Patents by Inventor Vincent L. Giranda

Vincent L. Giranda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PIM KINASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS
    Publication number: 20080161578
    Abstract: Inhibitors of Pim kinases, ways to make them and methods of treating patients using them are disclosed.
    Type: Application
    Filed: December 6, 2007
    Publication date: July 3, 2008
    Applicant: ABBOTT LABORATORIES
    Inventors: Thomas D. Penning, Sheela A. Thomas, Vincent L. Giranda
  • PIM KINASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS
    Publication number: 20080161559
    Abstract: Inhibitors of Pim kinases, ways to make them and methods of treating patients using them are disclosed.
    Type: Application
    Filed: December 6, 2007
    Publication date: July 3, 2008
    Applicant: ABBOTT LABORATORIES
    Inventors: Thomas D. Penning, Lisa A. Hasvold, Laura A. Hexamer, Vincent L. Giranda, Nan-horng Lin, Zhi-Fu Tao, Le Wang
  • COMBINATION THERAPY WITH PARP INHIBITORS
    Publication number: 20080146638
    Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.
    Type: Application
    Filed: January 8, 2008
    Publication date: June 19, 2008
    Applicant: Abbott Laboratories
    Inventors: Vincent L. Giranda, Thomas D. Penning, Wolfgang Wernet, David J. Frost, Cherrie K. Donawho
  • SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS
    Publication number: 20070259937
    Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
    Type: Application
    Filed: May 2, 2007
    Publication date: November 8, 2007
    Inventors: Vincent L. Giranda, Thomas D. Penning, Virajkamar B. Gandhi, Sheela A. Thomas, Gui-Dong Zhu, Jianchun Gong
  • Inhibitors of neuraminidases
    Patent number: 6831096
    Abstract: Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: December 14, 2004
    Assignee: Abbott Laboratories
    Inventors: Clarence J. Maring, Yu Gui Gu, Hui-Ju Chen, Yuanwei Chen, David A. Degoey, William J. Flosi, Vincent L. Giranda, David J. Grampovnik, Warren M. Kati, Dale J. Kempf, April Kennedy, Larry L. Klein, Allan C. Krueger, Zhen Lin, Darold L. Madigan, Keith F. McDaniel, Steven W. Muchmore, Hing L. Sham, Kent D. Stewart, Vincent S. Stoll, Minghua Sun, Noah P. Tu, Frank L. Wagenaar, Gary T. Wang, Sheldon Wang, Paul E. Wiedeman, Yibo Xu, Ming C. Yeung, Chen Zhao, Stephen Hanessian, Malken Bayrakdarian, Xuehong Luo
  • Kinase inhibitors
    Patent number: 6831175
    Abstract: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: December 14, 2004
    Assignee: Abbott Laboratories
    Inventors: Qun Li, Keith W. Woods, Gui-Dong Zhu, John P. Fischer, Jianchun Gong, Tongmei Li, Virajkumar Gandhi, Sheela A. Thomas, Garrick K. Packard, Xiaohong Song, Jason N. Abrams, Robert B. Diebold, Jürgen Dinges, Charles W. Hutchins, Vincent S. Stoll, Saul H. Rosenberg, Vincent L. Giranda
  • Inhibitors of neuraminidases
    Publication number: 20040097471
    Abstract: Disclosed are compounds of the formula: 1
    Type: Application
    Filed: September 24, 2002
    Publication date: May 20, 2004
    Inventors: Clarence J. Maring, Yu Gui Gu, Hui-Ju Chen, Yuanwei Chen, David A. Degoey, William J. Flosi, Vincent L. Giranda, David J. Grampovnik, Warren M. Kati, Dale J. Kempf, April Kennedy, Larry L. Klein, Allan C. Krueger, Zhen Lin, Darold L. Madigan, Keith F. McDaniel, Steven W. Muchmore, Hing L. Sham, Kent D. Stewart, Vincent S. Stoll, Minghua Sun, Noah P. Tu, Frank L. Wagenaar, Gary T. Wang, Sheldon Wang, Paul E. Wiedeman, Yibo Xu, Ming C. Yeung, Chen Zhao, Stephen Hanessian, Malken Bayrakdarian, Xuehong Luo
  • Peptide inhibitors of Akt and uses thereof
    Publication number: 20040038883
    Abstract: The subject invention relates to peptide inhibitors of Akt as well as to uses of these inhibitors. More specifically, the inhibitors may be used, for example, to induce apoptosis in cells and sensitize tumor cells to cancer therapies. The peptides may also be used to purify Akt.
