Abstract: The present disclosure relates to novel urocortin-2 polypeptides, having activity at the corticotropin-releasing hormone receptor-2 (CRHR2), pharmaceutical compositions comprising the polypeptides, and methods of using the polypeptides to treat disorders associated with CRHR2.

Abstract: An asset detection device and method of using a mmWave radar to determine whether a container is mounted to a transport chassis. The reflected signal may include multiple peaks and may be ambiguous. The device may determine if a peak is within a container range and is above a threshold magnitude. If the peak is not the highest peak in the reflected signal the device may disambiguate the signal by filtering it using a stored average no-container signal. If the peak is not the highest peak in the reflected signal the device may disambiguate the signal by determining if the highest peak is due to multipath. In some cases no peaks may be both above the threshold and within the container range, in which case the device determines there is no container present. The device reports container status determinations and reflected signal analysis to a remote server.

Abstract: Visual features of a vehicle, a vehicle's orientation with respect to a transaction terminal, and an individual associated with the vehicle are derived from video captured of the terminal and a surrounding area of the terminal. Additional information associated with brute force attacks in a location associated with the terminal are obtained as additional features. The visual features and the additional features are provided as input to a trained Machine-Learning Model (MLM) and the MLM provides as output a confidence value representing a prediction as to whether the current vehicle and the current individual are potentially about to engage in a brute force attack on the terminal. When the confidence value exceeds a threshold value, enhanced feature detection is enabled on the video, external systems are notified, and an incident packet of information is assembled.

Abstract: Embodiments of the present disclosure relate to compositions and methods for labeling of nucleotides, oligonucleotides, or polynucleotides with conjugated polymers or polymer dots. In particular, conjugated polymers or polymer dots can be used as detectable labels for nucleotides, oligonucleotides, or polynucleotides in sequencing by synthesis.

Abstract: A system for compensating for a relative motion between a probe and an apparatus. The system includes a probe assembly, a sensor, and a computer. The probe assembly includes an actuator pack positioned exterior to the apparatus and a probe insertable into the apparatus. The probe includes a first end coupled to the actuator pack, a second end, and an elongated body extending therebetween. The sensor senses data indicative of a relative motion between the apparatus and the probe assembly. The computer is operably coupled with the sensor and the probe assembly to move the probe of the probe assembly in response to the sensor sensing the data indicative of the relative motion between the apparatus and the probe assembly.

Abstract: A temporary wearable device, in the form of a cuff with electronics and arrays of skin electrodes, attachable to a limb at specific locations above various joints. When activated, such as by wireless actuation, the device stimulates specific nerves of interest to temporarily block pain signals with quick response and in a reversible manner without any permanent nerve damage to the animal.

Abstract: A portable oxygen concentrator includes a compressor and a controller. The compressor includes a motor, at least one chamber, and at least one piston operably coupled to the motor and movable within the at least one chamber. In some embodiments, the controller is configured to: determine actual motor speeds for commutations steps of the motor during a first rotational cycle; determine an average motor speed during the first rotational cycle; determine a voltage pattern based at least on a comparison of the average motor speed during the first rotational cycle and the actual motor speeds for the commutation steps of the motor during the first rotational cycle; and cause the voltage pattern to be applied to the motor during a second rotational cycle to reduce differences between applied motor torque and variable torque load imparted by the at least one piston.

Abstract: A device for converting a consumable into an aerosol with high heat without burning the consumable by packaging the consumable containing an internal susceptor inside an encasement with an induction heating element wrapped around the consumable-containing package to heat the susceptor using the induction heating element. Combustion of the consumable-containing package can be minimized by limiting air inside the consumable-containing package by compressing the consumable.

Abstract: Systems and methods are described for transmitting information optically in free space. For instance, a system may include an optical signal generator to generate an amplified beam of light. A telescope transmits the amplified beam through the medium and receives an inbound beam of light. A detector system may include one or more (or multiple) detectors and a routing system that transmits the inbound beam to a selected set of detectors. In some cases, the system can determine a re-configuration condition based on control parameters and perform a system re-configuration to direct the inbound beam to a different set of detectors. In some cases, the system includes a remote fiber head or wavelength division multiplexing.

Abstract: A modular system for delivering a fluid material is provided that may include a supply assembly for supplying a fluid material, a rate controlling assembly, and a pressure controlling assembly. The rate controlling assembly may be in fluid communication with the supply assembly and may vary a rate of a first portion of the fluid material supplied to a first applicator. The pressure controlling assembly may be in fluid communication with the supply assembly and may vary a pressure of a second portion of the fluid material supplied to a second applicator.

Abstract: Systems and methods are described for transmitting information optically in free space. For instance, a system may include an optical signal generator to generate an amplified beam of light. A telescope transmits the amplified beam through the medium and receives an inbound beam of light. A detector system may include one or more (or multiple) detectors and a routing system that transmits the inbound beam to a selected set of detectors. In some cases, the system can determine a re-configuration condition based on control parameters and perform a system re-configuration to direct the inbound beam to a different set of detectors. In some cases, the system includes a remote fiber head or wavelength division multiplexing.

