Patents by Inventor Viyyoor M. Girijavallabhan

Viyyoor M. Girijavallabhan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Farnesyl protein transferase inhibitors
    Patent number: 6740661
    Abstract: Disclosed are compounds of the formula: wherein R13 represents an imidazole ring; R14 represents a carbamate, urea, amide or sulfonamide group; R8 represents H when the alkyl chain between the amide group and the R13 imidazole group is substituted, or R8 represents a substituent such as arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R8 is H, and the alkyl chain between the amide group and the R13 imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: May 25, 2004
    Assignee: Schering Corporation
    Inventors: Arthur G. Taveras, Ronald J. Doll, Alan B. Cooper, Johan A. Ferreira, Timothy Guzi, Alan K. Mallams, Dinanath F. Rane, Viyyoor M. Girijavallabhan, Adriano Afonso, Cynthia J. Aki, Jianping Chao, Carmen Alvarez, Joseph M. Kelly, Tarik Lalwani, Jagdish A. Desai, James J-S Wang, Jay Weinstein
  • Novel pyrazolopyridines as cyclin dependent kinase inhibitors
    Publication number: 20040097516
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: September 17, 2003
    Publication date: May 20, 2004
    Applicant: Schering Corporation
    Inventors: Michael P. Dwyer, Timothy J. Guzi, Kamil Paruch, Ronald J. Doll, Kartik M. Keertikar, Viyyoor M. Girijavallabhan
  • Novel imidazopyridines as cyclin dependent kinase inhibitors
    Publication number: 20040097517
    Abstract: In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: September 17, 2003
    Publication date: May 20, 2004
    Applicant: Schering Corporation
    Inventors: Michael P. Dwyer, Timothy J. Guzi, Kamil Paruch, Ronald J. Doll, Kartik M. Keertikar, Viyyoor M. Girijavallabhan
  • Treatment of malaria with farnesyl protein transferase inhibitors
    Publication number: 20040087592
    Abstract: Disclosed is a method of treating Malaria comprising administering an effective amount of an FPT inhibitor to a patient in need of such treatment alone or in combination with an additional antimalarial agent and/or agent for reversing antimalarial resistance.
    Type: Application
    Filed: October 21, 2003
    Publication date: May 6, 2004
    Inventors: William T. Windsor, Patricia C. Weber, James J-S. Wang, Corey O. Strickland, F. George Njoroge, Timothy J. Guzi, Viyyoor M. Girijavallabhan, Johan A. Ferreira, Jagdish A. Desai, Alan B. Cooper, Michael Gelb
  • Novel imidazopyrazines as cyclin dependent kinase inhibitors
    Publication number: 20040072835
    Abstract: In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: September 19, 2003
    Publication date: April 15, 2004
    Applicant: SCHERING CORPORATION
    Inventors: Kamil Paruch, Timothy J. Guzi, Michael P. Dwyer, Ronald J. Doll, Viyyoor M. Girijavallabhan
  • Novel imidazopyrazines as cyclin dependent kinase inhibitors
    Publication number: 20040063715
    Abstract: In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: September 19, 2003
    Publication date: April 1, 2004
    Applicant: SCHERING CORPORATION
    Inventors: Kamil Paruch, Timothy J. Guzi, Michael P. Dwyer, Ronald J. Doll, Viyyoor M. Girijavallabhan, Alan Mallams
  • Process for producing (8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-B]pyridin-11-YL)-1-piperdine
    Patent number: 6706883
    Abstract: A process for producing compounds of the formula: is disclosed. The compound of formula 1.0 is produced by: (1) separating the atropisomers of  to obtain the atropisomers (2) heating the atropisomer of formula 2.0B at a suitable temperature in a suitable solvent to obtain a mixture of atropisomers of formulas 2.0A and 2.0B; (3) separating the atropisomers of formulas 2.0A and 2.0B of step (2); and (4) reducing the atropisomer of formula 2.0A to obtain a compound of formula 1.0. Preferably, R1 is Br, R2 is Cl and R3 is Br. Also disclosed is the (+)-atropisomer of formula 2.0 wherein R1 is Br, R2 is Cl and R3 is Br.
