Patents by Inventor Viyyoor M. Girijavallabhan

Viyyoor M. Girijavallabhan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds as inhibitors of hepatitis C virus NS3 serine protease
    Patent number: 7425576
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: September 16, 2008
    Assignee: Schering Corporation
    Inventors: Ashok Arasappan, F. George Njoroge, Angela I. Padilla-Acevedo, Kevin X. Chen, Frank Bennett, Mousumi Sannigrahi, Stephane L. Bogen, Srikanth Venkatraman, Edwin E. Jao, Anil K. Saksena, Viyyoor M. Girijavallabhan
  • Inhibitors of hepatitis C virus NS3 protease
    Patent number: 7423058
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: September 9, 2008
    Assignee: Schering Corporation
    Inventors: Stephane L. Bogen, Weidong Pan, Sumei Ruan, Kevin X. Chen, Ashok Arasappan, Srikanth Venkatraman, Latha G. Nair, Mousumi Sannigrahi, Frank Bennett, Anil K. Saksena, F. George Njoroge, Viyyoor M. Girijavallabhan
  • Substituted prolines as inhibitors of hepatitis C virus NS3 serine protease
    Patent number: 7399749
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: July 15, 2008
    Assignee: Schering Corporation
    Inventors: Ashok Arasappan, F. George Njoroge, Viyyoor M. Girijavallabhan
  • 3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis C virus NS3 serine protease
    Patent number: 7342041
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: March 11, 2008
    Assignee: Schering Corporation
    Inventors: F. George Njoroge, Srikanth Venkatraman, Ashok Arasappan, Francisco Velazquez, Viyyoor M. Girijavallabhan
  • Farnesyl protein transferase inhibitors as antitumor agents
    Patent number: 7342016
    Abstract: Disclosed are novel tricyclic compounds represented by the formula (1.0): and a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising compounds of formula 1.0. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: March 11, 2008
    Assignees: Schering Corporation, Pharmacopeia, Inc.
    Inventors: Hugh Y. Zhu, F. George Njoroge, Alan B. Cooper, Timothy J. Guzi, Dinanath F. Rane, Keith P. Minor, Ronald J. Doll, Viyyoor M. Girijavallabhan, Bama Santhanam, Patrick A. Pinto, Bancha Vibulbhan, Kartik M. Keertikar, Carmen S. Alvarez, John J. Baldwin, Ge Li, Chia-Yu Huang, Ray A. James, James J-S Wang, Jagdish A. Desai
  • Pyrazolopyrimidines as cyclin dependent kinase inhibitors
    Patent number: 7309705
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: December 18, 2007
    Assignee: Schering Corporation
    Inventors: Timothy J. Guzi, Kamil Paruch, Michael P. Dwyer, Ronald J. Doll, Viyyoor M. Girijavallabhan, Lawrence W. Dillard, Vinh D. Tran, Zhen Min He, Ray Anthony James, Haengsoon Park
  • Depeptidized inhibitors of hepatitis C virus NS3 protease
    Patent number: 7253160
    Abstract: The present invention discloses novel depeptidized compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: August 7, 2007
    Assignee: Schering Corporation
    Inventors: F. George Njoroge, Srikanth Venkatraman, Viyyoor M. Girijavallabhan
  • Inhibitors of hepatitis C virus NS3 protease
    Patent number: 7205330
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: April 17, 2007
    Assignee: Schering Corporation
    Inventors: Stephane L. Bogen, Weidong Pan, Sumei Ruan, Kevin X. Chen, Ashok Arasappan, Srikanth Venkatraman, Latha G. Nair, Mousumi Sannigrahi, Frank Bennett, Anil K. Saksena, F. George Njoroge, Viyyoor M. Girijavallabhan
  • Compounds as inhibitors of hepatitis C virus NS3 serine protease
    Patent number: 7192957
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: March 20, 2007
    Assignee: Schering Corporation
    Inventors: Srikanth Venkatraman, F. George Njoroge, Melissa L. Blackman, Wanli Wu, Latha G. Nair, Ashok Arasappan, Stephane L. Bogen, Kevin X. Chen, Mousumi Sannigrahi, Frank Bennett, Viyyoor M. Girijavallabhan
  • Compounds as inhibitors of hepatitis C virus NS3 serine protease
    Patent number: 7186747
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: March 6, 2007
    Assignee: Schering Corporation
    Inventors: Ashok Arasappan, F. George Njoroge, Angela I. Padilla-Acevedo, Kevin X. Chen, Frank Bennett, Mousumi Sannigrahi, Stephane L. Bogen, Srikanth Venkatraman, Edwin Jao, Anil K. Saksena, Viyyoor M. Girijavallabhan
  • Imidazopyrazines as cyclin dependent kinase inhibitors
    Patent number: 7186740
    Abstract: In its many embodiments, the present invention provides a novel class of imidazo[1,2-a] pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Grant
    Filed: September 19, 2003
    Date of Patent: March 6, 2007
    Assignee: Schering Corporation
    Inventors: Kamil Paruch, Timothy J. Guzi, Michael P. Dwyer, Ronald J. Doll, Viyyoor M. Girijavallabhan
  • Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus
    Patent number: 7173057
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: February 6, 2007
    Assignee: Schering Corporation
    Inventors: Kevin X. Chen, F. George Njoroge, Mousumi Sannigrahi, Latha G. Nair, Weiying Yang, Bancha Vibulbhan, Srikanth Venkatraman, Ashok Arasappan, Stephane L. Bogen, Frank Bennett, Viyyoor M. Girijavallabhan
  • Pyrazolopyrimidines as cyclin dependent kinase inhibitors
    Patent number: 7161003
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Grant
    Filed: September 3, 2003
    Date of Patent: January 9, 2007
    Assignees: Schering Corporation, Pharmacopeia Drug Discovery, Inc.
