Abstract: The present disclosure relates generally to the fields of oncology, virology and immunotherapy. It concerns poxviruses, specifically the highly attenuated modified vaccinia virus Ankara (MVA), and a recombinant modified vaccinia Ankara virus with deletion of vaccinia virulence factor E3 (MVA?E3L), each further modified to express human Fms-like tyrosine kinase 3 ligand (Flt3L) or GM-CSF. The disclosure relates to use of the foregoing recombinant viruses as cancer immunotherapeutic agents. The foregoing recombinant poxviruses can also be used in combination with immune checkpoint blockade therapy.

Abstract: The present invention discloses a stud sensor, which is used for detecting the object hidden behind a surface, including a first capacitor plate, a second capacitor plate, a first detection circuit coupled to the first capacitor plate, a second detection circuit coupled to the second capacitor plate and a micro control unit. The first detection circuit processes the voltage signal corresponding to the first capacitance of the first capacitor plate and outputs a first voltage signal to the micro control unit. The second detection circuit processes the voltage signal corresponding to the second capacitance of the second capacitor plate and outputs a second voltage signal to the micro control unit. The micro control unit compares the first voltage signal and the second voltage signal to determine the position information including the central position of the object.

Abstract: Disclosed herein are an imaging assembly and a method of controlling the imaging assembly. The assembly includes a housing having a sensor configured to detect radiation impinging on the sensor from a plurality of directions. The assembly may employ one or more shields, including a first internal shield having a first annular body between a first inner surface and a first outer surface. The first internal shield is configured to be placed in the housing such that the first inner surface at least partially surrounds the sensor. When the first internal shield is placed in the housing, the sensor is configured to receive a first central zone radiation through a first field of view, and a first peripheral zone radiation through a first peripheral view. The assembly is configured to provide at least one of a controllable field of view and reduced background contamination in an image domain.

Abstract: The present invention provides a retractable cutting tool, which includes: a cutting tool housing, the interior thereof forming a cavity; a blade exit portal, penetrating through the cutting tool housing and communicating with the cavity; a blade holder, moved or locked in the cutting tool housing; a blade, mounted to the blade holder and disposed opposite the blade exit portal; when the blade holder is moved, the front end of the blade protrudes out of the cutting tool housing or retracts into the cutting tool housing through the blade exit portal; a blade holder moving device, for moving the blade holder in the cutting tool housing; and a protrusion length control device, for controlling the protrusion length of the blade outside the cutting tool housing.

Abstract: The present invention provides a cleaning tool comprising a tool head device and a handle portion, the tool head device comprises a cutting edge, and the handle portion is rotatably connected to the tool head device; the cutting edge is exposed outside of the handle portion in the use state; and the cutting edge is entirely or partially covered by the handle portion in the non-use state.

Abstract: The present invention provides a cleaning tool comprising a tool head device and a handle portion, the tool head device comprises a cutting edge, and the handle portion is rotatably connected to the tool head device; the cutting edge is exposed outside of the handle portion in the use state; and the cutting edge is entirely or partially covered by the handle portion in the non-use state.

Abstract: The present invention discloses a utility knife, which includes a housing that has an internal chamber; a blade carrier for carrying a single blade; a locking piece for locking the single blade in the blade carrier; and a spare blade cartridge for storing more than one spare blade. The blade carrier, the locking piece and the spare blade cartridge are arranged in the internal chamber. The blade carrier is arranged to be movable between a first position and a second position, and when the blade carrier is at the first position, the blade carried by the blade carrier extends out of the housing, when the blade carrier is at the second position, the blade carried by the blade carrier retracts into the housing.

Abstract: The present invention provides STING crystals. The present invention also provides STING modulators that interact with sites present in and/or defined by such crystals. The present invention also provides methods of making and using such crystals and modulators. Other aspects and/or features of the present invention will be apparent to those skilled in the art, reading the present specification.

Abstract: The invention discloses a storage shelf, comprising upright posts (1) and transverse beams (2), and further comprising shelf boards (3), wherein first reinforcement ribs (4) are provided on the transverse beams; and the first reinforcement ribs can both reinforce the transverse beams and serve as supporting parts for the shelf boards, having a simple structure without reducing the strength of the transverse beams. The transverse beams and the upright posts are directly connected by way of clamping, and can be assembled and disassembled conveniently.

Abstract: Disclosed is a manual tool capable of unfolding only one work accessory. The conventional manual tools may bring hidden risk to safety with more than two work accessories that may be unfolded simultaneously.

Abstract: The present disclosure relates to infection-competent, but nonreplicative inactivated modified vaccinia Ankara (MVA) and its use as immunotherapy, alone, or in combination with immune checkpoint blocking agents for the treatment of malignant solid tumors. Particular embodiments relate to inducing an immune response in a subject diagnosed with a solid malignant tumor.

