Patents by Inventor Weihan Zhang

Weihan Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Costunolide Derivatives
    Publication number: 20090131427
    Abstract: Disclosed are methods for inhibiting TNF? expression, IL-1? expression, iNOS expression, and NF-?B activity and methods for treating autoimmune disease, cancer, or atherosclerosis with a compound of the following formula:
    Type: Application
    Filed: December 16, 2008
    Publication date: May 21, 2009
    Applicant: HUTCHISON MEDIPHARMA ENTERPRISES LIMITED
    Inventors: Weiguo Su, Hong Jia, Weihan Zhang, Xiaoqiang Yan, Jifeng Duan, Tao Wang, Yu Cai
  • ANDROGRAPHIS PANICULATA EXTRACT
    Publication number: 20090117210
    Abstract: An extract of Andrographis paniculata extract containing andrographolide, 14-deoxyandrographolide, 14-deoxy-11,12-dehydroandrographolide, neoandrographolide, polysacchorides, and flavanoids. Also disclosed is a pharmaceutical composition containing such an extract and its use for treating inflammatory bowel disease.
    Type: Application
    Filed: November 4, 2008
    Publication date: May 7, 2009
    Applicant: Hutchison MediPharma Enterprises Limited
    Inventors: Jifeng Duan, Zhiming Ma, Xiaoqiang Yan, Weihan Zhang, Tao Wang, Yu Cai
  • ANDROGRAPHIS PANICULATA EXTRACT
    Publication number: 20090117209
    Abstract: An extract of Andrographis paniculata extract containing andrographolide, 14-deoxyandrographolide, 14-deoxy-11,12-dehydroandrographolide, neoandrographolide, polysacchlorides, and flavanoids. Also disclosed is a pharmaceutical composition containing such an extract and its use for treating inflammatory bowel disease.
    Type: Application
    Filed: November 2, 2007
    Publication date: May 7, 2009
    Applicant: Hutchison Medipharma Enterprises Limited
    Inventors: Jifeng Duan, Zhiming Ma, Xiaoqiang Yan, Weihan Zhang, Tao Wang, Yu Cai
  • Costunolide derivatives
    Patent number: 7488836
    Abstract: A compound of the following formula: wherein X, Y, and Z are as defined herein. Also disclosed are methods for inhibiting TNF? expression, IL-1? expression, iNOS expression, and NF-?B activity and methods for treating autoimmune disease, cancer, or atherosclerosis with such a compound.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: February 10, 2009
    Assignee: Hutchison Medipharma Enterprises Limited
    Inventors: Weiguo Su, Hong Jia, Weihan Zhang, Xiaoqiang Yan, Jifeng Duan, Tao Wang, Yu Cai
  • PYRIMIDINE DERIVATIVES
    Publication number: 20080255172
    Abstract: A compound of the following formula: wherein R1, R2, R3, R4, R5,T, U, V, X, Y, Z, G, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder, e.g., cancer or age-related macular degeneration, with such a compound.
    Type: Application
    Filed: April 16, 2008
    Publication date: October 16, 2008
    Applicant: Hutchison MediPharma Enterprises Limeted
    Inventors: Wei-Guo Su, Hong Jia, Weihan Zhang, Yumin Cui, Xiaoqiang Yan, Yongxin Ren, Jifeng Duan, Yang Sai
  • Decahydronaphthalene Compounds
    Publication number: 20080139622
    Abstract: This invention relates to a compound of the following formula: wherein R1, R2, R3, G, and Z are defined herein. It also relates to is methods of treating autoimmune disease, cancer, and atherosclerosis with such a compound.
    Type: Application
    Filed: December 11, 2007
    Publication date: June 12, 2008
    Applicant: Hutchison Medipharma Limited
    Inventors: Tao Wang, Weihan Zhang, Xiaoqiang Yan, Weiguo Su, Jifeng Duan, Yu Cai
  • Crude extracts from
    Patent number: 7341748
    Abstract: This invention relates to a method of inhibiting TNF? or IL-1? expression with an extract of Andrographis paniculata. The extract contains andrographolide, 14-deoxy-andrographolide, 14-deoxy-11,12-dehydrogen-andrographolide, and neoandrographolide.
    Type: Grant
    Filed: April 27, 2005
    Date of Patent: March 11, 2008
    Assignee: Hutchison MediPharma Enterprises Limited
    Inventors: Xiaoqiang Yan, Tao Wang, Zhiming Ma, Weihan Zhang, Jifeng Duan, Yu Cai
  • COSTUNOLIDE DERIVATIVES
    Publication number: 20080051396
    Abstract: A compound of the following formula: wherein X, Y, and Z are as defined herein. Also disclosed are methods for inhibiting TNF? expression, IL-1? expression, iNOS expression, and NF-?B activity and methods for treating autoimmune disease, cancer, or atherosclerosis with such a compound.