    Inventors: Timothy J. Guzi, Kamil Paruch, Michael P. Dwyer, Ronald J. Doll, Viyyoor M. Girijavallabhan, Alan Mallams, Carmen S. Alvarez, Kartik M. Keertikar, Jocelyn Rivera, Tin-Yau Chan, Vincent Madison, Thierry O. Fischmann, Lawrence W. Dillard, Vinh D. Tran, Zhen Min He, Ray Anthony James, Haengsoon Park, Vidyadhar M. Paradkar, Douglas Walsh Hobbs
  • Pyrazolopyridines as cyclin dependent kinase inhibitors
    Patent number: 7151104
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Grant
    Filed: September 17, 2003
    Date of Patent: December 19, 2006
    Assignee: Schering Corporation
    Inventors: Michael P. Dwyer, Timothy J. Guzi, Kamil Paruch, Ronald J. Doll, Kartik M. Keertikar, Viyyoor M. Girijavallabhan
  • 17 ?-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
    Patent number: 7138396
    Abstract: There are disclosed compounds of the formula (I): prodrugs thereof, or pharmaceutically acceptable salts of the compounds or of said prodrugs which are useful as inhibitors of Type 3 17?-Hydroxysteroid Dehydrogenase. Also disclosed are pharmaceutical compositions containing said compounds and their use for the treatment or prevention of androgen dependent diseases.
    Type: Grant
    Filed: January 28, 2005
    Date of Patent: November 21, 2006
    Assignee: Schering Corporation
    Inventors: Timothy J. Guzi, Kamil Paruch, Alan K. Mallams, Jocelyn D. Rivera, Ronald J. Doll, Viyyoor M. Girijavallabhan, Jonathan A. Pachter, Yi-Tsung Liu, Anil K. Saksena
  • Pyrazolopyrimidines as cyclin dependent kinase inhibitors
    Patent number: 7119200
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Grant
    Filed: February 11, 2004
    Date of Patent: October 10, 2006
    Assignees: Schering Corporation, Pharmacopeia Drug Discovery, Inc.
    Inventors: Timothy J. Guzi, Kamil Paruch, Michael P. Dwyer, Ronald J. Doll, Viyyoor M. Girijavallabhan, Alan Mallams, Carmen S. Alvarez, Kartik M. Keertikar, Jocelyn Rivera, Tin-Yau Chan, Vincent Madison, Thierry O. Fischmann, Lawrence W. Dillard, Vinh D. Tran, Zhen Min He, Ray Anthony James, Haengsoon Park, Vidyadhar M. Hobbs, Douglas Walsh Hobbs
  • Substituted 5-oxo pyrazoles and [1,2,4]triazoles as antiviral agents
    Patent number: 7115749
    Abstract: The present invention provides compounds of formula I wherein X and R1–R7 are as defined herein.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: October 3, 2006
    Assignee: Schering Corporation
    Inventors: Gerald W. Shipps, Jr., Tong Wang, Kristin E. Rosner, Patrick J. Curran, Alan B. Cooper, Viyyoor M. Girijavallabhan
  • Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
    Patent number: 7115578
    Abstract: Ribavirin derivatives represented by the formula V, pharmaceutical compositions containing them as well as the use of the ribavirin derivatives represented by the formula V for the preparation of a medicament for the treatment of susceptible viral infections, for example, chronic hepatitis C infections administrating, the ribavirin derivatives being represented by formula V are disclosed.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: October 3, 2006
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Jinping McCormick, Raymond G. Lovey, Frank Bennett, Anil K. Saksena, Viyyoor M. Girijavallabhan
  • Pyrazolopyrimidines as cyclin dependent kinase inhibitors
    Patent number: 7084271
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Grant
    Filed: September 3, 2003
    Date of Patent: August 1, 2006
    Assignees: Schering Corporation, Pharmacopeia Drug Discovery, Inc.
    Inventors: Timothy J. Guzi, Kamil Paruch, Michael P. Dwyer, Ronald J. Doll, Viyyoor M. Girijavallabhan, Chad Knutson, Brian McKittrick, Lawrence W. Dillard, Vinh D. Tran, Zhen Min He, Ray Anthony James, Haengsoon Park
  • Pyrazolopyrimidines as cyclin dependent kinase inhibitors
    Patent number: 7078525
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Grant
    Filed: September 3, 2003
    Date of Patent: July 18, 2006
    Assignees: Schering Corporation, Pharmacopeia Drug Discovery, Inc.
    Inventors: Timothy J. Guzi, Kamil Paruch, Michael P. Dwyer, Ronald J. Doll, Viyyoor M. Girijavallabhan, Lawrence W. Dillard, Vinh D. Tran, Zhen Min He, Ray Anthony James, Haengsoon Park