Abstract: Disclosed herein are methods and compositions related to the treatment, prevention, and/or amelioration of cancer in a subject in need thereof. In particular aspects, the present technology relates to the use of poxviruses, including an engineered attenuated vaccinia vims (VACV) strain comprising a disruption of the N-terminal DNA binding domain of the E3L gene (E3L?A83N) with a deletion of thymidine kinase (E3L?83N-TK?) engineered to express an antibody specifically targeting cytotoxic T lymphocyte antigen (E3L?83N-TK?-anti-CTLA-4), alone or in combination with immune checkpoint blocking agents or immune stimulating agents, as an oncolytic and immunotherapeutic composition. In some aspects, the present technology relates to an E3L?83N-TK?-anti-CTLA-4 virus further engineered to express human Fms-like tyrosine kinase 3 ligand (hFlt3L) (E3L?83N-TK?-hFlt3L-anti-CTLA-4).

Abstract: The present invention provides a power-assisted folding knife, comprising a handle, a blade, a locking mechanism, an assisting mechanism and a second assisting mechanism. The blade is rotatably connected to the handle. The locking mechanism and the second assisting mechanism are provided inside the handle. The assisting mechanism is connected to the handle and the blade respectively. When the blade is in a folded position, the assisting mechanism and the second assisting mechanism are used for locking or unlocking the blade. When the blade is in an unfolded position, the locking mechanism is used for locking or unlocking the blade. When the power-assisted folding knife is unfolded, the assisting mechanism and the second assisting mechanism provide assisting force for the blade and/or the handle.

Abstract: Disclosed is a manual tool capable of unfolding only one work accessory. The conventional manual tools may bring hidden risk to safety with more than two work accessories that may be unfolded simultaneously.

Abstract: Disclosed herein are methods and compositions related to the treatment, prevention, and/or amelioration of cancer in a subject in need thereof. In particular aspects, the present technology relates to the use of poxviruses, including a recombinant modified vaccinia Ankara (MVA) virus or vaccinia virus with deletion of vaccinia host-range factor C7 (MVA?C7L and VACV?C7L, respectively), alone or in combination with immune checkpoint blocking agents, as an oncolytic and immunotherapeutic composition. In some embodiments, the technology of the present disclosure relates to a MVA?C7L or VACV?C7L virus further modified to express human Fms-like tyrosine kinase 3 ligand (Flt3L).

Abstract: The present invention discloses a connecting structure, a connecting method and an article containing the connecting structure. The connecting structure includes a fastener, a first connecting member adjacent to the trailing end of the fastener and a second connecting member away from the trailing end of the fastener. The second connecting member is provided with a threaded connecting hole, which in the axial direction thereof is provided with thread matching with the form of thread of the fastener and having a central angle of at least 180 degrees. The first connecting member is provided with a connecting hole, and the fastener connects the two connecting members through the threaded connecting hole and the connecting hole. The connecting method achieves quick connecting with the connecting hole of the first connecting member by preloading the fastener to the threaded connecting hole, without being affected by the assembly space.

Abstract: The present invention relates generally to the fields of oncology, virology and immunotherapy. More particularly, it concerns the use of a recombinant modified vaccinia Ankara (MVA) virus comprising an MVA harboring a human Fms-like tyrosine kinase 3 ligand (hFlt3L) (MVA-hFtl3L). The foregoing vaccinia Ankara (MVA) virus can be delivered to tumor cells of a subject afflicted with a malignant solid tumor, to treat the tumor. In a related aspect, the present disclosure concerns a recombinant modified vaccinia Ankara virus with deletion of vaccinia virulence factor E3 (MV At.E3L) modified to express human Fins-like 5 tyrosine kinase 3 ligand (hFlt3L) isolated, suitable for use as an immunotherapeutic agent against a malignant solid tumor.

Abstract: The present invention relates generally to the fields of oncology, virology and immunotherapy. More particularly, it concerns the use of poxviruses, specifically the replication competent attenuated vaccinia virus with deletion of thymidine kinase (VC-TK?) with and without the expression of human Flt3L or GM-CSF as oncolytic and immunotherapy. The foregoing poxviruses can also be used in combination with immune checkpoint blocking agents. The foregoing poxviruses can also be inactivated via Heat or UV-treatment and the inactivated virus can be used as immunotherapy either alone or in combination with immune checkpoint blocking agents.

Abstract: The present disclosure relates generally to the fields of oncology, virology and immunotherapy. It concerns poxviruses, specifically the highly attenuated modified vaccinia virus Ankara (MVA), and a recombinant modified vaccinia Ankara virus with deletion of vaccinia virulence factor E3 (MVA?E3L), each further modified to express human Fms-like tyrosine kinase 3 ligand (Flt3L) or GM-CSF. The disclosure relates to use of the foregoing recombinant viruses as cancer immunotherapeutic agents. The foregoing recombinant poxviruses can also be used in combination with immune checkpoint blockade therapy.