Abstract: The present invention first provides a utility knife with a replaceable blade, comprising a knife handle, a blade holder, a blade and a locking device that locks the blade in the blade holder. The blade holder and the blade are enabled to switch between a first position and a second position. When the blade holder and the blade are in the first position, the blade is used for cutting operation, and when the blade holder and the blade are in the second position, both the blade holder and the blade are received in the knife handle. The utility knife further includes a restriction means which is thus arranged as, when the blade holder is in the second position and the locking device is in unlocked state, the restriction means is used for preventing the detachment of the blade from the blade holder by confining the movement of the blade relative to the blade holder.

Abstract: An imaging assembly includes a radiation camera configured to obtain position-sensitive radiation data of at least one source of interest. The assembly includes a controller includes a processor and tangible, non-transitory memory on which is recorded instructions for executing a method for reducing background interference in the position-sensitive radiation data in an image domain. The controller is programmed to generate a first set of image data (G1) from the position-sensitive radiation data with a first energy window. A second set of image data (G2) is generated from the position-sensitive radiation data with a second energy window such that the second energy window does not overlap with the first energy window. A third set of image data (G3) is generated having reduced background interference, based at least partially on the first and second sets of image data.

Abstract: The present invention provides a screwdriver which includes a shaft, a handle and a speed increasing mechanism, in which the speed increasing mechanism includes a central axle connected to the shaft and provided with a toothed part on its periphery, a first member is disposed in the interior of the handle, at least one gear is connected to the first member, and a geared sleeve is sheathed outside the gear, in which the inner side of the geared sleeve has teeth on corresponding positions, engaging with the gear which is disposed at a side part of the central axle and is engaged with the toothed part of the periphery of the central axle. The present invention also includes a locking mechanism addressing the problem of torque being not high.

Abstract: The present disclosure relates to modified vaccinia Ankara (MVA) virus or MVAAE3L delivered intratumorally or systemically as an anticancer immunotherapeutic agent, alone, or in combination with one or more immune checkpoint blocking agents for the treatment of malignant solid tumors. Particular embodiments relate to mobilizing the host's immune system to mount an immune response against the tumor.

Abstract: A screwdriver, comprising a driver bit sleeve, wherein an inner hole of the driver bit sleeve is arranged to be capable of receiving only one driver bit in a working position, the inner hole includes a torque transmission segment located in a front part and a first guiding segment located in a rear part, and an inner wall of the first guiding segment is arranged as a guiding surface.

Abstract: A manual tool capable of unfolding only one work accessory comprises a handle (11, 21), a first work accessory (12, 22) and a second work accessory (13, 23) that are connected to the handle through a pivot and can be unfolded and folded, and an associated accessory (14, 24). The associated accessory can transform the working state from a folding state to an unfolding state. When the first work accessory and the second work accessory are both folded, the associated accessory does not prevent any work accessory from unfolding; and when one of the two work accessories is unfolded and the other one is folded, the associated accessory prevents the other one from unfolding, so as to ensure that only one work accessory can be unfolded during use, thereby eliminating the safety risk caused by unfolding multiple work accessories at the same time.

Abstract: An imaging assembly includes a radiation camera configured to obtain position-sensitive radiation data of at least one source of interest. The assembly includes a controller includes a processor and tangible, non-transitory memory on which is recorded instructions for executing a method for reducing background interference in the position-sensitive radiation data in an image domain. The controller is programmed to generate a first set of image data (G1) from the position-sensitive radiation data with a first energy window. A second set of image data (G2) is generated from the position-sensitive radiation data with a second energy window such that the second energy window does not overlap with the first energy window. A third set of image data (G3) is generated having reduced background interference, based at least partially on the first and second sets of image data.

Abstract: The present invention provides a power-assisted folding knife, including: a blade holder; a blade arranged in the blade holder; a handle rotatably connected to the blade holder; a locking mechanism for locking the blade holder in an unfolded position and/or a folded position; the power-assisted folding knife further includes a power-assisting mechanism connected to the blade holder and the handle, for providing assisting power when unfolding a power-assisted folding knife. The power-assisted folding knife in the present invention uses an assisting mechanism for providing assisting power when unfolding a folding knife, so as to facilitate easier unfolding of the folding knife and to allow single hand operation; the blade holder can be locked in an unfolded position and/or a folded position to ensure safe use of the power-assisted folding knife.

Abstract: A screwdriver, including driver bit sleeve, revolving wheel-shaped driver bit holder and pushrod, the revolving wheel-shaped screwdriver bit holder is rotatably arranged at the rear side of the driver bit sleeve, the revolving wheel-shaped driver bit holder is distributed with axial containing hole containing driver bit and the containing hole can be turned to axially coincide with the inner hole of the driver bit sleeve; pushrod is arranged at the rear side of the revolving wheel-shaped driver bit holder and axially coincides with the inner hole of the driver bit sleeve, the inner hole of the driver bit sleeve includes torque transmission segment at the front part and guiding segment at the rear part, the hole wall of the guiding segment is arranged as guiding surface; and it can also include handle, pushbutton set, pushrod which extends into one of containing holes of driver bit holder when pushbutton set is positioned at first positioning portion of the front part of slideway on the handle, pushing the dri