Patents by Inventor Vincent Guerlavais

Vincent Guerlavais has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF
    Publication number: 20180371021
    Abstract: The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.
    Type: Application
    Filed: May 9, 2018
    Publication date: December 27, 2018
    Inventors: Manuel AIVADO, Vincent GUERLAVAIS, Karen OLSON
  • PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1
    Publication number: 20180340009
    Abstract: The disclosed peptidomimetic macrocycles modulate the activity of MCL-1. Myeloid cell leukemia 1 (MCL-1) is a protein that inhibits cell death. Peptidomimetic macrocycles, pharmaceutical compositions, and methods disclosed herein can be used for the treatment of disease in which MCL-1 is over-expressed, such as cancer. In particular, MCL-1-modulating peptidomimetic macrocycles disclosed herein can be applied in the setting of resistance to BCL-2 family inhibitors, which is often engendered by MCL-1 over-expression or hyper-activation.
    Type: Application
    Filed: May 17, 2018
    Publication date: November 29, 2018
    Inventors: Vincent Guerlavais, Eric Feyfant
  • WARHEAD-CONTAINING PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF BFL-1
    Publication number: 20180273587
    Abstract: The disclosed peptidomimetic macrocycles modulate the activity of BFL-1 or a BCL-2 family protein. BFL-1, an anti-apoptotic BCL-2 family member, blocks p53-mediated apoptosis and has oncogenic transforming activity. Peptidomimetic macrocycles, pharmaceutical compositions, and methods disclosed herein can be used for the treatment of disease in which BFL-1 or a BCL-2 family protein is over-expressed, such as cancer. In particular, BFL-1-modulating or a BCL-2 family protein-modulating peptidomimetic macrocycles disclosed herein can be applied in the setting of resistance to BCL-2 family inhibitors, which is often engendered by BFL-1 or BCL-2 family protein over-expression or hyper-activation.
    Type: Application
    Filed: March 9, 2018
    Publication date: September 27, 2018
    Inventor: Vincent Guerlavais
  • Peptidomimetic macrocycles
    Patent number: 10059741
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: August 28, 2018
    Assignee: Aileron Therapeutics, Inc.
    Inventors: David Allen Annis, Vincent Guerlavais
  • Peptidomimetic macrocycles as modulators of MCL-1
    Patent number: 10023613
    Abstract: The disclosed peptidomimetic macrocycles modulate the activity of MCL-1. Myeloid cell leukemia 1 (MCL-1) is a protein that inhibits cell death. Peptidomimetic macrocycles, pharmaceutical compositions, and methods disclosed herein can be used for the treatment of disease in which MCL-1 is over-expressed, such as cancer. In particular, MCL-1-modulating peptidomimetic macrocycles disclosed herein can be applied in the setting of resistance to BCL-2 family inhibitors, which is often engendered by MCL-1 over-expression or hyper-activation.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: July 17, 2018
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Vincent Guerlavais, Eric Feyfant
  • Peptidomimetic macrocycles
    Patent number: 9957299
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: May 1, 2018
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Vincent Guerlavais, Noriyuki Kawahata
  • BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20170298099
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: April 21, 2017
    Publication date: October 19, 2017
    Inventors: Huw M. NASH, Rosana KAPELLER-LIBERMANN, Tomi K. SAWYER, Noriyuki KAWAHATA, Vincent GUERLAVAIS, Matthew IADANZA
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20170281720
    Abstract: Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence. Suitable sequences for stabilization include those with homology to the p53 protein. These sequences can bind to the MDM2 and/or MDMX proteins. Also provided herein are methods of using such macrocycles for the treatment of diseases and disorders, such as cancers or other disorders characterized by a low level or low activity of a p53 protein or high level of activity of a MDM2 and/or MDMX protein.
    Type: Application
    Filed: August 5, 2016
    Publication date: October 5, 2017
    Inventors: Vincent GUERLAVAIS, Carl ELKIN, Huw M. NASH, Tomi K. SAWYER, Bradford J. GRAVES, Eric FEYFANT
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20170226177
    Abstract: The present invention provides peptidomimetic macrocycles capable of modulating growth hormone levels and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: October 24, 2016
    Publication date: August 10, 2017
    Inventors: Noriyuki KAWAHATA, Vincent Guerlavais, Manoj Samant
  • PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF
    Publication number: 20170114098
    Abstract: Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease. Also provided here in are methods of using such macrocycles in combination with at least one additional pharmaceutically active agent for treatment of disorders, for example for treatment of cancer.
