Abstract: Provided herein are methods and systems for stratifying risk for a subject to develop a pathogen-associated disorder based on analysis of cell-free nucleic acid molecules from a biological sample of the subject. In various examples, screening frequency is determined based on the risk analysis. Also provided herein are methods and systems for analyzing variant patterns of a pathogen genome in cell-free nucleic acid molecules.

Abstract: A method (of generating a layout diagram) includes: identifying, in the layout diagram, a group of three or more cells which violates a horizontal constraint vector (HCV) and is arranged so as to exhibit two or more vertically-aligned edge-pairs (VEPs); each VEP including two members representing at least partial portions of vertical edges of corresponding cells of the group; relative to a horizontal direction, the members of each VEP being disposed in edgewise-abutment and separated by a corresponding actual gap; and the HCV having separation thresholds, each of which has a corresponding VEP and represents a corresponding minimum gap in the horizontal direction between the members of the corresponding VEP; and for each of at least one but fewer than all of the separation thresholds, selectively moving a given one of cells corresponding to one of the members of the corresponding VEP thereby to avoid violating the HCV.

Abstract: Cell-free DNA molecules in a mixture of a biological sample can be analyzed to detect viral DNA. Methylation of viral DNA molecules at one or more sites in the viral genome can be determined. Mixture methylation level(s) can be measured based on one or more amounts of the plurality of cell-free DNA molecules methylated at a set of site(s) of the particular viral genome. The mixture methylation level(s) can be determined in various ways, e.g., as a density of cell-free DNA molecules that are methylated at a site or across multiple sites or regions. The mixture methylation level(s) can be compared to reference methylation level(s), e.g., determined from at least two cohorts of other subjects. The cohorts can have different classifications (including the first condition) associated with the particular viral genome. A first classification of whether the subject has the first condition can be determined based on the comparing.

Abstract: An apparatus and system for delivering content having an applicable time limit and/or access right, including a time content capsule/module (100), a location content capsule/module (200), and/or a life content capsule/module (300) being operably connected with each other; wherein the time content capsule/module (100) is configured for generation and delivery of a content/information capsule/module intended to be delivered to a designated recipient or group of recipients by a content sender and having an access time restriction; the location content capsule/module (200) is configured for generation and delivery of a content/information capsule/module intended to be delivered to a designated recipient or group of recipients by a content sender and having an access location restriction; and the life content capsule/module (300) is configured for generation and delivery of a content/information capsule/module intended to be delivered to a designated recipient or group of recipients by a content sender and having

Abstract: Various embodiments are directed to applications (e.g., classification of biological samples) of the analysis of the count, the fragmentation patterns, and size of cell-free nucleic acids, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, such as viruses. Embodiments of one application can determine if a subject has a particular condition. For example, a method of present disclosure can determine if a subject has cancer or a tumor, or other pathology. Embodiments of another application can be used to assess the stage of a condition, or the progression of a condition over time. For example, a method of the present disclosure may be used to determine a stage of cancer in a subject, or the progression of cancer in a subject over time (e.g., using samples obtained from a subject at different times).

Abstract: This invention relates to a platinum electrodeposition bath which is capable of forming platinum deposits having an attractive shiny granular surface like a velvet, which is particularly useful in jewelry manufacturing. The velvet effect can be illustrated by comparing the surface roughness with a bright smooth platinum deposit.

Abstract: A method (of generating a layout diagram) includes: identifying, in the layout diagram, a group of three or more cells which violates a horizontal constraint vector (HCV) and is arranged so as to exhibit two or more vertically-aligned edge-pairs (VEPs); each VEP including two members representing at least partial portions of vertical edges of corresponding cells of the group; relative to a horizontal direction, the members of each VEP being disposed in edgewise-abutment and separated by a corresponding actual gap; and the HCV having separation thresholds, each of which has a corresponding VEP and represents a corresponding minimum gap in the horizontal direction between the members of the corresponding VEP; and for each of at least one but fewer than all of the separation thresholds, selectively moving a given one of cells corresponding to one of the members of the corresponding VEP thereby to avoid violating the HCV.

Abstract: Provided herein are methods and systems for identifying chimeric nucleic acid fragments, e.g., organism-pathogen chimeric nucleic acid fragments and chromosomal rearrangement chimeric nucleic acid fragments. Also provided herein are methods and systems relating to determining a pathogen integration profile or a chromosomal rearrangement in a biological sample and determining a classification of pathology based at least in part on a pathogen integration profile or a chromosomal rearrangement in a biological sample. In certain aspects of the present disclosure, cell-free nucleic acid molecules from a biological sample are analyzed.

Abstract: A method performed by at least one processor includes: accessing a layout of an integrated circuit (IC), where the layout includes a plurality of patterns in one or more layers of the layout; performing a coloring operation; forming a list comprising at least one uncolorable cell group (UCG) of the layout based on a result of the coloring operation, where each of the at least one UCG comprises at least one uncolorable cell; and performing a first refinement for each UCG on the list. The first refinement is performed through: performing a movement on at least one uncolorable cell of the UCG; determining whether the UCG is colorable; and refining the layout by accepting the movement and removing the UCG from the list in response to the UCG being determined to be colorable.

Abstract: A location based Quality Assurance System and a method to collect data in work spaces in terms of locations, environment conditions, time, workers and behaviours, thru the wireless interactions (M2M) of located and installed sensors on sites and PPE with detachable or built-in sensors, which data wirelessly transmitted to remote servers for big data analysis in order to enhance effective communication and management of safety, work flow, work forces, worker attendance and project in work spaces.