Abstract: The invention discloses a storage shelf, comprising upright posts (1) and transverse beams (2), and further comprising shelf boards (3), wherein first reinforcement ribs (4) are provided on the transverse beams; and the first reinforcement ribs can both reinforce the transverse beams and serve as supporting parts for the shelf boards, having a simple structure without reducing the strength of the transverse beams. The transverse beams and the upright posts are directly connected by way of clamping, and can be assembled and disassembled conveniently.

Abstract: The present disclosure relates to infection-competent, but nonreplicative inactivated modified vaccinia Ankara (MVA) and its use as immunotherapy, alone, or in combination with immune checkpoint blocking agents for the treatment of malignant solid tumors. Particular embodiments relate to inducing an immune response in a subject diagnosed with a solid malignant tumor.

Abstract: The present invention relates generally to the fields of oncology, virology and immunotherapy. More particularly, it concerns the use of poxviruses, specifically the replication competent attenuated vaccinia virus with deletion of thymidine kinase (VC-TK?) with and without the expression of human Flt3L or GM-CSF as oncolytic and immunotherapy. The foregoing poxviruses can also be used in combination with immune checkpoint blocking agents. The foregoing poxviruses can also be inactivated via Heat or UV-treatment and the inactivated virus can be used as immunotherapy either alone or in combination with immune checkpoint blocking agents.

Abstract: The present disclosure relates to modified vaccinia Ankara (MVA) virus or MVA?E3L delivered intratumorally or systemically as an anticancer immunotherapeutic agent, alone, or in combination with one or more immune checkpoint blocking agents for the treatment of malignant solid tumors. Particular embodiments relate to mobilizing the host's immune system to mount an immune response against the tumor.

Abstract: The present disclosure relates to infection-competent, but nonreplicative inactivated modified vaccinia Ankara (MVA) and its use as immunotherapy, alone, or in combination with immune checkpoint blocking agents for the treatment of malignant solid tumors. Particular embodiments relate to inducing an immune response in a subject diagnosed with a solid malignant tumor.

Abstract: A power-assisted folding knife, including: a blade holder; a blade arranged in the blade holder; a handle rotatably connected to the blade holder; a locking mechanism for locking the blade holder in an unfolded position and/or a folded position; the power-assisted folding knife further includes a power-assisting mechanism connected to the blade holder and the handle, for providing assisting power when unfolding a power-assisted folding knife. The power-assisted folding knife uses an assisting mechanism for providing assisting power when unfolding a folding knife, so as to facilitate easier unfolding of the folding knife and to allow single hand operation; the blade holder can be locked in an unfolded position and/or a folded position to ensure safe use of the power-assisted folding knife.

Abstract: The present invention provides a power-assisted folding knife, comprising a handle, a blade, a locking mechanism, an assisting mechanism and a second assisting mechanism. The blade is rotatably connected to the handle. The locking mechanism and the second assisting mechanism are provided inside the handle. The assisting mechanism is connected to the handle and the blade respectively. When the blade is in a folded position, the assisting mechanism and the second assisting mechanism are used for locking or unlocking the blade. When the blade is in an unfolded position, the locking mechanism is used for locking or unlocking the blade. When the power-assisted folding knife is unfolded, the assisting mechanism and the second assisting mechanism provide assisting force for the blade and/or the handle.

Abstract: Disclosed herein are an imaging assembly and a method of controlling the imaging assembly. The assembly includes a housing having a sensor configured to detect radiation impinging on the sensor from a plurality of directions. The assembly may employ one or more shields, including a first internal shield having a first annular body between a first inner surface and a first outer surface. The first internal shield is configured to be placed in the housing such that the first inner surface at least partially surrounds the sensor. When the first internal shield is placed in the housing, the sensor is configured to receive a first central zone radiation through a first field of view, and a first peripheral zone radiation through a first peripheral view. The assembly is configured to provide at least one of a controllable field of view and reduced background contamination in an image domain.

Abstract: A power-assisted folding knife is provided, including a blade holder, a blade arranged in the blade holder, a handle rotatably connected to the blade holder, a locking mechanism for locking the blade holder in an unfolded position and/or a folded position and a power-assisting mechanism connected to the blade holder and the handle. The power-assisted folding knife uses an assisting mechanism for providing assisting power when unfolding a folding knife, so as to facilitate easier unfolding of the folding knife and to allow single hand operation. Through the locking mechanism, the blade holder can be locked in an unfolded position and/or a folded position to ensure safe use of the power-assisted folding knife.