Abstract: The present invention relates to bispecific or biparatopic antigen binding proteins, polynucleotides encoding the same, and methods of making bispecific or biparatopic antigen binding proteins. Also described herein is a method to assemble IgG-like biparatopic or bispecific antibodies from VH only antigen binding proteins.

Abstract: Provided herein are heterodimeric bispecific antibodies that can mediate cytolysis of a target cell by an immune effector cell, nucleic acids encoding such antibodies, methods of making such antibodies, and methods of using such antibodies. These antibodies comprise two different polypeptide chains, each comprising two immunoglobulin variable regions and, optionally, a half life-extending moiety.

Abstract: A rigid-flexible coupled unmanned aerial vehicle (UAV) morphing wing and an additive manufacturing method thereof are disclosed. A shape memory alloy (SMA) strip/wire for controlling the wing upward deformation and an SMA strip/wire for controlling the wing downward deformation are arranged alternately, and a plurality of reinforcing ribs are arranged at intervals on the SMA strips/wires for controlling the wing upward deformation and the SMA strips/wires for controlling the wing downward deformation. The SMA strips/wires for controlling the wing upward deformation and the SMA strips/wires for controlling the wing downward deformation are arranged on a flexible substrate, and are wrapped with an insulating covering. The SMA strips/wires for controlling the wing upward deformation and the SMA strips/wires for controlling the wing downward deformation each are provided with an electric heating element.

Abstract: A computer system configured to overcome the conventional bottleneck of memory throughput. A wafer-on-wafer (WOW) technology is adapted to overcome the physical limitation of quantity and length in circuit deployments. The memory devices and the memory controllers in the logic circuit layer are improved to transmit data in differential signals. The differential signals can significantly reduce the error rate in high-speed transmissions, at a voltage level far lower than that of the conventional single-end signals. Thus, the power consumption of the computer system is significantly reduced. Furthermore, the memory controller in the computer system is improved to be an integrated controller having control over physical layer signals. Thereby, the conventional physical layer interface is no longer needed in the computer system, and therefore the cost to the computer system is further reduced.

Abstract: A computer system based on wafer-on-wafer architecture is provided, comprising a memory device and a logic circuit layer stacked in a wafer on wafer structural configuration. The memory device comprises a memory array and a circuit driver. The memory array comprises a shared circuit path and a plurality of memory cells, wherein the shared circuit path is connected to the memory cells. The circuit driver is connected to the shared circuit path, driving the memory cells. The logic circuit layer comprises a plurality of bounding pads for signal transmission, and a latency controller, connected to the memory array through the bounding pads, adjusting the number of memory cells connecting the shared circuit path, thereby dynamically adjusting the latency characteristics of the memory array. Embodiments of the memory device and the memory control method are also provided.

Abstract: Provide herein are variant-Fc-region fusion proteins, variant-Fc-region-antibodies and/or heterodimeric-variant-Fc-region-bispecific-antibodies optionally produced by a host cell line, nucleic acids encoding the variant-Fc-region fusion proteins, variant-Fc-region-antibodies and/or heterodimeric-variant-Fc-region-bispecific-antibodies, host cells containing such nucleic acids, and methods of treatment using the variant-Fc-region fusion proteins, variant-Fc-region-antibodies and/or heterodimeric-variant-Fc-region-bispecific-antibodies, or nucleic acids encoding the variant-Fc-region fusion proteins, variant-Fc-region-antibodies and/or heterodimeric-variant-Fc-region-bispecific-antibodies described herein. Also described are methods of producing the variant-Fc-region fusion proteins, variant-Fc-region-antibodies and/or heterodimeric-variant-Fc-region-bispecific-antibodies in host cells.

Abstract: A method for detecting the presence of slowing patterns in an EEG sample comprising a plurality of channels of EEG signals, each channel comprising one or more segments, the method comprising: obtaining a first classifier that is trained to classify EEG samples as containing abnormal slow waves or not; performing a sequence of artifact removal processes on the EEG sample to generate a preprocessed EEG sample; extracting a first feature set from the preprocessed EEG sample; and passing the first feature set to the first classifier to predict whether the EEG sample contains abnormal slow waves or not; wherein the sequence of artifact removal processes comprises removal of one or more ocular artifacts and removal of one or more electrode artifacts.

Abstract: Provided herein are heterodimeric bispecific antibodies that can mediate cytolysis of a target cell by an immune effector cell, nucleic acids encoding such antibodies, methods of making such antibodies, and methods of using such antibodies. These antibodies comprise two different polypeptide chains, each comprising two immunoglobulin variable regions and, optionally, a half life-extending moiety.

Abstract: The present invention discloses an automatic recognition method for spatial position and pose of parallel external fixator, including the following steps of: installing three markers on each of the two fixation rings of the parallel external fixator; obtaining 3D images of six marker balls after scanning and reconstruction by a common 3D clinical imaging system; recognizing the sphere center coordinates of the six marker balls by sphere fitting algorithm; according to the mounting configuration of the markers on the two fixation rings, establishing coordinate systems of two fixation rings and determining the spatial position and pose of the external fixator; in addition, by obtaining the 3D images of the fracture bone segments with the 3D clinical imaging system and simulating the movement of the fracture deformity correction, the adjustment schedule of the external fixator struts can be achieved.