    Type: Application
    Filed: September 2, 2016
    Publication date: April 27, 2017
    Inventors: Manuel AIVADO, Vincent GUERLAVAIS, Karen OLSON
  • PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1
    Publication number: 20170107252
    Abstract: The disclosed peptidomimetic macrocycles modulate the activity of MCL-1. Myeloid cell leukemia 1 (MCL-1) is a protein that inhibits cell death. Peptidomimetic macrocycles, pharmaceutical compositions, and methods disclosed herein can be used for the treatment of disease in which MCL-1 is over-expressed, such as cancer. In particular, MCL-1-modulating peptidomimetic macrocycles disclosed herein can be applied in the setting of resistance to BCL-2 family inhibitors, which is often engendered by MCL-1 over-expression or hyper-activation.
    Type: Application
    Filed: September 8, 2016
    Publication date: April 20, 2017
    Inventors: Vincent Guerlavais, Eric Feyfant
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20170002042
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease.
    Type: Application
    Filed: July 1, 2016
    Publication date: January 5, 2017
    Inventors: David Allen ANNIS, Vincent GUERLAVAIS
  • Peptidomimetic macrocycles
    Patent number: 9522947
    Abstract: The present invention provides peptidomimetic macrocycles capable of modulating growth hormone levels and methods of using such macrocycles for the treatment of disease.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: December 20, 2016
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Noriyuki Kawahata, Vincent Guerlavais, Manoj Samant
  • Peptidomimetic macrocycles
    Patent number: 9505804
    Abstract: Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence. Suitable sequences for stabilization include those with homology to the p53 protein. These sequences can bind to the MDM2 and/or MDMX proteins. Also provided herein are methods of using such macrocycles for the treatment of diseases and disorders, such as cancers or other disorders characterized by a low level or low activity of a p53 protein or high level of activity of a MDM2 and/or MDMX protein.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: November 29, 2016
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Vincent Guerlavais, Carl Elkin, Huw M. Nash, Tomi K. Sawyer, Bradford J. Graves, Eric Feyfant
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20160257716
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: April 21, 2016
    Publication date: September 8, 2016
    Inventors: Vincent GUERLAVAIS, Noriyuki KAWAHATA
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20160137710
    Abstract: The present invention provides peptidomimetic macrocycles capable of modulating growth hormone levels and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: June 25, 2015
    Publication date: May 19, 2016
    Inventors: Noriyuki Kawahata, Vincent Guerlavais, Manoj Samant
  • BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20160108089
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: May 21, 2015
    Publication date: April 21, 2016
    Inventors: Huw W. NASH, Rosana KAPELLER-LIBERMANN, Tomi K. SAWYER, Noriyuki KAWAHATA, Vincent GUERLAVAIS, Matthew IADANZA
  • PEPTIDOMIMETIC MACROCYCLES AND USE THEREOF IN REGULATING HIF1ALPHA
    Publication number: 20160052970
    Abstract: The present invention provides peptidomimetic macrocycles capable of regulating HIF1? and methods of using such macrocycles for the treatment of diseases.
    Type: Application
    Filed: September 2, 2015
    Publication date: February 25, 2016
    Inventors: Vincent GUERLAVAIS, Noriyuki KAWAHATA, Huw M. NASH, Carl ELKIN, Eric FEYFANT
  • Peptidomimetic macrocycles
    Patent number: 9096684
    Abstract: The present invention provides peptidomimetic macrocycles capable of modulating growth hormone levels and methods of using such macrocycles for the treatment of disease.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: August 4, 2015
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Noriyuki Kawahata, Vincent Guerlavais, Manoj Samant
  • TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20150183825
    Abstract: Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: January 29, 2015
    Publication date: July 2, 2015
    Inventors: Vincent GUERLAVAIS, Christopher R. CONLEE, Scott Paul LENTINI