Patents by Inventor Vincent L. Giranda

Vincent L. Giranda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzimidazole poly(ADP ribose)polymerase inhibitors
    Patent number: 8067613
    Abstract: Compounds which inhibit the activity of poly(ADP-ribose)polymerase (PARP), compositions containing the compounds and methods of treating diseases using them are disclosed.
    Type: Grant
    Filed: July 15, 2008
    Date of Patent: November 29, 2011
    Assignee: Abbott Laboratories
    Inventors: Virajkumar B. Gandhi, Vincent L. Giranda, Jianchun Gong, Thomas D Penning, Gui-Dong Zhu
  • Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors
    Patent number: 7999117
    Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: August 16, 2011
    Inventors: Vincent L. Giranda, Thomas D. Penning, Virajkumar B. Gandhi, Sheela A. Thomas, Gui-Dong Zhu, Jianchun Gong
  • COMBINATION THERAPY WITH PARP INHIBITORS
    Publication number: 20110151023
    Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.
    Type: Application
    Filed: March 1, 2011
    Publication date: June 23, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Wolfgang Wernet, Thomas D. Penning, Vincent L. Giranda
  • COMBINATION THERAPY WITH PARP INHIBITORS
    Publication number: 20110152336
    Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.
    Type: Application
    Filed: March 1, 2011
    Publication date: June 23, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Wolfgang Wernet, Thomas D. Penning, Vincent L. Giranda
  • Cyclobut-3-ene-1,2,-dione inhibitors of polo-like kinases
    Patent number: 7956185
    Abstract: Compounds of formula (I) where X1, C1, and D1 are defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: June 7, 2011
    Assignee: Abbott Laboratories
    Inventors: Robert B. Diebold, Stevan W. Djuric, Vincent L. Giranda, Laura A. Hexamer, Nan-Horng Lin, Julie M. Miyashiro, Thomas D. Penning, Magdalena Przytulinska, Thomas J. Sowin, Gerard M. Sullivan, Zhi-Fu Tao, Yunsong Tong, Anil Vasudevan, Le Wang, Keith W. Woods, Zhiren Xia, Henry Q. Zhang
  • 2-SUBSTITUTED-1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE PARP INHIBITORS
    Publication number: 20100234425
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Application
    Filed: April 22, 2010
    Publication date: September 16, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Thomas D. Penning, Vincent L. Giranda, Sheela Thomas
  • Pyrroloquinoxalinone inhibitors of poly(ADP-ribose)polymerase
    Patent number: 7790721
    Abstract: Compounds of formula I where X is a bond; A1 and A2, together with the atoms to which they are attached, is pyrrole; and A3 and A4, together with the atoms to which they are attached, are benzene; are poly(ADP-ribose)polymerase inhibitors. The compounds of formula I are useful for the treatment of diseases such as cancer.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: September 7, 2010
    Assignee: Abbott Laboratories
    Inventors: Vincent L. Giranda, Julie M Miyashiro, Thomas D Penning, Keith W. Woods
  • 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors
    Patent number: 7728026
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), method of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compound of Formula (I).
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: June 1, 2010
    Assignee: Abbott Laboratories, Inc.
    Inventors: Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Thomas D. Penning, Vincent L. Giranda, Sheela Thomas
  • POTENT PARP INHIBITORS
    Publication number: 20090298858
    Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
    Type: Application
    Filed: June 2, 2009
    Publication date: December 3, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Thomas D. Penning, Sheela A. Thomas, Philip J. Hajduk, Daryl R. Sauer, Kathy Sarris, Vincent L. Giranda
  • Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors
    Patent number: 7595406
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Grant
    Filed: July 30, 2007
    Date of Patent: September 29, 2009
    Assignee: Abbott Laboratories Inc.
    Inventors: Thomas D. Penning, Sheela A. Thomas, Gui-Dong Zhu, Jianchun Gong, Vincent L. Giranda, Viraj B. Gandhi
  • SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS
    Publication number: 20090186877
    Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
    Type: Application
    Filed: March 30, 2009
    Publication date: July 23, 2009
    Applicant: Abbott Laboratories
    Inventors: Vincent L. Giranda, Thomas D. Penning, Virajkumar B. Gandhi, Sheela A. Thomas, Gui-Dong Zhu, Jianchun Gong
  • 1H-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent PARP inhibitors
    Patent number: 7550603
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: June 23, 2009
    Assignee: Abbott Laboratories Inc.
    Inventors: Gui-Dong Zhu, Jianchun Gong, Virajkumar B. Gandhi, Thomas D. Penning, Vincent L. Giranda
  • BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS
    Publication number: 20090030016
    Abstract: Compounds which inhibit the activity of poly(ADP-ribose)polymerase (PARP), compositions containing the compounds and methods of treating diseases using them are disclosed.
    Type: Application
    Filed: July 15, 2008
    Publication date: January 29, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Virajkumar B. Gandhi, Vincent L. Giranda, Jianchun Gong, Thomas D. Penning, Gui-Dong Zhu
  • COMBINATION THERAPY WITH PARP INHIBITORS
    Publication number: 20090029966
    Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with temozolomide (TMZ).
    Type: Application
    Filed: May 8, 2008
    Publication date: January 29, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Cherrie K. Donawho, Vincent L. Giranda
  • Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors
    Patent number: 7462724
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: December 9, 2008
    Assignee: Abbott Laboratories
    Inventors: Thomas D. Penning, Sheela A. Thomas, Gui-Dong Zhu, Jianchun Gong, Vincent L. Giranda, Viraj B. Gandhi
  • COMBINATION THERAPY WITH PARP INHIBITORS
    Publication number: 20080293795
    Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with temozolomide (TMZ).
    Type: Application
    Filed: May 7, 2008
    Publication date: November 27, 2008
    Inventors: Cherrie K. Donawho, Vincent L. Giranda
  • COMBINATION THERAPY WITH PARP INHIBITORS
    Publication number: 20080280867
    Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with temozolomide (TMZ).
    Type: Application
    Filed: March 28, 2008
    Publication date: November 13, 2008
    Applicant: Abbott Laboratories
    Inventors: Vincent L. Giranda, Thomas D. Penning, Wolfgang Wernet, David J. Frost, Cherrie K. Donawho
  • INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE
    Publication number: 20080269234
    Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
    Type: Application
    Filed: June 12, 2008
    Publication date: October 30, 2008
    Applicant: ABBOTT LABORATORIES
    Inventors: Virajkumar B. Gandhi, Vincent L. Giranda, Jianchun Gong, Thomas D. Penning, Gui-Dong Zhu
  • INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE
    Publication number: 20080161280
    Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
    Type: Application
    Filed: December 27, 2007
    Publication date: July 3, 2008
    Applicant: Abbott Laboratories
    Inventors: Virajkumar B. Gandhi, Vincent L. Giranda, Jianchun Gong, Thomas D. Penning, Gui-Dong Zhu
  • INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE
    Publication number: 20080161292
    Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
    Type: Application
    Filed: December 27, 2007
    Publication date: July 3, 2008
    Applicant: Abbott Laboratories
    Inventors: Vincent L. Giranda, Julie M. Miyashiro, Thomas D. Penning, Keith W. Woods