    Type: Application
    Filed: February 12, 2003
    Publication date: February 26, 2004
    Inventors: Yan Luo, Vincent L. Giranda, Paul L. Richardson, Richard A. Smith
  • Kinase inhibitors
    Publication number: 20030199511
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: December 12, 2002
    Publication date: October 23, 2003
    Inventors: Qun Li, Keith W. Woods, Gui-Dong Zhu, John P. Fischer, Jianchun Gong, Tongmei Li, Virajkumar Gandhi, Sheela A. Thomas, Garrick K. Packard, Xiaohong Song, Jason N. Abrams, Robert B. Diebold, Jurgen Dinges, Charles W. Hutchins, Vincent S. Stoll, Saul H. Rosenberg, Vincent L. Giranda
  • Kinase inhibitors
    Publication number: 20030187026
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: November 18, 2002
    Publication date: October 2, 2003
    Inventors: Qun Li, Keith W. Woods, Gui-Dong Zhu, John P. Fischer, Jianchun Gong, Tongmei Li, Virajkumar Gandhi, Sheela A. Thomas, Garrick K. Packard, Xiaohong Song, Jason N. Abrams, Robert Diebold, Jurgen Dinges, Charles Hutchins, Vincent S. Stoll, Saul H. Rosenberg, Vincent L. Giranda
  • Peptide inhibitors of Akt and uses thereof
    Publication number: 20030181366
    Abstract: The subject invention relates to peptide inhibitors of Akt as well as to uses of these inhibitors. More specifically, the inhibitors may be used, for example, to induce apoptosis in cells and sensitize tumor cells to cancer therapies. The peptides may also be used to purify Akt.
    Type: Application
    Filed: March 21, 2002
    Publication date: September 25, 2003
    Inventors: Yan Luo, Vincent L. Giranda, Paul L. Richardson, Richard A. Smith
  • Neuraminidase inhibitors
    Patent number: 6593314
    Abstract: The present invention provides compounds of formula Ia and Ib or a pharmaceutically acceptable salt, prodrug, or ester thereof, useful in the inhibition of neuraminidase enzymes from disease-causing microorganisms, especially influenza neuraminidase, pharmaceutical formulations containing same, processes and intermediates for preparing said compounds, as well as methods of using said compounds, including preventing and treating diseases caused by microorganisms having said neuraminidase enzyme.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: July 15, 2003
    Assignee: Abbott Laboratories
    Inventors: Clarence J. Maring, Vincent L. Giranda, Yu Gui Gu, Stephen Hanessian, Dale J. Kempf, Darold L. Madigan, Kent Stewart, Vincent S. Stoll, Minghua Sun, Gary T. Wang, Jianchio Wang, Chen Zhao
  • Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
    Patent number: 6518305
    Abstract: Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
    Type: Grant
    Filed: October 19, 1999
    Date of Patent: February 11, 2003
    Assignee: Abbott Laboratories
    Inventors: Clarence J. Maring, Yuanwei Chen, David A. Degoey, Vincent L. Giranda, David J. Grampovnik, Yu Gui Gu, Warren M. Kati, Dale J. Kempf, April Kennedy, Allan C. Krueger, Zhen Lin, Darold L. Madigan, Steven W. Muchmore, Hing L. Sham, Kent D. Stewart, Vincent S. Stoll, Minghua Sun, Gary T. Wang, Sheldon Wang, Ming C. Yeung, Chen Zhao
  • DNA encoding human Cid1
    Publication number: 20020187522
    Abstract: An isolated and purified nucleic acid sequence encoding the human Cid1 gene and the polypeptide it encodes is disclosed.
    Type: Application
    Filed: March 6, 2001
    Publication date: December 12, 2002
    Inventors: Yan Luo, Vincent L. Giranda
  • Inhibitors of neuraminidases
    Patent number: 6455571
    Abstract: Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
    Type: Grant
    Filed: October 19, 1999
    Date of Patent: September 24, 2002
    Assignee: Abbott Laboratories
    Inventors: Clarence J. Maring, Yu Gui Gu, Hui-Ju Chen, Yuanwei Chen, David A. Degoey, William J. Flosi, Vincent L. Giranda, David J. Grampovnik, Warren M. Kati, Dale J. Kempf, April Kennedy, Larry L. Klein, Allan C. Krueger, Zhen Lin, Darold L. Madigan, Keith F. McDaniel, Steven W. Muchmore, Hing L. Sham, Kent D. Stewart, Vincent S. Stoll, Minghua Sun, Noah P. Tu, Frank L. Wagenaar, Gary T. Wang, Sheldon Wang, Paul E. Wiedeman, Yibo Xu, Ming C. Yeung, Chen Zhao, Stephen Hanessian, Malken Bayrakdarian, Xuehong Luo
  • DNA encoding human Cid2
    Publication number: 20020127556
    Abstract: An isolated and purified nucleic acid sequence encoding the human homolog of Schizosaccharomyces pombe Cid2 is disclosed.
    Type: Application
    Filed: March 6, 2001
    Publication date: September 12, 2002
    Inventors: Yan Luo, Vincent L. Giranda
  • Antisense oligonucleotides of the human chk1 gene and uses thereof
    Patent number: 6211164
    Abstract: The subject invention relates to antisense oligonucleotides of the human Chk1 gene and to uses thereof. The human ChK1 gene is a major G2/M checkpoint gene that is activated in response to DNA damage. In particular, the gene transduces the inhibitory signal from DNA damage sensors to the basic cell cycle machinery. Thus, antisense oligonucleotides to the human Chk1 gene may be used, for example, to inhibit the gene thereby preventing G2 arrest induced by DNA damaging agents. Such antisense oligonucleotides should also further sensitize tumor cells thereby making them more sensitive to therapy than normal cells.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: April 3, 2001
    Assignee: Abbott Laboratories
    Inventors: Yan Luo, Vincent L. Giranda, Shayna K. Rockow-Magnone