Abstract: Various embodiments of the present disclosure provide a casino floor service management system and method that integrates with a casino management system of a casino and leverages the knowledge and experience of casino floor service management system users, such as technicians, floor attendants, and hostesses, to efficiently resolve service floor events in a timely manner.

Abstract: Described herein is a dimeric, bispecific antibody format. Each polypeptide chain of the dimer comprises an immunoglobulin variable region, an immunoglobulin constant region, an Fc polypeptide chain, another immunoglobulin variable region, and another immunoglobulin constant region. Also described are methods of making and using such antibodies.

Abstract: A display substrate and a display apparatus are provided. The display substrate includes a base substrate; sub-pixels arranged in an array and on the base substrate; data line groups on the base substrate; each data line group includes data lines, each of which is connected to one column of sub-pixels; data selectors on the base substrate and connected to the data line groups in a one-to-one correspondence; data lines in a same data line group are connected to a same data selector; and a data selection signal lines, wherein different data selection signal lines output different data selection signals; and different data lines connected to a same data selector correspond to different data selection signal lines, respectively. The display panel provided may effectively reduce the resistance on the data selection signal lines, thereby reducing the delay of the data selection signals and further improving the charging uniformity of sub-pixels.

Abstract: A video playing control method includes obtaining a video playing policy, where the video playing policy determines information about a control algorithm used for video playing, determining according to the video playing policy, a target control algorithm used for video playing, downloading and playing a video by using the target control algorithm, collecting video playing quality indicator data in a process of downloading and playing the video, and uploading the quality indicator data to a server, to indicate the server to adjust the video playing policy based on the quality indicator data.

Abstract: A display panel includes a second substrate. The second substrate includes a second base substrate and a shielding layer, an array structure layer, an insulating layer and a reflective layer which are sequentially disposed on a second base substrate, the array structure layer includes gate lines; the shielding layer includes a plurality of groups of light shielding units sequentially arranged along a first direction, each group of the light shielding units includes a plurality of independent sub-light shielding units sequentially arranged along a second direction, the reflective layer includes a plurality of reflective units arranged in an array, the plurality of reflective units form a plurality of reflective rows and a plurality of reflective columns, a first space area is formed between adjacent reflective columns, and a second space area is formed between adjacent reflective rows forms.

Abstract: A method to determine authenticity of a security feature of an identification document, characterized by receiving a real-time video feed of the identification document with a light source directed at the identification document to make visible a security hologram; processing the real-time video feed into a plurality of image sequence; analysing each image from the plurality of image sequence for a glare and the security hologram, wherein the glare is a reflection of the light source from the identification document; analysing the position of the glare and the security hologram in each image from the plurality of image sequence; evaluating whether the position of the glare and the position of the security hologram is caused by the light source; and providing authenticity result of the identification document captured from the real-time video feed.

Abstract: An image processing method includes displaying an object following page in a first session page in response to an object following operation performed on a first image, the object following page including a setting control corresponding to at least one display object in the first image. The first session page is a page corresponding to a local user account. The method also includes creating an object following relationship between a selected display object and the local user account in response to a trigger operation performed on the setting control in the object following page. The object following relationship provides an image update prompt to the local user account, the image update prompt prompting to view an image associated with the selected display object. Apparatus and non-transitory computer-readable storage medium counterpart embodiments are also contemplated.

Abstract: A luminous touch keyboard includes a baseplate, a plurality of keycaps, a plurality of support mechanisms connected between the baseplate and the keycaps, and a keyboard composite electrode module disposed between the baseplate and the keycaps and configured to sense a non-pressing movement over the keycaps and to provide light emitting through the keycaps. The support mechanism supports the keycap to move relative to the baseplate and the keyboard composite electrode module. The keyboard composite electrode module includes a light source circuit and a plurality of electrode matrices arranged along a first direction and a second direction. Two of the electrode matrices adjacent in the second direction are mis-aligned. The light source circuit includes a plurality of light sources disposed in the plurality of electrode matrices in a one-to-one manner, and the position of the light source in the electrode matrix is correspondingly the same.

Abstract: The present disclosure provides a shift register, a gate driving circuit, a display panel, and a driving method thereof. The shift register includes: an input circuit; an output circuit; a first control circuit configured to provide a potential of a first control signal terminal to a pull-down node, and provide a potential of a reference signal terminal to the pull-down node according to the potential of the pull-up node; and a second control circuit connected to the pull-down node, a second control signal terminal, the output signal terminal, and the reference signal terminal, wherein the second control circuit is configured to pull down a potential of the output signal terminal during a display phase under the control of a potential of the pull-down node and a potential of the second control signal terminal, and pull up the potential of the output signal terminal in a power-off phase.

Abstract: The invention discloses a point cloud geometric compression method based on a depth auto-encoder, which comprises the following steps of: (1) point cloud preprocessing: collecting a type of point cloud to be compressed as a training set, and normalizing the training set into a unit circle; (2) point cloud down-sampling: down-sampling the point clouds in the training set so that each point cloud have the same point number m and each point in the point cloud has (x, y, z) three-dimensional coordinates; and adopting a farthest point down-sampling method by randomly selecting a point for the first time and then selecting the point farthest away from the selected point set every time to add into the selected point set until the selected point number meets the requirement; (3) training a compression model: inputting the point cloud sampled in step (2) into a point cloud geometric compression framework based on a depth auto-encoder for training; and (4) geometric compression of the point cloud: applying the trained