replicates speech characteristics, visual expressions, and actions of a professional in order to further relationships established by the professional in meetings that the professional is unavailable for. The system monitors meetings involving the professional at different stages of a workflow, and classifies the workflow stage associated with each meeting. The system models content, speech characteristics, and visual expressions expressed by the professional at each workflow stage based on commonality that is detected in a different set of meetings classified to a corresponding workflow stage. The modeling is used to generate an autonomous bot as a surrogate for the professional in a meeting that the professional is unavailable for.

Abstract: The present invention relates to the novel formulation for sustained or delayed release of rohitukine-rich Dysoxylum binectariferum extract/fraction and a process for preparing the same wherein the extract is wet-granulated using excipients i.e. biodegradable polymers and/or non-biodegradable polymers alone or in combination, and the said granules are either filled into a capsule or compressed into a tablet. The said formulation comprising a granulated extract/fraction of rohitukine-rich Dysoxylum binectariferum with polymers has resulted in a sustained release of the extract or fraction over a period of 16-24 hrs. The said formulations are useful in the treatment of inflammatory diseases.

Abstract: The present invention discloses a film comprising porous, amorphous polybenzimidazole (PBI) and at least one filler for use as a separator in a lithium ion battery and a process for preparation thereof.

Abstract: An example methodology includes, by a node of an active-passive high availability (HA) cluster, determining that a container on the node has failed with an error and, responsive to a determination that the error is a new error, creating an error object that represents the error, creating an error object that represents the error and initializing a value of an error_code_value attribute in the error object to an initial_value_to_error_code attribute that indicates an initial value to assign to the error_code_value. The method also includes, by the node, incrementing a failcount attribute that indicates a count of a number of container failures on the node, determining whether to restart or failover the container based on a comparison of the failcount attribute and a failure count threshold, and, responsive to a determination to restart the container, attempting a restart of the container on the node.

Abstract: A method for controlling characteristics of light emitted from a surgical light includes remotely configuring a surgical light, using a remote computing system communicatively connected to the surgical light, by selecting which of a plurality of characteristics of light emitted from the surgical light are adjustable by operation of a handle assembly of the surgical light. The method includes adjusting, using the handle assembly, at least one characteristic of the plurality of characteristics of the light emitted from the surgical light according to the selection of which of the plurality of characteristics of light emitted from the surgical light are adjustable by operation of the handle assembly.

Abstract: An example methodology includes, by a node of an active-passive high availability (HA) cluster, determining that a container on the node has failed with an error and, responsive to a determination that the error is a new error, creating an error object that represents the error, creating an error object that represents the error and initializing a value of an error_code_value attribute in the error object to an initial_value_to_error_code attribute that indicates an initial value to assign to the error_code_value. The method also includes, by the node, incrementing a failcount attribute that indicates a count of a number of container failures on the node, determining whether to restart or failover the container based on a comparison of the failcount attribute and a failure count threshold, and, responsive to a determination to restart the container, attempting a restart of the container on the node.

Abstract: A system to control operation of an HVAC unit for conditioning indoor air quality in a multi-zone area is disclosed, The system comprises a controller adapted to be operatively connected to an air handling unit (AHU) associated with the HVAC unit. The controller is configured to receive, from one or more sensors installed at a plurality of zones of an area of interest (AOI), a set of data packets pertaining to indoor air quality (IAQ) at each of the zones in real-time. Further, when the IAQ of any of the plurality of zones is detected to be above a first predefined level, the controller enables the AHU and the HVAC unit to circulate air from at least one of the remaining zones having the IAQ below the first predefined level to the zones having the IAQ above the first predefined level.