Abstract: The present disclosure relates to modified vaccinia Ankara (MVA) virus or MVA?E3L delivered intratumorally or systemically as an anticancer immunotherapeutic agent, alone, or in combination with one or more immune checkpoint blocking agents for the treatment of malignant solid tumors. Particular embodiments relate to mobilizing the host's immune system to mount an immune response against the tumor.

Abstract: The present disclosure relates to infection-competent, but nonreplicative inactivated modified vaccinia Ankara (MVA) and its use as immunotherapy, alone, or in combination with immune checkpoint blocking agents for the treatment of malignant solid tumors. Particular embodiments relate to inducing an immune response in a subject diagnosed with a solid malignant tumor.

Abstract: A power-assisted folding knife, including: a blade holder; a blade arranged in the blade holder; a handle rotatably connected to the blade holder; a locking mechanism for locking the blade holder in an unfolded position and/or a folded position; the power-assisted folding knife further includes a power-assisting mechanism connected to the blade holder and the handle, for providing assisting power when unfolding a power-assisted folding knife. The power-assisted folding knife uses an assisting mechanism for providing assisting power when unfolding a folding knife, so as to facilitate easier unfolding of the folding knife and to allow single hand operation; the blade holder can be locked in an unfolded position and/or a folded position to ensure safe use of the power-assisted folding knife.

Abstract: The present invention provides a power-assisted folding knife, comprising a handle, a blade, a locking mechanism, an assisting mechanism and a second assisting mechanism. The blade is rotatably connected to the handle. The locking mechanism and the second assisting mechanism are provided inside the handle. The assisting mechanism is connected to the handle and the blade respectively. When the blade is in a folded position, the assisting mechanism and the second assisting mechanism are used for locking or unlocking the blade. When the blade is in an unfolded position, the locking mechanism is used for locking or unlocking the blade. When the power-assisted folding knife is unfolded, the assisting mechanism and the second assisting mechanism provide assisting force for the blade and/or the handle.

Abstract: A power-assisted folding knife is provided, including a blade holder, a blade arranged in the blade holder, a handle rotatably connected to the blade holder, a locking mechanism for locking the blade holder in an unfolded position and/or a folded position and a power-assisting mechanism connected to the blade holder and the handle. The power-assisted folding knife uses an assisting mechanism for providing assisting power when unfolding a folding knife, so as to facilitate easier unfolding of the folding knife and to allow single hand operation. Through the locking mechanism, the blade holder can be locked in an unfolded position and/or a folded position to ensure safe use of the power-assisted folding knife.

Abstract: Disclosed herein are an imaging assembly and a method of controlling the imaging assembly. The assembly includes a housing having a sensor configured to detect radiation impinging on the sensor from a plurality of directions. The assembly may employ one or more shields, including a first internal shield having a first annular body between a first inner surface and a first outer surface. The first internal shield is configured to be placed in the housing such that the first inner surface at least partially surrounds the sensor. When the first internal shield is placed in the housing, the sensor is configured to receive a first central zone radiation through a first field of view, and a first peripheral zone radiation through a first peripheral view. The assembly is configured to provide at least one of a controllable field of view and reduced background contamination in an image domain.

Abstract: The present invention discloses a method of manufacturing a tool with a cutting edge comprising a substrate for supporting and a cladding layer for forming the cutting edge, and a transition zone connecting the substrate and the cladding layer; the method of manufacturing it includes: providing a first material used for forming the substrate and having a first side; providing a second material which is clad onto the first side by way of laser cladding to form the cladding layer, and forming a transition zone between the cladding layer and the substrate where the first material and the second material are metallurgically bonded. The tool obtained by adopting the manufacturing process according to the present invention combines the following advantages: good toughness of the cutter body, high hardness of the cutting edge, not easy breaking off of the cutter body and the cutting edge, and long service life.

Abstract: The present disclosure relates to modified vaccinia Ankara (MVA) virus or MVAAE3L delivered intratumorally or systemically as an anticancer immunotherapeutic agent, alone, or in combination with one or more immune checkpoint blocking agents for the treatment of malignant solid tumors. Particular embodiments relate to mobilizing the host's immune system to mount an immune response against the tumor.

