Abstract: The present disclosure is related to an imaging system. The imaging system may include at least one array radiation source and a detector. Each of the at least one array radiation source may include a plurality of point radiation sources. The at least one array radiation source may be configured to emit at least one radiation beam. The detector may be configured to detect at least part of the at least one radiation beam.

Abstract: The present invention discloses a hybrid nail gun, which comprises a power component and a drive component, wherein the power component is driven by the drive component, and the drive component comprises at least a gas driven device and an electric driven device. The present invention may be used as a pneumatic nail gun when it can be connected to a gas source. The present invention may use a power source to drive the power component to complete a nailing action when it is impossible or inconvenient to connect a gas source. The present invention can flexibly adapt to different work scenarios without the need to change different types of nail guns. Therefore, the work efficiency is improved and the cost is reduced.

Abstract: The present disclosure relates generally to the fields of oncology, virology and immunotherapy. It concerns poxviruses, specifically the highly attenuated modified vaccinia virus Ankara (MVA), and a recombinant modified vaccinia Ankara virus with deletion of vaccinia virulence factor E3 (MVA?E3L), each further modified to express human Fms-like tyrosine kinase 3 ligand (Flt3L) or GM-CSF. The disclosure relates to use of the foregoing recombinant viruses as cancer immunotherapeutic agents. The foregoing recombinant poxviruses can also be used in combination with immune checkpoint blockade therapy.

Abstract: Disclosed herein are methods and compositions related to the treatment, prevention, and/or amelioration of cancer in a subject in need thereof.

Abstract: An industrial rack apparatus includes upright support members, at least one pair of shelf beams that are supported by the upright support member, at least one shelf connected to one pair of the at least a pair of shelf beams; wherein one pair of the upright support members is positioned at one end of the rack apparatus, and the other pair of the upright support member is positioned at the opposite end of the rack apparatus; wherein each shelf beam of the at least one shelf beams is attached to two opposed upright members of the upright support members.

Abstract: An adjustable wrench includes a wrench body, a second jaw and an adjustment mechanism, the wrench body including a first jaw, a neck and a handle, wherein the first jaw is a front end of the wrench body, and the neck is located between the first jaw and the handle. The first jaw is disposed opposite the second jaw to form a holding space for holding an object. The neck is provided with a through hole, the adjustment mechanism is disposed in the through hole, and the second jaw is movably connected to the neck of the wrench body by the adjustment mechanism. The adjustment mechanism is used to adjust the movement of the second jaw relative to the first jaw. The adjustable wrench therefore includes a jaw that can move relatively fast and can also be effectively prevented from skidding or returning.

Abstract: Disclosed herein are methods and compositions related to the treatment, prevention, and/or amelioration of cancer in a subject in need thereof.

Abstract: The present invention discloses a hand riveter and relates to the field of hand-operated tools, and the hand riveter comprises a first handle, a second handle and a clamping and pulling mechanism, wherein the second handle is capable of rotating around a pivoting shaft with respect to the first handle; the second handle is separated into a force applying end and a warping end by the pivoting shaft, and the warping end and the clamping and pulling mechanism are connected via a connecting shaft; when the force applying end of the second handle is rotated and opened with respect to the first handle, the warping end of the second handle drives the clamping and pulling mechanism to move in a rivet-driving direction; and when the force applying end of the second handle is rotated and closed with respect to the first handle, the warping end of the second handle drives the clamping and pulling mechanism to move in a rivet-pulling direction.

Abstract: The present invention discloses a fastening device, comprising a main body and a holding part, wherein the main body constitutes a main plane, and the holding part and the main body are rotatably connected to each other; and the holding part comprises a first arm and a second arm, the first arm is provided with a first connection mechanism and a second connection mechanism, the first arm is rotatably connected to the main body via the first connection mechanism, and the second arm is rotatably connected to the first arm via the second connection mechanism. Such a fastening device can be used for the installation of floorings. Not only can the height of a handle be changed, but also the angle at which the handle is held can be changed at the same time. Moreover, the fastening device is further provided with a detachable auxiliary moving device, which can easily move a base during use, but the auxiliary moving device can be removed when it is not needed, which is convenient for packaging and transportation.

