Patents by Inventor Vincent L. Giranda

Vincent L. Giranda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPY WITH PARP INHIBITORS
    Publication number: 20160324829
    Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with temozolomide (TMZ).
    Type: Application
    Filed: July 22, 2016
    Publication date: November 10, 2016
    Applicant: AbbVie Inc.
    Inventors: Cherrie K. Donawho, Vincent L. Giranda
  • Inhibitors of poly(ADP-ribose)polymerase
    Patent number: 9283222
    Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: March 15, 2016
    Assignee: AbbVie Inc.
    Inventors: Virajkumar B. Gandhi, Vincent L. Giranda, Jianchun Gong, Thomas D. Penning, Gui-Dong Zhu
  • COMBINATION THERAPY WITH PARP INHIBITORS
    Publication number: 20150005355
    Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with temozolomide (TMZ).
    Type: Application
    Filed: September 12, 2014
    Publication date: January 1, 2015
    Inventors: Cherrie K. Donawho, Vincent L. Giranda
  • Combination Therapy With Parp Inhibitors
    Publication number: 20150005354
    Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.
    Type: Application
    Filed: September 12, 2014
    Publication date: January 1, 2015
    Inventors: Vincent L. Giranda, Cherrie K. Donawho
  • 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS
    Publication number: 20140296235
    Abstract: Compounds having formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
    Type: Application
    Filed: April 11, 2014
    Publication date: October 2, 2014
    Inventors: Thomas D. Penning, Sheela A. Thomas, Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Vincent L. Giranda
  • INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE
    Publication number: 20140212509
    Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
    Type: Application
    Filed: May 24, 2013
    Publication date: July 31, 2014
    Applicant: ABBVIE INC.
    Inventors: Virajkumar B. Gandhi, Vincent L. Giranda, Jianchun Gong, Thomas D. Penning, Gui-Dong Zhu
  • PYRAZOLOQUINOLONES ARE POTENT PARP INHIBITORS
    Publication number: 20140213610
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Application
    Filed: August 27, 2013
    Publication date: July 31, 2014
    Applicant: AbbVie Inc.
    Inventors: Thomas D. Penning, Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Vincent L. Giranda
  • 1H-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent PARP inhibitors
    Patent number: 8697736
    Abstract: Compound having formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: April 15, 2014
    Assignee: AbbVie Inc.
    Inventors: Thomas D. Penning, Sheela A. Thomas, Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Vincent L. Giranda
  • PARP INHIBITORS FOR THE TREATMENT OF CIPN
    Publication number: 20140093585
    Abstract: The present invention relates to the method of treating chemotherapy-induced neuropathy in a subject in need thereof with the use of a poly(ADP-ribose)polymerase (PARP) inhibitor.
    Type: Application
    Filed: December 5, 2013
    Publication date: April 3, 2014
    Inventors: Vincent L. Giranda, Alexander R. Shoemaker, Kaitlin E. Browman, Shailen K. Joshi, Jill-Desiree Brederson
  • VELIPARIB IN COMBINATION WITH WHOLE BRAIN RADIATION THERAPY FOR THE TREATMENT OF BRAIN METASTASES
    Publication number: 20130310625
    Abstract: The invention relates to a method for the treatment of brain metastases from non-small cell lung cancer in a subject, comprising administering to the subject an effective amount of 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide, or a pharmaceutically acceptable salt thereof, in combination with an effective amount of whole brain radiation.
    Type: Application
    Filed: May 15, 2013
    Publication date: November 21, 2013
    Applicant: ABBVIE INC.
    Inventor: Vincent L. Giranda
  • Pyrazoloquinolones are potent PARP inhibitors
    Patent number: 8546368
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: October 1, 2013
    Assignee: AbbVie Inc.
    Inventors: Thomas D. Penning, Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Vincent L. Giranda
  • COMBINATION THERAPY WITH PARP INHIBITORS
    Publication number: 20130225647
    Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.
    Type: Application
    Filed: September 21, 2012
    Publication date: August 29, 2013
    Applicant: AbbVie Inc.
    Inventors: Cherrie K. Donawho, Vincent L. Giranda
  • Inhibitors of poly(ADP-ribose)polymerase
    Patent number: 8466150
    Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
    Type: Grant
    Filed: June 12, 2008
    Date of Patent: June 18, 2013
    Assignee: Abbott Laboratories
    Inventors: Virajkumar B. Gandhi, Vincent L. Giranda, Jianchun Gong, Thomas D Penning, Gui-Dong Zhu
  • COMBINATION THERAPY WITH PARP INHIBITORS
    Publication number: 20120264795
    Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARD inhibitors in combination with temozolomide (TMZ).
    Type: Application
    Filed: June 22, 2012
    Publication date: October 18, 2012
    Inventors: Cherrie K. Donawho, Vincent L. Giranda
  • Combination Therapy With Parp Inhibitors
    Publication number: 20120190720
    Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.
    Type: Application
    Filed: April 9, 2012
    Publication date: July 26, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Vincent L. Giranda, Cherrie K. Donawho
  • 2-substituted-1H-benzimidazole-4-carboxamides are PARP inhibitors
    Patent number: 8217070
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: July 10, 2012
    Assignee: Abbott Laboratories
    Inventors: Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Thomas D. Penning, Vincent L. Giranda, Sheela Thomas
  • Potent PARP inhibitors
    Patent number: 8183250
    Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: May 22, 2012
    Assignee: Abbott Laboratories
    Inventors: Thomas D. Penning, Sheela A. Thomas, Philip J. Hajduk, Daryl R. Sauer, Kathy Sarris, Vincent L. Giranda
  • Substituted thieno[3,2-d]pyrimidine PIM kinase inhibitors as cancer chemotherapeutics
    Patent number: 8148384
    Abstract: Compounds of formula I wherein A1, A2, and A3 are as defined herein are inhibitors of PIM kinase. The compounds of formula I are useful for the treatment of diseases such as cancer.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: April 3, 2012
    Assignee: Abbott Laboratories
    Inventors: Thomas D. Penning, Lisa A. Hasvold, Laura A. Hexamer, Vincent L. Giranda, Nan-horng Lin, Zhi-Fu Tao, Le Wang
  • COMBINATION THERAPY WITH PARP INHIBITORS
    Publication number: 20120045524
    Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.
    Type: Application
    Filed: November 3, 2011
    Publication date: February 23, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Wolfgang Wernet, Thomas D. Penning, Vincent L. Giranda
  • BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS
    Publication number: 20120046303
    Abstract: Compounds which inhibit the activity of poly(ADP-ribose)polymerase (PARP), compositions containing the compounds and methods of treating diseases using them are disclosed.
    Type: Application
    Filed: October 27, 2011
    Publication date: February 23, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Virajkumar B. Gandhi, Vincent L. Giranda, Jianchun Gong, Thomas D. Penning, Gui-Dong Zhu