Patents by Inventor Wei Gao

Wei Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230025865
    Abstract: This disclosure provides compositions and methods for albumin nanoformulation of Bcl-2 and Bcl-xL inhibitor APG-1252 to suppress and/or inhibit growth of cancer cells (e.g., tumor cells). In particular, the present invention is directed to compositions comprising nanoparticles associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) APG-1252, methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings). Such nanoparticle formulations of APG-1252 are capable of increasing solubility, protecting against its degradation, reducing platelet toxicity, and expanding (improving) different indications to improve anticancer efficacy in various cancers and cancer metastasis in lymph nodes.
    Type: Application
    Filed: December 11, 2020
    Publication date: January 26, 2023
    Inventors: Duxin Sun, Wei Gao, Hongxiang Hu
  • Patent number: 11549128
    Abstract: A pretreatment method for producing a raw material of lycopene, comprising: uniformly mixing tomato peel residue with a fermenting agent, an antioxidant and an enzyme preparation, and subjecting the resultant to light-proof anaerobic fermentation. The present invention employs bacteria-enzyme-combined fermentation technology, which prolongs the storage period of wet tomato peel residue, and also destroys the cell wall of tomato peels, thus facilitating exaction of lycopene and improving the purity of lycopene extracted in the later stage.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: January 10, 2023
    Assignee: CHENGUANG BIOTECH GROUP CO., LTD.
    Inventors: Qingguo Lu, Wenjie Han, Zhiming Zhang, Xiaodong An, Wei Gao, Qianli Li
  • Patent number: 11553541
    Abstract: A Wi-Fi connection method and a device is provided. The method includes: searching an ambient environment of a device for a Wi-Fi access point, to obtain a list of Wi-Fi access points; determining a target access point in the list of Wi-Fi access points; sending a connection request to a device in which the target access point resides; receiving feedback information that is returned, according to the connection request, by the device in which the target access point resides, where the feedback information indicates whether the target access point is a portable Wi-Fi hotspot; and if the feedback information indicates that the target access point is a portable Wi-Fi hotspot, outputting prompt information, where the prompt information is used to remind a user of the device that the target access point is a portable Wi-Fi hotspot.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: January 10, 2023
    Assignee: Huawei Technologies Co., Ltd.
    Inventors: Zhong Wang, Huajiang Gao, Wei Gao, Bangbang Huang, Tie Liu
  • Patent number: 11549934
    Abstract: A portable biosensor for detecting and quantifying a target molecule in a biological sample and method of use include a biosensor fabricated with a recognition layer with an imprinted polymer, an electrode electrically coupled to the recognition layer, and a logic circuit that may include a processor and non-transitory memory with computer executable instructions embedded thereon, wherein the imprinted polymer is shaped to have a profile that substantially matches a profile of the target molecule, such that the target molecule can form-fit and bind to the imprinted polymer, thus changing an electrical property of the polymer layer that may be detected to identify the presence of the target molecule.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: January 10, 2023
    Assignee: California Institute of Technology
    Inventors: Wei Gao, Minqiang Wang
  • Patent number: 11542464
    Abstract: A single use probe, sterilizable by irradiation, for a single use component for use in a biopharmaceutical process, comprises at least one sensor relevant for the biopharmaceutical process, an RFID tag and a memory rewritable in principle, in which data with respect to an integrity check of the single use probe are stored. A method for quality assurance of such a single use probe comprises: providing the probe with an RFID tag and a memory rewritable in principle, in particular a FeRAM memory as part of the RFID tag; defining a measurement-principle-specific quality parameter of the single use probe; defining a tolerance value for the parameter; performing an integrity check of the probe by first determining and writing into the memory values of the defined quality parameter before sterilization of the probe by irradiation; determining the values of the defined quality parameter after irradiation; and comparing the values of the quality parameter determined before radiation to those determined after.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: January 3, 2023
    Assignee: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Christian Grimm, Wei Gao, Marco Leupold
  • Patent number: 11540537
    Abstract: Disclosed is a lycopene food colorant having a fresh-keeping function. The food colorant is prepared from the following raw materials in parts by weight: 1-3 parts of a lycopene crystal, 5-20 parts of an emulsifier, 0.5-5 parts of an antioxidant, 60-70 parts of glycerol, and 10-20 parts of water. The food colorant is prepared by mixing the raw materials and then emulsifying and grinding same. The granularity of the obtained lycopene colorant is moderate; the tone is suitable for coloring a minced fillet product; the lycopene colorant has high tinting strength, achieves a bright color, and has the effect of triggering myoglobin, so that the minced fillet product has a bright color and appears fresher; the lycopene colorant further has a fresh-keeping function and can kill some food microorganisms, so as to keep food fresh and prolong the shelf life.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: January 3, 2023
    Assignee: Chenguang Biotech Group Co., Ltd.