    Type: Grant
    Filed: July 1, 1999
    Date of Patent: March 16, 2004
    Assignee: Schering Corporation
    Inventors: F. George Njoroge, Bancha Vibulbhan, Viyyoor M. Girijavallabhan
  • 3,4-Di-substituted maleimide compounds as CXC chemokine receptor antagonists
    Publication number: 20040034229
    Abstract: Disclosed are compounds of the formula (I) 1
    Type: Application
    Filed: October 11, 2002
    Publication date: February 19, 2004
    Applicant: Schering Corporation
    Inventors: Arthur G. Taveras, Michael Dwyer, Johan A. Ferreira, Viyyoor M. Girijavallabhan, Jianping Chao, John J. Baldwin, J. Robert Merritt, Ge Li
  • Compounds useful for inhibition of farnesyl protein transferase
    Patent number: 6689789
    Abstract: Novel compounds of the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein: a represents N or NO−; R1 and R3 are the same or different and each represents halo; R2 and R4 are the same or different and each is selected from H and halo, provided that at least one of R2 and R4 is H; T is a substituent selected from SO2R or Z is O or S; n is zero or an integer from 1 to 6; R is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, heterocycloalkyl, or N(R5)2; R5 is H, alkyl, aryl, heteroaryl or cycloalkyl. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.
    Type: Grant
    Filed: September 4, 2002
    Date of Patent: February 10, 2004
    Assignee: Schering Corporation
    Inventors: Alan B. Cooper, Ronald J. Doll, Anil K. Saksena, Viyyoor M. Girijavallabhan
  • Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
    Patent number: 6673775
    Abstract: Ribavirin derivatives represented by formula I wherein at least one of R2, R3 or R5 is a straight or branched chain polyalkylene oxide polymer conjugate, and pharmaceutical compositions containing them as well as their use to treat patients having susceptible viral infections, alone and in combination with a therapeutically effective amount of interferon-alpha are disclosed.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: January 6, 2004
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Jinping McCormick, Raymond G. Lovey, Frank Bennett, Anil K. Saksena, Viyyoor M. Girijavallabhan
  • Novel farnesyl protein transferase inhibitors as antitumor agents
    Publication number: 20030229099
    Abstract: Disclosed are novel tricyclic compounds represented by the formula (1.
    Type: Application
    Filed: February 27, 2002
    Publication date: December 11, 2003
    Inventors: Hugh Y. Zhu, F. George Njoroge, Alan B. Cooper, Timothy Guzi, Dinanath F. Rane, Keith P. Minor, Ronald J. Doll, Viyyoor M. Girijavallabhan, Bama Santhanam, Patrick A. Pinto, Bancha Vibulbhan, Kartik M. Keertikar, Carmen S. Alvarez, John J. Baldwin, Ge Li, Chia-Yu Huang, Ray A. James, W. Robert Bishop, James J-S Wang, Jagdish A. Desai
  • Novel compounds as NS3-serine protease inhibitors of hepatitis C virus
    Publication number: 20030207861
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: January 21, 2003
    Publication date: November 6, 2003
    Applicant: SCHERING CORPORATION
    Inventors: Ashok Arasappan, Frank Bennett, Stephane L. Bogen, Kevin X. Chen, Edwin Jao, Yi-Tsung Liu, Raymond G. Lovey, Vincent S. Madison, Latha G. Nair, F. George Njoroge, Anil K. Saksena, Mousumi Sannigrahi, Srikanth Venkatraman, Viyyoor M. Girijavallabhan
  • Treatment of trypanosoma brucei with farnesyl protein transferase inhibitors
    Publication number: 20030134846
    Abstract: Disclosed is a method of treating and or preventing infections of Trypanosoma brucei by administering to a patient, in need of such treatment, an effective amount of a Farnesyl Protein Transferase Inhibitor alone or in combination with an additional anti-Trypanosoma brucei agent and/or an anti-Trypanosoma brucei resistance reversing agent.
