Abstract: The disclosure includes antisense oligonucleotides, including gapmer antisense oligonucleotides, along with methods of making and use, e.g., against HBV.

Abstract: The present disclosure generally relates to a system for data seclusion in image & audio files comprises a data processing unit for receiving input signals and converting into digitized image and audio data; a compressor unit for reducing size of the digitized image and audio data using a j-bit encoding at a variable rate; an encryption unit for encrypting the compressed digitized image and audio data using an advanced encryption standard (AES); a control unit for stripping the encrypted compressed digitized image and audio data into a plurality of portions, wherein the control unit generates a cryptographic key for decrypting every encrypted image and audio data; and a blockchain database configured with a cloud server for receiving the portions of the encrypted compressed digitized image and audio data and proportionately storing the portions of the encrypted compressed digitized image and audio data onto a plurality of storage media.

Abstract: A method for determining a viscosity of a medium based on damping of an oscillation mode of a measurement tube comprises exciting oscillations of an oscillation mode; detecting a sequence of provisional damping measurement values for the measurement tube oscillation mode; and calculating target measurement values. The influence of the cross-sensitivity of the damping for the flow rate of the medium is corrected by determining rectified damping measurement values that correspond to damping when the medium is at rest and determining viscosity on the basis of the rectified damping measurement values, or correcting the influence of the cross-sensitivity of the damping for the flow rate of the medium by determining provisional intermediate values of a damping-dependent variable, determining rectified intermediate values that correspond to the intermediate values when the medium is at rest, and determining the target measurement values on the basis of the rectified intermediate values.

Abstract: A traction battery venting system includes, among other things, an engine exhaust system that discharges engine exhaust gas to an area outside an electrified vehicle. The engine exhaust gas is emitted from an internal combustion engine of the electrified vehicle. The system further includes a sound deadening device of the engine exhaust system, a traction battery, and a battery vent system that communicates battery vent byproducts to the engine exhaust system at a position that is downstream from the sound deadening device. The battery vent byproducts are emitted from the traction battery of the electrified vehicle.

Abstract: Oligonucleotides comprising modifications at the 2? and/or 3? positions(s) along with methods of making and use against Alzheimer disease and other tauopathies are disclosed.

Abstract: Methods and systems are provided for adjusting a position of an exhaust valve that regulates engine exhaust noise. In one example, the position of the exhaust valve is adjusted according to a distance between a first vehicle and a second vehicle. The exhaust valve may be adjusted to reduce an exhaust noise level when the distance between the first vehicle and the second vehicle is less than a threshold distance.

Abstract: Methods and systems are provided for controlling imbalance with an exhaust tuning valve. In one example, a method may include adjusting a first exhaust tuning valve in response to combustion torque imbalance in a first and second group of cylinders. Additionally or alternatively, the position of the second exhaust tuning valve may be adjusted in response to an imbalance generated by the same group of cylinders.

Abstract: The disclosure relates to system and method for providing assistance to a user using augmented reality. The method includes acquiring a video stream and a set of data associated with a task being performed by a user, in real-time, using a camera and/or a sensor device. The video stream includes sequential frames.

Abstract: The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed.

Abstract: In traditional systems, every time a digital twin of a component needs to be generated, behavioral as well as operational data specific to the component needs to be fetched, which has practical difficulties owing to complex nature of processes/equipment the component is associated with. The disclosure herein generally relates to building digital twins, and, more particularly, to a method and system for building digital twin by leveraging existing knowledge. The system determines extent of similarity between two components, and based on the determined extent of similarity, uses different approaches to retrain a ANN data-driven model to obtain a desired accuracy for features of the component for which the digital twin is being generated.

Abstract: The present embodiments relate to updating a dataflow interactive cluster with zero downtime. A request to update a first dataflow cluster can be received, and a second dataflow cluster can be generated as a replacement cluster to execute received queries. Generating the second dataflow cluster can include identifying a second series of executor nodes that are configured to execute queries from the gateway node via a second driver node. A first update to a configuration of a host configuration node can be performed to register the second dataflow cluster as an active endpoint and identify the first dataflow cluster as an inactive endpoint. When no active queries exist, a second update to the configuration can be provided to remove the first dataflow cluster from the configuration to direct subsequent queries from the gateway node to the second dataflow cluster.

