Patents by Inventor Vincent Guerlavais

Vincent Guerlavais has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
    Patent number: 8987414
    Abstract: Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: March 24, 2015
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Vincent Guerlavais, Christopher R. Conlee, Scott Paul Lentini
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20150051155
    Abstract: Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence. Suitable sequences for stabilization include those with homology to the p53 protein. These sequences can bind to the MDM2 and/or MDMX proteins. Also provided herein are methods of using such macrocycles for the treatment of diseases and disorders, such as cancers or other disorders characterized by a low level or low activity of a p53 protein or high level of activity of a MDM2 and/or MDMX protein.
    Type: Application
    Filed: September 26, 2014
    Publication date: February 19, 2015
    Inventors: Vincent GUERLAVAIS, Carl ELKIN, Huw M. NASH, Tomi K. SAWYER, Bradford J. GRAVES, Eric FEYFANT
  • Peptidomimetic macrocycles
    Patent number: 8927500
    Abstract: Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence. Suitable sequences for stabilization include those with homology to the p53 protein. These sequences can bind to the MDM2 and/or MDMX proteins. Also provided herein are methods of using such macrocycles for the treatment of diseases and disorders, such as cancers or other disorders characterized by a low level or low activity of a p53 protein or high level of activity of a MDM2 and/or MDMX protein.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: January 6, 2015
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Vincent Guerlavais, Carl Elkin, Huw M. Nash, Tomi K. Sawyer, Bradford J. Graves, Eric Feyfant
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20140378390
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: August 15, 2014
    Publication date: December 25, 2014
    Inventors: Vincent GUERLAVAIS, Noriyuki KAWAHATA
  • BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20140323701
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: January 15, 2014
    Publication date: October 30, 2014
    Applicant: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, Rosanna Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Vincent Guerlavais, Matthew Iadanza
  • Peptidomimetic macrocycles
    Patent number: 8859723
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Grant
    Filed: August 13, 2011
    Date of Patent: October 14, 2014
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Vincent Guerlavais, Noriyuki Kawahata
  • Chemical linkers with single amino acids and conjugates thereof
    Patent number: 8664407
    Abstract: The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Grant
    Filed: February 20, 2008
    Date of Patent: March 4, 2014
    Assignee: Medarex, LLC
    Inventors: Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Nils Lonberg, Qian Zhang
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20130274205
    Abstract: Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: February 14, 2013
    Publication date: October 17, 2013
    Inventors: Vincent Guerlavais, Carl Elkin, Huw M. Nash, Tomi K. Sawyer, Bradford J. Graves, Eric Feyfant
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20130210743
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: August 13, 2011
    Publication date: August 15, 2013
    Inventors: Vincent Guerlavais, Noriyuki Kawahata
  • Chemical linkers and cleavable substrates and conjugates thereof
    Patent number: 8461117
    Abstract: The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: June 11, 2013
    Assignee: Medarex, Inc.
    Inventors: Bilal Sufi, Vincent Guerlavais, Liang Chen, Sanjeev Gangwar, Qian Zhang, David B. Passmore
  • Chemical linkers and conjugates thereof
    Patent number: 8399403
    Abstract: The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Grant
    Filed: November 2, 2009
    Date of Patent: March 19, 2013
    Assignee: Medarex, Inc.
    Inventors: Sharon E. Boyd, Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Kilian Horgan, Zhi-Hong Li, Bilal Sufi
  • BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20130023646
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: August 8, 2012
    Publication date: January 24, 2013
    Applicant: AILERON THERAPEUTICS, INC.
    Inventors: Huw M. NASH, Rosana KAPELLER-LIBERMANN, Tomi K. SAWYER, Noriyuki KAWAHATA, Vincent GUERLAVAIS, Matthew IADANZA
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20110223149
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties, such as protease resistance, relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: October 14, 2010
    Publication date: September 15, 2011
    Applicant: AILERON THERAPEUTICS, INC.
    Inventors: Huw M. NASH, David Allen ANNIS, Vincent GUERLAVAIS, Lawrence LICKLIDER
  • Biologically Active Peptidomimetic Macrocycles
    Publication number: 20110144303
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: October 13, 2009
    Publication date: June 16, 2011
    Applicant: AILERON Therapeutics, Inc.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Vincent Guerlavais, Matthew Iadanza
  • CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF
    Publication number: 20100145036
    Abstract: The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Application
    Filed: December 28, 2007
    Publication date: June 10, 2010
    Applicant: Medarex, Inc.
    Inventors: Bilal Sufi, Vincent Guerlavais, Liang Chen, Sanjeev Gangwar, Qian Zhang, David B. Passmore
  • CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF
    Publication number: 20100113476
    Abstract: The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Application
    Filed: February 20, 2008
    Publication date: May 6, 2010
    Inventors: Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Nils Lonberg, Qian Zhang
  • CHEMICAL LINKERS AND CONJUGATES THEREOF
    Publication number: 20100092496
    Abstract: The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Application
    Filed: November 2, 2009
    Publication date: April 15, 2010
    Applicant: Medarex, Inc.
    Inventors: Sharon E. Boyd, Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Killian Horgan, Zhi-Hong Li, Bilal Sufi
  • Chemical linkers and conjugates thereof
    Patent number: 7691962
    Abstract: The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: April 6, 2010
    Assignee: Medarex, Inc.
    Inventors: Sharon E. Boyd, Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Killian Horgan, Zhi-Hong Li, Bilal Sufi
  • BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20090326192
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: April 8, 2009
    Publication date: December 31, 2009
    Applicant: AILERON THERAPEUTICS, INC.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Vincent Guerlavais, Matthew Iadanza
  • Cytotoxic compounds and conjugates
    Patent number: 7517903
    Abstract: The present disclosure provides drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-cleavable substrate conjugates, and to methods of treatment using them.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: April 14, 2009
    Assignee: Medarex, Inc.
    Inventors: Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Zhi-Hong Li, Bilal Sufi