    Inventors: Jianzhong Xu, Xinchao Jia, Hong Tian, Wei Gao, Hongxia Wang, Lijuan Jiao
  • Publication number: 20220415685
    Abstract: A ventilated puck is provided. The ventilated puck includes an upper box, a spider plate, and a lower box. In particular, the upper box is fitted on the lower box to form a hollow structure, in which the spider plate is disposed. A ventilation channel for communicating the hollow structure with an external environment is provided in the upper box, or in the lower box or at interface between the upper box and the lower box. The ventilated puck of the present application may ensure gas exchange during the gas protection process conducted on semiconductor wafers, thereby preventing deformation of the puck due to pressure differences. Optionally, the interior of the ventilation channel is provided with a dustproof labyrinth structure, thereby preventing the entry of dust.
    Type: Application
    Filed: March 17, 2022
    Publication date: December 29, 2022
    Inventor: Wei Gao
  • Publication number: 20220415684
    Abstract: A ventilated wafer cassette is provided. The cassette comprises an upper box, a lower box, and an inner box, wherein the upper box is fitted on the lower box to form a hollow structure, in which the inner box is disposed. At least one ventilation channel connecting the hollow structure with an external environment is provided in the upper box, in the lower box or at the connection between the upper box and the lower box. The ventilated wafer cassette of the present application can ensure gas exchange during the gas protection process conducted on semiconductor wafers, thereby preventing deformation of the wafer cassette due to pressure differences. Preferably, the interior of the ventilation channel is provided with a dustproof labyrinth structure, thereby preventing the entry of dust.
    Type: Application
    Filed: March 17, 2022
    Publication date: December 29, 2022
    Inventor: Wei Gao
  • Patent number: 11539000
    Abstract: The present disclosure provides a compound having a formula (I): where A represents a nitrogen-containing heteroaromatic ring substituent; and L is one or more selected from a single bond, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C1-C8 alkoxy, substituted or unsubstituted C3-C8 heterocyclyl, substituted or unsubstituted C6-C40 aryl, and substituted or unsubstituted C4-C40 heteroaryl.
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: December 27, 2022
    Assignees: Wuhan Tianma Micro-Electronics Co., Ltd., Wuhan Tianma Microelectronics Co., Ltd. Shanghai Branch
    Inventors: Yang Li, Lei Zhang, Jinghua Niu, Wei Gao, Wenpeng Dai, Ying Liu
  • Publication number: 20220389473
    Abstract: Methods for in vitro transcription and translation from an RCA product are provided. The methods comprise providing a double-stranded RCA product, wherein the double-stranded RCA product consists essentially of tandem repeats of a minimalistic expression sequence. The methods further comprise expressing a protein from the double-stranded RCA product in a cell-free expression system.
    Type: Application
    Filed: July 19, 2022
    Publication date: December 8, 2022
    Inventors: John Richard Nelson, Robert Scott Duthie, Erik Leeming Kvam, Wei Gao
  • Publication number: 20220378342
    Abstract: Systems and methods for a microfluidic biosensor patch and health monitoring system may include an iontophoresis module, a multi-inlet microfluidic sweat collection and sampling module, and a molecularly imprinted polymer (MIP) organic compound sensor module. An iontophoresis module may provide for stimulation of a biofluid sample. A biofluid may be a sweat sample. Stimulation may be achieved via electrostimulation and/or application of hydrogel. A microfluidic sweat collection and sample module may include several adhesive layers with carefully designed inlets, channels, a reservoir, and an outlet for the efficiently collection and sampling of biofluid. A MIP sensor module may quickly and accurately identify concentrations of key metabolites present in a biofluid sample which may indicate certain health conditions.
    Type: Application
    Filed: May 25, 2022
    Publication date: December 1, 2022
    Applicant: California Institute of Technology
    Inventors: Wei Gao, Minqiang Wang, Yiran Yang, Jihong Min
  • Patent number: 11512976
    Abstract: The disclosure discloses a latitude-free initial alignment method under a swaying base based on gradient descent optimization. Firstly, swaying base latitude-free alignment is regarded as a Wahba attitude determination problem to inhibit device noise interference, and an objective function is established based on a gravitational acceleration vector under an earth system; then an exact solution of the objective function is obtained through a gradient descent optimization method, and inertial system conversion quaternion estimation is achieved under the latitude-free condition; and finally, an attitude quaternion is determined by only using information of an accelerometer and a gyroscope of a strapdown attitude heading reference system, and therefore latitude-free initial alignment under the swaying base is achieved.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: November 29, 2022
    Assignee: HARBIN INSTITUTE OF TECHNOLOGY
    Inventors: Ya Zhang, Qian Sun, Wei Gao, Fei Yu, Yanyan Wang, Xiuwei Xia, Jianxiong Wei, Weiqi Miao
  • Publication number: 20220375192
    Abstract: Disclosed is an optimization method for constructing a target detection network. The method includes: obtaining high-quality visual media data, low-quality visual media data corresponding to the high-quality visual media data, and a corresponding true label, extracting a first backbone network side output feature generated by a preset prior network for the high-quality visual media data, and extracting a second backbone network side output feature generated by a preset target detection network to be trained for the low-quality visual media data; constructing a feature correlation loss, a salient target position loss and a salient prediction loss based on the first backbone network side output feature, the second backbone network side output feature, and the true label; and optimizing the preset target detection network to be trained based on the feature correlation loss, the salient target position loss, and the salient prediction loss to obtain the target detection network.