Abstract: Disclosed herein are novel methods of treating pain in a patient in need thereof by providing to the patient a selective dopamine D3 receptor antagonist/partial agonist which when used with an opioid analgesic, can mitigate the development of opioid dependence, by preventing the need for dose escalation while either maintaining the opioid analgesic effect or providing analgesia with a lower dose of the opioid. In addition, the D3 antagonists/partial agonists described herein may be used to augment the effectiveness of current Medication Assisted Treatment regimens (e.g. methadone or buprenorphine) for the treatment of opioid use disorders.

Abstract: Methods and systems are provided for controlling engine oil dilution in automotive vehicles. The method comprises heating coolant by operating an exhaust gas heat recovery device and circulating the heated coolant via a first coolant loop between the exhaust gas heat recovery device and a heat exchanger; and heating coolant by operating an exhaust gas recirculation cooler and circulating the heated coolant via a second coolant loop between the exhaust gas recirculation cooler and the heat exchanger, wherein the heated coolant from both the exhaust gas heat recovery device and the exhaust gas recirculation cooler mix at the heat exchanger and allows heating of an engine oil via the heat exchanger. In one example, the method prevents excessive accumulation of water and/or fuel in the engine oil.

Abstract: Methods and systems are provided for controlling engine oil dilution in automotive vehicles. The method comprises heating coolant by operating an exhaust gas heat recovery device and circulating the heated coolant via a first coolant loop between the exhaust gas heat recovery device and a heat exchanger; and heating coolant by operating an exhaust gas recirculation cooler and circulating the heated coolant via a second coolant loop between the exhaust gas recirculation cooler and the heat exchanger, wherein the heated coolant from both the exhaust gas heat recovery device and the exhaust gas recirculation cooler mix at the heat exchanger and allows heating of an engine oil via the heat exchanger. In one example, the method prevents excessive accumulation of water and/or fuel in the engine oil.

Abstract: Systems and methods for continuous monitoring of the behavior of animals, such as small rodents, are provided. Monitoring can include video, audio, and other sensor modalities. In one embodiment, the system can include cameras, arena design, environmental sensors, and ultrasonic sensors. The system uniquely provides a continuous long-term monitoring system suitable for mouse behavioral study. Further provided is a neural network based tracker configured for use with video data acquired by the monitoring system. Three different neural network architectures have been tested to determine their performance on genetically diverse mice under varying environmental conditions. It has been observed that that an encoder-decoder segmentation neural network achieves high accuracy and speed with minimal training data.

Abstract: Synthetic CT is estimated for planning or other purposes from surface data (e.g., depth camera information). The estimation uses parameterization, such as landmark and/or segmentation information, in addition to the surface data. In training and/or application, the parameterization may be used to correct the predicted CT volume. The CT volume may be predicted as a sub-part of the patient, such as estimating the CT volume for scanning one system, organ, or type of tissue separately from other system, organ, or type of tissue.

Abstract: Systems and methods for selecting items from a pool of items based on comparisons of composite embeddings are disclosed. A first initial embedding is obtained from a first database for each item in a pool of items and a second initial embedding is obtained from a second database for each item in the pool of items. The first initial embedding is generated using a first embedding model and the second initial embedding is generated using a second embedding model. A first composite embedding is generated for each item in the pool of items comprising the first initial embedding and the second initial embedding; and compare the first composite embedding for each item in the pool of items to a first anchor embedding, wherein the first anchor embedding comprises a first initial anchor embedding generated using the first embedding model and a second initial anchor embedding generated using the second embedding model.

Abstract: The present disclosure generally relates to text correction and generating text correction models. In an example process for text correction, text input is received. In response to receiving the text input, a text string corresponding to the text input is displayed. The text string is represented by a token sequence. The process determines whether an end of the token sequence corresponds to a text boundary. In accordance with a determination that the end of the token sequence corresponds to a text boundary, the process determines, based on a context state of the token sequence, one or more textual errors at one or more tokens of the token sequence. An error indication for a portion of the text string corresponding to the one or more tokens is displayed.

Abstract: Examples for enhancing veracity of data are described herein. Data from a repository may be received based on a data receiving rule. From the received data, a first dataset may be generated using statistical modeling. Also, a first data veracity score for the first dataset is generated which is indicative of a degree of usability of the dataset. Another aspect relates to identifying an anomaly in the first dataset, the corrector, for each anomaly, to identify a correction technique from amongst a plurality of correction techniques. Further, a second dataset is generated using the identified correction technique having second data veracity score higher than the first data veracity score.

Abstract: Disclosed herein novel dopamine D3 receptor selective antagonists/partial agonists compounds with high affinity and metabolic stability useful for the treatment of psychiatric and neurological disorders and as research and diagnostic tools. Also disclosed are methods of making the compounds.