Abstract: The present invention discloses a fastening device, comprising a main body and a holding part, wherein the main body constitutes a main plane, and the holding part and the main body are rotatably connected to each other; and the holding part comprises a first arm and a second arm, the first arm is provided with a first connection mechanism and a second connection mechanism, the first arm is rotatably connected to the main body via the first connection mechanism, and the second arm is rotatably connected to the first arm via the second connection mechanism. Such a fastening device can be used for the installation of floorings. Not only can the height of a handle be changed, but also the angle at which the handle is held can be changed at the same time. Moreover, the fastening device is further provided with a detachable auxiliary moving device, which can easily move a base during use, but the auxiliary moving device can be removed when it is not needed, which is convenient for packaging and transportation.

Abstract: The present disclosure relates generally to the fields of oncology, virology and immunotherapy. It concerns poxviruses, specifically the highly attenuated modified vaccinia virus Ankara (MVA), and a recombinant modified vaccinia Ankara virus with deletion of vaccinia virulence factor E3 (MVA?E3L), each further modified to express human Fms-like tyrosine kinase 3 ligand (Flt3L) or GM-CSF. The disclosure relates to use of the foregoing recombinant viruses as cancer immunotherapeutic agents. The foregoing recombinant poxviruses can also be used in combination with immune checkpoint blockade therapy.

Abstract: The present invention discloses a screwdriver comprising: a main shaft; a driving mechanism, the driving mechanism comprising a driving means and a reversing means, which are coupled to each other; and a handle for input of a torque. The handle engages with the driving means. By means of the driving means, regardless of a rotation direction of the rotation means, the torque is transmitted in a predetermined direction to the main shaft and output thereby. By means of the reversing means, the predetermined direction can be altered.

Abstract: Disclosed in the present invention is a total synthesis method for vitamin A and derivative thereof and deuterated compound thereof. ?-cyclocitral is used as a starting material to produce alkenyl boronate, then the alkenyl boronate (or hydrolyzed alkenyl boric acid) is subjected to a series of reactions to produce retinal or retinal with substituent, and the retinal or retinal with substituent is further subjected to a reduction reaction to obtain vitamin A or vitamin A with substituent; the vitamin A or vitamin A with substituent is subjected to an esterification reaction to obtain vitamin A ester or vitamin A ester with substituent; or said retinal or retinal with substituent is subjected to an oxidation reaction to obtain vitamin A acid or vitamin A acid with substituent. When deuterated allenol is used, deuterated vitamin A and derivative thereof are obtained.

Abstract: The present invention relates generally to the fields of oncology, virology and immunotherapy. More particularly, it concerns the use of poxviruses, specifically the replication competent attenuated vaccinia virus with deletion of thymidine kinase (VC-TK?) with and without the expression of human Flt3L or GM-CSF as oncolytic and immunotherapy. The foregoing poxviruses can also be used in combination with immune checkpoint blocking agents. The foregoing poxviruses can also be inactivated via Heat or UV-treatment and the inactivated virus can be used as immunotherapy either alone or in combination with immune checkpoint blocking agents.

Abstract: An industrial rack apparatus includes upright support members, at least one pair of shelf beams that are supported by the upright support member, at least one shelf connected to one pair of the at least a pair of shelf beams; wherein one pair of the upright support members is positioned at one end of the rack apparatus, and the other pair of the upright support member is positioned at the opposite end of the rack apparatus; wherein each shelf beam of the at least one shelf beams is attached to two opposed upright members of the upright support members.

Abstract: The present invention relates generally to the fields of oncology, virology and immunotherapy. More particularly, it concerns the use of poxviruses, specifically the replication competent attenuated vaccinia virus with deletion of thymidine kinase (VC-TK?) with and without the expression of human Flt3L or GM-CSF as oncolytic and immunotherapy. The foregoing poxviruses can also be used in combination with immune checkpoint blocking agents. The foregoing poxviruses can also be inactivated via Heat or UV-treatment and the inactivated virus can be used as immunotherapy either alone or in combination with immune checkpoint blocking agents.

Abstract: The present disclosure relates to a modular fastener gun comprising at least a gun body that can accept any number of fastener cartridges using a same connection assembly mechanism. In one example, a fastener cartridge comprises a fastener box used to hold fasteners, the fastener box including a first alignment structure and a second alignment structure, the first alignment structure used to detachably connect the fastener cartridge to a fastener gun body, and the second alignment structure used to lock the fastener cartridge to the gun body. In this way, a plurality of fastener cartridges that each can house different fastener types, can readily be used with a same fastener gun.

Abstract: The present invention discloses a hybrid nail gun, which comprises a power component and a drive component, wherein the power component is driven by the drive component, and the drive component comprises at least a gas driven device and an electric driven device. The present invention may be used as a pneumatic nail gun when it can be connected to a gas source. The present invention may use a power source to drive the power component to complete a nailing action when it is impossible or inconvenient to connect a gas source. The present invention can flexibly adapt to different work scenarios without the need to change different types of nail guns. Therefore, the work efficiency is improved and the cost is reduced.