    Type: Application
    Filed: May 18, 2022
    Publication date: November 24, 2022
    Applicant: PEKING UNIVERSITY SHENZHEN GRADUATE SCHOOL
    Inventors: Wei GAO, Guibiao LIAO, Ge LI
  • Publication number: 20220377254
    Abstract: The embodiments of the disclosure provide a video processing method and apparatus, and terminal and storage medium. The method includes: turning on a first camera on a first side and a second camera on a second side of a terminal in response to a first preset operation, wherein the first side and the second side are opposite or have different directions; and using the first camera and the second camera for simultaneous video recording. According to the method of the disclosure, a video recording method is improved by using the cameras on two sides of the terminal for simultaneous video recording, so that more flexible choices may be provided for video presentation and editing.
    Type: Application
    Filed: October 27, 2020
    Publication date: November 24, 2022
    Inventors: Lili WANG, Chi FANG, Dong WANG, Wei GAO, Haizhou ZHU
  • Patent number: 11505691
    Abstract: An aqueous thickener blend composition comprising an aqueous hydrophobically-modified alkali soluble or alkali swellable thickener composition and an acid-suppressible associative thickener composition, affording high thickening efficiency and providing an aqueous coating composition comprising such aqueous thickener blend composition with good heat-age stability and color float stability.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: November 22, 2022
    Assignees: Dow Global Technologies LLC, Rohm and Haas Company
    Inventors: Longlan Cui, Rui Wang, Ling Li, Wei Gao
  • Patent number: 11505834
    Abstract: The present invention provides a method for detecting Brucella infection, i.e., a serum and blood cell synchronous detection method. The detection method comprises two operation steps of serum sample detection and living blood cell sample detection and uses a supporting kit. The kit can be used for pretreatment of blood samples for clinically detecting Brucella in vitro. The serum and blood cell synchronous detection method can be used for early clinical rapid diagnosis of Brucella infection and medication guidance in the treatment process, and can also be used for prognosis, epidemiological survey of brucellosis, etc. The present invention can also be used for early clinical rapid diagnosis of other intracellular parasitic infection.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: November 22, 2022
    Assignee: INNER MONGOLIA UNIVERSITY FOR THE NATIONALITIES
    Inventors: Jingbo Zhai, Changlong Lv, Yongsheng Chen, Wei Gao, Leheng Zhao, Zeliang Chen
  • Patent number: 11506598
    Abstract: A multiband IR adjunct (MIRA) sensor to spectroscopically determine the content and the concentration of chemical composition of a targeted object, includes a sensor housing, a first front optics in a first optical channel, a second front optics in the first optical channel, an acousto-optic tunable filter (AOTF), a photo detector (PD), a set of back optics in the first optical channel that focuses polarized narrow-band light beams received from the AOTF device onto the PD, the PD converting the polarized narrow-band light beams into an electrical signal, and a data acquisition unit signal-connected to the PD, the data acquisition unit collecting the electrical signals. Multiple optical channels can be provided within the housing to analyze UV/VIS/near infrared (NIR), short-wavelength infrared (SWIR), mid-wavelength infrared (MWIR), and LWIR wavelength ranges respectively.
    Type: Grant
    Filed: November 29, 2019
    Date of Patent: November 22, 2022
    Assignee: EPIR, INC.
    Inventors: Wei Gao, Chang Yong, Silviu Velicu, Sivalingam Sivananthan
  • Patent number: 11499043
    Abstract: An aqueous dispersion of a hydrophobically-modified alkali-soluble multistage polymer useful as a thickener affording high thickening efficiency and an aqueous coating composition comprising such aqueous dispersion showing good stability after heat aging without compromising stability upon addition of colorants.
    Type: Grant
    Filed: December 25, 2017
    Date of Patent: November 15, 2022
    Assignees: Dow Global Technologies LLC, Rohm and Haas Company
    Inventors: Longlan Cui, Rui Wang, Siyuan Jiang, Wei Gao
  • Patent number: 11499052
    Abstract: The present invention relates to a method for preparing lycopene crystals with high purity and low harm. The method comprises the following steps: (1) mixing lycopene oleoresin with a mixed solvent consisting of an alkane and a lower alcohol, and heating and stirring the resultant for dissolution to form a homogenous solution; (2) cooling the homogenous solution for crystallization, filtering the resultant to obtain a filter cake; and (3) washing the filter cake successively using a lower alcohol and an alkane, and drying the resultant to obtain lycopene crystals. According to the method provided by the present invention, lycopene crystals can be obtained using a mixed solvent by means of one step crystallization, and the crystal content is further improved and harmful substances in the crystals are reduced by means of a two-step crystal washing process to obtain lycopene crystals with high purity and low harm.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: November 15, 2022
    Assignee: CHENGUANG BIOTECH GROUP CO., LTD.
    Inventors: Qingguo Lu, Yunhe Lian, Zhiming Zhang, Xiaodong An, Qianli Li, Wei Gao
  • Patent number: D971918
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: December 6, 2022
    Assignee: AIYOS TECHNOLOGY CO., LTD.
    Inventor: Wei Gao