Abstract: A method performed by at least one processor includes: accessing a layout of an integrated circuit (IC), where the layout includes a plurality of patterns in one or more layers of the layout; performing a coloring operation; forming a list comprising at least one uncolorable cell group (UCG) of the layout based on a result of the coloring operation, where each of the at least one UCG comprises at least one uncolorable cell; and performing a first refinement for each UCG on the list. The first refinement is performed through: performing a movement on at least one uncolorable cell of the UCG; determining whether the UCG is colorable; and refining the layout by accepting the movement and removing the UCG from the list in response to the UCG being determined to be colorable.

Abstract: In various example embodiments, a system and method for providing information in an augmented reality display are provided. In example embodiments, an initial continuous stream of image data captured by a client device is received. An object within the continuous stream of image data is initially identified. The continuous stream of image data is further received and comprises additional image data regarding the object. The additional image data provides more visual details and features of the object than the initially received image data. Using the additional visual data, the identification of the object is refined to indicate a specific type of object. Based on the refined identification of the object, a search for information pertaining to the specific type of object is performed. A result is formatted to be displayed with a real-time image of the object on the client device.

Abstract: Cell-free DNA molecules in a mixture of a biological sample can be analyzed to detect viral DNA. Methylation of viral DNA molecules at one or more sites in the viral genome can be determined. Mixture methylation level(s) can be measured based on one or more amounts of the plurality of cell-free DNA molecules methylated at a set of site(s) of the particular viral genome. The mixture methylation level(s) can be determined in various ways, e.g., as a density of cell-free DNA molecules that are methylated at a site or across multiple sites or regions. The mixture methylation level(s) can be compared to reference methylation level(s), e.g., determined from at least two cohorts of other subjects. The cohorts can have different classifications (including the first condition) associated with the particular viral genome. A first classification of whether the subject has the first condition can be determined based on the comparing.

Abstract: A computer implemented method for routing a first path in a circuit design is presented. The method includes iteratively building a multitude of partial-paths to route the first path by adding an incremental length to a selected previously built partial-path when the computer is invoked to route the first path in the circuit design, the adding being performed in accordance with at least a first design rule. The multitude of partial-paths start at a first location. The method further includes comparing each of the multitude of partial-paths to each other when the multitude of partial-paths end on a common second location different from the first location, and saving one of the multitude of partial-paths that leads to a shortest first path. The method further includes eliminating one of the multitude of partial-paths that are not selected to lead to the shortest first path.

Abstract: Methods are provided to improve the positive predictive value for cancer detection using cell-free nucleic acid samples. Various embodiments are directed to applications (e.g., diagnostic applications) of the analysis of the fragmentation patterns and size of cell-free DNA, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, including viruses. Embodiments of one application can determine if a subject has a particular condition. For example, a method of present disclosure can determine if a subject has cancer or a tumor, or other pathology. Embodiments of another application can be used to assess the stage of a condition, or the progression of a condition over time. For example, a method of the present disclosure may be used to determine a stage of cancer in a subject, or the progression of cancer in a subject over time (e.g., using samples obtained from a subject at different times).

Abstract: A toy figure display stand displays a toy figure behind a transparent fluid-retaining wall, thus simulating immersion of the toy figure within the transparent fluid. The simulated immersion provides an additional level of engagement between the toy figure and a child or collector. The wall may include an interior transparent shell portion and an exterior transparent shell portion. The interior transparent shell portion and the exterior transparent shell portion may together define a cavity. A fluid may be received within the cavity.

Abstract: A device may aggregate dropped connection information associated with multiple dropped network connections. The dropped connection information may include at least one of: information associated with a mobile device that experienced a dropped network connection, information associated with a user of the mobile device, information associated with an access point that experienced the dropped network connection, information associated with a network from which the mobile device was dropped, or information that identifies a location associated with the dropped network connection. The device may identify a pattern associated with the multiple dropped network connections based on aggregating the dropped connection information, and may provide reporting information associated with the pattern.

Abstract: Various embodiments are directed to applications (e.g., classification of biological samples) of the analysis of the count, the fragmentation patterns, and size of cell-free nucleic acids, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, such as viruses. Embodiments of one application can determine if a subject has a particular condition. For example, a method of present disclosure can determine if a subject has cancer or a tumor, or other pathology. Embodiments of another application can be used to assess the stage of a condition, or the progression of a condition over time. For example, a method of the present disclosure may be used to determine a stage of cancer in a subject, or the progression of cancer in a subject over time (e.g., using samples obtained from a subject at different times).

Abstract: Methods and systems for making competitive sales or incentive offers from merchants through a service provider to a user while protecting user privacy enable merchants to make offers that are based on a user shopping wish list—which may be either transient (having a pre-set expiration time) or non-transient—in which the wish lists are provided from users through the service provider to merchants in a secure and private manner. A computer-implemented method includes: sending, to a merchant device of a merchant, some wish list data about a wish list item for a user, the wish list data containing no specifically identifying information about the user; receiving, by a service provider device of a service provider, an offer about the wish list item from the merchant based on the wish list data; and providing, to a user device for the user, the offer about the wish list item.

Abstract: A computer implemented method for designing an integrated circuit (IC) having dimensions along first and second directions, and comprising at least a first block is presented. The method includes evaluating a demand ratio for the first block, the demand ratio being reflective of a ratio of a conductive wiring demand along the first direction and a conductive wiring demand along the second direction, when the computer is invoked to evaluate the demand ratio for the first block. The method further includes creating one or more wiring reservation blocks in accordance with the demand ratio.