Abstract: The present disclosure provides a method and system for a dynamic fluoroscopy of a C-shaped arm device. The method comprises: photographing a subject during a photography cycle, obtaining, during the photography cycle, first fluoroscopic data of a radiation source irradiating the subject at a first energy, and obtaining second fluoroscopic data of the radiation source irradiating the subject at a second energy different from the first energy (210); photographing the subject in multiple successive photography cycles (220); and displaying a dynamic image of the subject based on the first fluoroscopic data and the second fluoroscopic data obtained in each of the multiple successive photography cycles (230).

Abstract: The present invention relates to a nailing device, which includes a nail gun and a support frame. The nail gun has a nail ejection portion, and the nail ejection portion is used to provide a nail ejection channel to drive a nail out. The support frame has a support surface. The support frame is used to support the nail gun. The support frame is adjustably connected to the nail gun. The nailing device of the present invention can, after the support frame is connected to the nail gun, help the nail gun to stably perform inclined nailing, which can be used as a nail gun for nailing a flooring. The support frame and the nail gun may be in a quick-change connection, which is convenient to use. The position where the support frame is connected to the nail gun is adjustable, which is applicable to edge nailing of plates with different thicknesses, and the scope of application is enlarged. The nailing device of the present invention has a simple structure and low production costs, and is economical and practical.

Abstract: The present invention discloses a fastening device, comprising a main body and a holding part, wherein the main body constitutes a main plane, and the holding part and the main body are rotatably connected to each other; and the holding part comprises a first arm and a second arm, the first arm is provided with a first connection mechanism and a second connection mechanism, the first arm is rotatably connected to the main body via the first connection mechanism, and the second arm is rotatably connected to the first arm via the second connection mechanism. Such a fastening device can be used for the installation of floorings. Not only can the height of a handle be changed, but also the angle at which the handle is held can be changed at the same time. Moreover, the fastening device is further provided with a detachable auxiliary moving device, which can easily move a base during use, but the auxiliary moving device can be removed when it is not needed, which is convenient for packaging and transportation.

Abstract: A method and an apparatus for displaying interactive information in a panoramic video are disclosed. The method includes determining a first interactive information display area corresponding to a perspective of a first camera position of the panoramic video; and displaying first interactive information in the first interactive information display area corresponding to the perspective of the first camera position when playing an image associated with the perspective of the first camera position. According to the present disclosure, a display position of the first interactive information is not changed along with a head turning action of a user, etc. As such, when the user wants to see the first interactive information, the user can adjust the line of sight to a determined position for viewing, thus increasing an attraction of the first interactive information display area to the user, and helping to enhance the user experience.

Abstract: The present invention provides a laser ranging apparatus, including: a holder, a measuring part mounted to the holder, and a housing detachably connected to the holder, wherein the housing includes a first casing. The first casing is an integrally formed tubular structure detachably sleeved outside the holder. An advantage of the present invention is to provide a laser ranging apparatus for fixedly mounting a measuring component on a holder and installing a detachable casing on the outside of the holder so as to ensure that the position of the measuring component will not be moved during the disassembly and assembly of the casing and the ranging precision of the measuring part will not be affected. The casing is composed of several simple components, which can effectively reduce the process difficulty of the casing parts.

Abstract: The present disclosure relates generally to the fields of oncology, virology and immunotherapy. It concerns poxviruses, specifically the highly attenuated modified vaccinia virus Ankara (MVA), and a recombinant modified vaccinia Ankara virus with deletion of vaccinia virulence factor E3 (MVA?E3L), each further modified to express human Fms-like tyrosine kinase 3 ligand (Flt3L) or GM-CSF. The disclosure relates to use of the foregoing recombinant viruses as cancer immunotherapeutic agents. The foregoing recombinant poxviruses can also be used in combination with immune checkpoint blockade therapy.

Abstract: A method of manufacturing a cutting member include cutting a first metal material to form a first portion of the cutting member; cutting second metal material to form a second portion of the cutting member, wherein a first edge of the second portion has at least two line segments, a curve formed by the at least two line segments being mathematically continuously differentiable; welding the first portion and the second portion together; raising the cutting member blank to a first temperature at a first rate and holding raising the cutting member blank from the first temperature to a second temperature at a second rate lower than the first rate and holding, and raising the cutting member blank from the second temperature to a third temperature at a third rate not higher than the second rate and holding.

Abstract: The present invention discloses a A bidirectional mechanical converting unit, comprising includes: a main shaft; a driving mechanism, which including a driving means assembly and a reversing means assembly which are coupled to each other; and a rotation means assembly for inputting torque, an rotation axis of the rotation means assembly being coaxial with the main shaft, the rotation means assembly and the driving mechanism being coupled to each other, and the driving mechanism delivering the torque to output at the main shaft at a predetermined direction, no matter in which direction the rotation means assembly rotates; wherein the predetermined direction can be switched via the reversing means assembly. The present invention is simple structured, not only can efficiently utilizes the movements of the rotation means in either way, but also can switch the rotation direction of the output shaft conveniently upon demand, with easy operations.