Abstract: The present invention relates generally to the fields of oncology, virology and immunotherapy. More particularly, it concerns the use of poxviruses, specifically the replication competent attenuated vaccinia virus with deletion of thymidine kinase (VC-TK?) with and without the expression of human Flt3L or GM-CSF as oncolytic and immunotherapy. The foregoing poxviruses can also be used in combination with immune checkpoint blocking agents. The foregoing poxviruses can also be inactivated via Heat or UV-treatment and the inactivated virus can be used as immunotherapy either alone or in combination with immune checkpoint blocking agents.

Abstract: The present invention provides a multifunctional stapler including a housing, a nailing portion arranged at a front end of the housing, and a toggling device, a part of which being arranged inside the housing and a part of which extending to the outside of the housing. The nailing portion comprises: a staple feeding member arranged at a front end of the bottom of the housing, a staple feeding groove arranged on the surface at one side of the staple feeding member for receiving staples, a striking member, a part of which being inserted into the staple feeding groove, the toggling device controlling the striking member to strike the staples, and an adjusting device, a part of which being arranged outside the housing, for adjusting a depth of the staple feeding groove.

Abstract: The present invention discloses a method for manufacturing a screwdriver head, the screwdriver head including a head portion for being inserted into a slot of a screw head and a basal body for supporting the head portion; the manufacturing method including: providing the screwdriver head made of a first metal material; preparing alloying coating; coating the alloying coating on the surface of the head portion of the screwdriver head; conducting laser surface alloying treatment on the surface of the head portion coated with the alloying coating to form an alloyed layer; and conducting low temperature tempering treatment on the screwdriver head after the laser surface alloying treatment. The present invention further discloses a screwdriver head, the surface of the position at which the head portion of the screwdriver head contacts with the slot of the screw head is provided with an alloyed layer formed through the laser surface alloying treatment.

Abstract: The present invention discloses a cutting tool with a cutting edge, including a base and a cutting edge, where the cutting edge includes a laser cyclic heat treatment hardened layer, and the hardness of the hardened layer is higher than the hardness of the base. The present invention also discloses a method for manufacturing the foregoing tool.

Abstract: A method and an apparatus for displaying interactive information in a panoramic video are disclosed. The method includes determining a first interactive information display area corresponding to a perspective of a first camera position of the panoramic video; and displaying first interactive information in the first interactive information display area corresponding to the perspective of the first camera position when playing an image associated with the perspective of the first camera position. According to the present disclosure, a display position of the first interactive information is not changed along with a head turning action of a user, etc. As such, when the user wants to see the first interactive information, the user can adjust the line of sight to a determined position for viewing, thus increasing an attraction of the first interactive information display area to the user, and helping to enhance the user experience.

Abstract: The present invention discloses a cutting assembly. The cutting assembly includes a substrate, a cutting edge, and a welding portion. The substrate includes a first metal portion, and the first metal portion has a first side surface. The cutting edge is formed by overlapping a second metal portion with a third metal portion used for an edge, the second metal portion is of high-strength alloy steel and has a second side surface, and the third metal portion is of high-speed tool steel and has a third side surface. The welding portion connects the first metal portion and the second metal portion. The present invention further provides a method for manufacturing a cutting assembly, including: welding a composite steel strip to a substrate, to form a blank body of the cutting assembly; and then performing low-temperature tempering treatment on a welding portion.

Abstract: The present utility model discloses a utility knife with dual blades, comprising a housing having an opening at both ends, a blade carrier which is mounted and is movable within the housing, a movement assembly connected to the blade carrier for driving the blade carrier to respectively move in a direction towards both ends of the housing, wherein it further comprises a stop member. The blade carrier is provided with an abutment portion thereon, and the stop member has a stop portion being able to change its position with respect to the abutment portion, so that the blade carrier can move in a single direction so as to prevent the blade carrier from accidentally sliding and pushing the blade out to injure a user.