Abstract: Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to anew class of small-molecules having a tetrahydroindazole structure which function as modulators (e.g., activators or inhibitors) of sigma-1 and/or sigma-2 receptors, and their use as therapeutics for the treatment of cancer and other diseases (e.g., neurological conditions) characterized with sigma-1 and/or sigma-2 receptor activity.

Abstract: A method for co-production of monophenols and cellulose by transition metal oxide catalytic oxidation of biomass is disclosed. The method uses transition metal oxide as catalyst and pretreated dry biomass as raw material to obtain high purity and selectivity of monophenolic chemicals with co-produced cellulose under mild conditions.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a direct-lit backlight unit. The backlight unit may include an array of light-emitting diodes on a printed circuit board. The backlight unit may include first, second, and third light spreading layers formed over the array of light-emitting diodes. A color conversion layer may be formed over the first, second, and third light spreading layers. First and second brightness enhancement films may be formed over the color conversion layer.

Abstract: A high temperature resistant wire is provided. The high temperature resistant wire comprises a carbon nanotube wire and a boron nitride layer coated on a surface of the carbon nanotube wire. The boron nitride layer is coaxially arranged with the carbon nanotube wire. A working temperature of the high temperature resistant wire in the air ranges from 0K to 1600K. A working temperature of the high temperature resistant wire in vacuum ranges from 0K to 2500K. A detector using the high temperature resistant wire is also provided.

Abstract: Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.

Abstract: The application provides a method for data reading and writing processing, data center, disaster recovery system and storage medium. The method includes receiving, by a first data center, a data reading request including a first user identification; determining, in response to the data reading request, whether a writing user identification set stored in the first data center includes the first user identification, the writing user identification set including user identifications corresponding to data writing requests; and under a condition that the writing user identification set includes the first user identification, forwarding the data reading request to a second data center, to read, in the second data center, data to be read as indicated by the data reading request, the second data center being configured to receive and process a data writing request sent by a user terminal or forwarded by the first data center.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a direct-lit backlight unit. The backlight unit may include an array of light-emitting diodes on a printed circuit board. The backlight unit may include first, second, and third light spreading layers formed over the array of light-emitting diodes. A color conversion layer may be formed over the first, second, and third light spreading layers. First and second brightness enhancement films may be formed over the color conversion layer.

Abstract: A portable electronic device can include a housing defining an aperture and a display positioned in the aperture. The portable electronic device can include a number of components that can provide desired functionalities and levels of performance. For example, the device can include one or more couplers that interconnect various portions of the housing together. Additionally or alternatively, the portable electronic device can include one or more millimeter-wave antennas. Additionally, or alternatively, the electronic device can include one or more grounding elements or layers that reliably and electrically ground the display to the housing.

Abstract: The invention describes products, uses thereof, compositions thereof, and methods to prepare products formed from Maillard reaction products from a sugar donor and/or sweet tea extracts, stevia extracts, swingle (mogroside) extracts, one or more sweet tea extract components, one or more steviol glycosides, one or more mogrosides, one or more glycosylated sweet tea glycosides, one or more glycosylated steviol glycosides or one or more glycosylated mogrosides and an amine donor/reactant.

Abstract: The present invention discloses a modular intelligent combined wind power converter and a control method thereof. The modular intelligent combined wind power converter comprises separate bridge arm power units, wherein a plurality of the bridge arm power units are connected in parallel to form a high-capacity bridge arm power module, three bridge arm power modules form a three-phase full-controlled bridge power module, and the three-phase full-controlled bridge power module comprises an electric reactor, a capacitor, a fuse and a circuit breaker to form a basic converter module, and the basic converter module forms a high-capacity wind power converter through a modular intelligent combination method.

Abstract: Disclosed are an antibody-drug conjugate (ADC), an intermediate thereof, a preparation method therefor and an application thereof. The present invention provides an ADC. A structural general formula thereof is Ab-(L3-L2-L1-D)m. The ADC has better biological activity, stability, and uniformity, has reduced toxic and side effects, and has a faster release rate of enzyme cutting in tumor cells. The use of the novel ADC can achieve a wide application of a cytotoxic drug particularly camptothecin in the field of ADCs in treating tumor patients resistant to microtubule ADC.

Abstract: Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a direct-lit backlight unit. The backlight unit may include an array of light-emitting diodes on a printed circuit board. The backlight unit may include first, second, and third light spreading layers formed over the array of light-emitting diodes. A color conversion layer may be formed over the first, second, and third light spreading layers. First and second brightness enhancement films may be formed over the color conversion layer.

Abstract: The invention describes products, uses thereof, compositions thereof, and methods to prepare products formed from Maillard reaction products from a sugar donor and/or sweet tea extracts, stevia extracts, swingle (mogroside) extracts, one or more sweet tea extract components, one or more steviol glycosides, one or more mogrosides, one or more glycosylated sweet tea glycosides, one or more glycosylated steviol glycosides or one or more glycosylated mogrosides and an amine donor/reactant.

Abstract: The invention describes products, uses thereof, compositions thereof, and methods to prepare products formed from Maillard reaction products from a sugar donor and/or sweet tea extracts, stevia extracts, swingle (mogroside) extracts, one or more sweet tea extract components, one or more steviol glycosides, one or more mogrosides, one or more glycosylated sweet tea glycosides, one or more glycosylated steviol glycosides or one or more glycosylated mogrosides and an amine donor/reactant.

Abstract: A p-y curve-based element test device is provided. An upper support plate is located above a lower support plate and is fixedly connected to the lower support plate through truss supports symmetrically arranged on left and right sides, and at least one truss support is arranged on each side. A sample container, a servo consolidation mechanism and multidirectional servo actuators are connected to the truss support on the two sides. The servo consolidation mechanism is located above the sample container, and the multidirectional servo actuators are arranged above the servo consolidation mechanism and below the sample container, respectively. Identical loads are synchronously applied from above and below to realize horizontal movement of a pile element to simulate the load condition of a soil body, and a pressure is applied by a servo consolidation device to simulate the stress condition of the soil body at a certain depth.

Abstract: A p-y curve-based element test device is provided. An upper support plate is located above a lower support plate and is fixedly connected to the lower support plate through truss supports symmetrically arranged on left and right sides, and at least one truss support is arranged on each side. A sample container, a servo consolidation mechanism and multidirectional servo actuators are connected to the truss support on the two sides. The servo consolidation mechanism is located above the sample container, and the multidirectional servo actuators are arranged above the servo consolidation mechanism and below the sample container, respectively. Identical loads are synchronously applied from above and below to realize horizontal movement of a pile element to simulate the load condition of a soil body, and a pressure is applied by a servo consolidation device to simulate the stress condition of the soil body at a certain depth.

Abstract: The invention describes products, uses thereof, compositions thereof, and methods to prepare products formed from Maillard reaction products from a sugar donor and/or sweet tea extracts, stevia extracts, swingle (mogroside) extracts, one or more sweet tea extract components, one or more steviol glycosides, one or more mogrosides, one or more glycosylated sweet tea glycosides, one or more glycosylated steviol glycosides or one or more glycosylated mogrosides and an amine donor/reactant.