    Type: Application
    Filed: October 7, 2002
    Publication date: July 17, 2003
    Applicant: Schering Corporation
    Inventors: William T. Windsor, Patricia C. Weber, Corey Strickland, Rosalinda Syto, Viyyoor M. Girijavallabhan, James J. Kaminski, Zhuyan Guo
  • Treatment of malaria with farnesyl protein transferase inhibitors
    Publication number: 20030092705
    Abstract: Disclosed is a method of treating Malaria comprising administering an effective amount of an FPT inhibitor to a patient in need of such treatment alone or in combination with an additional antimalarial agent and/or agent for reversing antimalarial resistance.
    Type: Application
    Filed: January 18, 2002
    Publication date: May 15, 2003
    Applicant: Schering Corporation
    Inventors: William T. Windsor, Patricia C. Weber, James J-S Wang, Corey O. Strickland, F. George Njoroge, Timothy J. Guzi, Viyyoor M. Girijavallabhan, Johan A. Ferreira, Jagdish A. Desai, Alan B. Cooper, Michael Gelb
  • Compounds useful for inhibition of farnesyl protein transferase
    Publication number: 20030092726
    Abstract: Novel compounds of the formula: 1
    Type: Application
    Filed: September 4, 2002
    Publication date: May 15, 2003
    Inventors: Alan B. Cooper, Ronald J. Doll, Anil K. Saksena, Viyyoor M. Girijavallabhan
  • Farnesyl protein transferase inhibitors
    Patent number: 6528523
    Abstract: The present invention describes compounds useful for the inhibition of Farnesyl Protein Transferase. This invention also discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with FPT.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: March 4, 2003
    Assignee: Schering Corporation
    Inventors: F. George Njoroge, Bancha Vibulbhan, Viyyoor M. Girijavallabhan, Xiongwei Shi
  • Farnesyl protein transferase inhibitors
    Publication number: 20030040520
    Abstract: Disclosed are compounds of the formula: 1
    Type: Application
    Filed: December 20, 2001
    Publication date: February 27, 2003
    Inventors: Timothy Guzi, Dinanath F. Rane, Alan K. Mallams, Alan B. Cooper, Ronald J. Doll, Viyyoor M. Girijavallabhan, Arthur G. Taveras, Corey Strickland, Joseph M. Kelly, Jianping Chao
  • Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
    Publication number: 20030004119
    Abstract: Ribavirin derivatives represented by formula I 1
    Type: Application
    Filed: April 18, 2001
    Publication date: January 2, 2003
    Inventors: Ashit K. Ganguly, Jinping McCormick, Raymond G. Lovey, Frank Bennett, Anil K. Saksena, Viyyoor M. Girijavallabhan
  • Novel farnesyl protein transferase inhibitors as antitumor agents
    Publication number: 20020198216
    Abstract: The present invention discloses novel tricyclic compounds represented by the formula (1.
    Type: Application
    Filed: August 28, 2001
    Publication date: December 26, 2002
    Inventors: F. George Njoroge, Bancha Vibulbhan, Alan B. Cooper, Timothy Guzi, Dinanath F. Rane, Keith P. Minor, Ronald J. Doll, Viyyoor M. Girijavallabhan, Bama Santhanam, Patrick A. Pinto, Hugh Y. Zhu, Kartik M. Keertikar, Carmen S. Alvarez, John J. Baldwin, Ge Li, Chia-Yu Huang, Ray A. James, W. Robert Bishop, James J-S Wang, Jagdish A. Desai
  • Diaryl peptides as NS3-serine protease inhibitors of hepatitis C virus
    Publication number: 20020147139
    Abstract: The present invention is directed to certain diaryl amide compounds as NS3-Serine protease inhibitors of hepatitis C virus.
    Type: Application
    Filed: December 10, 2001
    Publication date: October 10, 2002
    Applicant: SCHERING CORPORATION
    Inventors: Zhaoning Zhu, Zhong-Yue Sun, Srikanth Venkatraman, F. George Njoroge, Ashok Arasappan, Bruce A. Malcolm, Viyyoor M. Girijavallabhan, Raymond G. Lovey, Kevin X. Chen