Abstract: The present disclosure relates generally to the fields of oncology, virology and immunotherapy. It concerns poxviruses, specifically the highly attenuated modified vaccinia virus Ankara (MVA), and a recombinant modified vaccinia Ankara virus with deletion of vaccinia virulence factor E3 (MVA?E3L), each further modified to express human Fms-like tyrosine kinase 3 ligand (Flt3L) or GM-CSF. The disclosure relates to use of the foregoing recombinant viruses as cancer immunotherapeutic agents. The foregoing recombinant poxviruses can also be used in combination with immune checkpoint blockade therapy.

Abstract: The present invention discloses a screwdriver comprising: a main shaft; a driving mechanism, the driving mechanism comprising a driving means and a reversing means, which are coupled to each other; and a handle for input of a torque. The handle engages with the driving means. By means of the driving means, regardless of a rotation direction of the rotation means, the torque is transmitted in a predetermined direction to the main shaft and output thereby. By means of the reversing means, the predetermined direction can be altered.

Abstract: Disclosed in the present invention is a total synthesis method for vitamin A and derivative thereof and deuterated compound thereof. ?-cyclocitral is used as a starting material to produce alkenyl boronate, then the alkenyl boronate (or hydrolyzed alkenyl boric acid) is subjected to a series of reactions to produce retinal or retinal with substituent, and the retinal or retinal with substituent is further subjected to a reduction reaction to obtain vitamin A or vitamin A with substituent; the vitamin A or vitamin A with substituent is subjected to an esterification reaction to obtain vitamin A ester or vitamin A ester with substituent; or said retinal or retinal with substituent is subjected to an oxidation reaction to obtain vitamin A acid or vitamin A acid with substituent. When deuterated allenol is used, deuterated vitamin A and derivative thereof are obtained.

Abstract: The present invention relates generally to the fields of oncology, virology and immunotherapy. More particularly, it concerns the use of poxviruses, specifically the replication competent attenuated vaccinia virus with deletion of thymidine kinase (VC-TK?) with and without the expression of human Flt3L or GM-CSF as oncolytic and immunotherapy. The foregoing poxviruses can also be used in combination with immune checkpoint blocking agents. The foregoing poxviruses can also be inactivated via Heat or UV-treatment and the inactivated virus can be used as immunotherapy either alone or in combination with immune checkpoint blocking agents.

Abstract: An industrial rack apparatus includes upright support members, at least one pair of shelf beams that are supported by the upright support member, at least one shelf connected to one pair of the at least a pair of shelf beams; wherein one pair of the upright support members is positioned at one end of the rack apparatus, and the other pair of the upright support member is positioned at the opposite end of the rack apparatus; wherein each shelf beam of the at least one shelf beams is attached to two opposed upright members of the upright support members.

Abstract: The present invention relates generally to the fields of oncology, virology and immunotherapy. More particularly, it concerns the use of poxviruses, specifically the replication competent attenuated vaccinia virus with deletion of thymidine kinase (VC-TK?) with and without the expression of human Flt3L or GM-CSF as oncolytic and immunotherapy. The foregoing poxviruses can also be used in combination with immune checkpoint blocking agents. The foregoing poxviruses can also be inactivated via Heat or UV-treatment and the inactivated virus can be used as immunotherapy either alone or in combination with immune checkpoint blocking agents.

Abstract: The present disclosure relates to a modular fastener gun comprising at least a gun body that can accept any number of fastener cartridges using a same connection assembly mechanism. In one example, a fastener cartridge comprises a fastener box used to hold fasteners, the fastener box including a first alignment structure and a second alignment structure, the first alignment structure used to detachably connect the fastener cartridge to a fastener gun body, and the second alignment structure used to lock the fastener cartridge to the gun body. In this way, a plurality of fastener cartridges that each can house different fastener types, can readily be used with a same fastener gun.