Abstract: An e-commerce backbone system for facilitating a unified marketplace for unique items includes: a dealer system interface configured to communicate over a computer network with a plurality of dealer marketplace systems; a normalization engine configured to: translate data received from the plurality of dealer marketplace systems into data compliant with a standardized data model; and translate data sent to the plurality of dealer marketplace systems from data compliant with the standardized data model into data compliant with requirements of each individual dealer marketplace system; a dealer mappings database configured to store mappings that define translation methods for each individual dealer marketplace system; and a marketplace application programming interface (API) engine configured to present an API for sending and receiving data from one or more unified marketplace systems.

Abstract: A surface cleaner has a surface cleaning head having a solid collection chamber that is separated from a surface cleaning head liquid collection chamber by a porous divider wherein, in use, the solid collection chamber is positioned at a lower elevation than the surface cleaning head liquid collection chamber. An upright section is moveably mountable to the surface cleaning head between an upright storage position and a reclined surface cleaning position, wherein the upright section comprises a cleaning liquid reservoir and an upright section liquid collection reservoir. The upright surface cleaner is operable in a floor cleaning mode in which liquid is collected in the surface cleaning head liquid collection chamber and in the upright section liquid collection reservoir, and the upright surface cleaner is operable in an above floor cleaning mode in which liquid is collected in the upright section liquid collection reservoir.

Abstract: A payment system reduces transaction costs for online merchants. The payment system receives a transaction amount for the purchase of goods or services by a consumer from an online merchant. The payment system receives bank identification numbers for a plurality of accounts of the consumer that could be used by the consumer to pay for the good or services. The payment system determines transaction costs associated with processing a payment transaction with an acquirer processor using each of the consumer accounts. The payment system determines a recommended consumer account to use for the purchase of the good or services based at least in part on the transaction costs. Tender steering information is generated and sent to the consumer. Tender steering information includes the recommended consumer account information and one or more incentives to incentivize the consumer to use the recommended consumer account for the payment of the goods or services.

Abstract: A hand vacuum cleaner has an air treatment chamber and a main body which houses a suction motor which has a motor axis of rotation which extends in a common direction with the central longitudinally extending axis. A pistol grip handle having an upper end that is provided on the main body, a lower end and a handle axis that extends centrally through the pistol grip handle from the lower end of the pistol grip handle to the upper end of the pistol grip handle wherein the handle axis intersects the suction motor. The hand vacuum cleaner has a front openable door, which comprises a front wall of the air treatment chamber. The front door is moveable between a closed position and an open position, wherein an air inlet conduit is moveable with the front door.

Abstract: A pre-processing and fulfillment system and method are described. In some implementations, the method may include receiving an order containing a retail component and a pharmacy component, processing the order for the pharmacy component and the retail component, and generating a tracking token identifying the order and authorizing a party to receive a component of the order. The method may include transmitting fulfillment instructions to a fulfillment system based on processed information for the order, and transmitting the tracking token to a computing device of the authorized party. Some implementations may also include receiving a signal indicating receipt of the tracking token and an authorized transfer of the component, and updating a status of the order based on the received signal.

Abstract: The combine harvester includes a grain tank having a cover includes pivotable panels connected by collapsible connections so that the cover forms a funnel-shaped extension of the main receptacle of the tank when the cover is fully deployed. At least one of the panels includes an aperture and a door configured to close or open the aperture by pivoting about a pivot axis. When the cover is deployed, the door either closes the aperture and is secured thereto so that the panel has the same function as in a conventional harvester. However, when the door is opened, and supported by a support structure of the harvester, the door obtains the function of a walking plank that enables a person to walk on the plank and thereby access the interior of the tank.

Abstract: Methods for forming a through-glass vias in glass-based substrates include irradiating a glass-based substrate with a laser beam to form a damage track extending from a first major surface to a second major surface of the glass-based substrate, and contacting the glass-based substrate with a first etchant, including a base, to form a preliminary through-glass via. The method includes contacting the glass-based substrate with a second etchant, including an acid. The contacting with the second etchant widens a first cross-sectional area of the preliminary through-glass via at the first major surface of the glass-based substrate and widens a second cross-sectional area of the preliminary through-glass via at the second major surface of the glass-based substrate.

Abstract: A method for performing multi-touch (MT) data fusion is disclosed in which multiple touch inputs occurring at about the same time are received to generating first touch data. Secondary sense data can then be combined with the first touch data to perform operations on an electronic device. The first touch data and the secondary sense data can be time-aligned and interpreted in a time-coherent manner. The first touch data can be refined in accordance with the secondary sense data, or alternatively, the secondary sense data can be interpreted in accordance with the first touch data. Additionally, the first touch data and the secondary sense data can be combined to create a new command.

Abstract: The present invention is directed to a combination therapy involving a type II anti-CD20 antibody and a selective Bcl-2 inhibitor for the treatment of a patient suffering from cancer, particularly, a CD20-expressing cancer.