Patents by Inventor Vincent Guerlavais

Vincent Guerlavais has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20230119612
    Abstract: Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence. Suitable sequences for stabilization include those with homology to the p53 protein. These sequences can bind to the MDM2 and/or MDMX proteins. Also provided herein are methods of using such macrocycles for the treatment of diseases and disorders, such as cancers or other disorders characterized by a low level or low activity of a p53 protein or high level of activity of a MDM2 and/or MDMX protein.
    Type: Application
    Filed: June 22, 2022
    Publication date: April 20, 2023
    Inventors: Vincent GUERLAVAIS, Carl ELKIN, Huw M. NASH, Tomi K. SAWYER, Bradford J. GRAVES, Eric FEYFANT
  • COMBINATION THERAPY OF PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20230037284
    Abstract: The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.
    Type: Application
    Filed: May 28, 2021
    Publication date: February 2, 2023
    Inventors: Vincent GUERLAVAIS, David Allen ANNIS
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20220000968
    Abstract: Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence. Suitable sequences for stabilization include those with homology to the p53 protein. These sequences can bind to the MDM2 and/or MDMX proteins. Also provided herein are methods of using such macrocycles for the treatment of diseases and disorders, such as cancers or other disorders characterized by a low level or low activity of a p53 protein or high level of activity of a MDM2 and/or MDMX protein.
    Type: Application
    Filed: January 22, 2021
    Publication date: January 6, 2022
    Inventors: Vincent GUERLAVAIS, Carl ELKIN, Huw M. NASH, Tomi K. SAWYER, Bradford J. GRAVES, Eric FEYFANT
  • COMBINATION THERAPY OF PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20210363189
    Abstract: The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.
    Type: Application
    Filed: May 28, 2021
    Publication date: November 25, 2021
    Inventors: Vincent GUERLAVAIS, David Allen ANNIS
  • Peptidomimetic macrocycles and uses thereof
    Patent number: 11091522
    Abstract: The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: August 17, 2021
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Manuel Aivado, Vincent Guerlavais, Karen Olson, David Allen Annis
  • Peptidomimetic macrocycles
    Patent number: 11008366
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: May 18, 2021
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Vincent Guerlavais, Noriyuki Kawahata
  • Peptidomimetic macrocycles
    Patent number: 10967042
    Abstract: Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence. Suitable sequences for stabilization include those with homology to the p53 protein. These sequences can bind to the MDM2 and/or MDMX proteins. Also provided herein are methods of using such macrocycles for the treatment of diseases and disorders, such as cancers or other disorders characterized by a low level or low activity of a p53 protein or high level of activity of a MDM2 and/or MDMX protein.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: April 6, 2021
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Vincent Guerlavais, Carl Elkin, Huw M. Nash, Tomi K. Sawyer, Bradford J. Graves, Eric Feyfant
  • PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF
    Publication number: 20200369728
    Abstract: Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease. Also provided here in are methods of using such macrocycles in combination with at least one additional pharmaceutically active agent for treatment of disorders, for example for treatment of cancer.
    Type: Application
    Filed: May 22, 2020
    Publication date: November 26, 2020
    Inventors: Manuel AIVADO, Vincent GUERLAVAIS, Karen OLSON
  • Peptidomimetic macrocycles
    Patent number: 10703780
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: July 7, 2020
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Vincent Guerlavais, Noriyuki Kawahata
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20200102351
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 6, 2019
    Publication date: April 2, 2020
    Inventors: Vincent GUERLAVAIS, Noriyuki KAWAHATA
  • PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF
    Publication number: 20200040048
    Abstract: The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.