    Type: Application
    Filed: August 14, 2007
    Publication date: February 28, 2008
    Applicant: Hutchison Medipharma Limited
    Inventors: Weiguo Su, Hong Jia, Weihan Zhang, Xiaoqiang Yan, Jifeng Duan, Tao Wang, Yu Cai
  • DIHYDROBENZOQUINONE COMPOUNDS
    Publication number: 20070286906
    Abstract: Dihydrobenzoquinone compounds of the following formula: wherein R1, R2, R3, and R4 are defined herein. Also disclosed is a method of treating cancer with one of the dihydrobenzoquinone compounds.
    Type: Application
    Filed: April 27, 2007
    Publication date: December 13, 2007
    Applicant: Hutchison MediPharma Enterprises Limited
    Inventors: Weihan Zhang, Weiguo Su, Yumin Cui, Yongxin Ren, Xiaoqiang Yan, Jifeng Duan
  • Crude extracts from andrographis paniculata
    Publication number: 20060246156
    Abstract: This invention relates to a method of inhibiting TNF? or IL-1? expression with an extract of Andrographis paniculata. The extract contains andrographolide, 14-deoxy-andrographolide, 14-deoxy-11,12-dehydrogen-andrographolide, and neoandrographolide.
    Type: Application
    Filed: April 27, 2005
    Publication date: November 2, 2006
    Inventors: Xiaoqiang Yan, Tao Wang, Zhiming Ma, Weihan Zhang, Jifeng Duan, Yu Cai
  • Anti-cancer agents
    Publication number: 20060160895
    Abstract: This invention relates to a method of treating gastric adenocarcinoma or lung carcinoma by administering to a subject in need thereof an effective amount of an effective amount of a diterpene compound of the following formula: wherein R1, R2, R3, R4, and R5 are defined herein.
    Type: Application
    Filed: December 1, 2005
    Publication date: July 20, 2006
    Inventors: Weihui Huang, Yumin Cui, Jian Zuo, Weihan Zhang
  • Cancer chemotherapy
    Publication number: 20060110467
    Abstract: This invention relates to a method of treating cancer by administering to a subject in need thereof an effective amount of a chemotherapeutic agent and an effective amount of a diterpene compound of the following formula: wherein R1, R2, R3, R4, and R5 are defined herein.
    Type: Application
    Filed: November 8, 2005
    Publication date: May 25, 2006
    Inventors: Weihui Huang, Yumin Cui, Jian Zuo, Weihan Zhang, Weiwei Wu, Jianhua Yan
  • Benzoquinone compounds as anti-cancer agents
    Publication number: 20050288379
    Abstract: This invention relates to a method of treating certain cancers by administering an effective amount of a compound of the following formula: wherein R1, R2, R3, and R4 are defined herein.
    Type: Application
    Filed: June 17, 2005
    Publication date: December 29, 2005
    Inventors: Xiaoqiang Yan, Yumin Cui, Jianhua Yan, Weihan Zhang, Jifeng Duan, Jian Zuo
  • Cancer chemotherapy
    Publication number: 20050288378
    Abstract: This invention relates to a method of treating cancer by administering to a subject in need thereof an effective amount of a cancer chemotherapeutic agent and an effective amount of a benzoquinone compound of the following formula: wherein R1, R2, R3, and R4 are defined herein.
    Type: Application
    Filed: June 17, 2005
    Publication date: December 29, 2005
    Inventors: Xiaoqiang Yan, Yumin Cui, Weihan Zhang, Jian Zuo
  • Extract of sophora flavescens flavonoids and uses thereof
    Publication number: 20050226943
    Abstract: Compositions containing a Sophora flavescens flavonoids extract or its active ingredients, Kurarinone, 2?-methoxy-Kurarinone, and Sophoraflavanone G are described. Also disclosed is a method of treating TNF? and IL-1? related diseases using such compositions.
    Type: Application
    Filed: March 30, 2005
    Publication date: October 13, 2005
    Inventors: Xiaoqiang Yan, Yumin Cui, Tao Wang, Zhiming Ma, Ke Pan, Weihan Zhang, Weihui Huang, Jianrong Hong, Jeff Duan, Yu Cai
  • Andrographolide and analogues as inhibitors of TNFalpha and IL-1beta expression
    Publication number: 20050215628
    Abstract: This invention relates to a method of inhibiting the expression of TNF? or IL-1? with a compound of the following formula: wherein R1 and R2 are defined herein. It also relates to is a method of treating inflammatory bowel disease with such a compound.
    Type: Application
    Filed: March 11, 2005
    Publication date: September 29, 2005
    Inventors: Xiaoqiang Yan, Tao Wang, Zhiming Ma, Ke Pan, Weihan Zhang, Jianrong Hong, Jeff Duan, Yu Cai
  • 5-(hydroxymethyl) furfural and derivatives as inhibitors of TNFalpha and IL-1beta production
    Publication number: 20050124684
    Abstract: A method of inhibiting TNF? or IL-1? expression with 5-hydroxymethyl furfural and its derivatives. Also disclosed is a method of treating TNF? or IL-1? related disorders using these compounds.
    Type: Application
    Filed: August 30, 2004
    Publication date: June 9, 2005
    Inventors: Ying Du, Kevin Pan, Weihan Zhang, Xiaoqiang Yan, Jianrong Hong