    Type: Application
    Filed: July 23, 2019
    Publication date: February 6, 2020
    Inventors: Manuel AIVADO, Vincent GUERLAVAIS, Karen OLSON, David Allen ANNIS
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20190343914
    Abstract: Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence. Suitable sequences for stabilization include those with homology to the p53 protein. These sequences can bind to the MDM2 and/or MDMX proteins. Also provided herein are methods of using such macrocycles for the treatment of diseases and disorders, such as cancers or other disorders characterized by a low level or low activity of a p53 protein or high level of activity of a MDM2 and/or MDMX protein.
    Type: Application
    Filed: December 18, 2018
    Publication date: November 14, 2019
    Inventors: Vincent GUERLAVAIS, Carl ELKIN, Huw M. NASH, Tomi K. SAWYER, Bradford J. GRAVES, Eric FEYFANT
  • TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20190292224
    Abstract: Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: January 30, 2019
    Publication date: September 26, 2019
    Inventors: Vincent Guerlavais, Christopher R. Conlee, Scott Paul Lentini
  • PEPTIDOMIMETIC MACROCYCLES AND USE THEREOF IN REGULATING HIF1ALPHA
    Publication number: 20190225650
    Abstract: The present invention provides peptidomimetic macrocycles capable of regulating HIF1? and methods of using such macrocycles for the treatment of diseases.
    Type: Application
    Filed: January 30, 2019
    Publication date: July 25, 2019
    Inventors: Vincent GUERLAVAIS, Noriyuki KAWAHATA, Huw M. NASH, Carl ELKIN, Eric FEYFANT
  • WARHEAD-CONTAINING PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF BFL-1
    Publication number: 20190185518
    Abstract: The disclosed peptidomimetic macrocycles modulate the activity of BFL-1 or a BCL-2 family protein. BFL-1, an anti-apoptotic BCL-2 family member, blocks p53-mediated apoptosis and has oncogenic transforming activity. Peptidomimetic macrocycles, pharmaceutical compositions, and methods disclosed herein can be used for the treatment of disease in which BFL-1 or a BCL-2 family protein is over-expressed, such as cancer. In particular, BFL-1-modulating or a BCL-2 family protein-modulating peptidomimetic macrocycles disclosed herein can be applied in the setting of resistance to BCL-2 family inhibitors, which is often engendered by BFL-1 or BCL-2 family protein over-expression or hyper-activation.
    Type: Application
    Filed: March 9, 2018
    Publication date: June 20, 2019
    Inventor: Vincent Guerlavais
  • Peptidomimetic macrocycles
    Patent number: 10308699
    Abstract: The present invention provides peptidomimetic macrocycles capable of modulating growth hormone levels and methods of using such macrocycles for the treatment of disease.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: June 4, 2019
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Noriyuki Kawahata, Vincent Guerlavais, Manoj Samant
  • Peptidomimetic macrocycles and use thereof in regulating HIF1alpha
    Patent number: 10246491
    Abstract: The present invention provides peptidomimetic macrocycles capable of regulating HIF1? and methods of using such macrocycles for the treatment of diseases.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: April 2, 2019
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Vincent Guerlavais, Noriyuki Kawahata, Huw M. Nash, Carl Elkin, Eric Feyfant
  • Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
    Patent number: 10227380
    Abstract: Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: March 12, 2019
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Vincent Guerlavais, Christopher R. Conlee, Scott Paul Lentini
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20190062377
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 10, 2018
    Publication date: February 28, 2019
    Inventors: Vincent Guerlavais, Noriyuki Kawahata
  • Peptidomimetic macrocycles
    Patent number: 10213477
    Abstract: Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence. Suitable sequences for stabilization include those with homology to the p53 protein. These sequences can bind to the MDM2 and/or MDMX proteins. Also provided herein are methods of using such macrocycles for the treatment of diseases and disorders, such as cancers or other disorders characterized by a low level or low activity of a p53 protein or high level of activity of a MDM2 and/or MDMX protein.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: February 26, 2019
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Vincent Guerlavais, Carl Elkin, Huw M. Nash, Tomi K. Sawyer, Bradford J. Graves, Eric Feyfant